DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and chd5

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_009304380.1	Gene:	chd5 / 553422	ZFINID:	ZDB-GENE-120314-2	Length:	2024	Species:	Danio rerio

Alignment Length:	2130	Identity:	1102/2130 - (51%)
Similarity:	1362/2130 - (63%)	Gaps:	316/2130 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQN--DEDDDYDPEDSRRKKKGKKRKTR 63
            :::|:|..|:...|::..:|.....:.|    .||.|.:.  .|:|:.        |:.||:||.
Zfish     5 LSNEDEGQDDMDFEDDVPDDEEGELQRS----VPLSPLERFFSEEDNV--------KQHKKKKTS 57

  Fly    64 K---GEEKGRKKKKRKKN--------ESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQA------ 111
            |   |:|...||||:|:.        ...||.......|...|.:..|:.:|.:|:|:.
Zfish    58 KIMEGKEPKVKKKKKKEGLPSGLDDMSDREDHGHRSGSESSTYSALKKKKKKPREKKERKMKQRK 122

  Fly   112 --------------AKEKESASSGMP--SVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVR 160
                          .||.:|:|..|.  .:|||..||         ||::.:::|.||||...:|
Zfish   123 KEDDEDEDDDDDGNMKEPKSSSQLMQEWGLEDVQYAF---------SEDDYKTITNYKAFSQFLR 178

  Fly   161 PILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRS 225
            |::.|:||||...|::.::.||||||..:||.    .|.:.:..:|..|.:|.......|...||
Zfish   179 PLIAKKNPKIPMSKMMTVLGAKWREFSANNPF----KGTSATAVAAAVAAAVETVNVAPPICIRS 239

  Fly   226 SRNEKPDDIYEEAVEEEEEEEEEEKKPR----RKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSS 286
            .:...|....::|..:|.:....:||.:    .|:.|:.||.:..:|..        ||||:.||
Zfish   240 IQQISPTGPIKKAKTKEGKGPGAKKKSKPGKETKKKGKPKKSKSKAGPG--------GKRKKGSS 296

  Fly   287 DEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKI 351
            .||......|:.| |:.......:||.||                              .||.|.
Zfish   297 SEEDFLDDFSDFD-DISIHSASVRSDTSA------------------------------AAKKKS 330

  Fly   352 GNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGK 416
            ..|.:||.|.:      :|:..|.:|||||||||||||||||||||||||||||:|||::.||||
Zfish   331 SRKGRKKRKRE------DGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGK 389

  Fly   417 WSCPHCEADG------GAAEEED------DDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPL 469
            |||||||.:|      ...||||      :|:|.||||||||||||||||:|||:||..||||||
Zfish   390 WSCPHCEKEGIQWEAKDDEEEEDEVAGEEEDDHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPL 454

  Fly   470 DTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRS-------NDDGPSTSKGSKN--SNSRVREYF 525
            ..||:|:|.||||.||||.||.:||:.|.|....       ..||......:|.  .....|:.|
Zfish   455 PEIPNGEWLCPRCMCPPLKGKVQKILHWSWGDPPLPPEVPLGPDGEKVDNLAKTPLKGRPERQLF 519

  Fly   526 IKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGM 590
            :||..:|||||.||.|:||:::|.:|.|::|||.||:|||.::....|.:...:: :|.||
Zfish   520 VKWAGLSYWHCSWVSELQLELYHTVMYRNYQRKNDMDEPPPYDYGSGEEELNNEK-RRSKD---- 579

  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDI--- 652
               .....:|||||:.|:||||||:.|::||...:||...||:|||:||||:.:||.:..|:
Zfish   580 ---PQYAAMEERFYRYGIKPEWLIIHRILNHSFDKDGDVQYLIKWRDLPYDQCSWEADDFDVPDY 641

  Fly   653 QGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKY 717
            ..|:||   |.|.|.....|..|  ....:||::.|        ..:|...|||:.|..|...|:
Zfish   642 DSLKQA---YWDHRNQVLGENHQ--PLLFRKGKRPK--------EEMKRREPPPDTPVVDPTIKF 693

  Fly   718 EDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGP 782
            |.||.:::.||..|||||:||:||||:||.||.|||||||||||||:||:.||||||||||.:||
Zfish   694 EQQPWYIDDTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGP 758

  Fly   783 FLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR-GSKVSRL-RTTQ 845
            |||:.||||::|||||||:||||||.:||.|||:|||:|||||.:||:.|:: |.||.|: :.|.
Zfish   759 FLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRAIIRENEFTFEDSAVKSGRKVFRMKKDTP 823

  Fly   846 YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQN 910
            .||:|||||||||::|.|.||||.||.||||||||||:||||||||||.|.|.||||||||||||
Zfish   824 IKFHVLLTSYELITIDQAILGSITWACLVVDEAHRLKNNQSKFFRILNGYKIYYKLLLTGTPLQN 888

  Fly   911 NLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEF 975
            ||||||||||||:.::||:|:.|..||||:|||:|:|:||::||||||||||.||.||||:|:|.
Zfish   889 NLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTEL 953

  Fly   976 IVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAG 1040
            |||||||.||||:||||||:|:||||||.||...||:|||||||||||||||||.||.||.....
Zfish   954 IVRVELSPMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPN 1018

  Fly  1041 GLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITG 1105
            |.|:.|.|.|::|||.||.|||.:||...||||||||||||||:||||||.|.||||||||||||
Zfish  1019 GSYDGNLLVKSSGKLTLLQKMLIKLKDGGHRVLIFSQMTKMLDLLEDFLEFEGYKYERIDGGITG 1083

  Fly  1106 TLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQAN 1170
            .|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||..
Zfish  1084 GLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNK 1148

  Fly  1171 KVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKED-- 1233
            ||||||||||.|||||:||||||||||||||||||:|.|..:.:||||||||:||||:|||:|
Zfish  1149 KVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDDVE 1213

  Fly  1234 ----------------------------------DKEE-----AIHYDDKAVAELLDRTNRGIEE 1259
                                              |.:|     .|||||.|:::||||:....|:
Zfish  1214 AARTMGELKVLEMKSIVLPLCVPIAEVLNLSSTGDNKEGEEVSVIHYDDNAISKLLDRSQDATED 1278

  Fly  1260 KE-SWANEYLSSFKVASYATKEEEEEEET--EIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSL 1321
            .| ...||||||||||.|..:||:.|||.  |||||: ||.||.||.|||||||||.|||:.|:|
Zfish  1279 TEIQNMNEYLSSFKVAQYVVREEDGEEEVQREIIKQE-ENVDPDYWEKLLRHHYEQQQEDLARNL 1342

  Fly  1322 GKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQ-NGAERKAK 1385
            |||||:||||||.       |.:::|..|||:.|:..||||.||:::  |:||::: .|..|.::
Zfish  1343 GKGKRIRKQVNYN-------DASQEDQEWQDDLSDNQSEYSVGSEDE--DEDFEERPEGGRRHSR 1398

  Fly  1386 RRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSER 1450
            |:|:...|:|||||||||.||||||||||||||:|||||||:||||||||||.|||||||||||:
Zfish  1399 RQLKSDRDKPLPPLLARVSGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEK 1463

  Fly  1451 NFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMP 1515
            .|:||||||||||||||||.|||||||||||||||||||||||||||:|||||||||:||.:|.|
Zfish  1464 EFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKFSTP 1528

  Fly  1516 ELILKPCEPVRSALKQDVAALEAPP-------------------------TGGNVDKSATTSNSV 1555
            :.|     ||...||:...::.:.|                         :|...||......:.
Zfish  1529 DRI-----PVGLELKKLTESVSSDPNTPVPASPVPTQPSTPVPSDKTESVSGSQEDKEIAEPENT 1588

  Fly  1556 TP--ATSAAPSPAPASEK---GEDKDKDSEKEKDKTSAEKSEVKQEQ-EAEEDKKPGDVKQ-ENP 1613
            .|  .....|.|:||.||   ||:....|.:||....:|||:....| |...::.|...|| |.|
Zfish  1589 KPLDPEPVVPEPSPAPEKTNEGEETKNGSPEEKRLEESEKSDTPPVQSEPSANQAPPPTKQCEQP 1653

  Fly  1614 VEEAAGD------TKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVI 1672
            ..:...|      |.|...|.|....|||.||:  .|.:.::.|:|:..:.:|:.:|.:
Zfish  1654 ANQTPSDCGKGKETSPERGETKPSPPKTEDKEQ--KPAIPDDVKSEDPPENQVNGEKDV------ 1710

  Fly  1673 DDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGF 1737
                                    :|:             |.:|..|....:|.:||||||||||
Zfish  1711 ------------------------RDE-------------TDEGHRDDKSSIKTRFMFNIADGGF 1738

  Fly  1738 TELHTLWLNEEKAAV-PGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVG 1801
            |||||||.|||:||| .|:.|:|||||||||||||||||||.||||||||.|:||:|||||.::.
Zfish  1739 TELHTLWQNEERAAVSSGKIYDIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYAILNEPFKTEMH 1803

  Fly  1802 KGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHL 1866
            |||:||:|||||||||||||||||||||||||||||:.||||||||:||.|||||||||||||||
Zfish  1804 KGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPSHPAMALNTRFAEVECLAESHQHL 1868

  Fly  1867 SKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATA 1931
            ||||||||||||||||||||||||||||||:||:|||:.|:|:|||:.|||||||.||||| .:.
Zfish  1869 SKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRVPPVSARLQMSERGILSRL-TSR 1932

  Fly  1932 GNASNAAQLMAQ------------FPAGFQ---GTTLPAFTSGPAGNFAN 1966
            ||.....|...|            |..||:   ||.:..::..|.|.:.:
Zfish  1933 GNEPPPQQPFPQGSFGCSQMYNSSFAGGFRGPGGTAMVNYSQMPLGPYVS 1982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	21/51 (41%)
		PHD1_CHD_II	380..422	CDD:277006	37/41 (90%)
		PHD2_CHD_II	440..482	CDD:277007	32/41 (78%)
		CHROMO	490..558	CDD:237991	26/76 (34%)
		CHROMO	615..667	CDD:214605	22/54 (41%)
		SNF2_N	734..1028	CDD:278600	220/295 (75%)
		DEXDc	751..907	CDD:238005	116/157 (74%)
		Helicase_C	1053..1167	CDD:278689	101/113 (89%)
		DUF1087	<1292..1337	CDD:283996	32/44 (73%)
		DUF1086	1380..1517	CDD:283992	112/136 (82%)
		CHDCT2	1756..1927	CDD:285336	145/170 (85%)
chd5	XP_009304380.1	CHDNT	159..208	CDD:285335	22/57 (39%)
		PHD1_CHD_II	353..395	CDD:277006	37/41 (90%)
		PHD2_CHD_II	425..467	CDD:277007	32/41 (78%)
		CHROMO	500..553	CDD:214605	20/52 (38%)
		Chromo	600..651	CDD:278797	22/53 (42%)
		SNF2_N	710..1006	CDD:278600	220/295 (75%)
		DEXDc	727..885	CDD:238005	116/157 (74%)
		Helicase_C	1030..1145	CDD:278689	101/114 (89%)
		DUF1087	1301..1361	CDD:283996	41/67 (61%)
		DUF1086	1390..1530	CDD:283992	113/139 (81%)
		BASP1	<1548..1692	CDD:283191	37/145 (26%)
		CHDCT2	1758..1929	CDD:285336	145/170 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56712
Inparanoid	1	1.050	1990	1.000	Inparanoid score	I51
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm24896
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980