DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and chd3

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_009301392.1	Gene:	chd3 / 568230	ZFINID:	ZDB-GENE-121031-4	Length:	2101	Species:	Danio rerio

Alignment Length:	2116	Identity:	1114/2116 - (52%)
Similarity:	1389/2116 - (65%)	Gaps:	277/2116 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKK---GKKRKTRK- 64
            :||.:|:...:|.|.:.|:|||  ..::.|...|:..|:..:....|:..|||   .||::|:|
Zfish    24 DEEEEDDGDLDENASDINSPAA--PRETAARAAPDDGDDIGEASDRDNLGKKKRGPKKKKETKKK 86

  Fly    65 -GEEKGR--KKKKRKKNESEEDSDFVQHDEEVEYPSTS--------------KRGRKRKEEKQAA 112
             .|::|:  |.:||||.||:     ::.|.|.:|...|              |:.:.:||:|...
Zfish    87 DKEKEGKIAKARKRKKIESD-----IERDSEPDYAMNSDSAASDYGGEKKKKKKHKDKKEKKTKK 146

  Fly   113 KEKESASS---------GMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENP 168
            |:||...|         .|.:...:...:.:.:|:..::||:.::||.||||...:||::.|:||
Zfish   147 KKKEDEDSTHEETTKPVEMKTSAQLAREWGLEDVDHTFTEEDYRTLTNYKAFSQFLRPMIAKKNP 211

  Fly   169 KIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDE-------PEEP------ 220
            ||...|::.::.||||||..:||.   :|.||....:|..|.:...::       ||.|
Zfish   212 KIPMSKMMTILGAKWREFSSNNPF---KGSAAAVAAAAAAAAAAVAEQVSAATASPEPPPQPPPL 273

  Fly   221 RSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKL--LG-KRK 282
            |.:::...:.|.  |::  ..:.....::|||:.|             |:..|:|||  :| |||
Zfish   274 RKAKTKEGKGPG--YKK--RSKSPRVSDKKKPKPK-------------KMAPLRIKLGAIGNKRK 321

  Fly   283 RDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKA 347
            :.||.||.|                   .|||..|..:..||       :.:.|.||     :..
Zfish   322 KSSSSEEVD-------------------EDDSEQENSSVHSS-------SVRSDSSG-----RVK 355

  Fly   348 KTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEP 412
            |.|.|...|||   ||.....:|:..|.:|||||||||||||||||||||||||||||||||::.
Zfish   356 KNKRGRPAKKK---KKALGDEDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELEKA 417

  Fly   413 PEGKWSCPHCEADG-------------------------GAAEEEDDDEHQEFCRVCKDGGELLC 452
            |||||||||||.:|                         |...||::|:|.||||||||||||||
Zfish   418 PEGKWSCPHCEKEGIQWEAKEEDFEEFEEECDDVRDVESGLGGEEEEDDHMEFCRVCKDGGELLC 482

  Fly   453 CDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQ-------RSNDDGPST 510
            ||||||:||..||||||..||:|:|.||||:|||:.|:.:||:.|||.:       ....|.|..
Zfish   483 CDSCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPPIKGRVQKILHWRWGEPPPPVPVPPPPDAPPD 547

  Fly   511 SKGSKNSNSR-VREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLD-- 572
            :........| .||:|:|....|||||.|:.|:||::.|.:|.|::|||.||:|||    |||
Zfish   548 APPPPPMKGRPEREFFVKLTAQSYWHCTWITELQLEIFHSVMFRNYQRKTDMDEPP----SLDYG 608

  Fly   573 ---EADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVK 634
               |.|:.....:|.||       ....:|||::|:.|:||||::|.|:|||...:.|:..||||
Zfish   609 SGGEEDSGKSEKRRAKD-------PQYAILEEKYYRYGIKPEWMMVHRIINHSVDKKGNYHYLVK 666

  Fly   635 WRELPYDKSTWEEEGDDIQ--GLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDR 697
            ||:|.||:.|||.:..||.  .|.:.. |::...||...:        .:|.||.:.:.|:||
Zfish   667 WRDLTYDQCTWERDELDIPEFALHKTA-YWRHREAVMKED--------PEKPRKMRRREENDE-- 720

  Fly   698 PVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGK 762
                   .|..|..|...|||:||.|:..||..||.||:||:||||:||.||.||||||||||||
Zfish   721 -------APSTPVNDPTIKYEEQPEFVTETGGTLHLYQLEGLNWLRFSWAQGTDTILADEMGLGK 778

  Fly   763 TIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELS 827
            ||||:.|||||:||||.:|||||:.||||::|||||||:||||||.:||.|||||||:|||||.:
Zfish   779 TIQTIVFLYSLFKEGHTKGPFLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKDSRAIIRENEFT 843

  Fly   828 FEEGAIRGSKVS-RL-RTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFR 890
            |::.|::|.|.: :| |....||:||||||||:::|...|.|||||.||||||||||:|||||||
Zfish   844 FDDTAVKGGKKAFKLRREAPIKFHVLLTSYELVTIDQNVLKSIDWACLVVDEAHRLKNNQSKFFR 908

  Fly   891 ILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGP 955
            .||.|.|.:|||||||||||||||||||||||:.::||:|:.|..||||:|||:|:|:||::|||
Zfish   909 RLNDYKIDHKLLLTGTPLQNNLEELFHLLNFLTPNRFNNLEGFLEEFADISKEDQIKKLHDLLGP 973

  Fly   956 HMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKK 1020
            |||||||.||.||||:|:|.|||||||.||||:||||||:|:||||||.||...||:||||||||
Zfish   974 HMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKK 1038

  Fly  1021 CCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDIL 1085
            |||||||||.||.||.....|.||...||||:|||:||.|||::||.|.||||:|||||||||:|
Zfish  1039 CCNHPYLFPVAAAEAPKTPSGAYEGVGLTKASGKLMLLQKMLRKLKEQGHRVLVFSQMTKMLDLL 1103

  Fly  1086 EDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSD 1150
            ||||:.|.||||||||||||.||||||||||||||.||.||||||||||||||||||||||:|||
Zfish  1104 EDFLDSEGYKYERIDGGITGALRQEAIDRFNAPGAVQFCFLLSTRAGGLGINLATADTVIIFDSD 1168

  Fly  1151 WNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTK 1215
            ||||||||||||||||||||||||||||||.|||||:||||||||||||||||||:|.|..:.:|
Zfish  1169 WNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKAGSMSK 1233

  Fly  1216 QELDDILRFGTEDLFKE--------DDKEEAIHYDDKAVAELLDRTNRGIEEKESW-ANEYLSSF 1271
            |||||||:||||:|||:        ||....||||:.|:..||||:....::.:.. .|||||||
Zfish  1234 QELDDILKFGTEELFKDEIEAGDNKDDDMSVIHYDNAAIERLLDRSQDATDDSDMQNMNEYLSSF 1298

  Fly  1272 KVASYATKEEE--EEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYT 1334
            |||.|..||::  ||.|.|||||: ||.||.||.|||||||||.|||:.|:|||||||||||||.
Zfish  1299 KVAQYTVKEDDKIEEIEREIIKQE-ENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRVRKQVNYN 1362

  Fly  1335 DGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPL 1399
                   |..::|..|..:.|:..||||.||:|:  |:|||::....|:::|:|....|:|||||
Zfish  1363 -------DAAQEDQEWHADISDNQSEYSVGSEEE--DEDFDERPEGRRQSRRQLRNEKDKPLPPL 1418

  Fly  1400 LARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLC 1464
            ||||||||||||||.||||:|||||||:|||.||||:|||||||||||||:.|||||||||||||
Zfish  1419 LARVGGNIEVLGFNTRQRKAFLNAIMRWGMPAQDAFSSQWLVRDLRGKSEKEFKAYVSLFMRHLC 1483

  Fly  1465 EPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSAL 1529
            ||.||.:||||||||||||.||.||||||||||::|||||||||||.:||||  |||...|.|
Zfish  1484 EPVADGSETFADGVPREGLCRQPVLTRIGVMSLVKKKVQEFEHINGKWSMPE--LKPEITVDS-- 1544

  Fly  1530 KQDVAALEAPPTGGNVDKSATTSNSVTPATS--AAPSPAPASEK-GEDKDKDS-------EKEKD 1584
            |:...|  :.||......:...|.:.||.||  |.|||...:|| .::.:||.       |:|::
Zfish  1545 KKSSRA--SSPTIKTDTPTPELSCNNTPCTSKPATPSPPDKTEKSAKEAEKDEAESLTEPERERE 1607

  Fly  1585 KTSA-EKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKE 1648
            |..| |..|.:..:..|..:..|:..:::|:......|..|.|...::.:||:     ::|::.:
Zfish  1608 KEKAKEAKEGESVESTEHGEATGNEGEKDPITSEKSQTSESPAAAASDDSKTK-----ENPDISQ 1667

  Fly  1649 EPKTEEKEKEKVDDK--KPIPPTTVIDDDDDDVMIVKEDG--------------ELEKPSASSP- 1696
            .|..|:.||||.:::  |...|:|   :...|...|||:.              |.||..||||
Zfish  1668 SPPKEKNEKEKQEEEEGKEKEPST---EKPSDSPSVKEESKEALKGDKKEKAGEEKEKTEASSPP 1729

  Fly  1697 ---KDQKAVAAATSAATGATGKGAEDS-----------LEVLKR-----KFMFNIADGGFTELHT 1742
               .::|.....:|.......||..|:           .:|:.|     :|||||||||||||||
Zfish  1730 SETTEKKDKLDQSSEVKKEEVKGERDAGKEVRVQREEVPKVISRPAERPRFMFNIADGGFTELHT 1794

  Fly  1743 LWLNEEKAAV-PGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFL 1806
            ||.|||:||: .|:..||||||||:|||:|||.|||.||||||||.:|||||||||....|||||
Zfish  1795 LWQNEERAAISSGKINEIWHRRHDFWLLSGIVCHGYARWQDIQNDPQFAIINEPFKTQANKGNFL 1859

  Fly  1807 EIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESL 1871
            |:|||||||||||||||||||||||||||||:.|||:||||:|||||||||||||||||||||||
Zfish  1860 EMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPTHPAMALNARFAEVECLAESHQHLSKESL 1924

  Fly  1872 AGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASN 1936
            |||||||||||||||||||||||||:||:||||||:|:||:..||||||||||||| |..||.::
Zfish  1925 AGNKPANAVLHKVLNQLEELLSDMKADVTRLPATLSRVPPITARLQMSERSILSRL-ANKGNETH 1988

  Fly  1937 AAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFS 1972
                           |.|....||.....||.|.|:
Zfish  1989 ---------------TPPPIPPGPYATPQNFGPPFT 2009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	22/51 (43%)
		PHD1_CHD_II	380..422	CDD:277006	38/41 (93%)
		PHD2_CHD_II	440..482	CDD:277007	33/41 (80%)
		CHROMO	490..558	CDD:237991	25/75 (33%)
		CHROMO	615..667	CDD:214605	22/53 (42%)
		SNF2_N	734..1028	CDD:278600	215/295 (73%)
		DEXDc	751..907	CDD:238005	111/157 (71%)
		Helicase_C	1053..1167	CDD:278689	98/113 (87%)
		DUF1087	<1292..1337	CDD:283996	33/44 (75%)
		DUF1086	1380..1517	CDD:283992	109/136 (80%)
		CHDCT2	1756..1927	CDD:285336	146/170 (86%)
chd3	XP_009301392.1	CHDNT	181..233	CDD:285335	22/51 (43%)
		PHD1_CHD_II	385..427	CDD:277006	38/41 (93%)
		PHD2_CHD_II	470..512	CDD:277007	33/41 (80%)
		Chromo	647..>681	CDD:278797	18/33 (55%)
		SNF2_N	750..1046	CDD:278600	215/295 (73%)
		DEXDc	767..925	CDD:238005	111/157 (71%)
		Helicase_C	1070..1185	CDD:278689	98/114 (86%)
		DUF1087	<1324..1368	CDD:283996	32/50 (64%)
		DUF1086	1397..1536	CDD:283992	110/140 (79%)
		CHDCT2	1809..1980	CDD:285336	146/170 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I537
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1990	1.000	Inparanoid score	I51
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm24896
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880