Protein Alignment Mi-2 and ercc6

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_688972.2
• Gene: ercc6 / 560477
• ZFINID: ZDB-GENE-070228-1
• Length: 1390
• Species: Danio rerio
• Alignment Length: 1911
• Identity: 412/1911 - (21%)
• Similarity: 656/1911 - (34%)
• Gaps: 685/1911 - (35%)

  Fly    16 EAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKK-----KR 75
            |..||.| .:.||:...| |.|...:::....|..||.:......:| .|.:..||.:     .|
Zfish     4 EGTEDQA-LSPLSSPVSA-LTPGAPEDNGLSIPGSSREEPAAACPET-VGAQNSRKSQPLLQINR 65

  Fly    76 KKNESEEDSDFVQ---------HDEEV-EYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCS 130
            ::..|.:.|....         :|::| |.....:..|..:|..|||.:.|:.......::||.|
Zfish    66 QEILSVDHSSQAAELQGLGVDVYDQDVLEQGVLQQVDRAIQEANQAAAKAEAQKEYESVLDDVRS 130

  Fly   131 AFSVCNVEIEYSEEELQSLTTYKAFMHHV-RPI----LQKENPKIAAPKLVMLVAAKWREFCESN 190
                |...:::..:.|:.||.:.|....: |.|    .||||.:    |.:..:.||.:..
Zfish   131 ----CTSALKHINKILEQLTPHAASSKDISRKIESVKRQKENKE----KQLKKIRAKQKRL---- 183

  Fly   191 PHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEE---------- 245
                 :....|......:|..:..|: |||..|.......|      |.|.|.||
Zfish   184 -----QALLDGEDIQKLEAELLIEDD-EEPGPSTLGSMLMP------AQESEWEELIRTGHMTPF 236

  Fly   246 ------EEEEKKPRR----KRSGRGK-----KGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGA 295
                  ::|:|:||:    :.||..|     .....|.|.|.:|.|...|...:::..::..:|:
Zfish   237 GSRIPQKQEKKEPRKVMLTENSGFDKYLADQALLADSRKRPIMKKKTTKKHSGETTPNKEKKNGS 301

  Fly   296 -SERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKN 359
             |.:|..|: :|||                |...:|..|          ..||:.|:.   |:..
Zfish   302 LSSKDKKLQ-KRML----------------KLQRTALRA----------HPKARPKVE---KELP 336

  Fly   360 KLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEA 424
            ::||.|:     |.||...      .:|.|.:..|             ||.:|.|
Zfish   337 RVKKRKS-----DWEHASD------SEGSEYVPSD-------------ELMDPEE---------- 367

  Fly   425 DGGAAEEEDDDE-----HQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSC 484
                .|.:||||     |:|:                                          ..
Zfish   368 ----PERDDDDELWVDDHEEY------------------------------------------QL 386

  Fly   485 PPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHP 549
            .|...|.|               |.|.|..|...|.                :::|
Zfish   387 KPYKKKKE---------------PKTRKPKKEDESD----------------DYIP--------- 411

  Fly   550 LMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLI 614
                               .|.:|.|::       |.....|..||.::   ..|:..::
Zfish   412 -------------------SSSEEEDSQ-------KGGKVKKCKDDGDI---ECYRQRIR----- 442

  Fly   615 VQRVINHRTARDGSTMYLVKW-----RELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETT 674
                               ||     ||....:...|||.|:..
Zfish   443 -------------------KWKRQRLREKEAKREAGEEESDESD--------------------- 467

  Fly   675 QSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGI 739
                            .|.||...:                     |.||   ..:|..||..|:
Zfish   468 ----------------AEFDEGFKI---------------------PGFL---WKKLFKYQQTGV 492

  Fly   740 NWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSL-YKEGHCR---------GPFLVAVPLSTLVN 794
            .|:.....|....||.||||||||||.:.||..| |.:...|         ||.::..|.:.:..
Zfish   493 RWMWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKLKTRGSNYRYAGLGPTVIVCPATVMHQ 557

  Fly   795 WEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELIS 859
            |.:||..|.|.|..          ||:.:.      |:....|...:........:|:|||..|.
Zfish   558 WVKEFHTWWPPFRV----------AVLHDT------GSFTSKKEKLIPEIVASHGILITSYSYIR 606

  Fly   860 MDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSR 924
            :....:...||..:::||.|::::..:........:...::.:|:|:|:||||:||:.|.:|:..
Zfish   607 IMQDYIQRYDWHYVILDEGHKIRNPNAGVTTACKQFRTPHRFILSGSPMQNNLKELWSLFDFVFP 671

  Fly   925 DKFNDLQAF---------QGEFADVSKEEQVKR-------LHEMLGPHMLRRLKTDVLKN--MPS 971
            .|...|..|         .|.:|:.| ..||:.       |.:.:.|::|||:|.||..|  :|.
Zfish   672 GKLGTLPVFMEQFSVPITMGGYANAS-PVQVQTAYKCACVLRDTINPYLLRRMKADVKANLSLPD 735

  Fly   972 KSEFIVRVELSAMQKKFYKFILTKN--YEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEE 1034
            |:|.::...|:..|::.|:..|...  |:.||     |...:.:.::.|:|.||||.||
Zfish   736 KNEQVLFCRLTEDQRQVYQTFLDSKEVYQILN-----GDMQVFSGLIALRKICNHPDLF------ 789

  Fly  1035 ATTAAGG---LYEI--NSLT--------KAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILE 1086
                .||   |..|  :.||        |.:||::::..:|:....|.||||:|:|..:||:|||
Zfish   790 ----TGGPRLLRGIPHDQLTEEEHFGYWKRSGKMIVVESLLRLWHKQGHRVLLFTQSRQMLEILE 850

  Fly  1087 DFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDW 1151
            .|::...:.|.::||..|...||..|.:|| .....|||:|:||.||||:||..|:.|:|||.||
Zfish   851 VFVKENGFSYLKMDGTTTIASRQPLIAQFN-QNKDIFVFILTTRVGGLGVNLTGANRVVIYDPDW 914

  Fly  1152 NPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQ 1216
            ||..|.||..||.||||..:|.:||.:|..::||::......|..||:.|::.         .||
Zfish   915 NPSTDTQARERAWRIGQKQQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKD---------PKQ 970

  Fly  1217 ELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRT----NRGIEEKESWANEYLSSFKVASYA 1277
            .     ||     ||.:|           :.||...:    ::|.|....:|.
Zfish   971 R-----RF-----FKSND-----------IYELFTLSSPDGSQGTETSAIFAG------------ 1002

  Fly  1278 TKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAAD 1342
                 ...:.::.|:. :.|.|:....         :..:..|...|.|....||    |:...:
Zfish  1003 -----TGSDVQVPKRH-KTSSPSQGTT---------RPSLSHSTDSGNRNTTSVN----GLPNNN 1048

  Fly  1343 TTRDDSNWQDNGSEYNSEYSAGSDE-----------------DGGDDDFDDQNGAERKAKRRLER 1390
            |:...:|..::.|..|...|:.|..                 :..:.|....:|.:||.|:|...
Zfish  1049 TSESPNNKLESRSNANGLTSSTSKALSSMNSPQKHREKKKHCETPEKDTIPSDGHKRKHKKRKHS 1113

  Fly  1391 RDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAY 1455
            .|.|                         |..|.:.:            ||:..|.|.|.:
Zfish  1114 EDAR-------------------------FEGARISH------------LVKKRRYKKEED---- 1137

  Fly  1456 VSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRI----GVMSLIR-KKVQEFEHINGYYSMP 1515
                            |...|....|..|..:||.::    |:.|::: ..:.|       .|.|
Zfish  1138 ----------------EEKEDERKNEKRSDDYVLAKLFKKSGIHSVMKHDTIME-------ASNP 1179

  Fly  1516 ELILKPCEPVRSALKQDVAALEA-------PPTGGNVDKSATTSNSVTPATSAAPSPAPASEK-G 1572
            :.:|...|..|.| |..:.||:.       |.:.|:           |.||     |||..:: |
Zfish  1180 DYVLVEAEANRVA-KDALRALKVSRQRCRLPYSRGS-----------TTAT-----PAPVKKRFG 1227

  Fly  1573 EDKD-----------KDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVK--QENPVEEAAGDTKPS 1624
            :.|:           |.:||.||....:||.|         ||||...  .....|:.:|....|
Zfish  1228 QKKNSLLSQSSGTMTKSAEKCKDAEIVKKSVV---------KKPGSAAHFSGEGAEDESGSLSSS 1283

  Fly  1625 DAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELE 1689
            ..     :|:...:...|.|:.:|:.:.|..:...|:
Zfish  1284 SL-----LARMRARNHLKKPQSQEDEEEESTQSVAVN---------------------------- 1315

  Fly  1690 KPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLK--------------RKFMFNIADGGFTEL 1740
              :|.:..|:..|......|..|...|...:.|:|:              |:.:.||.     |.
Zfish  1316 --AAPTEHDELLVDLRNFVAFQAQVDGQASTKEILEYFTPRLTSTQMPVFRELLNNIC-----EF 1373

  Fly  1741 HTLWLNEEKAAVPGREYEIWHRRHDY 1766
            |.|         ||:| .:|..:.||
Zfish  1374 HRL---------PGKE-GMWKLKADY 1389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	13/57 (23%)
		TNG2	<282..422	CDD:227367	27/140 (19%)
		PHD1_CHD_II	380..422	CDD:277006	7/41 (17%)
		PHD2_CHD_II	440..482	CDD:277007	0/41 (0%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	8/69 (12%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	8/58 (14%)
		PLN03142	720..>1234	CDD:215601	174/556 (31%)
		DUF1087	<1292..1334	CDD:461922	7/41 (17%)
		CHDII_SANT-like	1380..1517	CDD:461920	24/141 (17%)
		CHDCT2	1757..1902	CDD:462358	3/10 (30%)
ercc6	XP_688972.2	cc_ERCC-6_N	71..147	CDD:411064	16/79 (20%)
		SMC_N	<152..>359	CDD:481474	57/267 (21%)
		HepA	<438..965	CDD:440319	178/644 (28%)
		CSB_WHD	1317..1390	CDD:439329	20/88 (23%)