DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and Chd6

DIOPT Version :9

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_775544.2 Gene:Chd6 / 71389 MGIID:1918639 Length:2711 Species:Mus musculus


Alignment Length:2033 Identity:530/2033 - (26%)
Similarity:810/2033 - (39%) Gaps:562/2033 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 RKEEKQAAKEKESASSGM-----------PSVEDVCSAFSVCNVE-----------IEYSEEELQ 147
            :|:|||.:|.:....|.|           ||..| ||.....|:|           :..:|||..
Mouse     6 QKKEKQLSKLRALNHSPMSDASVNFDYKSPSPFD-CSPDQGENIEEAANHCLPHKNLYTTEEEAD 69

  Fly   148 SLTTYKAFMHH-----------VRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAG 201
            :|.:.|...|:           |:...:|:.|.                        :|||....
Mouse    70 TLFSRKLTSHNGMEDSGGRGTGVKKKRKKKEPG------------------------EQEGTKGS 110

  Fly   202 SGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRP 266
            ........|.....||:|||.::..:..|.        .:|.::::..||||:.|...|.|.   
Mouse   111 KDREPKPKRKREPKEPKEPRRAKEPKRAKE--------PKETKQKDGVKKPRKHREASGTKE--- 164

  Fly   267 SGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAP 331
                        ||.||..:|                                   ......|..
Mouse   165 ------------GKEKRSCTD-----------------------------------YGSRTKSKK 182

  Fly   332 AAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTC 396
            |:::.|. .||.|||       |.|:||:...       |..|.:|                 :.
Mouse   183 ASREQGP-TPVERKK-------KGKRKNETTV-------ESLELDH-----------------SL 215

  Fly   397 PRAYHLVCLEPELDEPPEGKWSCPHCEAD------GGAAEEEDDDEHQEFCRVCKDGGELLCCDS 455
            |        .|.|..|.|     |...||      |...:....:|..:| :|..|.||.:....
Mouse   216 P--------NPSLQSPEE-----PSESADSQKRRSGRQVKRRKYNEDLDF-KVVDDDGETIAVLG 266

  Fly   456 C--PSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSN 518
            .  .||.....|....:..|:.|           ....|||:..:..|..:...|...       
Mouse   267 AGRTSALSASTLAWQAEEPPEDD-----------ANIIEKILASKTVQEVHPGEPPFD------- 313

  Fly   519 SRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQR 583
              :..:::|:.|.||.||:|....:|                 |:.|:..:          :|:|
Mouse   314 --LELFYVKYRNFSYLHCKWATMEEL-----------------EKDPRIAQ----------KIKR 349

  Fly   584 HKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGS-----TMYLVKWRELPYDKS 643
            .::|.....:...|..|:.|     .|:::.:.|::.....:|..     |.|||||..|||::|
Mouse   350 FRNKQAQMKHIFTEPDEDLF-----NPDYIEIDRILEVAHTKDAETGEEVTHYLVKWCSLPYEES 409

  Fly   644 TWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEK 708
            |||.|.|        :|                 ..|.|:....::..|      |||.    |:
Mouse   410 TWELEED--------VD-----------------PAKVKEFESLQILPE------VKHV----ER 439

  Fly   709 PTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSL 773
            |.:|..:|.|....:....  :|..||:||:|||.::|....:.|||||||||||||::.||..:
Mouse   440 PASDAWQKLETSREYRNSN--RLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSIAFLSEI 502

  Fly   774 YKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKV 838
            :..| ..||||:..||||:.||||||..|. :...|.|.|.:.||.:|::.|:.:.:.  :|:.:
Mouse   503 FVRG-IHGPFLIIAPLSTITNWEREFRTWT-EMNAIVYHGSQISRQMIQQYEMVYRDA--QGNPL 563

  Fly   839 SRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLL 903
            |.:    :||:|::|::|:|..|...|..|.|:.:::|||||||:...|....|....:.:|:||
Mouse   564 SGV----FKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLL 624

  Fly   904 TGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKN 968
            |||||||::||||.|||||...:|....||..||.|:..|||||:|..:|.|.||||||.||.||
Mouse   625 TGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDDVEKN 689

  Fly   969 MPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSC-SLINIMMDLKKCCNHPYLFPSAA 1032
            :..|.|.|:.|||:.:|||:|:.||.||:..|...:...:. :|||.||:|:||||||||...|.
Mouse   690 LAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAE 754

  Fly  1033 E-------EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLE 1090
            |       :|.::....:::.::.:|||||||:.|:|.:|.|..|:|||||||.:.||||||:|.
Mouse   755 EKILEDFRKAHSSEASDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLI 819

  Fly  1091 GEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHN 1155
            ..:|.||||||.:.|.|||.|||||..|.:.:|||||.||||||||||..|||.||:||||||.|
Mouse   820 QRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQN 884

  Fly  1156 DIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV----RPGMGGKGANFTKQ 1216
            |:||.:|.|||||:..|.:||.:||||.|..:...|..|:.|...::    |.|........:|.
Mouse   885 DLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAILQDINRKGSTNGVQQLSKM 949

  Fly  1217 ELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEE 1281
            |::|:||.|...... |:::|...:.::.:.::|.|....|..:.....   |:|..||:.....
Mouse   950 EVEDLLRKGAYGALM-DEEDEGSKFCEEDIDQILQRRTHTITIQSEGKG---STFAKASFVASGN 1010

  Fly  1282 EEEEETEIIKQDAENSDPAY---WVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADT 1343
                     :.|....||.:   |.|:.....|.:.|.....:.: .|||||            |
Mouse  1011 ---------RTDISLDDPNFWQKWAKIAELDTEANNEKESLVIDR-PRVRKQ------------T 1053

  Fly  1344 TRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIE 1408
            ...:|..:|...|: ||..:.|||             .....|||..|..|.|.....||..|:.
Mouse  1054 KHYNSFEEDELMEF-SELDSDSDE-------------RPTRSRRLSDRARRYLRAECFRVEKNLL 1104

  Fly  1409 VLGF----------------NARQRKSFLNAIMRYGM------------------PPQD------ 1433
            :.|:                |.:..:....|::.|.:                  |.:|      
Mouse  1105 IFGWGRWKDILTHGRFKWPLNEKDMEMICRALLVYCVKHYKGDEKIKSFIWELITPSKDGQVQTL 1169

  Fly  1434 ---AFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFA----------DGVPREGLSR 1485
               :..|..:.|..:||..:|          .|..|...||:..|          ||..:.  .:
Mouse  1170 QNHSGLSAPVPRGRKGKKTKN----------QLLLPELKNADWLATCNPEVVLHDDGYKKH--LK 1222

  Fly  1486 QH---VLTRIGVMSLIRKKVQEFEHINGYYSMP----ELILKPCEPVR----------------- 1526
            ||   ||.|:.::..::.::........:...|    :::|...:.|.                 
Mouse  1223 QHCNKVLLRVRMLYYLKAEILGEAADKAFEGTPARELDVLLPDIDYVEIPVDWWDAEADKSLLIG 1287

  Fly  1527 ---------SALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKE 1582
                     :|::.|.|.......|...:||.:....||..||..|      |:|....:||.::
Mouse  1288 VFKHGYERYNAMRADPALCFLEKVGMPDEKSLSAEQGVTDGTSDIP------ERGNIDKEDSAED 1346

  Fly  1583 K----DKTSAEKS--------EVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKT 1635
            |    .|.:|..|        |.|.:.:|.:|....| |...||..|.      .|.::..|...
Mouse  1347 KLDGLQKQTASPSDGSDGIFGEKKDDSQAAQDGSDPD-KSPWPVSSAL------TARLRRLVTIY 1404

  Fly  1636 E--PKEETKDPE----------VKEE--PKTEEKE------------KEKVDDKKPIPPTTVIDD 1674
            :  .::|...||          |:||  .:|.|.:            :|:.|..:.:....|:.|
Mouse  1405 QRCNRKELCRPEILGPGNQGYWVQEEVFRRTSEMDLINKEAQKRWTRREQADFYRTVSSFGVVYD 1469

  Fly  1675 DDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMF---NIA--- 1733
                                  :::||.............|.:::|||.....|:.   |:.   
Mouse  1470 ----------------------QEKKAFDWTQFRIISRLDKKSDESLEHYFYSFVAMCRNVCRLP 1512

  Fly  1734 ---DGG--FTELHTLWLNEEKAAV-----------------------------PGREYEIWHR-- 1762
               |.|  ...::...:.||:||.                             |.....:|..  
Mouse  1513 AWKDDGPPDASIYVEPITEERAAKTLYRIELLRKVREQVLMCPQLHERLQLCRPSLYLPVWWECG 1577

  Fly  1763 RHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQA---L 1824
            :||..||.|...||..|..       :.|:|:|      :.:||:....: |:..:...||   |
Mouse  1578 KHDRDLLIGTAKHGLNRTD-------YYIMNDP------QLSFLDAYRNY-AQHKRTDTQAPGSL 1628

  Fly  1825 VIEEQLRRAAYLNLAQDP-SHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQL 1888
            ....|.....|.:|...| |..:.||.:....:..:.....||....  |..| :......::::
Mouse  1629 CCLYQSNSKLYESLTYTPVSRTSESLESEPENLMRMESRDDHLCLPE--GGLP-DITCENFVSKV 1690

  Fly  1889 EELLSDMKSDVSRLPATL 1906
            :|::| :..|.:.||.:|
Mouse  1691 QEVIS-LDHDENLLPESL 1707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 10/73 (14%)
PHD1_CHD_II 380..422 CDD:277006 6/41 (15%)
PHD2_CHD_II 440..482 CDD:277007 10/43 (23%)
CHROMO 490..558 CDD:237991 13/67 (19%)
CHROMO 615..667 CDD:214605 18/56 (32%)
SNF2_N 734..1028 CDD:278600 138/294 (47%)
DEXDc 751..907 CDD:238005 64/155 (41%)
Helicase_C 1053..1167 CDD:278689 74/113 (65%)
DUF1087 <1292..1337 CDD:283996 12/47 (26%)
DUF1086 1380..1517 CDD:283992 33/196 (17%)
CHDCT2 1756..1927 CDD:285336 35/157 (22%)
Chd6NP_775544.2 Required for DNA-dependent ATPase activity. /evidence=ECO:0000250 1..746 267/965 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 14/46 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..243 55/303 (18%)
PTZ00449 <101..372 CDD:185628 80/450 (18%)
CD1_tandem_CHD5-9_like 287..352 CDD:349315 18/111 (16%)
CD2_tandem_CHD5-9_like 371..429 CDD:349310 21/82 (26%)
PLN03142 459..>984 CDD:215601 244/533 (46%)
DEAD-like_helicase_N 460..681 CDD:391939 103/228 (45%)
DEAH box 597..600 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1318..1389 20/77 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1951..1978
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1997..2059
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2124..2147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2321..2350
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2373..2419
BRK 2402..2435 CDD:383088
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2550..2602
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2641..2711
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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