DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and dom

DIOPT Version :9

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster


Alignment Length:2205 Identity:419/2205 - (19%)
Similarity:668/2205 - (30%) Gaps:1011/2205 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 LQKEN-------PKIAAP------------KLVMLVA-----AKWREFCES------NPHIQQEG 197
            ||:|.       ||:..|            ::|.|.|     .||::....      ..:.|.:.
  Fly   531 LQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKA 595

  Fly   198 GAAGSGGSAG--QARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEE----------EEEEK 250
            .||.....|.  |.:.|......|.:|..|:..:..:..::..:||:.::          ::.||
  Fly   596 TAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEK 660

  Fly   251 KPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSA 315
            ..::...|..|.    ....|:|....|...||:|.|:.:..|| ||.|.    |.:.:..:|:|
  Fly   661 FSQQLVEGMNKS----VADTPSLNSSRLTSPKRESDDDFRPESG-SEDDE----ETIAKAEEDAA 716

  Fly   316 DEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDY 380
            |.|| .|::.|..|.....|..:..|....:.:.|:..  ::::...||:...:.:|.|.|    
  Fly   717 DVKE-EVTALAKESEMDFDDFLNDLPPGYLENRDKLMK--EEQSSAIKTETPDDSDDSEFE---- 774

  Fly   381 CEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCK 445
                                                           |.|..||||         
  Fly   775 -----------------------------------------------AKEASDDDE--------- 783

  Fly   446 DGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPST 510
                                    :||                .|.|:      |::..|     
  Fly   784 ------------------------NTI----------------SKQEE------AEQEID----- 797

  Fly   511 SKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEAD 575
                                    |.:.:.|::.|  :.|.:.....||..|:||        :.
  Fly   798 ------------------------HKKEIDELEAD--NDLSVEQLLAKYKSEQPP--------SP 828

  Fly   576 TRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPY 640
            .|.|...|..:   :.::||:..::                   :...:.|.:|       |...
  Fly   829 KRRKLAPRDPE---LDSDDDSTAVD-------------------STEESEDAAT-------EDEE 864

  Fly   641 DKST------WEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDD--EDR 697
            |.||      .||:.:...||:..:     ..|..||....|.|.....|.|      ||  .|.
  Fly   865 DLSTVKTDTDMEEQDEQEDGLKSLM-----ADADATSGAAGSGSTAGASGNK------DDMLNDA 918

  Fly   698 PVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGK 762
            .....:..|:..|..........|..|:.:   |..||..|::||.....:.::.||||||||||
  Fly   919 AALAESLQPKGNTLSSTNVVTPVPFLLKHS---LREYQHIGLDWLVTMNERKLNGILADEMGLGK 980

  Fly   763 TIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELS 827
            ||||:..|..|.......||.|:.||.|.::|||.||:.|.|.|..:||.|.:..|         
  Fly   981 TIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKER--------- 1036

  Fly   828 FEEGAIRGSKVSRLRTTQ-YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRI 891
                     |:.|:..|: ..|:|.:|||:|:..|........|..|::|||..:|:.:|:.:::
  Fly  1037 ---------KLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQL 1092

  Fly   892 LNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVS----------KEEQV 946
            |.:::...:||||||||||:|.||:.|::||....|:..:.|:..|::..          .|..:
  Fly  1093 LLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLI 1157

  Fly   947 KRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILT--KNYEALNSKSGGGSC 1009
            .|||:::.|.:|||||.:|.|.||.|.|.::...||..|:..|:..::  |..|.|.:   |...
  Fly  1158 TRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQT---GNLL 1219

  Fly  1010 SLINIMMDLKKCCNHPYLF---------------------------------------------- 1028
            |:||::|.|:|.||||.:|                                              
  Fly  1220 SVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHL 1284

  Fly  1029 ----------------------------------------------------------------- 1028
                                                                             
  Fly  1285 EQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGAS 1349

  Fly  1029 ----------------------------------------------------------------- 1028
                                                                             
  Fly  1350 PAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVL 1414

  Fly  1029 --------------PSAAEEATT-----------------AAGGLYEINSLTKAA---------- 1052
                          |:.|:.|.|                 |||....:.|.|.|:          
  Fly  1415 SNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTV 1479

  Fly  1053 ----------------------------------------------------------------- 1052
                                                                             
  Fly  1480 TASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAA 1544

  Fly  1053 ----------------------------------------------------------------- 1052
                                                                             
  Fly  1545 LKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLL 1609

  Fly  1053 ----------------------------------------------------------------- 1052
                                                                             
  Fly  1610 KSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPI 1674

  Fly  1053 ------------------GKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERI 1099
                              |||..:.::|:|||...||||||:|||||||:||.||....:.|.|:
  Fly  1675 ISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRL 1739

  Fly  1100 DGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAH 1164
            ||......||..::|||. ..:.|.|:||||:||:||||..|||||.|||||||..|.||..|.|
  Fly  1740 DGSTRVEQRQILMERFNG-DKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCH 1803

  Fly  1165 RIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFT-----KQELDDILRF 1224
            ||||...|.|||.|:..::|..:.:.|.:|.||:.:.:      :|.|||     ...:.|:  |
  Fly  1804 RIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAI------EGGNFTTTYFKSSTIKDL--F 1860

  Fly  1225 GTEDLFKEDDKEEAIHYDDKAVA--ELLDRTNRGIE-EKESWANEYLSSFKVASYATKEEEEEEE 1286
            ..|...:::..:|.....|:.||  .|.|..:..:| ||:|     |.:|:.|..|.::|::.:.
  Fly  1861 TMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQS-----LRAFEHALAAAEDEQDVQA 1920

  Fly  1287 T---------------------------------EIIKQDAENSDPAYWVKLLRHHYEQHQEDVG 1318
            |                                 |:.|.|.|..:....:..:..:..:..|:.|
  Fly  1921 TKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETG 1985

  Fly  1319 ---------------------------RSLGKGKRVRKQVNYTDGGVVAADTTRDDSN------- 1349
                                       .::.|.:.:.||  .|:...:...:.:|.||       
  Fly  1986 AAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQ--ETEAEEMLTYSRKDSSNQVWISRN 2048

  Fly  1350 -------W------QDNGSEYNSEYSAG------------------------SDEDGGDDDFDDQ 1377
                   |      |||.::...:||..                        |..|.|.|     
  Fly  2049 TMEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYD----- 2108

  Fly  1378 NGAERKAKRRLERRD---------DRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQ- 1432
             |:.|..|.|  |.|         |||.|. |||:...::    :.|.|.||...:...|:.|| 
  Fly  2109 -GSRRPNKMR--REDNYVPPRSLFDRPTPQ-LARLRRELK----SQRFRGSFKPNMPIPGLKPQL 2165

  Fly  1433 --------DAFNSQWLVRD----------LRG--------------------------------- 1446
                    :|. ::|.|.:          |:|                                 
  Fly  2166 PTKPLTEPEAM-AEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSA 2229

  Fly  1447 -----------------------KSERNFK-----AYVSLFMRHLCEPG---ADNAETF------ 1474
                                   |.::..|     .|:...:|:|....   :||..:|      
  Fly  2230 RQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRS 2294

  Fly  1475 -ADGVPREGLSRQHVLTR-IGVMSLIRKK----VQEFEHINGYYSMPELILKPCEPVRSALKQDV 1533
             .|.:....|.:.....| ....||:..|    :|||..:|  |..|   :.|         |::
  Fly  2295 RFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILN--YDQP---VSP---------QNI 2345

  Fly  1534 AALEA--------------PPTG-GNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEK 1583
            ||::|              ||.| |.|.:....|..   ....||.|.|..::.:...:..::::
  Fly  2346 AAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQ---QQQPAPPPLPQQQQPQQVVQQVQQQQ 2407

  Fly  1584 DKTSAEKSEVKQEQEAEEDKKP--GDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEET 1641
                 ::.:.:|:|:..:.:.|  .:|:|..||::.            .|:.:.:|...|
  Fly  2408 -----QQQQQQQQQQVVQQQLPTVSNVQQTLPVQQT------------VELVQQQPTTTT 2450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 11/56 (20%)
PHD1_CHD_II 380..422 CDD:277006 0/41 (0%)
PHD2_CHD_II 440..482 CDD:277007 2/41 (5%)
CHROMO 490..558 CDD:237991 8/67 (12%)
CHROMO 615..667 CDD:214605 10/57 (18%)
SNF2_N 734..1028 CDD:278600 110/306 (36%)
DEXDc 751..907 CDD:238005 57/156 (37%)
Helicase_C 1053..1167 CDD:278689 63/113 (56%)
DUF1087 <1292..1337 CDD:283996 8/71 (11%)
DUF1086 1380..1517 CDD:283992 44/240 (18%)
CHDCT2 1756..1927 CDD:285336
domNP_001286676.1 HSA 543..614 CDD:214727 14/70 (20%)
ASF1_hist_chap <674..831 CDD:304562 50/309 (16%)
FAM176 <824..>868 CDD:291517 11/80 (14%)
SNF2_N 952..1238 CDD:278600 110/306 (36%)
DEXDc 969..1108 CDD:238005 57/156 (37%)
Helicase_C 1692..1806 CDD:278689 63/114 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467170
Domainoid 1 1.000 47 1.000 Domainoid score I705
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.930

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