Protein Alignment Mi-2 and smarcal1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001072923.1
• Gene: smarcal1 / 780385
• XenbaseID: XB-GENE-493391
• Length: 942
• Species: Xenopus tropicalis
• Alignment Length: 1061
• Identity: 227/1061 - (21%)
• Similarity: 375/1061 - (35%)
• Gaps: 318/1061 - (29%)

  Fly   314 SADEKEAPVSSKADNSAPAAQDDGSG---APVVRKKAKTK---IGNKFKKKNKLKKTKNFPEGED 372
            ||....|..:|:|.||..|.|...||   ||.|...|..|   :||:
 Frog    58 SAQSINATGTSRAANSKYAFQKSPSGGNTAPSVPGAAGNKVQAVGNR------------------ 104

  Fly   373 GEHEHQDYCEVCQ--QGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCP---HCEADGGAAEEE 432
             .|:.:...:..:  :|...:               ||....|.|..:.|   |....|....:|
 Frog   105 -SHDSKSLTDPAKDVKGNYTV---------------PEAQSVPSGPSNAPNPRHLYPAGTTPGQE 153

  Fly   433 DDDEHQEFCRVCKDGGELLCCD----------SCPSAYHTFCLNP------PLD--TIPDGDWRC 479
            .......:.|    ...|..||          |..:....:...|      |:.  |:.:|..|
 Frog   154 SAKHSNSYSR----PEPLTACDNDTTGPGPLRSTTTITKFYGAGPGSKPAVPVSNKTVSEGRER- 213

  Fly   480 PRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQL 544
                  .:||.|.:.:..:.|     .|.:..:..|::.||.|                 .||..
 Frog   214 ------GVTGSAAEAVPAKKA-----SGATRGRCVKHAESRFR-----------------VEVGY 250

  Fly   545 DVHHPLMIRSFQRK-YDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGV 608
            ......:.::...| || .....:...|::..:....:|: ...|.:||.:..|         ||
 Frog   251 SAELIALFKTIPSKNYD-PATKMWNFGLEDYASLMSEVQQ-LQSVELKALEGME---------GV 304

  Fly   609 KPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQG---------LRQAIDYYQD 664
            :         |....|..|.|    ....|....:.|:.....::|         ....|.|:.:
 Frog   305 Q---------IAPPPATGGGT----NINALLAMCNNWQRPSATLRGRCILVSRSRFEMEIGYHAE 356

  Fly   665 LRAVCTSETTQSRSKKSKKGRKSKLKVEDDE-----------------DRPVKHYTPPPEKPTTD 712
            :..:.....|::...|:   ||....:||.:                 .|||.....|....||.
 Frog   357 IIGLFKQMNTRNYDTKT---RKWSFMLEDYQKLMESVRNIQQVEVEPLPRPVLQAFAPQFGKTTI 418

  Fly   713 LKKKYE--DQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYK 775
            ::::..  |........|..|.|:|.:|:|:.....|:   .:|||:||||||||.:.......|
 Frog   419 IREEIPEVDLSQVDSKLGSNLMPFQRDGVNFAVSREGR---LLLADDMGLGKTIQAICIAAYYRK 480

  Fly   776 EGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSR 840
            |    .|.||..|.|....|...|:.|.|                           :||...|
 Frog   481 E----WPLLVVAPSSVRFTWAEAFQRWLP---------------------------SIRPESV-- 512

  Fly   841 LRTTQYKFNVLLTSYE--------LISMDAACLGSID------WAVLVVDEAHRLKSNQSKFFRI 891
                    ||::|..:        ::|.|  .||.:|      :.|:::||:|.||:.::...:.
 Frog   513 --------NVIVTGRDSQSASLINIVSFD--LLGKMDKQIAATFQVIIIDESHFLKNVKTARCKA 567

  Fly   892 LNSYTIAYK--LLLTGTPLQNNLEELFHLL-----NFLSRDKFNDL---------QAFQGEFADV 940
            ......:.|  :||:|||..:...||:..:     :|..|  |:|.         ..:..:::..
 Frog   568 AMPLLKSAKRVMLLSGTPAMSRPAELYTQIAAVRPSFFPR--FHDFGIRYCDAKQMPWGWDYSGS 630

  Fly   941 SKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIV-----------RVELSAMQKKFYKFILT 994
            |...::|.|.|  ...|:||||::||..:|:|...:|           :..|:|..|:..|...:
 Frog   631 SNLNELKLLLE--ESIMIRRLKSEVLSQLPAKQRKMVVVAPEGITAKTKAALAAAAKEMAKGFKS 693

  Fly   995 K--NYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVL 1057
            |  ..|||                         .||.:...||        :|.|         :
 Frog   694 KVQEKEAL-------------------------LLFYNRTAEA--------KIRS---------V 716

  Fly  1058 LSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQ 1122
            |..::..|::...:.|:|:....:||.:.:.|..:...|.||||..:...||....:|.. ..:.
 Frog   717 LEYIMDLLESGREKFLVFAHHKLVLDHICEELGKKDVPYIRIDGNTSSADRQSLCHKFQM-SEKS 780

  Fly  1123 FVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERV 1187
            .|.:||..|..:|:.|::||.|:..:..|||...|||..|.|||||.:.|.|:..|.:.:.::.:
 Frog   781 CVAVLSITAANMGLTLSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVNIHYLVAKGTADDYL 845

  Fly  1188 TQVAKRKMMLTHLVVRPGMGG-KGANFTKQELDDILRFGTE--DLFKEDDKEEAIHYDDKAVAEL 1249
            ..:.:.|:.:.      |..| ..|||::.         ||  |.|.:|.|::.|:
 Frog   846 WPMIQEKIKVL------GQAGLSEANFSET---------TESTDYFYKDPKQKTIY--------- 886

  Fly  1250 LDRTNRGIEEK--ESWANEYL 1268
             |...|...|:  |:.|:|.|
 Frog   887 -DLFQRSFSEEGAETNADEAL 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367	25/118 (21%)
		PHD1_CHD_II	380..422	CDD:277006	6/46 (13%)
		PHD2_CHD_II	440..482	CDD:277007	10/59 (17%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	11/69 (16%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	9/62 (15%)
		PLN03142	720..>1234	CDD:215601	135/559 (24%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
smarcal1	NP_001072923.1	PTZ00436	<7..205	CDD:185616	35/184 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..214		38/200 (19%)
		HARP	244..298	CDD:462166	10/72 (14%)
		HARP	347..401	CDD:462166	8/56 (14%)
		DEXHc_HARP_SMARCAL1	439..648	CDD:350768	62/258 (24%)
		DESH box	552..555		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	647..664		8/16 (50%)
		SF2_C_SNF	711..836	CDD:350180	41/142 (29%)