Protein Alignment Mi-2 and CHR8

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001324142.1
• Gene: CHR8 / 816391
• AraportID: AT2G18760
• Length: 1246
• Species: Arabidopsis thaliana
• Alignment Length: 1552
• Identity: 348/1552 - (22%)
• Similarity: 575/1552 - (37%)
• Gaps: 493/1552 - (31%)

  Fly    41 DEDDDY-----------DPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNE-----SEEDSDFVQH 89
            :||:|.           :|||..:|...:..|....:|.|..::|..:.|     |...::.:..
plant     2 EEDEDQFLLSSLGVTSANPEDLEQKILDEATKKPDNDEGGSVEEKSTQLEGTNLLSSSQNELLNK 66

  Fly    90 DEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKA 154
            ...|::                  |.::.:|.:.:|:::.:...:...:    |.:||.|.:..|
plant    67 LRAVKF------------------EIDAVASTVENVDEIAAEKGLKKDD----ESDLQGLHSGSA 109

  Fly   155 FMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEE 219
            ..|           .:|..:|..|...|          ||.|             :.:||...:.
plant   110 LQH-----------ALATDRLRSLKKRK----------IQLE-------------KELTGLHGQS 140

  Fly   220 PRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPS---GKVPTLKIKLLGKR 281
            ..||....|     :..:.|:|         ||..||  :.|:.|:||   ||    |:|::..|
plant   141 ASSSADHGN-----LLRDLVKE---------KPSLKR--KLKEIRKPSRRDGK----KVKVVSFR 185

  Fly   282 KRDSSDEEQDASGA----SERDSDLE------------FERMLQKSDDSADEKEAPVSSKADNSA 330
            :....|...|.:.|    :|||..:.            |||.||:...|
plant   186 EDTDFDAVFDGASAGFVETERDELVRKGILTPFHKLDGFERRLQQPGPS---------------- 234

  Fly   331 PAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDT 395
                                            .::|.|||:|   |::|        ..||
plant   235 --------------------------------NSRNLPEGDD---ENED--------SSII---- 252

  Fly   396 CPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAY 460
             .||...:.|                      ||:             .:...:||..:..|.
plant   253 -DRAVQSMSL----------------------AAK-------------ARPTTKLLDAEDLPK-- 279

  Fly   461 HTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYF 525
                |.||  |.|   :|           :..|:  ::.....:::......|.|:..:|
plant   280 ----LEPP--TAP---FR-----------RLRKL--YKTPNSPDNEAKKRKAGKKSKKTR----- 317

  Fly   526 IKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGM 590
                                   ||..:.::                      |||.|  :...:
plant   318 -----------------------PLPEKKWR----------------------KRISR--EDSSL 335

  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMY---LVKWRELPYDKSTWEEEGDDI 652
            :.:|.|.:|:        .|: :.:..|||.....|.|..:   |.|:...|:
plant   336 QGSDKAVILD--------LPD-VEISHVINAMLLSDKSQQFLPMLSKFFFFPH------------ 379

  Fly   653 QGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKY 717
            ..|.:...|  |:.:.|.......|...:....:.:|...||.|                   ..
plant   380 LSLCKPTSY--DVDSCCNVSGDGRRILTTSSCEEEELDDFDDAD-------------------DN 423

  Fly   718 EDQPAFLEGTGM--------QLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSL- 773
            |.....||| |:        :|..||..|:.||.....|....|:.||||||||||.::||.||
plant   424 ERSSVQLEG-GLNIPECIFRKLFDYQRVGVQWLWELHCQRAGGIIGDEMGLGKTIQVLSFLGSLH 487

  Fly   774 ----YKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYC-ITYIGDKDS---RAVIRENELSFE- 829
                ||      |.::..|::.|..|.||.:.|.|||:. |.:...:||   :...:.:|..::
plant   488 FSKMYK------PSIIICPVTLLRQWRREAQKWYPDFHVEILHDSAQDSGHGKGQGKASESDYDS 546

  Fly   830 EGAIRGSKVSRLRTTQ-----------YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKS 883
            |.::......:.:.|:           .:..:|:|:||.:.:....|.:|:|...|:||.||:::
plant   547 ESSVDSDHEPKSKNTKKWDSLLNRVLNSESGLLITTYEQLRLQGEKLLNIEWGYAVLDEGHRIRN 611

  Fly   884 NQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEF---------AD 939
            ..|....:.......:::::||.|:||.|.||:.|.:|:...|...|..|:.||         |:
plant   612 PNSDITLVCKQLQTVHRIIMTGAPIQNKLTELWSLFDFVFPGKLGVLPVFEAEFSVPITVGGYAN 676

  Fly   940 VSKEEQVKR-------LHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK-FILTKN 996
            .| ..||..       |.:::.|::|||:|.||..::..|:|.::...|:..|:..|: |:.:..
plant   677 AS-PLQVSTAYRCAVVLRDLIMPYLLRRMKADVNAHLTKKTEHVLFCSLTVEQRSTYRAFLASSE 740

  Fly   997 YEAL-----NSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLV 1056
            .|.:     ||..|      |::|   :|.||||.|............|.       .:.:||:.
plant   741 VEQIFDGNRNSLYG------IDVM---RKICNHPDLLEREHSHQNPDYGN-------PERSGKMK 789

  Fly  1057 LLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQ 1121
            :::::||..|.|.||||:|||..:||||||.||...:|.|.|:||......|...||.|| ....
plant   790 VVAEVLKVWKQQGHRVLLFSQTQQMLDILESFLVANEYSYRRMDGLTPVKQRMALIDEFN-NSED 853

  Fly  1122 QFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEER 1186
            .|||:|:|:.||||.||..|:.|||:|.||||.||:||..||.||||...|.:||.:||.::||:
plant   854 MFVFVLTTKVGGLGTNLTGANRVIIFDPDWNPSNDMQARERAWRIGQKKDVTVYRLITRGTIEEK 918

  Fly  1187 VTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLD 1251
            |......|..||:.:::...  :...|..:::.|:.      :.|:|....|........::|.:
plant   919 VYHRQIYKHFLTNKILKNPQ--QRRFFKARDMKDLF------ILKDDGDSNASTETSNIFSQLAE 975

  Fly  1252 RTN-RGIE-EKESWANEYLSSFKVASYATKE----------EEEEEETEIIKQ--DAE------- 1295
            ..| .|:: :|:..::..|:..|.|..::::          |..:|||.|:|.  ||.
plant   976 EINIVGVQSDKKPESDTQLALHKTAEGSSEQTDVEMTDKTGEAMDEETNILKSLFDAHGIHSAVN 1040

  Fly  1296 -----NSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYT-------DGGVVAADTTRDDS 1348
                 |::.......|.|...|..:....:|.:.:.:|.:.:.:       .|...|..:.|
plant  1041 HDAIMNANDEEEKMRLEHQASQVAQRAAEALRQSRMLRSRESISVPTWTGRSGCAGAPSSVR--- 1102

  Fly  1349 NWQDNGSEYNSEYSAGSDEDGGDDDFDDQNG-----AERKAKRRLERRDDRPLPPLLARVGGNIE 1408
              :..||..||..:     ..||.....:||     :..||....|         ||.|:.|:.|
plant  1103 --RRFGSTVNSRLT-----QTGDKPSAIKNGISAGLSSGKAPSSAE---------LLNRIRGSRE 1151

  Fly  1409 -VLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLC 1464
             .:|....|              ||.:|.|.      .|.|.|.......:.:|.:|
plant  1152 QAIGVGLEQ--------------PQSSFPSS------SGSSSRVGSLQPEVLIRKIC 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	10/52 (19%)
		TNG2	<282..422	CDD:227367	24/155 (15%)
		PHD1_CHD_II	380..422	CDD:277006	5/41 (12%)
		PHD2_CHD_II	440..482	CDD:277007	9/41 (22%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	6/69 (9%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	11/56 (20%)
		PLN03142	720..>1234	CDD:215601	178/564 (32%)
		DUF1087	<1292..1334	CDD:461922	8/55 (15%)
		CHDII_SANT-like	1380..1517	CDD:461920	19/86 (22%)
		CHDCT2	1757..1902	CDD:462358
CHR8	NP_001324142.1	HepA	<435..923	CDD:440319	168/511 (33%)
		CSB_WHD	1179..1245	CDD:439329	2/10 (20%)