Protein Alignment Mi-2 and chd4b

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_021322613.1
• Gene: chd4b / 560622
• ZFINID: ZDB-GENE-030131-4532
• Length: 1953
• Species: Danio rerio
• Alignment Length: 2112
• Identity: 1099/2112 - (52%)
• Similarity: 1360/2112 - (64%)
• Gaps: 329/2112 - (15%)

  Fly     1 MASEEENDDNFQE-----EEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKR 60
            |:..|::.|.|:.     ||:..|.:.|                            :.|||.|.:
Zfish     1 MSGSEDDRDRFEPMGDDIEEQISETDTP----------------------------KSKKKKKAK 37

  Fly    61 KTRKGEEKGRKKKKRKK--------------NESEEDSDFVQHDEE--VEY-PSTSKRGR---KR 105
            |:|:.....|:|..|::              .|.||:.|.|...|.  .:| ||..|:.|   .:
Zfish    38 KSRESRTSKRQKVIREEIAVSSPEVMEAIRMAEGEEEEDRVMRSESEGSDYAPSKKKKKRSSSSK 102

  Fly   106 KEEKQAAKEKESASSGM-------PSVED---------------VCSAFSVCNVEIEYSEEELQS 148
            ..:|.:|.||...|.|.       |..||               :.:.:.:.:::..:::|:..|
Zfish   103 DRKKGSAGEKAGGSGGKSKRKEPEPEEEDDDDDDDGQEPKSSSQLLADWGMKDIDYTFTQEDYNS 167

  Fly   149 LTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAG------------ 201
            ||.||||...|||::..:|||||..|::|::.||||||..:||   ..|.|:.
Zfish   168 LTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNP---MRGSASANAALAAANVAAA 229

  Fly   202 ---------SGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRS 257
                     :||..|.|.:..     .|.::.:.....|......||...:.:.:|.|.|..:|.
Zfish   230 VESMVTKVDAGGGGGPALATA-----PPTTTAAPVAAPPPPQQPPAVPLRKAKTKEGKGPNARRK 289

  Fly   258 GR------GKKGRRPSGKVPTLKIKLLG-KRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSA 315
            .:      .||.:  :.||..|||||.. ||||.||.||.|  |.|:.||       ...||.|.
Zfish   290 TKPTPKPQDKKSK--AKKVAPLKIKLGNFKRKRSSSGEEDD--GESDFDS-------FSVSDGSN 343

  Fly   316 DEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDG-EHEHQD 379
            ..     ||::.|                ||||:.           ||.|...|..|| |.:|||
Zfish   344 SR-----SSRSKN----------------KKAKSS-----------KKKKKMDEDADGYETDHQD 376

  Fly   380 YCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADG-----------GAAE--- 430
            ||||||||||||||||||||||:|||:|:::..|||.|||||||.:|           |..|
Zfish   377 YCEVCQQGGEIILCDTCPRAYHMVCLDPDMERAPEGTWSCPHCEKEGIQWEAREESSEGEEENDD 441

  Fly   431 --------EEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPL 487
                    ||:||.|.||||||||||||||||:|||:||..||||||..||:|:|.||||..|||
Zfish   442 GRRDDGDVEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHLHCLNPPLPDIPNGEWICPRCLSPPL 506

  Fly   488 TGKAEKIITWRWAQ--------RSND-----DGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWV 539
            .||.:|::||||.:        |..|     ..|....|.|.     ||:|:||.|.|||||.||
Zfish   507 KGKVQKVLTWRWGEAPPPMPVPRPADLPAEAPDPPPMIGRKE-----REFFVKWCNKSYWHCSWV 566

  Fly   540 PEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLD-EADTRYKRIQRHKDKVGMKANDDAEVLEERF 603
            .|:||:::..:|.|::|||.||||||..|...: :.|...||  ::||....:       :|:::
Zfish   567 QELQLELNCQVMFRNYQRKTDMEEPPNLEMGAEGDEDKSCKR--KNKDPFYAR-------MEDKY 622

  Fly   604 YKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAV 668
            .:.|||.|||.:.|::||...:..:..||:|||:||||:||||.|..|:........:|.:.|.:
Zfish   623 GRFGVKIEWLFIHRILNHSVDKKNNVHYLIKWRDLPYDQSTWESEDMDVPDFETYKQHYWNHREL 687

  Fly   669 CTSETTQSRSKKSKKGRK-SKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLH 732
            ...|       :.:.|:| .|:||...|        .||..|..|...|::.||.:|:.||..||
Zfish   688 MLGE-------EGRPGKKMKKVKVRKTE--------RPPANPVVDPTIKFDRQPDYLDSTGGTLH 737

  Fly   733 PYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWER 797
            |||:||:||||:||.||.|||||||||||||:||..||||||||||.:|||||:.||||::||||
Zfish   738 PYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWER 802

  Fly   798 EFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR-GSKVSRL-RTTQYKFNVLLTSYELISM 860
            |||:||||.|.:||:|||||||||||||.:||:.||| |.|.|:: :....||:|||||||||::
Zfish   803 EFEMWAPDMYVVTYVGDKDSRAVIRENEFTFEDNAIRGGKKASKMKKEAAVKFHVLLTSYELITI 867

  Fly   861 DAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRD 925
            |.|.|||||||.||||||||||:|||||||:||:|.:.:|||||||||||||||||||||||:.:
Zfish   868 DQAILGSIDWACLVVDEAHRLKNNQSKFFRVLNNYPLQHKLLLTGTPLQNNLEELFHLLNFLTPE 932

  Fly   926 KFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK 990
            :||:|:.|..||||::||:|:|:||:|||||||||||.||.|:||||:|.|||||||.||||:||
Zfish   933 RFNNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKHMPSKTELIVRVELSPMQKKYYK 997

  Fly   991 FILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKL 1055
            :|||:|:||||::.||...||:|::||||||||||||||:||.||.....|:|:.::||||:|||
Zfish   998 YILTRNFEALNTRGGGNQVSLLNVVMDLKKCCNHPYLFPTAATEAPKMPNGMYDGSALTKASGKL 1062

  Fly  1056 VLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGA 1120
            :||.||||:||...||||||||||||||:||||||.|.|||||||||:||.:|||||||||||||
Zfish  1063 MLLFKMLKKLKEGGHRVLIFSQMTKMLDLLEDFLENEGYKYERIDGGVTGGMRQEAIDRFNAPGA 1127

  Fly  1121 QQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEE 1185
            .|||||||||||||||||||||||||||||||||||||||||||||||..|||||||||:.||||
Zfish  1128 PQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTKASVEE 1192

  Fly  1186 RVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKE-----DDKEE---AIHYD 1242
            |:|||||:||||||||||||:|.|..:.:||||||||:||||.|||:     |:|||   .||||
Zfish  1193 RITQVAKKKMMLTHLVVRPGLGSKAGSMSKQELDDILKFGTEQLFKDELGEGDNKEEDSSVIHYD 1257

  Fly  1243 DKAVAELLDRTNRGIEEKESWA-NEYLSSFKVASYATKEEEEEEE---TEIIKQDAENSDPAYWV 1303
            |||:..||||.....|:.|..: ||||||||||.|..|:|:||||   .|||||: |:.||.||.
Zfish  1258 DKAIDRLLDRNQDATEDTELQSMNEYLSSFKVAQYVVKDEDEEEEDVDREIIKQE-ESVDPDYWE 1321

  Fly  1304 KLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDED 1368
            |||||||||.|||:.|.||||||.||.|||.|.......:.||   |||:.|:..|:||..|:|
Zfish  1322 KLLRHHYEQQQEDLARHLGKGKRPRKPVNYNDCSQEDRGSRRD---WQDDQSDNQSDYSVASEE- 1382

  Fly  1369 GGDDDFDDQNGA---ERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMP 1430
             ||:|||:::.|   .|.:::.|....|:||||||||||||||||||||||||:||||:||||||
Zfish  1383 -GDEDFDERSEAANSRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAVMRYGMP 1446

  Fly  1431 PQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVM 1495
            |||||.:||||||||||||:.||||||||||||||||||.|||||||||||||||||||||||||
Zfish  1447 PQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVM 1511

  Fly  1496 SLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATS 1560
            ||||||||||||:||.:|||  .:|..|..:.|..  :||.|.|          .|.::.|||.:
Zfish  1512 SLIRKKVQEFEHVNGQWSMP--WMKELEESKRAAA--IAAGEDP----------KTPSTGTPADT 1562

  Fly  1561 AAPSPAP--------ASEKGEDKDKDSEK------------------EKDKTSAEKSEVKQEQEA 1599
            ...:|||        ..|..|..:.|.||                  ||..:||:|.| |.::|:
Zfish  1563 QPNTPAPEDLSKTEDIKELEEKTEGDGEKEVKGSRQEDEIIEIPDEGEKSPSSAKKEE-KTDKES 1626

  Fly  1600 E----------EDKKPGD-VKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTE 1653
            |          |::|.|: .|.....|..:.|.|...::.......|:.|||:.:.::...|.::
Zfish  1627 EASSEKDGGSRENEKDGEKEKSAESKENMSSDVKADGSDATNSGDSTKTKEESSEEKMDTSPASD 1691

  Fly  1654 EKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKG-A 1717
            || ||..|:|..:.|       :|...:  ::||..|                  .|...|.| :
Zfish  1692 EK-KELKDEKDGVKP-------EDSAKL--QNGENAK------------------ETSGGGDGVS 1728

  Fly  1718 EDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAA-VPGREYEIWHRRHDYWLLAGIVTHGYGRWQ 1781
            |:..:.:|::||||||||||||||:||.|||:|| |..:.||||||||||||||||:.|||.|||
Zfish  1729 EEKKKAVKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIIFHGYARWQ 1793

  Fly  1782 DIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPA 1846
            |:|||.||||:|||||.::.:|||||||||||||||||||||||||||||||||||:.:|||||:
Zfish  1794 DVQNDPRFAILNEPFKGEMSRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMTEDPSHPS 1858

  Fly  1847 MSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPP 1911
            |:||.||:||||||||||||||||::|||||||||||||.||||||||||:||:|||||:|||||
Zfish  1859 MALNTRFSEVECLAESHQHLSKESMSGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPP 1923

  Fly  1912 VAQRLQMSERSILSRLAATAGNASNAAQLMAQ 1943
            ||.||||||||||||||:   ......|..||
Zfish  1924 VAVRLQMSERSILSRLAS---RGPEVTQTQAQ 1952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	24/52 (46%)
		TNG2	<282..422	CDD:227367	64/140 (46%)
		PHD1_CHD_II	380..422	CDD:277006	33/41 (80%)
		PHD2_CHD_II	440..482	CDD:277007	32/41 (78%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	31/82 (38%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	22/53 (42%)
		PLN03142	720..>1234	CDD:215601	386/520 (74%)
		DUF1087	<1292..1334	CDD:461922	29/41 (71%)
		CHDII_SANT-like	1380..1517	CDD:461920	115/139 (83%)
		CHDCT2	1757..1902	CDD:462358	121/144 (84%)
chd4b	XP_021322613.1	CHDNT	155..210	CDD:462357	24/54 (44%)
		PHD1_CHD_II	377..419	CDD:277006	33/41 (80%)
		PHD2_CHD_II	459..501	CDD:277007	32/41 (78%)
		CD1_tandem_CHD3-4_like	506..584	CDD:349314	31/82 (38%)
		CD2_tandem_CHD3-4_like	629..683	CDD:349309	22/53 (42%)
		PLN03142	734..>1274	CDD:215601	396/539 (73%)
		DEXHc_CHD4	736..967	CDD:350814	168/230 (73%)
		DUF1087	1308..1351	CDD:461922	31/43 (72%)
		CHDII_SANT-like	1397..1531	CDD:461920	112/133 (84%)
		PTZ00121	<1534..>1738	CDD:173412	56/244 (23%)
		CHDCT2	1769..1914	CDD:462358	121/144 (84%)