Protein Alignment Mi-2 and CHD7

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Alignment Length: 2146
• Identity: 562/2146 - (26%)
• Similarity: 841/2146 - (39%)
• Gaps: 631/2146 - (29%)

  Fly   161 PILQKENP---KIAAPKLVMLVAAKWREFCESNP----------HIQQEGGAAG------SGGSA 206
            |.|:|..|   :::.|...::.:..:....|..|          ||..|..:.|      .||..
Human   561 PFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFPGGVD 625

  Fly   207 GQ---ARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSG 268
            .|   ..|:.|.:.|:.:..||...:.|.:..|...::|.:|.:..|.|:..:..:.||.:..:.
Human   626 NQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATP 690

  Fly   269 KVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQK-----SDDSADEKEAPVSSKADN 328
            |         .|..:.||:::.|:..::       .::.:.|     |::|..:|..|      .
Human   691 K---------PKSSKKSSNKKPDSEASA-------LKKKVNKGKTEGSENSDLDKTPP------P 733

  Fly   329 SAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILC 393
            |.|..:|:..|   |:|          ::.::..|.|.:.|.
Human   734 SPPPEEDEDPG---VQK----------RRSSRQVKRKRYTED----------------------- 762

  Fly   394 DTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEED------DDEHQEFCRVCKDGGELLC 452
                       ||.::.:.          |||...|...|      ..|.||  .|..:|
Human   763 -----------LEFKISDE----------EADDADAAGRDSPSNTSQSEQQE--SVDAEG----- 799

  Fly   453 CDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNS 517
                                             |:   .|||::.|..::..:.|...
Human   800 ---------------------------------PV---VEKIMSSRSVKKQKESGEEV------- 821

  Fly   518 NSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQ 582
              .:.|:::|:.|.||.||:|.              |.:   |:|:..:.::          :|:
Human   822 --EIEEFYVKYKNFSYLHCQWA--------------SIE---DLEKDKRIQQ----------KIK 857

  Fly   583 RHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGS----TMYLVKWRELPYDKS 643
            |.|.|.|.  |.....:|:..:    .|:::.|.|:::...:.|..    |.|||||..|||:.|
Human   858 RFKAKQGQ--NKFLSEIEDELF----NPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDS 916

  Fly   644 TWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEK 708
            |||.        ||.||                   ::|.....||...:.|...|       |:
Human   917 TWER--------RQDID-------------------QAKIEEFEKLMSREPETERV-------ER 947

  Fly   709 PTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSL 773
            |..|..||.|....:....  :|..||:||:|||.::|....:.|||||||||||||::||||.:
Human   948 PPADDWKKSESSREYKNNN--KLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEI 1010

  Fly   774 YKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEE---GAIRG 835
            |.:| ..|||||..||||:.||||||..|. :...:.|.|.:.||..|:..|:.|::   ..|:|
Human  1011 YLKG-IHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKG 1073

  Fly   836 SKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYK 900
            |         |||:.::|::|:|..|...|.:|.|..:|:|||||||:...|....|....:.:|
Human  1074 S---------YKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHK 1129

  Fly   901 LLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDV 965
            :|||||||||.:||||.||:||...:|.....|..||.|:..||||::|..:|.|.||||||.||
Human  1130 VLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDV 1194

  Fly   966 LKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSC---SLINIMMDLKKCCNHPYL 1027
            .||:..|.|.|:.|||:.:|||:|:.||.||:..|:  .|||..   :|:|.||:|:||||||||
Human  1195 EKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFLS--KGGGQANVPNLLNTMMELRKCCNHPYL 1257

  Fly  1028 FPSAAE-------EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDIL 1085
            ...|.|       |...|....:::.::.:|||||||:.|:|.:|||..|||||||||.:.||||
Human  1258 INGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDIL 1322

  Fly  1086 EDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSD 1150
            ||:|...:|.||||||.:.|.|||.|||||:.|.:.:|||||.||||||||||..|||.||:|||
Human  1323 EDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSD 1387

  Fly  1151 WNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGA---- 1211
            |||.||:||.:|.|||||:..|.|||.:||||.|..:...|..|:.|...|::...|.:.|
Human  1388 WNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGV 1452

  Fly  1212 -NFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVAS 1275
             ..:|:|::|:||.|......:::.|.:...::.....||.||:....|.|...    |:|..||
Human  1453 QQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKG----STFAKAS 1513

  Fly  1276 YATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGK------RVRKQVNYT 1334
            :.....         :.|....||.:|.|..:    :.:.|:....|:..      |||||...
Human  1514 FVASGN---------RTDISLDDPNFWQKWAK----KAELDIDALNGRNNLVIDTPRVRKQTRL- 1564

  Fly  1335 DGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDD-QNGAERKAKRRLERRDDRPLPP 1398
                                      |||..:::  ..:|.| ::.:|.|...:..|..|:....
Human  1565 --------------------------YSAVKEDE--LMEFSDLESDSEEKPCAKPRRPQDKSQGY 1601

  Fly  1399 LLA---RVGGNIEVLGF--------NARQRK--------SFLNAIMRYGM--------------- 1429
            ..:   ||..|:.|.|:        :.|.::        :....|:.|.:
Human  1602 ARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWD 1666

  Fly  1430 ---PPQDA-----FNSQWLVRDL-RGKSERNFKAYV-----------------SLF--------M 1460
               |..|.     .|...|...: ||:..:..||..                 :||        :
Human  1667 LITPTADGQTRALVNHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHL 1731

  Fly  1461 RHLCEPGADNAETFADGV-------------PREGLSRQHVLTRIGVMSLIRKKV---QEFEHIN 1509
            :|.|....:||   .|.:             |.|. |...||.|:.::..:|::|   |..:.:.
Human  1732 KHHCNNSGNNA---TDQLYVLASCDLEQVIQPLED-SLSWVLLRVRMLYYLRQEVIGDQADKILE 1792

  Fly  1510 GYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSAT-----------TSNSVTPA----- 1558
            |..|....:..| ||..:.:..|....||       |||..           .|....||
Human  1793 GADSSEADVWIP-EPFHAEVPADWWDKEA-------DKSLLIGVFKHGYEKYNSMRADPALCFLE 1849

  Fly  1559 -TSAAPSPAPASEK---------GEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENP 1613
             .....:.|.|:|:         |:..:.|.|.|..:....::..|.|.: |....|.:.|:|:.
Human  1850 RVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEID-EFANSPSEDKEESM 1913

  Fly  1614 VEEAAGDTKPSDAE-------------------------------------VKTEVAKTEPKEET 1641
            ...|.|....|:||                                     :||:..:..|:||.
Human  1914 EIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEV 1978

  Fly  1642 KDPEVKEEPKTEEK-----EKEKVDDKKPIPPTTVIDDDDDDV-----------MIVKEDGELE- 1689
            :..|.:.|....||     .:|:.|..:.:....||.|.....           :..|.|..||
Human  1979 RALEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEK 2043

  Fly  1690 -----------------KPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGF 1737
                             ||....|.....:...|......|....|     |.||....:
Human  2044 YFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIE-----LLRKIREQV----- 2098

  Fly  1738 TELHTLWLNEE-KAAVPGREYEIWHR--RHDYWLLAGIVTHGYGRWQ-DIQND--IRFAIINEPF 1796
              ||...|.|. |...|..:...|..  |||..||.|...||..|.. .|.||  :.|...::.|
Human  2099 --LHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKNF 2161

  Fly  1797 KMDVGKGNFLEIKNKFLARRF----KLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVE 1857
            ..:.|.||...:..  ||..|    .::..|.:.:|::...|. ...::|.:||........|.|
Human  2162 AQNRGAGNTSSLNP--LAVGFVQTPPVISSAHIQDERVLEQAE-GKVEEPENPAAKEKCEGKEEE 2223

  Fly  1858 CLAESHQHLSKESLAGNKPANAVLHKVLNQL------------------------EELLSDMKSD 1898
               |......|||   .:...|....|.|:|                        |:|..|.||:
Human  2224 ---EETDGSGKES---KQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDKSE 2282

  Fly  1899 VSRLP----------------ATLARI--------------PPVAQRLQ---------MSERSIL 1924
            .|..|                |:::..              |.|||.|.         ..:|.::
Human  2283 ESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMI 2347

  Fly  1925 SRLAATAGNASNAAQLMAQFPAG------FQGTTLPAFTSGPAG------NFANFRPQFSVPGQL 1977
            :||    .|...|. |..::|..      ||| .:|.:|.....      :||    :.|:.||.
Human  2348 NRL----DNICEAV-LKGKWPVNRRQMFDFQG-LIPGYTPTTVDSPLQKRSFA----ELSMVGQA 2402

  Fly  1978 S 1978
            |
Human  2403 S 2403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	6/32 (19%)
		TNG2	<282..422	CDD:227367	19/144 (13%)
		PHD1_CHD_II	380..422	CDD:277006	2/41 (5%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	14/69 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	21/57 (37%)
		PLN03142	720..>1234	CDD:215601	251/531 (47%)
		DUF1087	<1292..1334	CDD:461922	12/47 (26%)
		CHDII_SANT-like	1380..1517	CDD:461920	38/220 (17%)
		CHDCT2	1757..1902	CDD:462358	43/177 (24%)
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830	5/16 (31%)
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	20/141 (14%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	23/83 (28%)
		PLN03142	967..>1566	CDD:215601	274/655 (42%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800