DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and Chd5

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_017449128.1	Gene:	Chd5 / 691589	RGDID:	1582725	Length:	2000	Species:	Rattus norvegicus

Alignment Length:	2131	Identity:	1108/2131 - (51%)
Similarity:	1374/2131 - (64%)	Gaps:	358/2131 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKG 65
            :.:|||....|.||.|.:|      |:|.:.|..|     :..:|:.|.:.....|.|.:|.::.
  Rat     5 LGTEEELPRLFAEEMENEE------EMSEEEDGGL-----EGFEDFFPAEPVSLPKKKPKKLKES 58

  Fly    66 EEKGRKKKKRKKN----ESEEDSDFVQHDEEVEYPSTSKRGRKRKE--EKQAAKE---------- 114
            :.||::|||...|    |:|||.:.....|..:|..|.|:.:|.||  ||:|.::
  Rat    59 KSKGKRKKKEGSNDELSENEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKAKRKKRDEDEEDNE 123

  Fly   115 ----KESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKL 175
                ||..|||....|     :.:.:|:..:||::..:||.||||...:||::.|:||||...|:
  Rat   124 DGGLKEPKSSGQLMAE-----WGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKM 183

  Fly   176 VMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVT-----------GDEPEEPRSSRSSRNE 229
            :.::.||||||..:|| .:....||.:...|....:||           ..:|...|.:::...:
  Rat   184 MTVLGAKWREFSANNP-FKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQPLPVRKAKTKEGK 247

  Fly   230 KPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKL--LGKRKRDSSDEEQDA 292
            .|      .|.::.:..::.||     .||||       :|..||.:.  :.|||:.||.||.:
  Rat   248 GP------GVRKKNKGAKDSKK-----KGRGK-------RVAGLKFRFGGISKRKKGSSSEEDE- 293

  Fly   293 SGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKK 357
                ..||||:               .|.:.|.:                ||.:....:|.|.|:
  Rat   294 ----PEDSDLD---------------NASIHSSS----------------VRSECSAALGKKNKR 323

  Fly   358 KNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHC 422
            :   :|.|...:|:..|.:|||||||||||||||||||||||||||||:|||::.||||||||||
  Rat   324 R---RKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHC 385

  Fly   423 EADG--------------GAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIP 473
            |.:|              |..|||:|| |.||||||||||||||||:|||:||..||||||..||
  Rat   386 EKEGIQWEPKDDDEEEEEGGCEEEEDD-HMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIP 449

  Fly   474 DGDWRCPRCSCPPLTGKAEKIITWRWAQRSND-----DGPSTSKGSKN----SNSRVREYFIKWH 529
            :|:|.||||:||||.||.::|:.|||.:....     .||....|...    .....||:|:||.
  Rat   450 NGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPEVEPGMPPPRPLEGIPEREFFVKWA 514

  Fly   530 NMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKAND 594
            .:|||||.||.|:||:::|.:|.|::|||.||:|||.|:....:.|.:.:: :::||.:..|
  Rat   515 GLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEK-RKNKDPLYAK--- 575

  Fly   595 DAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAI 659
                :|||||:.|:||||::|.|::||...:.|...||:||::||||:.|||.:..|       |
  Rat   576 ----MEERFYRYGIKPEWMMVHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEIDEID-------I 629

  Fly   660 DYYQDL-------RAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKY 717
            .||.:|       |.:...|..:...:..|||:|.|   :|.:::       ||:.|..|...|:
  Rat   630 PYYDNLKQTYWGHRELMLGEDARLPKRLVKKGKKLK---DDKQEK-------PPDTPIVDPTVKF 684

  Fly   718 EDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGP 782
            :.||.:::.||..|||||:||:||||:||.||.|||||||||||||:||:.||||||||||.:||
  Rat   685 DKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGP 749

  Fly   783 FLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR-GSKVSRL-RTTQ 845
            :||:.||||::|||||||:||||||.:||.|||:||:||||||.|||:.||| |.||.|: :..|
  Rat   750 YLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQ 814

  Fly   846 YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQN 910
            .||:|||||||||::|.|.||||:||.||||||||||:|||||||:||||.|.||||||||||||
  Rat   815 IKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQN 879

  Fly   911 NLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEF 975
            ||||||||||||:.::||:|:.|..||||:|||:|:|:||::||||||||||.||.||||:|:|.
  Rat   880 NLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTEL 944

  Fly   976 IVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAG 1040
            |||||||.||||:||||||:|:||||||.||...||:|||||||||||||||||.||.||.....
  Rat   945 IVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPMLPN 1009

  Fly  1041 GLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITG 1105
            |.|:.:||.|::|||:||.||||:|:.:.||||||||||||||:||||||.|.||||||||||||
  Rat  1010 GSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITG 1074

  Fly  1106 TLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQAN 1170
            .|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||..
  Rat  1075 GLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNK 1139

  Fly  1171 KVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKED-- 1233
            ||||||||||.|||||:||||||||||||||||||:|.|..:.|||||||||:||||:|||:|
  Rat  1140 KVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVE 1204

  Fly  1234 -----------------------------------------DKEEA--IHYDDKAVAELLDRTNR 1255
                                                     |.|::  |||||.|:::||||...
  Rat  1205 GMMSQGQRPTTPIPDVQSTKGGSLAAGAKKKHGGTPPGDNKDVEDSSVIHYDDAAISKLLDRNQD 1269

  Fly  1256 GIEEKE-SWANEYLSSFKVASYATKEEE--EEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDV 1317
            ..::.| ...||||||||||.|..:||:  ||.|.|:|||: ||.||.||.|||||||||.|||:
  Rat  1270 ATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQE-ENVDPDYWEKLLRHHYEQQQEDL 1333

  Fly  1318 GRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDD----QN 1378
            .|:||||||:||||||.|    |:...:....|||..|:..||||.||:::  |:||::    |:
  Rat  1334 ARNLGKGKRIRKQVNYND----ASQEDQGACEWQDELSDNQSEYSIGSEDE--DEDFEERPEGQS 1392

  Fly  1379 GAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRD 1443
            | .|:::|:|:...|:||||||||||||||||||||||||:|||||||:||||||||||.|||||
  Rat  1393 G-RRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRD 1456

  Fly  1444 LRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHI 1508
            ||||||:.|:||||||||||||||||.|||||||||||||||||||||||||||:|||||||||:
  Rat  1457 LRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHV 1521

  Fly  1509 NGYYSMPELI------LKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAP 1567
            ||.||.|:|:      .||.|.:.|                       ..|:..||:.|...|||
  Rat  1522 NGKYSTPDLVPEGPEGKKPGEVISS-----------------------DPNTPVPASPAQLPPAP 1563

  Fly  1568 ----------------ASEKGEDKDKDS--------------EKEKDKTSAEKSEVKQEQEAEED 1602
                            ..|.|..|.|.|              .::|.::|..|...::|:..|.:
  Rat  1564 LGLPADKMEAQLGYTDEKESGTQKPKKSLEIQALPTALDRVEAEDKHQSSDSKDRAREERMEEVE 1628

  Fly  1603 KKPGDVKQENPVEEAAGDTKPSDAEV--KTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKP 1665
            |..|  ..|.|::|   :|.|....|  |.|::.:...:...|     :||.||||
  Rat  1629 KAQG--SPEQPLKE---ETLPDKEPVPDKLELSLSHSNDFRPD-----DPKAEEKE--------- 1674

  Fly  1666 IPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMF 1730
              ||.           .:::|:.|:......:|:..                       |.||||
  Rat  1675 --PTE-----------TQQNGDREEDEEGKKEDKNG-----------------------KFKFMF 1703

  Fly  1731 NIADGGFTELHTLWLNEEKAAV-PGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINE 1794
            ||||||||||||||.|||:||| .|:.|||||||||||||||||||||.||||||||.|:.|:||
  Rat  1704 NIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNE 1768

  Fly  1795 PFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECL 1859
            |||.:|.|||:||:|||||||||||||||||||||||||||||:.|||:||||:||||.||||||
  Rat  1769 PFKSEVHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECL 1833

  Fly  1860 AESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSIL 1924
            |||||||||||||||||||||||||||||||||||||:||:|||:.|:||||||.||||||||||
  Rat  1834 AESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSIL 1898

  Fly  1925 SRLAATAGNASNAAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFSVPG 1975
            |||...||:           |...||    ||.|....| .:|.|.|..||
  Rat  1899 SRLTNRAGD-----------PTIQQG----AFGSSQMYN-NSFGPNFRGPG 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	22/51 (43%)
		PHD1_CHD_II	380..422	CDD:277006	37/41 (90%)
		PHD2_CHD_II	440..482	CDD:277007	32/41 (78%)
		CHROMO	490..558	CDD:237991	27/76 (36%)
		CHROMO	615..667	CDD:214605	21/58 (36%)
		SNF2_N	734..1028	CDD:278600	222/295 (75%)
		DEXDc	751..907	CDD:238005	118/157 (75%)
		Helicase_C	1053..1167	CDD:278689	101/113 (89%)
		DUF1087	<1292..1337	CDD:283996	33/44 (75%)
		DUF1086	1380..1517	CDD:283992	114/136 (84%)
		CHDCT2	1756..1927	CDD:285336	148/170 (87%)
Chd5	XP_017449128.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I517
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56712
Inparanoid	1	1.050	1991	1.000	Inparanoid score	I48
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm44821
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880