DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and EP400

DIOPT Version :10

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_056224.3 Gene:EP400 / 57634 HGNCID:11958 Length:3123 Species:Homo sapiens


Alignment Length:2516 Identity:437/2516 - (17%)
Similarity:685/2516 - (27%) Gaps:1161/2516 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 PSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSL-TTYKA----- 154
            |.||......|:..:..:|...||..|..:...|         ::|..:|:|:| ..:|.     
Human   335 PLTSVGNTGMKKVPKKLEEIPPASPEMAQMRKQC---------LDYHYQEMQALKEVFKEYLIEL 390

  Fly   155 -FMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPE 218
             |:.|.:            ..::..:|.|.:.:.....:::|                       
Human   391 FFLQHFQ------------GNMMDFLAFKKKHYAPLQAYLRQ----------------------- 420

  Fly   219 EPRSSRSSRNEKPDDIYEEAVEEEEEEE------------------------------------- 246
                     |:.  ||.||..|||||||                                     
Human   421 ---------NDL--DIEEEEEEEEEEEEKSEVINDEQQALAGSLVAGAGSTVETDLFKRQQAMPS 474

  Fly   247 ----EEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERM 307
                |:.|:||.:...:|...:.|.........:|:...:.......|.|..|.:|.|.      
Human   475 TGMAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQ------ 533

  Fly   308 LQKSDDSADEKEAPVSSKADNSAPAAQDDG----SGAP---------------VVRKKAKTKIGN 353
             |:.|.|..   .||.:.|....|..|..|    :|.|               ||..:.:.:|..
Human   534 -QQYDPSTG---PPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPV 594

  Fly   354 KFKKKN-----------------KLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIIL----CDTCP 397
            |.::.|                 ..:...:.|.....:.:......:.|......|    ...||
Human   595 KTQQPNVPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCP 659

  Fly   398 RAYHL--------------------------------VCLEPELDEPPEGKWSC---PHCEADGG 427
            |....                                ..|.|.....|....|.   |...|...
Human   660 RPLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNA 724

  Fly   428 AAEEEDDDE------------HQEFCRVCKDG----GELLCCDSC--PSAYHTFCLNP----PLD 470
            .:.::...:            ||....:.|.|    ..|......  |.::..:.|..    ..|
Human   725 TSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATD 789

  Fly   471 TIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGP-STSKGSKNSNSRVR----------EY 524
            ...:..|:         ...|:|::  |...|.:::.. ...:|.|...||:|          |.
Human   790 FAQERRWK---------VAAAKKLV--RTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIEC 843

  Fly   525 FIKWHNMSYWHCEWVPEVQLDVH------HPLMIRSFQRKYDMEEPPKF----EESLDEADTRYK 579
            |  |.|:     |.|.|::|.|.      ..|.::...|:.....|..|    |.|||...:..|
Human   844 F--WSNI-----EQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRK 901

  Fly   580 R---IQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELP-- 639
            |   |....|:|    :|:.|.:||.....|          |::|:|....    |.|..|||  
Human   902 RKASISLTDDEV----DDEEETIEEEEANEG----------VVDHQTELSN----LAKEAELPLL 948

  Fly   640 -----YD-----KSTW------------EEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSK 682
                 |:     .|.|            ||:.||..|.|::   .:|| .:..|.....:.|.::
Human   949 DLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCPGDRES---RKDL-VLIDSLFIMDQFKAAE 1009

  Fly   683 KGRKSKLKVEDDEDRPVKHYTPPPE---KPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRY 744
            :....|...:|..|.........|:   :.||.:|   .:.|:.|.|.   |..||..|::||..
Human  1010 RMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK---FNAPSLLYGA---LRDYQKIGLDWLAK 1068

  Fly   745 SWGQGIDTILADEMGLGKTIQTVTFLYSL-YKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYC 808
            .:.:.::.|||||.|||||:|.:.|...| ..||:. ||.||.|....::.||.|.:.|.|....
Human  1069 LYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW-GPHLVVVRSCNILKWELELKRWCPGLKI 1132

  Fly   809 ITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVL 873
            ::|||..      ||.:...:|.|...|           |:|.:|||............:.|..|
Human  1133 LSYIGSH------RELKAKRQEWAEPNS-----------FHVCITSYTQFFRGLTAFTRVRWKCL 1180

  Fly   874 VVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFL----SRDKFND-LQAF 933
            |:||..|:|....:.:..:.:.....:|||..:||.|...||:.:::||    ||...:. |:|.
Human  1181 VIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAP 1245

  Fly   934 QGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTK--N 996
            ..|..|. ..:.|.|||.:..|.:|||.|.||.|.:..|.|.:::..||..||..|:.::.:  .
Human  1246 SEESQDY-YHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGT 1309

  Fly   997 YEALNSKSGGGSCSLINIMMDLKKCCNHPYL----------------FPSAA------------- 1032
            .|||.|   |...::::|::.|::.||||.|                :|||:             
Human  1310 QEALKS---GHFVNVLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKE 1371

  Fly  1033 ---------------------------------EEATTAA------------------------- 1039
                                             ||.:|:|                         
Human  1372 ADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQK 1436

  Fly  1040 ----------------------------------------------------------------- 1039
                                                                             
Human  1437 PEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQ 1501

  Fly  1040 ----------------------------------------------------------------- 1039
                                                                             
Human  1502 PASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGE 1566

  Fly  1040 ----------------------------------------------------------------- 1039
                                                                             
Human  1567 VVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQP 1631

  Fly  1040 ----------------------------------------------------------------- 1039
                                                                             
Human  1632 YLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPAS 1696

  Fly  1040 --GG----------------LYEIN---------------------------------------- 1046
              ||                :|.:|                                        
Human  1697 PIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEA 1761

  Fly  1047 ----SLTKA-------------------------------------------------------- 1051
                |.|.:                                                        
Human  1762 GPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRILR 1826

  Fly  1052 ----------------------------------AGKLVLLSKMLKQLKAQNHRVLIFSQMTKML 1082
                                              :|||..|:.:|::||::..||||.|||..||
Human  1827 QGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMILML 1891

  Fly  1083 DILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIY 1147
            ||||.||......|.|||...:...|||.:..||. ..:.|..:|||.:...||||..||||:.|
Human  1892 DILEMFLNFHYLTYVRIDENASSEQRQELMRSFNR-DRRIFCAILSTHSRTTGINLVEADTVVFY 1955

  Fly  1148 DSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGAN 1212
            |:|.||..|.:|.....|||:...:.|||.|:.||:||:                          
Human  1956 DNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEK-------------------------- 1994

  Fly  1213 FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKES--------------- 1262
                    :|:.||:||.    :|.|...:|.::|.|..||.:.:.|..|               
Human  1995 --------LLKNGTKDLI----REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFV 2047

  Fly  1263 ---------------WANEYLSSFKVASYATKEEEEEEE-------TEIIKQDAEN----SDPAY 1301
                           .|..::.:.|...|..::.::..:       |:.:..|:||    .:|:.
Human  2048 VLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQ 2112

  Fly  1302 WVKL------------------------LRHHYEQHQEDVGRSLGKG-----------KRVRKQV 1331
            ..:|                        :....|::.||...:..:.           :..|.::
Human  2113 LEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRL 2177

  Fly  1332 NYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDG-------------GDDDFD-------- 1375
            ...:..::.  .||:|:        |:.|| ...|.||             ..||.|        
Human  2178 EQEEAELLT--YTREDA--------YSMEY-VYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMC 2231

  Fly  1376 ---------------------------DQNGAERKAKRR-----LERRD--DRPLPPLL-ARVGG 1405
                                       |.:.|.||.|:|     :..|.  ||..|.|| .|..|
Human  2232 LMYEATPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREG 2296

  Fly  1406 NIEVLGFNARQRKSFLNAIMRYGMPP----QDAFNSQW--------------------------- 1439
            ..:......:|:..|...:..:..|.    ||  |.:|                           
Human  2297 KEQKKNILLKQQVPFAKPLPTFAKPTAEPGQD--NPEWLISEDWALLQAVKQLLELPLNLTIVSP 2359

  Fly  1440 -------LVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPR-EGLSRQHVLTRIGVMS 1496
                   ||.|:.....|.:::      ...|....:|..     :|| ||.|:.:...|   .|
Human  2360 AHTPNWDLVSDVVNSCSRIYRS------SKQCRNRYENVI-----IPREEGKSKNNRPLR---TS 2410

  Fly  1497 LIRKKVQEFEHINGYYSMPELI----------LKPCEPVRSALKQDVAALEAPPTGGNVDKSATT 1551
            .|..:.:...|...|.|..:|:          :||...:....|....|.....:|.|.||    
Human  2411 QIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDK---- 2471

  Fly  1552 SNSVTPATSAAPSPAP----ASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQEN 1612
                         |.|    ||.:.|...|:.:...|:..|::..|.|....:....|...:...
Human  2472 -------------PLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPP 2523

  Fly  1613 PV--EEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDD 1675
            |:  .:|||...|:.                 .|.|:.:|             :|.|.|.     
Human  2524 PLPQPQAAGSQPPAG-----------------PPAVQPQP-------------QPQPQTQ----- 2553

  Fly  1676 DDDVMIVKEDGELEKPSASSPKDQKAVAAATSAA-------TGATG 1714
                         .:|..:..|.|.|:....|||       |..||
Human  2554 -------------PQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTG 2586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357 9/59 (15%)
TNG2 <282..422 CDD:227367 32/214 (15%)
PHD1_CHD_II 380..422 CDD:277006 10/80 (13%)
PHD2_CHD_II 440..482 CDD:277007 7/51 (14%)
CD1_tandem_CHD3-4_like 487..557 CDD:349314 19/86 (22%)
CD2_tandem_CHD3-4_like 610..664 CDD:349309 17/77 (22%)
PLN03142 720..>1234 CDD:215601 180/1020 (18%)
DUF1087 <1292..1334 CDD:461922 9/80 (11%)
CHDII_SANT-like 1380..1517 CDD:461920 37/183 (20%)
CHDCT2 1757..1902 CDD:462358
EP400NP_056224.3 EP400_N 1..469 CDD:434938 31/188 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..154
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..261
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..359 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..558 14/58 (24%)
PAT1 518..>780 CDD:401645 39/271 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..622 1/24 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..734 10/85 (12%)
HSA 764..835 CDD:214727 13/81 (16%)
HepA 849..>1338 CDD:440319 151/538 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..931 17/65 (26%)
Interactions with RUVBL1 and RUVBL2 915..1329 128/459 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..988 7/26 (27%)
DEAD-like_helicase_N 1055..1271 CDD:475120 73/234 (31%)
DEAH box-like 1183..1186 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1431..1546 0/114 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1771 2/19 (11%)
SF2_C_SNF 1861..1986 CDD:350180 56/125 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2083..2108 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2251..2275 6/23 (26%)
Interaction with ZNF42. /evidence=ECO:0000250 2488..2753 27/147 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2488..2566 20/125 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2785..2833
SP1-4_N <2840..3065 CDD:425404
PRK12323 <3004..>3123 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3079..3123
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.