DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mi-2 and SMARCA1

DIOPT Version :9

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001269803.1 Gene:SMARCA1 / 6594 HGNCID:11097 Length:1070 Species:Homo sapiens


Alignment Length:1252 Identity:350/1252 - (27%)
Similarity:535/1252 - (42%) Gaps:306/1252 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   507 GPSTS-----------------KGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRS 554
            |||||                 ||.|.....|..:                :::|....|     
Human    30 GPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSF----------------QLKLAAKAP----- 73

  Fly   555 FQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVI 619
               |.:.|..|::||.: :|| |.||.:....:..:.|:    .::....|:...|        :
Human    74 ---KSEKEMDPE
YEEKM-KAD-RAKRFEFLLKQTELFAH----FIQPSAQKSPTSP--------L 121

  Fly   620 NHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKG 684
            |.:..|             |..|.      |:.|.|..|.||                       
Human   122 NMKLGR-------------PRIKK------DEKQSLISAGDY----------------------- 144

  Fly   685 RKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQG 749
            |..:.:.|:||:      .....:.|:::..::|..|::::|.  .|..|||.|:|||...:..|
Human   145 RHRRTEQEEDEE------LLSESRKTSNVCIRFEVSPSYVKGG--PLRDYQIRGLNWLISLYENG 201

  Fly   750 IDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGD 814
            ::.|||||||||||:||:..|..|....:..||.:|.||.|||.||..||:.|.|....|.::||
Human   202 VNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGD 266

  Fly   815 KDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAH 879
            ||:||....:|:...|                 ::|.:||||::..:.:......|..||:||||
Human   267 KDARAAFIRDEMMPGE-----------------WDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAH 314

  Fly   880 RLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD---VS 941
            |:|:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|..   :.
Human   315 RIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLG 379

  Fly   942 KEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGG 1006
            .::.|:|||.:|.|.:|||:||||.|::|.|.|..:.:.||.||:::|..||.|:.:.|||....
Human   380 DQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKM 444

  Fly  1007 GSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS-LTKAAGKLVLLSKMLKQLKAQNH 1070
            ....|:||:|.|:|||||||||..|      ..|..|..:. :...:||:|:|.|:|.:||.|..
Human   445 DKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGS 503

  Fly  1071 RVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQ------------EAIDRFNAPGAQQF 1123
            |||||||||::||||||:.....|:|.|:||......|:            |||:.||||.:.:|
Human   504 RVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKF 568

  Fly  1124 VFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVT 1188
            :|:|||||||||||||:||.||:|||||||..|:||..|||||||...|.::|.:|.|:||||:.
Human   569 IFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIV 633

  Fly  1189 QVAKRKMMLTHLVVRPG--MGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLD 1251
            :.|:.|:.|..:|::.|  :..:.....|:|:..::|.|...:|...:.|    ..|:.:..:|:
Human   634 ERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESE----LTDEDITTILE 694

  Fly  1252 RTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQED 1316
            |.    |:|.:..||.|           ::..|......:.|.|.|       |.:...|.::|.
Human   695 RG----EKKTAEMNERL-----------QKMGESSLRNFRMDIEQS-------LYKFEGEDYREK 737

  Fly  1317 VGRSLG------KGKRVRKQVNY------------TDGGVVAADTTRDDSNWQD----------- 1352
              :.||      ..||.|| .||            ::..:..|.......|.||           
Human   738 --QKLGMVEWIEPPKRERK-ANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFEL 799

  Fly  1353 ---NGSEYNSE--YSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGF 1412
               ....|...  |....     :.|..:...|:|:.:::::..:  ||.|........:...||
Human   800 LEKEILYYRKTIGYKVPR-----NPDIPNPALAQREEQKKIDGAE--PLTPEETEEKEKLLTQGF 857

  Fly  1413 ---NARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETF 1474
               ..|....|:.|..:||....|.     :.|::.|||......|.::|.....|         
Human   858 TNWTKRDFNQFIKANEKYGRDDIDN-----IAREVEGKSPEEVMEYSAVFWERCNE--------- 908

  Fly  1475 ADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAP 1539
                                       :|:.|.|.......|..::....::.||...:|..:||
Human   909 ---------------------------LQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAP 946

  Fly  1540 PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKD--------KTSAEKSEVKQE 1596
            .....:                        :.|..|.|:..:|:|        |...::..|.:|
Human   947 FHQLRI------------------------QYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEE 987

  Fly  1597 -----QEAEEDKKPGDVKQENPVE-EAAGDT-----KPSDAEVKTEVAKTEPKEETKDP---EVK 1647
                 :.|.:.:....:|....:| :...:|     :..:.|::......:.|..||.|   :.|
Human   988 LRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMSQKRK 1052

  Fly  1648 EEPKTEEKEKEKVDDKK 1664
            .|..||...|:.|...|
Human  1053 AESATESSGKKDVKKVK 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335
PHD1_CHD_II 380..422 CDD:277006
PHD2_CHD_II 440..482 CDD:277007
CHROMO 490..558 CDD:237991 11/67 (16%)
CHROMO 615..667 CDD:214605 10/51 (20%)
SNF2_N 734..1028 CDD:278600 127/296 (43%)
DEXDc 751..907 CDD:238005 60/155 (39%)
Helicase_C 1053..1167 CDD:278689 70/125 (56%)
DUF1087 <1292..1337 CDD:283996 14/62 (23%)
DUF1086 1380..1517 CDD:283992 23/139 (17%)
CHDCT2 1756..1927 CDD:285336
SMARCA1NP_001269803.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..82 13/75 (17%)
PLN03142 87..1069 CDD:215601 333/1169 (28%)
DEAH box 311..314 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..849 6/31 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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