DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mi-2 and SMARCA4

DIOPT Version :10

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001122321.1 Gene:SMARCA4 / 6597 HGNCID:11100 Length:1679 Species:Homo sapiens


Alignment Length:1741 Identity:410/1741 - (23%)
Similarity:663/1741 - (38%) Gaps:587/1741 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 KRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMP 123
            :|.|........|..||.|.:|..::...   |::|.....::.|||:::.|             
Human   425 RRDTALETALNAKAYKRSKRQSLREARIT---EKLEKQQKIEQERKRRQKHQ------------- 473

  Fly   124 SVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCE 188
                            ||....||....:|.:                                 
Human   474 ----------------EYLNSILQHAKDFKEY--------------------------------- 489

  Fly   189 SNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEE--EKK 251
               |                 |||||         :..:..|....|....|.|:::|.|  ||:
Human   490 ---H-----------------RSVTG---------KIQKLTKAVATYHANTEREQKKENERIEKE 525

  Fly   252 PRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSAD 316
            ..|:.....::|.|          ||:.::|                  |.....:||::|:.  
Human   526 RMRRLMAEDEEGYR----------KLIDQKK------------------DKRLAYLLQQTDEY-- 560

  Fly   317 EKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNF--------PEGEDG 373
                 |::..:              :||:....::..:.|||.|.||.:|.        |:||..
Human   561 -----VANLTE--------------LVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPL 606

  Fly   374 EHEHQ----DYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDD 434
            :...|    ....:..:.|:|:.....|:|..   ||..|:..| |....|..:::...:|||::
Human   607 DETSQMSDLPVKVIHVESGKILTGTDAPKAGQ---LEAWLEMNP-GYEVAPRSDSEESGSEEEEE 667

  Fly   435 DEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRW 499
            :|.:|                                       .|:.:.||.....||      
Human   668 EEEEE---------------------------------------QPQAAQPPTLPVEEK------ 687

  Fly   500 AQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEP 564
                                                 :.:|:...|                   
Human   688 -------------------------------------KKIPDPDSD------------------- 696

  Fly   565 PKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGST 629
                 .:.|.|.|:                                   |::..           
Human   697 -----DVSEVDARH-----------------------------------IIENA----------- 710

  Fly   630 MYLVKWRELPYDKSTWEEEGDDIQGLRQAI-----DYYQDLRAVCTSETTQSRSKKSKKGRKSKL 689
                            :::.||..|:.||:     .||....||     |:...|:|.       
Human   711 ----------------KQDVDDEYGVSQALARGLQSYYAVAHAV-----TERVDKQSA------- 747

  Fly   690 KVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTIL 754
                                              |...|: |..|||:|:.||...:...::.||
Human   748 ----------------------------------LMVNGV-LKQYQIKGLEWLVSLYNNNLNGIL 777

  Fly   755 ADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRA 819
            ||||||||||||:..:..|.:.....||||:.||||||.||..||:.|||....::|.|..    
Human   778 ADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSP---- 838

  Fly   820 VIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSN 884
                        |.|.:.|.:||:.  |||||||:||.|..|...|..|.|..::|||.||:|::
Human   839 ------------AARRAFVPQLRSG--KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNH 889

  Fly   885 QSKFFRILNSYTIA-YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ----------GEFA 938
            ..|..::||::.:| .:||||||||||.|.||:.|||||....|.....|:          ||..
Human   890 HCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKV 954

  Fly   939 DVSKEEQ---VKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK------FILT 994
            |:::||.   ::|||::|.|.:|||||.:|...:|.|.|::::.::||:|:..|:      .:||
Human   955 DLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLT 1019

  Fly   995 KNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAE---EATTAAGGLYEINSLTKAAGKLV 1056
            ...|. :.|..||:.:|:|.:|.|:|.|||||:|....|   |.....||:.:...|.:|:||..
Human  1020 DGSEK-DKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFE 1083

  Fly  1057 LLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQ 1121
            ||.::|.:|:|.||:||:|.|||.::.|:||:.....:||.|:||......|...:..||.||::
Human  1084 LLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSE 1148

  Fly  1122 QFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEER 1186
            .|:|||||||||||:||.:||||||:|||||||.|:||..|||||||.|:|.:.|..|.|||||:
Human  1149 YFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEK 1213

  Fly  1187 VTQVAKRKMMLTHLVVRPGMGGKGAN-----------FTKQELDDILRFGT-------------- 1226
            :...||.|:.:...|::.||..:.::           ...:|.|:.....|              
Human  1214 ILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPP 1278

  Fly  1227 ----EDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKE-----EE 1282
                .||.:...|||....||:.|.:::.|..   ||.:.:....|...:..:...|.     ||
Human  1279 AGVNPDLEEPPLKEEDEVPDDETVNQMIARHE---EEFDLFMRMDLDRRREEARNPKRKPRLMEE 1340

  Fly  1283 EEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDG-------GVVA 1340
            :|..:.|||.|||         :.|...|:.:|   :..|:|.|.||:|:|:|.       ..:.
Human  1341 DELPSWIIKDDAE---------VERLTCEEEEE---KMFGRGSRHRKEVDYSDSLTEKQWLKKIT 1393

  Fly  1341 ADTTRDDSNWQDNGSEYN-----SEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLL 1400
            .....|.::....|.::.     ...::.:.|:|..::.::: ..::|:.|:.:|..|       
Human  1394 GKDIHDTASSVARGLQFQRGLQFCTRASKAIEEGTLEEIEEE-VRQKKSSRKRKRDSD------- 1450

  Fly  1401 ARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCE 1465
              .|.:.......:|.:........:.|.||.:..:..  ..:|..|.::...|.:.        
Human  1451 --AGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPN--PPNLTKKMKKIVDAVIK-------- 1503

  Fly  1466 PGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPC------EP 1524
                    :.|.      |....|:.:.:....||::.|      ||   |||.||.      |.
Human  1504 --------YKDS------SSGRQLSEVFIQLPSRKELPE------YY---ELIRKPVDFKKIKER 1545

  Fly  1525 VR-------SALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKE 1582
            :|       :.|::||..|.......|::.|....:|:.                          
Human  1546 IRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIV-------------------------- 1584

  Fly  1583 KDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVK 1647
               ..:..:.|:|:.|.|:|.:..:.::|...||...:::....:||.::.:   ||:.:|    
Human  1585 ---LQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGR---KEKAQD---- 1639

  Fly  1648 EEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKD 1698
             ..|...:...:....||     |:.|||.:     |:.|.::..:.|.:|
Human  1640 -RLKGGRRRPSRGSRAKP-----VVSDDDSE-----EEQEEDRSGSGSEED 1679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357 5/52 (10%)
TNG2 <282..422 CDD:227367 29/151 (19%)
PHD1_CHD_II 380..422 CDD:277006 10/41 (24%)
PHD2_CHD_II 440..482 CDD:277007 1/41 (2%)
CD1_tandem_CHD3-4_like 487..557 CDD:349314 4/69 (6%)
CD2_tandem_CHD3-4_like 610..664 CDD:349309 8/58 (14%)
PLN03142 720..>1234 CDD:215601 223/565 (39%)
DUF1087 <1292..1334 CDD:461922 12/41 (29%)
CHDII_SANT-like 1380..1517 CDD:461920 20/136 (15%)
CHDCT2 1757..1902 CDD:462358
SMARCA4NP_001122321.1 DEGH box 881..884 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1254..1299 8/44 (18%)
SnAC 1322..1389 CDD:464219 21/78 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1432..1492 10/71 (14%)
Bromo_SNF2L2 1490..1596 CDD:99947 27/165 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1596..1679 21/100 (21%)
KIKL. /evidence=ECO:0000269|PubMed:29567837 1628..1631 1/2 (50%)
Necessary for interaction with SS18L1/CREST. /evidence=ECO:0000250 1..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..177
Med15 42..>222 CDD:312941
QLQ 171..205 CDD:462622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..352
Smc <364..>570 CDD:440809 44/287 (15%)
HSA 460..532 CDD:214727 24/162 (15%)
RNA-binding region which is sufficient for binding to lncRNA Evf2. /evidence=ECO:0000250|UniProtKB:Q3TKT4 462..728 78/577 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..610 10/32 (31%)
BRK 612..656 CDD:197800 10/47 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 647..699 15/158 (9%)
DEXHc_SMARCA4 731..981 CDD:350820 112/314 (36%)
PLN03142 750..>1232 CDD:215601 215/501 (43%)
Sufficient for interaction with DLX1. /evidence=ECO:0000250|UniProtKB:Q3TKT4 837..916 37/96 (39%)
Blue background indicates that the domain is not in the aligned region.

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