Protein Alignment Mi-2 and chd2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_021323365.1
• Gene: chd2 / 569795
• ZFINID: ZDB-GENE-050419-256
• Length: 1817
• Species: Danio rerio
• Alignment Length: 1934
• Identity: 541/1934 - (27%)
• Similarity: 823/1934 - (42%)
• Gaps: 543/1934 - (28%)

  Fly     6 ENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGR 70
            :|....||:|.:.:.||.:...|.:|:                      :.|.:..::...|:|.
Zfish     3 KNKSKKQEDEGSTQSNASSNSASEESN----------------------RSGSESGSQSESEQGS 45

  Fly    71 KKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVC 135
            :|.:.:.:||...||...|.|.    .:...|.|..:.....|:|
Zfish    46 EKAQSRHSESNSTSDSESHSES----GSESNGSKSHQSSAQVKDK-------------------- 86

  Fly   136 NVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHI------- 193
                                     |:.:|:|  :|..|.|      .::..|.:|.:
Zfish    87 -------------------------PVRKKDN--LADVKKV------HKKMWEEHPDVYGVRRSS 118

  Fly   194 --QQEG-----GAAGSGGSAGQARSVTGDEPEEPRSSRSSRNE---KPDDIY-EEAVEEE---EE 244
              :||.     ||.||..|.|        |..:.:|||..:.|   |.||.. ||.||||   .|
Zfish   119 RSRQEPARLNIGAEGSSDSEG--------ESSKRKSSRQKKKENTWKDDDSNDEEDVEEETSSSE 175

  Fly   245 EEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGK--RKRDSSDEEQDASGASERDSDLEFERM 307
            .|:||||.|.:|    ...|||..|....|....|:  ||::||||:.|
Zfish   176 SEQEEKKVRSRR----LPARRPQTKSSASKQSQKGRKQRKQESSDEDDD---------------- 220

  Fly   308 LQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGED 372
                ||..||::.|...                  .|::|.||:..|             .:..|
Zfish   221 ----DDDDDEEDTPKRQ------------------TRRRAATKVSYK-------------EDQND 250

  Fly   373 GEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEH 437
            .|.:..|..|:.:                                         ||.|::|||..
Zfish   251 FETDSDDLIEMAE-----------------------------------------GAEEQQDDDSE 274

  Fly   438 QEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGK--AEKIITWRWA 500
                                      .:...:||               .|||  |....|..:|
Zfish   275 --------------------------TIEKVVDT---------------RTGKKGATGASTTLYA 298

  Fly   501 QRSNDD-----GPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYD 560
            ...|.|     .|...:|.       .::.|||...||.|..|.....|         :.|:...
Zfish   299 IEENGDPGADFDPEKEEGE-------TQFLIKWKGWSYIHNTWESVDSL---------TQQKVKG 347

  Fly   561 MEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLE-ERFYKNGVKPEWLIVQRVINHRTA 624
            |::...|::..:|.:...|:          .:.:|.|... ::...|.:..::.|::|||..||.
Zfish   348 MKKLENFKKKNEELNAWLKK----------ASPEDLEYYNCQQELTNDLSKQFQIIERVIATRTG 402

  Fly   625 R-------------DGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQS 676
            :             .|...||.||..|||.:.|||:.....:..:..||.:.:..   :|:|..|
Zfish   403 KSQATSDTPSHKSSSGEPEYLCKWMGLPYAECTWEDSALIKKKFQACIDSFHNRN---SSKTVPS 464

  Fly   677 RSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINW 741
            :..|..|            .||  .:.|        |||    ||:::....::|..||::|:||
Zfish   465 KDCKVLK------------QRP--RFVP--------LKK----QPSYIGDENLELRDYQLDGVNW 503

  Fly   742 LRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDF 806
            |.:||.:....||||||||||||||::||..|:.:....|||:|.||||||.:|:|||:.||||.
Zfish   504 LAHSWCRCNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFIVVVPLSTLTSWQREFDTWAPDM 568

  Fly   807 YCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWA 871
            ..:.|:||..||..||:.|.            ...:|.:.|||.|||:||::..|...||:|:||
Zfish   569 NVVVYLGDVTSRKTIRDYEW------------INPQTKRIKFNALLTTYEILLKDKGVLGNINWA 621

  Fly   872 VLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGE 936
            .|.||||||||::.|..::.|..:...::||:|||||||:|:||:.||:||..|||...:.|:.|
Zfish   622 FLGVDEAHRLKNDDSLLYKTLIDFRSNHRLLITGTPLQNSLKELWSLLHFLMSDKFESWEDFEDE 686

  Fly   937 FADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALN 1001
            ... .::...:.||::|.|.:|||:|.||.|::|:|.|.|:||::||.||:|||:|||:|::||:
Zfish   687 HGK-GRDNGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVDMSAQQKQFYKWILTRNFKALS 750

  Fly  1002 SKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLK 1066
            ..:.|.|...:||:|:|||||||.:|.....:....|.  ...:.||.:..||||||.|:|.:||
Zfish   751 KGTRGSSSGFLNIVMELKKCCNHAFLIKQPEDGENDAP--QEHLQSLVRGGGKLVLLDKLLTRLK 813

  Fly  1067 AQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRA 1131
            .:.:||||||||.:|||||.|:|..::|:::|:||.|.|.||::|:|.|||.|::.|.|||||||
Zfish   814 DRGNRVLIFSQMVRMLDILADYLSMKRYQFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRA 878

  Fly  1132 GGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMM 1196
            ||||||||:||||:|:||||||.||:||.:|||||||..:|.|||.||:.:|||.:.:.||:||:
Zfish   879 GGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEDIIERAKKKMV 943

  Fly  1197 LTHLVV-------RPGMGGKGAN-----FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAEL 1249
            |.|||:       |..:....||     |.|:||..||:||.||||||.:.||: ...:..:.|:
Zfish   944 LDHLVIQRMDTTGRTVLDNSSANSNSNPFNKEELSAILKFGAEDLFKEAEGEES-EPQEMDIDEI 1007

  Fly  1250 LD-RTNRGIEEKESWANEYLSSFKVASYATKEEEEE-------EETEIIKQDAENSDPAYWVKLL 1306
            |. ...|..::..|..:|.||.||||::...|...:       :..|||.::...       |:.
Zfish  1008 LRLAETRESDQGSSATDELLSQFKVANFTMDESTPDLDEKPGRDWDEIIPEEQRR-------KVE 1065

  Fly  1307 RHHYEQHQEDV---GRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDED 1368
            ....::..||:   .||....|:.  |.|.:|               .|.||:.... |:|||.:
Zfish  1066 EEQKQKEMEDIYMLPRSRSSNKKA--QANDSD---------------SDVGSKLKHR-SSGSDSE 1112

  Fly  1369 GGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMP--- 1430
              .||.:|....:|:.:.|..:              .|:|  ||...:.:.|:.|..::|.|
Zfish  1113 --TDDSEDDKRPKRRGRPRARK--------------NNVE--GFTDAEIRRFIKAYKKFGAPLER 1159

  Fly  1431 ----PQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTR 1491
                .:|:...:..:.||:...|....:.|:....|......:..|....| .|.|::.:....:
Zfish  1160 LEAIARDSELVEKSIADLKRLGELVHNSCVTAVQEHEEHLKENPVEAKGPG-KRRGINIKISGVQ 1223

  Fly  1492 IGVMSLIRKKVQEFEHI-------------------------------------------NGY-- 1511
            :...|:|:.: :|||.:                                           :||
Zfish  1224 VNAKSIIQHE-EEFEPLHKAVPSNPAERNKFQLTCRVKTPHFDVDWDIHDDTQLLLGIYEHGYGN 1287

  Fly  1512 ---------YSMPELIL------KP--------CEPVRSALKQDVAALEAPPTGG---------N 1544
                     ..:.|.||      ||        .:.:...||:|:.:.:|...|.         .
Zfish  1288 WDLIKTDPDLKLSEKILLDDPEKKPQGKQLQMRTDYLLKMLKKDLESQDAIKAGDEPKIKKRKPR 1352

  Fly  1545 VDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVK 1609
            :.|.|.::..|....|...|..| ||:||.||..:|    ||..:|.:.|..:|.:|  |.|..|
Zfish  1353 MKKKAPSNELVNEIASPRLSDNP-SEEGEVKDDGAE----KTPTKKKQKKDNKENKE--KTGTPK 1410

  Fly  1610 QENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDD 1674
            :|          |..|.:.|    :::||:|...|..|  .|..:.........:|||    |.:
Zfish  1411 KE----------KEGDKDKK----RSKPKKEKAKPAGK--GKKAQGPVHITQGSEPIP----IGE 1455

  Fly  1675 DDDDV-----MIVKED--------GELEKPSAS-SPKDQKAVAAATSAATG------ATGKGAED 1719
            :||::     .|.||.        .:|:||... |.:||...........|      .......:
Zfish  1456 EDDELDQETFSICKERMRPVKKALKQLDKPDEGLSVQDQLQHTRTCLLKIGDRITECLKSYSDPE 1520

  Fly  1720 SLEVLKRK---FMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHD 1765
            .:::.:|.   |:....:.|..:||.|:...:|..  .:|.|..|::.|
Zfish  1521 HIKIWRRNLWIFVSKFTEFGAQKLHRLYKKAQKKR--SQEGEKEHKKKD 1567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	7/52 (13%)
		TNG2	<282..422	CDD:227367	20/139 (14%)
		PHD1_CHD_II	380..422	CDD:277006	1/41 (2%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	18/76 (24%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	19/66 (29%)
		PLN03142	720..>1234	CDD:215601	258/525 (49%)
		DUF1087	<1292..1334	CDD:461922	8/44 (18%)
		CHDII_SANT-like	1380..1517	CDD:461920	27/197 (14%)
		CHDCT2	1757..1902	CDD:462358	3/9 (33%)
chd2	XP_021323365.1	CD1_tandem_CHD1-2_like	272..356	CDD:349313	24/140 (17%)
		CD2_tandem_CHD1-2_like	389..456	CDD:349308	19/66 (29%)
		DEAD-like_helicase_N	473..709	CDD:475120	112/262 (43%)
		PLN03142	479..>1054	CDD:215601	275/594 (46%)
		CDH1_2_SANT_HL1	1137..1225	CDD:477096	16/88 (18%)
		DUF4208	1455..1549	CDD:464035	18/93 (19%)
		PTZ00449	<1503..>1796	CDD:185628	12/67 (18%)