DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mi-2 and PHF21A

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_011518459.1	Gene:	PHF21A / 51317	HGNCID:	24156	Length:	688	Species:	Homo sapiens

Alignment Length:	434	Identity:	98/434 - (22%)
Similarity:	148/434 - (34%)	Gaps:	139/434 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 LTTYKAFMHHVRPILQKEN---------PKIAAPKL------------------------VMLVA 180
            ||....|:..|||....:|         |.:|||:|                        |.:|.
Human   232 LTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVN 296

  Fly   181 AKWREFCESNPHIQQEGGAAGSGGS--AGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEE 243
            .:.....::.|..|.......:.|:  ||         |:..:.|:.|       :.::.|:...
Human   297 GQTATIAKTFPMAQLTSIVIATPGTRLAG---------PQTVQLSKPS-------LEKQTVKSHT 345

  Fly   244 EEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERML 308
            |.:|::.:.|........|.:|.........:..||....|..:|             ::.:|..
Human   346 ETDEKQTESRTITPPAAPKPKREENPQKLAFMVSLGLVTHDHLEE-------------IQSKRQE 397

  Fly   309 QKSDDSADEKEAPVSSKADNSAPAAQDDGSGA---PVVRKKAKTKIGNKF----KKKNKLKKTKN 366
            :|...:|:    ||.              |||   |..:|.|.|.:.:..    :|:.:..|
Human   398 RKRRTTAN----PVY--------------SGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPK--- 441

  Fly   367 FPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDE------PPEGKWSCPHCEAD 425
                         |..|...|.   |..|.|::.|....|.|..|      .|....|.|
Human   442 -------------YNAVLGFGA---LTPTSPQSSHPDSPENEKTETTFTFPAPVQPVSLP----- 485

  Fly   426 GGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGK 490
              :....|.|.|::||.||:..|:||.||:|...||..||:|||.|||.|.|.||||....|  |
Human   486 --SPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQML--K 546

  Fly   491 AEKIITWRWAQRSNDDGPSTSK------GSKNSNSRVREYFIKW 528
            .|:.|.|          |.|..      ..|.:....::..:||
Human   547 KEEAIPW----------PGTLAIVHSYIAYKAAKEEEKQKLLKW 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	14/73 (19%)
		PHD1_CHD_II	380..422	CDD:277006	13/47 (28%)
		PHD2_CHD_II	440..482	CDD:277007	24/41 (59%)
		CHROMO	490..558	CDD:237991	9/45 (20%)
		CHROMO	615..667	CDD:214605
		SNF2_N	734..1028	CDD:278600
		DEXDc	751..907	CDD:238005
		Helicase_C	1053..1167	CDD:278689
		DUF1087	<1292..1337	CDD:283996
		DUF1086	1380..1517	CDD:283992
		CHDCT2	1756..1927	CDD:285336
PHF21A	XP_011518459.1	ING	<382..544	CDD:331088	58/218 (27%)
PHF21A	XP_011518459.1	PHD_PHF21A	498..540	CDD:276998	24/41 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900