Protein Alignment Mi-2 and chd7

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_697956.4
• Gene: chd7 / 569471
• ZFINID: ZDB-GENE-070912-179
• Length: 3140
• Species: Danio rerio
• Alignment Length: 2181
• Identity: 547/2181 - (25%)
• Similarity: 835/2181 - (38%)
• Gaps: 701/2181 - (32%)

  Fly    23 PAAELSNDSDAP-LKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDF 86
            |:.|:...|..| :.||....:.|...::|..|.|.|            ||||.|.:|.:|.::
Zfish   615 PSLEIITSSKTPAMGPNLQPANCDLQQKESELKPKKK------------KKKKAKVSEGQECNN- 666

  Fly    87 VQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTT 151
            :..:...|..:....|.......:...||:|
Zfish   667 ISSEAGGEVTALMNEGDSLITPVEKPAEKKS---------------------------------- 697

  Fly   152 YKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDE 216
                         |:.||...||                                         |
Zfish   698 -------------KKKPKEKEPK-----------------------------------------E 708

  Fly   217 PEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKR 281
            |:||::.::.:..|         ..:|.:|.:|||. :..:.:.|..::||.|
Zfish   709 PKEPKTPKTPKTPK---------TPKEPKEPKEKKV-KTATPKPKSSKKPSAK------------ 751

  Fly   282 KRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKK 346
               .||.|   ||.|.:.   |.:|..:.|..|..||..|.|.:.::      |||     |:|
Zfish   752 ---KSDSE---SGNSTKK---EAKRKREPSVTSDVEKTPPQSPEEED------DDG-----VQK- 795

  Fly   347 AKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDE 411
                     ::.::..|.|.:.|.                                  ||..:.:
Zfish   796 ---------RRSSRQVKRKRYTED----------------------------------LEFRISD 817

  Fly   412 PPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGD 476
            ..:|.        |....:.....|.||                                :||.:
Zfish   818 DDDGD--------DSAGPKSPTTSEQQE--------------------------------LPDAE 842

  Fly   477 WRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPE 541
                    .|:   .|||:..|..::....|         ....|.|:::|:...||.||.|.
Zfish   843 --------GPV---VEKIMGMRMGKKELASG---------EEIEVEEFYVKFKGFSYLHCRWA-- 885

  Fly   542 VQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTR-YKRIQRHKDKVGMKANDDAEVLEERFYK 605
                              |:||.        |.|.| .::|:|.:.|..: :....|:.:|.|
Zfish   886 ------------------DIEEL--------EKDKRIQQKIKRFRAKQAL-STFVTEMDDEPF-- 921

  Fly   606 NGVKPEWLIVQRV--INHRTARDGS--TMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLR 666
               .|:::.|.||  ::..|..:|.  |:|||||..|||:.||||.:.|..|   ..|:.::.:.
Zfish   922 ---NPDYVEVDRVLDVSESTDENGELVTLYLVKWCSLPYEDSTWELKADIDQ---VKIEEFERVM 980

  Fly   667 AVCTSETTQSRSKKSKKGRKSKLK-VEDDEDRPVKHYTPPPEKPTTDLKK-----KYEDQPAFLE 725
            |                 |:.:|| ||    ||          ||:|.:|     :|::..|
Zfish   981 A-----------------REPQLKRVE----RP----------PTSDWQKSESSREYKNANA--- 1011

  Fly   726 GTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLS 790
                 |..||:||:|||.::|....:.|||||||||||||::||||.:|.:| ..|||||..|||
Zfish  1012 -----LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKG-IHGPFLVIAPLS 1070

  Fly   791 TLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEE---GAIRGSKVSRLRTTQYKFNVLL 852
            |:.||||||..|. :...:.|.|.:.||..|:..|:.:.:   ..|:|:         |||:.::
Zfish  1071 TIPNWEREFRTWT-ELNVVVYHGSQASRKTIQAYEMYYRDTQGRIIKGA---------YKFHAVI 1125

  Fly   853 TSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFH 917
            |::|:|..|...|.::.|..:::|||||||:...|....|....:.:|:|||||||||.:||||.
Zfish  1126 TTFEMILTDCPELRNVPWRCVIIDEAHRLKNRNCKLLEGLKMMDMEHKVLLTGTPLQNTVEELFS 1190

  Fly   918 LLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELS 982
            |||||..|:|.....|..||.|:..||||::|..:|.|.||||||.||.||:..|.|.|:.|||:
Zfish  1191 LLNFLEPDRFPSESTFMQEFGDLKTEEQVQKLQGILKPMMLRRLKEDVEKNLAPKEETIIEVELT 1255

  Fly   983 AMQKKFYKFILTKNYEALNSKSGGGSCS----------LINIMMDLKKCCNHPYLFPSAAE---- 1033
            .:|||:|:.||.||: |..||||.|..|          |:|.||:|:||||||||...|.|
Zfish  1256 NVQKKYYRAILEKNF-AFLSKSGAGGGSGGGGGSNVPNLLNTMMELRKCCNHPYLINGAEEKIME 1319

  Fly  1034 ---EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYK 1095
               |........:.:.::.:|||||||:.|:|.:|||..|||||||||.:.||||||:|...:|.
Zfish  1320 EFRETHPLDQPEFHLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYP 1384

  Fly  1096 YERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAF 1160
            ||||||.:.|.|||.|||||:.|.:.:|||||.||||||||||..|||.||:||||||.||:||.
Zfish  1385 YERIDGRVRGNLRQAAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQ 1449

  Fly  1161 SRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGA-----NFTKQELDD 1220
            :|.|||||:..|.|||.:||||.|..:...|..|:.|...|::...|.:.|     ..:|:|::|
Zfish  1450 ARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENAANGVQQLSKKEIED 1514

  Fly  1221 ILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIE-EKESWANEYLSSFKVASYATKEEEEE 1284
            :||.|......|:: :|...:.::.:.::|.|..:.|. |.|...    |:|..||:.:...
Zfish  1515 LLRKGAYGALMEEE-DEGSKFCEEDIDQILQRRTQTITIESEGKG----STFAKASFVSAGN--- 1571

  Fly  1285 EETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGK------RVRKQVNYTDGGVVAADT 1343
                  :.|....||.:|.|..:    :.:.|:....|:..      |||||            |
Zfish  1572 ------RTDISLEDPDFWQKWAK----KAELDLDAINGRNNLVIDTPRVRKQ------------T 1614

  Fly  1344 TRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIE 1408
            ....|..:|:..||:...|            |.::...:|.:|..:|....|..... ||..|:.
Zfish  1615 RHYSSMKEDDLMEYSELES------------DSEDKPIQKPRRPQDRTQGYPRSECF-RVEKNLL 1666

  Fly  1409 VLGFN--------------ARQR--KSFLNAIMRYGM------------------PPQDAFNSQW 1439
            |.|:.              .|:|  ::...|::.|.:                  |.:|. .|:.
Zfish  1667 VYGWGRWGDILSHGRFKRPLRERDVETICRALLAYCLLHYRGDENIKGFIWDLITPTEDG-QSRT 1730

  Fly  1440 LVRDL-------RGKSERNFKAYVSLFMRHLCEPGADNAETFADGVP----REGLSRQH------ 1487
            |....       ||:..:..|..|:       :.....|:..||..|    :|...::|
Zfish  1731 LTNHSGLSAPVPRGRKGKKGKLPVA-------QTRMPQADWLADCNPDLLLQEDSYKRHLKHHCN 1788

  Fly  1488 -VLTRIGVMSLIRKKV--------------------------------------------QEFEH 1507
             ||.|:.::..:|::|                                            ..|:|
Zfish  1789 KVLLRVRMLYYLRQEVIGDQADRILEGTDSSELDIWIPQPFHADVPTDWWDLDADKSLLIGVFKH 1853

  Fly  1508 INGYYSMPELILKP--CEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASE 1570
              ||.....:...|  |...|..: .|..|:.|...|.::...........|..    .|...|.
Zfish  1854 --GYEKYNSMRADPTLCFLERVGM-PDAKAIAAEQRGADMMADGVEGEEEDPEY----KPLRMSF 1911

  Fly  1571 KGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDA------EVK 1629
            |.:..|..:....|.......|..:..:..|:.|||::.           ..|:.|      .:.
Zfish  1912 KDDLDDFTNSPLDDNNDGMDGETGEAPKLGENGKPGNLY-----------WPPASALTARLRRLI 1965

  Fly  1630 TEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSAS 1694
            |...:|..:|:.:           ::...|.|.::..|        .||::.:..:|....|..:
Zfish  1966 TAYQRTHKREQLR-----------QEAMAKPDRRRRRP--------RDDILAMVTEGGAYVPDGA 2011

  Fly  1695 --------------SP--KDQKAVAAATSA----------------------------------- 1708
                          ||  .|..|:.|.::|
Zfish  2012 VAFMADGGAFMAKGSPFIPDSAALLADSAAYFKERRQRWTRREEADFYRVVSTFGVVYDVHRQCF 2076

  Fly  1709 ------ATGATGKGAEDSLE------VLKRKFMFNIADGGFTEL----------------HTLW- 1744
                  |.....|..::|||      |...|.:..:.....|||                .||:
Zfish  2077 DWSQFRAFARLDKKTDESLEKYYCSFVAMCKRVCRMPLKSETELPDPTIIIDPITEERASRTLYR 2141

  Fly  1745 ---------------LNEEKAAV--PGREYEIWHR--RHDYWLLAGIVTHGYGRWQDIQNDIRFA 1790
                           |.||:.::  |..:...|..  |||..||.|...||..|..       :.
Zfish  2142 IELLRRIREQVLPHPLLEERLSLCQPSPDLPAWWEPGRHDRDLLRGAAKHGVSRTD-------YH 2199

  Fly  1791 IINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAE 1855
            |:|:|      :.:|||...||  .:.|.:|..:::.:.|   ..|.|.:|........:....:
Zfish  2200 ILNDP------ELSFLEAYRKF--TQGKGVELPVIVSDPL---TPLTLPKDEEVKEEQGDVTLPK 2253

  Fly  1856 VE------CLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPV-- 1912
            ||      ...|..:.||.:....|:.....|.......||.:...:.||:.....:.::.||
Zfish  2254 VENGSIEDVKEEKSEALSPKKEVKNEEDENGLGPKQEPKEEKMEVEEKDVTEFKTDVEQVCPVDG 2318

  Fly  1913 -AQRLQMSERSILSRLAATAGNASNAAQLMAQFPAG 1947
             .::..|.:....:..::...||.:..:|    |.|
Zfish  2319 MVEKKPMDQEPTDTLPSSEDKNAQDEKEL----PTG 2350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	5/52 (10%)
		TNG2	<282..422	CDD:227367	25/139 (18%)
		PHD1_CHD_II	380..422	CDD:277006	3/41 (7%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	13/69 (19%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	22/57 (39%)
		PLN03142	720..>1234	CDD:215601	253/538 (47%)
		DUF1087	<1292..1334	CDD:461922	12/47 (26%)
		CHDII_SANT-like	1380..1517	CDD:461920	36/232 (16%)
		CHDCT2	1757..1902	CDD:462358	35/152 (23%)
chd7	XP_697956.4	Med15	<30..>317	CDD:312941
		PAT1	<258..>399	CDD:401645
		Atrophin-1	362..>608	CDD:460830
		CD1_tandem_CHD5-9_like	840..905	CDD:349315	23/112 (21%)
		CD2_tandem_CHD5-9_like	923..980	CDD:349310	22/59 (37%)
		PLN03142	1012..>1618	CDD:215601	275/647 (43%)
		BRK	2741..2784	CDD:462196