DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and chd4a

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_021323760.1	Gene:	chd4a / 558344	ZFINID:	ZDB-GENE-041111-187	Length:	1931	Species:	Danio rerio

Alignment Length:	2067	Identity:	1100/2067 - (53%)
Similarity:	1367/2067 - (66%)	Gaps:	286/2067 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKG 65
            |:..|::.|:|:.....||::....||| ::|||                  :.||.||.|....
Zfish     1 MSGSEDDRDDFEHRSVMQEEDDLEEELS-ENDAP------------------KVKKKKKAKKSSR 46

  Fly    66 EEKGRKKKKRKKNE----SEE-----DSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSG 121
            |.||.|:.:.::.|    |.|     |.|..:.|......|....|||:|:....||:|:..||.
Zfish    47 ESKGSKRNRSRREEIGISSPEPGEGPDLDDGEEDRSESEGSDYTPGRKKKKRASTAKDKKRNSSA 111

  Fly   122 M-----------PSVED--------------VCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRP 161
            .           |..|:              :...:.:.:::..::||:.::||.||||...|||
Zfish   112 AERNSAASKRREPEEEEDEDDDDSEPKSSSQLLDTWGMEDIDHIFTEEDYRTLTNYKAFSQFVRP 176

  Fly   162 ILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSS 226
            ::..:|||||..|::|::.||||||..:||       ..||..|...|.||  :.|.|..:|.|:
Zfish   177 LIAAKNPKIAVSKMMMVLGAKWREFSTNNP-------LRGSATSLVAAASV--ETPPETPTSASA 232

  Fly   227 RNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRP------SGKVPTLKIKLLG---KRK 282
            ....|:......|.:.:.:|.:....|:|    .|...:|      :.||..|||||.|   |||
Zfish   233 AQISPESTPAAPVRKAKTKEGKGPNARKK----SKPAPKPQEKKVKTKKVAPLKIKLGGFNSKRK 293

  Fly   283 RDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGS-GAPVVRKK 346
            |.||:|:       :.|.|.:|                              |||| .:..|...
Zfish   294 RSSSEED-------DVDVDSDF------------------------------DDGSINSVSVSNG 321

  Fly   347 AKTKIGNKFKKKNKLKKTKNFPEGEDG-EHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELD 410
            :.::......||...||||...|..|| |.:|||||||||||||||||||||||||:|||:|:::
Zfish   322 SNSRSSRSSAKKKPKKKTKKADEDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDME 386

  Fly   411 EPPEGKWSCPHCEADG-----------------GAAEEEDDDEHQEFCRVCKDGGELLCCDSCPS 458
            :.|||.|||||||..|                 ...|.|:||.|.||||||||||||||||||||
Zfish   387 KAPEGTWSCPHCEKMGIQWEAREDASEGEEDNEAGGEAEEDDHHMEFCRVCKDGGELLCCDSCPS 451

  Fly   459 AYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQ--------RSND---DGPSTSK 512
            :||..||||||..||:|:|.||||:||.:.||.:||:||||.:        |.:|   |.|..:.
Zfish   452 SYHIHCLNPPLPEIPNGEWICPRCTCPSMKGKVQKILTWRWTEPPPPTPVPRPSDLPTDAPDPTP 516

  Fly   513 GSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFE---ESLDEA 574
            .:....   ||:|:||.|||||||.||.|:||::|..:|.|::|||.||:|||..:   |..:|.
Zfish   517 LAGRPE---REFFVKWQNMSYWHCSWVTELQLEIHCQVMFRNYQRKNDMDEPPPIDFGGEGEEEK 578

  Fly   575 DTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELP 639
            ..:.|:    ||....:       :||::|:.|:|.||:::.|::||...:..:..||:|||:|.
Zfish   579 SDKRKK----KDPTYAR-------MEEKYYRFGIKMEWMVIHRILNHSVDKKNNCHYLIKWRDLT 632

  Fly   640 YDKSTWEEEGDDIQGLRQAIDY------YQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRP 698
            ||::|||.|..|:.      ||      |.:.|.:...:..:...|...||:..||      ||
Zfish   633 YDQATWELEDMDLP------DYDTYKLQYWNHRELMMGDEGKPGKKIKIKGKMRKL------DR- 684

  Fly   699 VKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKT 763
                  |||.|..|...|:|.||.:|:.||..|||||:||:||||:||.||.|||||||||||||
Zfish   685 ------PPENPVVDPTIKFERQPDYLDTTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKT 743

  Fly   764 IQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSF 828
            :||..||||||||||.:|||||:.||||::|||||||:||||.|.:||:|||||||||||||.||
Zfish   744 VQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAVIRENEFSF 808

  Fly   829 EEGAIR-GSKVSRL-RTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRI 891
            |..||| |.|.|:: :....||:|||||||||::|.|.|||||||.||||||||||:||||||||
Zfish   809 ENNAIRGGKKPSKMKKEASVKFHVLLTSYELITIDTAVLGSIDWACLVVDEAHRLKNNQSKFFRI 873

  Fly   892 LNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPH 956
            ||:|.:.:|||||||||||||||||||||||:.::|::|:.|..||||::||:|:|:||:|||||
Zfish   874 LNNYPLQHKLLLTGTPLQNNLEELFHLLNFLTPERFSNLEGFLEEFADIAKEDQIKKLHDMLGPH 938

  Fly   957 MLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKC 1021
            ||||||.||.|:||||:|.|||||||.||||:||||||:|:||||::.||...||:|::||||||
Zfish   939 MLRRLKADVFKHMPSKTELIVRVELSPMQKKYYKFILTRNFEALNTRGGGNQVSLLNVVMDLKKC 1003

  Fly  1022 CNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILE 1086
            ||||||||:||.||.....|:||...|||::|||:||.|||::||...||||||||||||||:||
Zfish  1004 CNHPYLFPAAAMEAAKMPNGMYEGGGLTKSSGKLLLLQKMLRKLKEGGHRVLIFSQMTKMLDLLE 1068

  Fly  1087 DFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDW 1151
            ||||.|.||||||||||||.:|||||||||||||.|||||||||||||||||||||||:||||||
Zfish  1069 DFLENEGYKYERIDGGITGGMRQEAIDRFNAPGAPQFVFLLSTRAGGLGINLATADTVVIYDSDW 1133

  Fly  1152 NPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQ 1216
            |||||||||||||||||..|||||||||:.|||||:|||||:||||||||||||:|.|..:.:||
Zfish  1134 NPHNDIQAFSRAHRIGQNKKVMIYRFVTKASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQ 1198

  Fly  1217 ELDDILRFGTEDLFKEDDKEE---------AIHYDDKAVAELLDRTNRGIEEKESWA-NEYLSSF 1271
            ||||||:||||:|||::.:.|         .|||||||:..||||.....::.|..: |||||||
Zfish  1199 ELDDILKFGTEELFKDEGEGENKEGQEDSSVIHYDDKAIDRLLDRNQDATDDTELQSMNEYLSSF 1263

  Fly  1272 KVASYATKEEEEEEE---TEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNY 1333
            |||.|..|:|||.||   .|||||: |:.||.||.|||||||||.|||:.|:||||||:||||||
Zfish  1264 KVAQYVVKDEEEAEEEVQREIIKQE-ESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNY 1327

  Fly  1334 TDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGA-ERKAKRRLERRD-DRPL 1396
            .||       :::|.:|||:.|:..|:||..|:|  ||:|||:::.| .|:..|:..|.| |:||
Zfish  1328 NDG-------SQEDRDWQDDQSDGQSDYSVASEE--GDEDFDERSEANSRRPNRKGLRNDKDKPL 1383

  Fly  1397 PPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMR 1461
            |||||||.||||||||||||||:||||:|||||||||||.:|||||||||||||.||||||||||
Zfish  1384 PPLLARVSGNIEVLGFNARQRKAFLNAVMRYGMPPQDAFTTQWLVRDLRGKSEREFKAYVSLFMR 1448

  Fly  1462 HLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVR 1526
            ||||||||.||:||||||||||||||||||||||||||||||||||:||.:|||.::
Zfish  1449 HLCEPGADGAESFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGQWSMPWMM-------- 1505

  Fly  1527 SALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAP-----ASEKGEDKDK------DSE 1580
             .|.::.....|   |.:.|..:.|..:.||:.:...:|||     |.:.|:|.||      |.|
Zfish  1506 -ELSENKTTSTA---GSHPDSPSKTPTTGTPSDTQPNTPAPDGVPKAEDAGKDADKEKVKNGDGE 1566

  Fly  1581 KE--------------KDKTSAEKSEVKQEQEAEEDKKP--------GDVKQENPVEEAAGDTKP 1623
            ||              :|..:|..||.|::.:.|::|.|        .|.|||...||.|   |.
Zfish  1567 KEANENKNSEVIAVPDEDGRAASASEEKEKGKEEKEKTPESSSEAEKADGKQEEKEEENA---KS 1628

  Fly  1624 SDAEVKTEVAKTEPKEETKDPEVKEEPK-TEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGE 1687
            .|:|.||        ::|..|:..|..| |.:.:.||.||:.....||.:.|:.......|:.|:
Zfish  1629 GDSEEKT--------DDTDKPKGSEADKETSDAKGEKKDDEPEKMDTTPVTDEKKGQKDEKDSGK 1685

  Fly  1688 LEK----PSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEE 1748
            .|:    |:..|.||            .|.|.|.|:..:. |.:||||||||||||||:||.|||
Zfish  1686 TEEAGKLPNGESAKD------------SAAGAGIEERKKA-KTRFMFNIADGGFTELHSLWQNEE 1737

  Fly  1749 KAA-VPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKF 1812
            :|| |..:..|||||||||||||||:.|||.||||||||:||||:|||||.::.:||||||||||
Zfish  1738 RAATVTKKTNEIWHRRHDYWLLAGIIQHGYARWQDIQNDVRFAILNEPFKGEINRGNFLEIKNKF 1802

  Fly  1813 LARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPA 1877
            |||||||||||||||||||||||||:.:|||||:|:||.||:||||||||||||||||::|||||
Zfish  1803 LARRFKLLEQALVIEEQLRRAAYLNMTEDPSHPSMALNTRFSEVECLAESHQHLSKESMSGNKPA 1867

  Fly  1878 NAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAA 1929
            ||||||||.||||||||||:||:|||||:|||||||.|||||||:||||||:
Zfish  1868 NAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLAS 1919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	24/51 (47%)
		PHD1_CHD_II	380..422	CDD:277006	33/41 (80%)
		PHD2_CHD_II	440..482	CDD:277007	33/41 (80%)
		CHROMO	490..558	CDD:237991	32/78 (41%)
		CHROMO	615..667	CDD:214605	19/57 (33%)
		SNF2_N	734..1028	CDD:278600	216/295 (73%)
		DEXDc	751..907	CDD:238005	117/157 (75%)
		Helicase_C	1053..1167	CDD:278689	99/113 (88%)
		DUF1087	<1292..1337	CDD:283996	32/44 (73%)
		DUF1086	1380..1517	CDD:283992	116/138 (84%)
		CHDCT2	1756..1927	CDD:285336	143/170 (84%)
chd4a	XP_021323760.1	CHDNT	153..206	CDD:311840	24/52 (46%)
		OxoGdeHyase_C	196..>280	CDD:330401	27/96 (28%)
		PHD1_CHD_II	356..398	CDD:277006	33/41 (80%)
		PHD2_CHD_II	433..475	CDD:277007	33/41 (80%)
		CHROMO	<522..559	CDD:237991	21/39 (54%)
		Chromo	607..659	CDD:306815	19/57 (33%)
		SNF2_N	709..>1250	CDD:331286	394/540 (73%)
		DUF1087	1280..1334	CDD:310812	37/61 (61%)
		DUF1086	1368..1502	CDD:310809	113/133 (85%)
		Neuromodulin_N	<1547..>1713	CDD:331332	52/188 (28%)
		CHDCT2	1747..1917	CDD:311841	143/169 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1990	1.000	Inparanoid score	I51
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm24896
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4509
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010