Protein Alignment Mi-2 and rad54l2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001076824.1
• Gene: rad54l2 / 733747
• XenbaseID: XB-GENE-5829376
• Length: 1396
• Species: Xenopus tropicalis
• Alignment Length: 1665
• Identity: 317/1665 - (19%)
• Similarity: 540/1665 - (32%)
• Gaps: 653/1665 - (39%)

  Fly   211 SVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKI 275
            |::|.|||          ..|:|:.||..::|:::||||::
 Frog     5 SISGSEPE----------LDPEDMEEEEEDDEDDDEEEEEE------------------------ 35

  Fly   276 KLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKA--DNSAPAAQDDGS 338
                       ::|:|..|..|.|.    :.:.:||.::|..:::|...:.  ..|..:.| .|.
 Frog    36 -----------EDEEDNDGDDEDDK----QDINEKSQNAALGEDSPEQGEEGWKRSTTSGQ-SGQ 84

  Fly   339 GAPVVRKKAKTKIGN------KFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCP 397
            .:...:||...|..|      |..::::|:......:.|:.|...:    :.||..:..|..|.|
 Frog    85 ESDEAKKKRLQKPANLRRNIRKLLREDQLESVTKTAQQEELERRKR----LEQQRKDYPLPLTLP 145

  Fly   398 RAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHT 462
            ..        .||                 ..:||.:....:..::.| ..|::|.||
 Frog   146 PV--------SLD-----------------FLQEEIELRAADVSQLVK-SQEIICLDS------- 177

  Fly   463 FCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIK 527
                                                            |.|..:...:|:.:.||
 Frog   178 ------------------------------------------------SSGESDDEGKVKSHSIK 194

  Fly   528 WHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKA 592
                        .|:                        .|.|..|.|             .::.
 Frog   195 ------------DEI------------------------IELSSGEED-------------NLQI 210

  Fly   593 NDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQ 657
            :|:|:                                             ||.|.:||
 Frog   211 SDNAD---------------------------------------------STNEVDGD------- 223

  Fly   658 AIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPA 722
                       .|:|.:.|....:       |...|...|.:.:...||.:....|..:
 Frog   224 -----------ITTENSGSHVNDA-------LNQADHLGRVLVNINHPPNEKDIFLAPQ------ 264

  Fly   723 FLEGTGMQLHPYQIEGINWL---------RYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGH 778
                ....:..:||.||.:|         |:|...|...|||..||||||:|.::||..|::...
 Frog   265 ----LARAVKSHQIGGIRFLYDNLVESLERFSGSSGFGCILAHSMGLGKTLQVISFLDVLFQHTS 325

  Fly   779 CRGPFLVAVPLSTLVNWEREFELWAPD----------------FYCITYIGDKDSRAVIRE---N 824
            .: ..|..||::||.||..||.:|.|.                .:.:..:.|:......|.   |
 Frog   326 AK-TVLAIVPVNTLQNWLAEFNMWLPPPESLPKDHNQELVQPRAFKVHTMNDEHKTTAARAKVVN 389

  Fly   825 ELSFEEGA-IRGSKVSRLRTTQYKFNV-------LLTSYELISMD-----AACLGSIDWA----- 871
            :.:.:.|. :.|.::.||.:.:..|..       ......:|.:|     ...|..|:.|
 Frog   390 DWATDGGVLLMGYEMYRLLSLKKSFTAGRKKKSKKAAGPVIIDLDEEDRQQEMLKGIEKALSRPG 454

  Fly   872 --VLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ 934
              |::.||.||:|:..:...:.|.:.....:::|||.||||||.|.:.:::|:..|.....|.|.
 Frog   455 PDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFS 519

  Fly   935 GEFAD-------VSKEEQVKR--------LHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAM 984
            ..|..       |....|.||        ||.:|...:.||..|.:...:|.|.|.::.|.||.:
 Frog   520 NMFERPILNGQCVDSTPQDKRLMRYRSHVLHSLLEGFVQRRGHTVLKAQLPFKEEHVILVRLSKI 584

  Fly   985 QKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCC---NHPYLFPSAAEEATTA-------- 1038
            |:..|...:.:..:|.||...|     :|.:.....||   |||.:...|.::...|
 Frog   585 QRDLYTEFMNRFRDAGNSGWLG-----LNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVE 644

  Fly  1039 -----------AGGL-YEINSLTKAAG-------------------------------------- 1053
                       :|.: .|.|||....|
 Frog   645 DLGTNNRCNAQSGKIKVEPNSLGALMGETAHTKQLQGIVLNPSHEKANQVVTYEWAKEILSDYIP 709

  Fly  1054 -------KLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFL--------------EGEQY--- 1094
                   |:|||..::::......::|:|||....|.|:|:||              ||..:
 Frog   710 GQLQNSPKMVLLFHLIEESMRMGDKILVFSQSLSTLSIMEEFLAKRKMPIPAGSDGQEGHTWIRN 774

  Fly  1095 -KYERIDGGITGTLRQEAIDRFNAPGAQQ-FVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI 1157
             .|.|:||..:.:.|:..|::||.|..:: ::||||||||.||:||..|:.|:::|:.|||.:|.
 Frog   775 VNYYRLDGSTSASERERLINQFNDPSNEKVWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDA 839

  Fly  1158 QAFSRAHRIGQANKVMIYRFVTRNSVEERV--TQVAKRKMMLTHLVVRPGMGGK-------GANF 1213
            ||..|.:|.||.....|||.|:..::|:::  .|:.|:           ||..:       ..||
 Frog   840 QAVCRVYRYGQRKPCYIYRLVSDFTLEKKIYDRQITKQ-----------GMSDRVVDDLNPEVNF 893

  Fly  1214 TKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYAT 1278
            |::|::::|.|     .:|:......|.|..:..|       .:.:|......:|        .|
 Frog   894 TRREVENLLHF-----VEEEPDASRQHLDSSSFHE-------AVLQKACLQYPHL--------IT 938

  Fly  1279 KEEEEEEETEIIKQD-----AENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGV 1338
            ||..:.|...:.:::     ||.       |..:..||:.:             |..|.||
 Frog   939 KEPFQHESLLLDRKEQKLTLAEK-------KAAKRGYEEEK-------------RASVPYT---- 979

  Fly  1339 VAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARV 1403
                           ...|...|.|.....|....|..::.      |.|.:.||||:..
 Frog   980 ---------------RPSYTQYYPAPDHNLGNIPAFSQRHW------RPLMKGDDRPVAS----- 1018

  Fly  1404 GGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLC--EP 1466
                                                 ||.|:...       :.:..||:.  .|
 Frog  1019 -------------------------------------VRPLQSTP-------IPMLPRHVSVNHP 1039

  Fly  1467 GADNAETFADGVP-----REGLSRQHVLTRIGVM-------SLIRKKVQEFEHINGYYSMPELIL 1519
            |:.:|.......|     |.|:..|.|:|...::       :.::.::...|.|:.........:
 Frog  1040 GSASASVHPYNFPVNYLQRAGVLVQKVVTTTDIVIPGMTTSTDVQARISAGESIHVIRGTKGTYI 1104

  Fly  1520 KPCE----PVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSE 1580
            :..:    .:|::.||         ..|.|.:.||        :.|..|.||....|
 Frog  1105 RTSDGRIFAIRASGKQ---------KSGEVRRQAT--------SGAQGSSAPYLSNG-------- 1144

  Fly  1581 KEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAK----------- 1634
              :..||:     ..:|::|:..:|               ..|...|:..|:.|
 Frog  1145 --RHSTSS-----PSQQDSEDPPRP---------------LSPDSPEILNELQKYADAAAARGSH 1187

  Fly  1635 TEPK-------EETKDPEVKEEPKTEEKEKEKVDDKKPIP 1667
            |.|:       .:..:|..|.:|:   |.|:..|.....|
 Frog  1188 TAPQLQNLGLHHQGINPAPKLQPR---KRKDPQDQSSHWP 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367	27/147 (18%)
		PHD1_CHD_II	380..422	CDD:277006	7/41 (17%)
		PHD2_CHD_II	440..482	CDD:277007	5/41 (12%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	6/69 (9%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	5/53 (9%)
		PLN03142	720..>1234	CDD:215601	168/672 (25%)
		DUF1087	<1292..1334	CDD:461922	7/46 (15%)
		CHDII_SANT-like	1380..1517	CDD:461920	22/150 (15%)
		CHDCT2	1757..1902	CDD:462358
rad54l2	NP_001076824.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		30/147 (20%)
		DEXHc_ARIP4	269..545	CDD:350827	71/276 (26%)
		HepA	<272..885	CDD:440319	161/629 (26%)
		DEAH box	461..464		2/2 (100%)
		LXXLL motif 1	549..553		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1117..1168		17/97 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1194..1250		7/34 (21%)
		LXXLL motif 2	1273..1277
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1340..1396