Protein Alignment Mi-2 and chd1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_009303375.1
• Gene: chd1 / 563236
• ZFINID: ZDB-GENE-030131-7120
• Length: 1778
• Species: Danio rerio
• Alignment Length: 1993
• Identity: 563/1993 - (28%)
• Similarity: 871/1993 - (43%)
• Gaps: 508/1993 - (25%)

  Fly    69 GRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFS 133
            ||.:.:...|.|.|.|:   .|:|....|.|..|........::.:..|:.||..|     .:.|
Zfish     3 GRSEDESVSNSSGESSN---SDDESGSGSGSGSGSSSSSSSSSSSQSGSSDSGSGS-----DSGS 59

  Fly   134 VCNVEIEYSEE--ELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQE 196
            ..:.:.|.|:|  :..:.....||.:        .||.|    |.:...|..|:.......:||
Zfish    60 QSDSDSEKSKEKNDQDNKIDGAAFWN--------SNPSI----LTVQRTAMLRKQQIQQQQLQQ- 111

  Fly   197 GGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGK 261
                       |:.|.||.: |:..||                    :|.:::.|.|.|.||
Zfish   112 -----------QSSSNTGSD-EDSSSS--------------------DESDDDSKSRSKGSG--- 141

  Fly   262 KGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAP---VS 323
                                   |..:....||:...||..|.|   ..||:|..:.|..   .|
Zfish   142 -----------------------SDSDSGSGSGSGSSDSSAEEE---ANSDESVSDYEPSHKVKS 180

  Fly   324 SKADNSAPAAQDDGSGAPVVRKK---AKTKIGNKFKK-----KNKLKKTKNFPEGEDGEHEHQDY 380
            .|..|.|.|.....:.||  :||   :.:...:.:||     :.:.....::.|.|:.:.:..|.
Zfish   181 RKPSNKANARNGRNNKAP--KKKPSHSSSDDEDDYKKALAGPRRQATVNVSYKEDEELKTDSDDL 243

  Fly   381 CEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCK 445
            .|||   ||                    |.||                .|||:.|..|  ||.:
Zfish   244 VEVC---GE--------------------DVPP----------------PEEDEFETLE--RVME 267

  Fly   446 DGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPST 510
                                              .|.....:||    .:|..:|..:  ||...
Zfish   268 ----------------------------------MRIGRKGVTG----AVTTVYAVEA--DGDPN 292

  Fly   511 SKGSKNSNSRVREYFIKWHNMSYWHCEWVPE---VQLDVHHPLMIRSFQRKYDMEEPPKFEESLD 572
            :....|......:|.|||.|.|:.|..|..|   .|.:|.....:.:|::|  .:|..|:.::..
Zfish   293 ANFDPNRQPGEVQYLIKWKNWSHIHNTWETEETLKQQNVKGMKKLDNFKKK--EQEKKKWLKAAS 355

  Fly   573 EADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARD--GSTMYLVKW 635
            ..|..|...|:             |::::      :..::.:|:|:|.|...:.  |...||.||
Zfish   356 PEDVEYFNCQQ-------------ELMDD------LHSQYQLVERIIGHSNQKSAAGYPDYLCKW 401

  Fly   636 RELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVK 700
            :.|||.:.:||:.....:..::.||.|.. |..|  :|..||..|..|            .||
Zfish   402 QGLPYSECSWEDGALISKKFQKCIDEYMS-RNQC--KTIPSRDCKVLK------------QRP-- 449

  Fly   701 HYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQ 765
            .:.|        :||    ||.::.|.|::|..||::|:||:.:||.:|...|||||||||||||
Zfish   450 RFVP--------MKK----QPHYIGGEGLELRDYQLDGLNWMAHSWCKGNSCILADEMGLGKTIQ 502

  Fly   766 TVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEE 830
            |::||..|:.|....||||:.||||||.:|:||.:||||....:.|:||.:||.:||.:|....:
Zfish   503 TISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQLWAPLMNVVVYLGDINSRNMIRTHEWMHPQ 567

  Fly   831 GAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSY 895
                        |.:.|.|:|||:||::..|.:.||::.||.:.||||||||::.|..::.:..:
Zfish   568 ------------TKRLKLNILLTTYEILLKDKSFLGNVSWAFIGVDEAHRLKNDDSLLYKTMIEF 620

  Fly   896 TIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRR 960
            ...::||:|||||||:|:||:.||:|:..:||:..:.|:.|... .::.....||:.|.|.:|||
Zfish   621 KSNHRLLITGTPLQNSLKELWSLLHFIMPEKFHSWEMFEEEHGK-GRDSGYTSLHKELEPFLLRR 684

  Fly   961 LKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHP 1025
            :|.||.|::|:|.|.|:|||:||:||::||:|||:||:||:..:.|.:...:||||:|||||||.
Zfish   685 VKKDVEKSLPAKVEQILRVEMSAVQKQYYKWILTRNYKALSKGTKGSTSGFLNIMMELKKCCNHC 749

  Fly  1026 YLF-PSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFL 1089
            ||. |....|......||   ..|.:::|||:||.|:|.:||.:.|||||||||.:|||||.::|
Zfish   750 YLIKPPDDNEFYNRQEGL---QHLVRSSGKLILLDKLLVRLKERGHRVLIFSQMVRMLDILAEYL 811

  Fly  1090 EGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPH 1154
            :..|:.::|:||.|.|.:|::|:|.|||.|::.|.|||||||||||||||:||||:|:||||||.
Zfish   812 KYRQFLFQRLDGSIKGEMRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQ 876

  Fly  1155 NDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV-RPGMGGK-----GA-- 1211
            ||:||.:|||||||..:|.|||.||:.||||.:.:.||:||:|.|||: |....||     ||
Zfish   877 NDLQAQARAHRIGQKKQVNIYRLVTKGSVEEEIIERAKKKMVLDHLVIQRMDTTGKTVLHTGAAP 941

  Fly  1212 ----NFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDR--TNRGIEEKESWANEYLSS 1270
                .|.|:||..||:||.|:||||.:.||. ...:..:.|:|.|  |........:...|.||.
Zfish   942 SSSTPFNKEELSAILKFGAEELFKEPEGEEQ-EPQEMDIDEILKRAETRENDPGPSTVGEELLSQ 1005

  Fly  1271 FKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGK-----RVRK- 1329
            ||||:::..|:||      |..|.|.:| ..|..::...:.:..|:..|.....:     |:||
Zfish  1006 FKVANFSMMEDEE------IDMDTERND-RNWDDIIPEDHRRRLEEEERQKELAEIYLLPRMRKC 1063

  Fly  1330 ---QVNYTDGGVVAADTTRDDSNWQDNGSE----YNSEYSAGSDEDGGDDDFDDQNGAERKAKRR 1387
               |:|:                   ||:|    .|..||| ||.|...|           .||.
Zfish  1064 AKQQMNF-------------------NGNEGRRSRNRRYSA-SDSDSVSD-----------RKRP 1097

  Fly  1388 LERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMP-------PQDAFNSQWLVRDLR 1445
            .:|...|.:|        ...:.||...:.:.|:.:..::|.|       .:||........|||
Zfish  1098 KKRGRPRTIP--------RENIKGFTDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSEHDLR 1154

  Fly  1446 GKSERNFKAYVSLFMRHLCEP--------GADNAETF-ADGVPREGLSRQHVLTRIGVMSLIRKK 1501
            ..:|......:.....:.|.|        |.....|| ..||.   ::.:.|::....::.:.|.
Zfish  1155 RLAETVHNGCLRTLKENPCGPERTSGGRRGKVKGPTFRISGVQ---VNAKLVISHEEELAPLHKA 1216

  Fly  1502 VQE-----------------------------------FEHINGYYSM----PELILK----PCE 1523
            :..                                   :|:..|.:.|    |:|.|.    |.:
Zfish  1217 IPADPEERKRYIIPCHSKAAHFDIEWGKEDDSSLLIGIYEYGYGSWEMIKMDPDLNLTHKLLPDD 1281

  Fly  1524 PVR---------------SALKQDVAALEAPPTGG-----NVDKSATTSNSVTPA---TSAAPSP 1565
            |.:               ..|.:|:|..||....|     |.......:.:|.|.   .:.:.|.
Zfish  1282 PDKKPQAKQLQTRADYLIKLLSKDLAKKEAQKQAGTAKSRNRKPRGKKNKAVKPKMEDVTNSLSS 1346

  Fly  1566 APASEKGEDKDKDSEKEKDKTS-------------AEKSEVKQEQEAEEDKKPGDVKQENPVEEA 1617
            ||.|:|..| ::|.:.|:||.:             .|::.:::|.:::||    :::...|||:
Zfish  1347 APPSDKSSD-EEDEKDEEDKETPPPVKLPNRRARVPERTVMEEEDDSDED----ELEDAAPVEK- 1405

  Fly  1618 AGDTKPSDAEVKTEVAKTEPKE-------ETKDPEVKEEP--KTEEKEKEKVDDKKPIPPTTV-I 1672
              ||  .:..||.||.|.:.:|       |.|:.|:|.||  :.::...|.||.|.....|.| .
Zfish  1406 --DT--PEKVVKKEVKKEKKEEGRDSKEREVKEKEIKPEPLQREDDSPAEAVDIKAEKADTPVHT 1466

  Fly  1673 DDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLK--RKFMFNIADG 1735
            ....|.:.:.:|..||::.:.|..|::.....|.........||..:. |.|:  |:.:..|.|
Zfish  1467 PTGGDAIPLSEESEELDQKTFSVCKERMRPVKAALKQLDRPEKGLSER-EQLEHTRQCLIKIGD- 1529

  Fly  1736 GFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDV 1800
            ..||....:.|.|       :.:.|  |.:.|:
Zfish  1530 HITECLREYTNPE-------QIKQW--RKNLWI-------------------------------- 1553

  Fly  1801 GKGNFLEIKNKFLARRF-KLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNA---RFAEVECLAE 1861
                |:....:|.||:. ||.:.|:...::..:||..|.:        ::|.   :.|:||.|.|
Zfish  1554 ----FVSKFTEFDARKLHKLYKHAIKKRQENAQAAEQNTS--------TVNTQSFKHADVERLKE 1606

  Fly  1862 SHQ-HLSKESLAGNKPANAVLHKVLNQLEELLSD--MKSDVSR 1901
            |.| ..|::|.:.::..::..|:  :..|...||  .||..||
Zfish  1607 SQQDESSRDSYSSDRHHSSRYHE--HSKEHHASDSYRKSSDSR 1647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	11/54 (20%)
		TNG2	<282..422	CDD:227367	33/150 (22%)
		PHD1_CHD_II	380..422	CDD:277006	8/41 (20%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	19/72 (26%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	17/55 (31%)
		PLN03142	720..>1234	CDD:215601	258/526 (49%)
		DUF1087	<1292..1334	CDD:461922	11/50 (22%)
		CHDII_SANT-like	1380..1517	CDD:461920	29/191 (15%)
		CHDCT2	1757..1902	CDD:462358	31/152 (20%)
chd1	XP_009303375.1	CD1_tandem_CHD1-2_like	258..340	CDD:349313	23/123 (19%)
		CD2_tandem_CHD1-2_like	375..431	CDD:349308	17/56 (30%)
		PLN03142	457..>987	CDD:215601	263/546 (48%)
		CDH1_2_SANT_HL1	1112..1199	CDD:477096	18/89 (20%)
		DUF4208	1481..1571	CDD:464035	25/136 (18%)
		U2AF_lg	1661..>1751	CDD:273727