DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mi-2 and SMARCAD1

DIOPT Version :10

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001121901.1 Gene:SMARCAD1 / 56916 HGNCID:18398 Length:1028 Species:Homo sapiens


Alignment Length:1321 Identity:309/1321 - (23%)
Similarity:502/1321 - (38%) Gaps:455/1321 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASEEENDDNFQEEEEAQEDNAPAAEL---SNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKT 62
            :::||||     .|.|....|.|.:::   :.||..|..|            |:.||......|.
Human    38 LSAEEEN-----AEGEVSRANTPDSDITEKTEDSSVPETP------------DNERKASISYFKN 85

  Fly    63 RKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQ-----AAKEKESASSGM 122
            ::|.:.               .|.....|:|..|:.|...:::...|.     :...::..|.|:
Human    86 QRGIQY---------------IDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGL 135

  Fly   123 PSV----EDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKE-NPKIAAPKLVMLVAAK 182
            |::    :|:.....:..:| :..:.:||:|               || .|:.:...|:.|:   
Human   136 PTMARRNDDISELEDLSELE-DLKDAKLQTL---------------KELFPQRSDNDLLKLI--- 181

  Fly   183 WREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEE 247
                 ||...:.         |:...|..:.||....||..:.|.:.:|   ||   |:|..:::
Human   182 -----ESTSTMD---------GAIAAALLMFGDAGGGPRKRKLSSSSEP---YE---EDEFNDDQ 226

  Fly   248 EEKKPRRKRSGRGKKGRRPSG---KVPTLKIKLLGKRKRDSSDEEQDASGASERD----SDLEFE 305
            ..||.|........:....|.   |..::.:||  :::..:.|:::......|.:    ..||..
Human   227 SIKKTRLDHGEESNESAESSSNWEKQESIVLKL--QKEFPNFDKQELREVLKEHEWMYTEALESL 289

  Fly   306 RMLQKSDDS--ADEKEAP----VSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKK-----N 359
            ::..:..|.  ..:.|.|    |||::.|             ..:...|||:..||..|     |
Human   290 KVFAEDQDMQYVSQSEVPNGKEVSSRSQN-------------YPKNATKTKLKQKFSMKAQNGFN 341

  Fly   360 KLKKTKNF-PEG--EDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPH 421
            |.:|...| |:.  ||.|::         .|.::                               
Human   342 KKRKKNVFNPKRVVEDSEYD---------SGSDV------------------------------- 366

  Fly   422 CEADGGAAEEEDDDEHQEFCRVCKDG--GELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSC 484
                 |::.:||....:|   |.:||  |::|         | |..:..:..:.    ..|:|| 
Human   367 -----GSSLDEDYSSGEE---VMEDGYKGKIL---------H-FLQDASIGELT----LIPQCS- 408

  Fly   485 PPLTGKAEKIITWRWAQRSNDDGPSTS------KGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQ 543
               ..||:||...|         |..|      |.||.:.  :.|..|       |||:      
Human   409 ---QKKAQKITELR---------PFNSWEALFTKMSKTNG--LSEDLI-------WHCK------ 446

  Fly   544 LDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGV 608
                                                                 .:::||.     
Human   447 -----------------------------------------------------TLIQERD----- 453

  Fly   609 KPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSET 673
                 :|.|::|.                                        .:|:....|.:.
Human   454 -----VVIRLMNK----------------------------------------CEDISNKLTKQV 473

  Fly   674 TQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEG 738
            |.      ..|......:|                           ||:.| ...:.|.|||..|
Human   474 TM------LTGNGGGWNIE---------------------------QPSIL-NQSLSLKPYQKVG 504

  Fly   739 INWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWA 803
            :|||......|::.|||||||||||||.:.||..||:||: .||.|:.||.||:.||.||..||.
Human   505 LNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWC 568

  Fly   804 PDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELI---SMDAACL 865
            |....:.|.|.::.|..||.|                :.:....:||::|:|...   |.|.:..
Human   569 PTLKVLCYYGSQEERKQIRFN----------------IHSRYEDYNVIVTTYNCAISSSDDRSLF 617

  Fly   866 GSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFL-------- 922
            ..:.....:.||.|.||:..|..::.|.:.....:|||||||:||||.||..||||:        
Human   618 RRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSS 682

  Fly   923 ---------SRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVR 978
                     |:.|..|.|:       :.::|::....:::.|.:|||:|.:|||.:|.|.:   |
Human   683 TSEIRRMFSSKTKSADEQS-------IYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKD---R 737

  Fly   979 VELSAM---QKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLF------------ 1028
            :||.||   |::.|..:..:..:::|:.....:..:.|:||.|:|..|||.|.            
Human   738 IELCAMSEKQEQLYLGLFNRLKKSINNLVTEKNTEMCNVMMQLRKMANHPLLHRQYYTAEKLKEM 802

  Fly  1029 -------PSAAE----------EATTAAGGLYEINSLTKA----------------AGKLVLLSK 1060
                   |:..|          |..|.    :|::.|.|.                :||..:|..
Human   803 SQLMLKEPTHCEANPDLIFEDMEVMTD----FELHVLCKQYRHINNFQLDMDLILDSGKFRVLGC 863

  Fly  1061 MLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVF 1125
            :|.:||.:..||::|||.|.||||||..|:..|::|.|:||....:.|...||.||. ....|||
Human   864 ILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNT-DMDIFVF 927

  Fly  1126 LLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQV 1190
            ||||:||||||||.:|:.||::|.|.||:||.||..|.||:||..:|::.:.:::.::||.:.::
Human   928 LLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKI 992

  Fly  1191 AKRKMMLTHLVVRPGMGGKGA 1211
            .::|:.|...:.....|.:|:
Human   993 NQQKLKLEQDMTTVDEGDEGS 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357 11/53 (21%)
TNG2 <282..422 CDD:227367 26/157 (17%)
PHD1_CHD_II 380..422 CDD:277006 1/41 (2%)
PHD2_CHD_II 440..482 CDD:277007 8/43 (19%)
CD1_tandem_CHD3-4_like 487..557 CDD:349314 15/75 (20%)
CD2_tandem_CHD3-4_like 610..664 CDD:349309 3/53 (6%)
PLN03142 720..>1234 CDD:215601 187/560 (33%)
DUF1087 <1292..1334 CDD:461922
CHDII_SANT-like 1380..1517 CDD:461920
CHDCT2 1757..1902 CDD:462358
SMARCAD1NP_001121901.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..82 15/60 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..251 12/53 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..328 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..373 5/63 (8%)
HepA <496..999 CDD:440319 181/534 (34%)
DEGH box 628..631 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000255 721..738 8/19 (42%)
DEGD box 1007..1010 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

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