DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and CG10445

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	193/926 - (20%)
Similarity:	343/926 - (37%)	Gaps:	286/926 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 EKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQL-DVHHPLMIRSF 555
            :||:|....||..::..|.:|...:....:.:...:...:.    |::..::| :....:.|...
  Fly    78 QKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLEALG----EFLDTLRLREDQQEIKIEDN 138

  Fly   556 QRKYDMEEPPKFEESLDEADTRYK--------RIQRHKDKV--GMK----------ANDDAEVLE 600
            ....|..|.||: .:|.....||:        :..:||..:  .:|          |.||.|
  Fly   139 SELVDHTEQPKW-SNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDDLE--- 199

  Fly   601 ERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWREL-PYDKSTWEEEGDDIQGLRQAIDYYQD 664
                    |...|::.|::.|:.:       .:||.:. ...|.:.....||: ||.:.:..
  Fly   200 --------KQPALLLVRLLKHQQS-------CLKWMQFRERQKISGGILADDM-GLGKTLSM--- 245

  Fly   665 LRAVCTSETTQSRSKKSKKGRKS----------------KLKVEDDEDRPVK--HYTPPPEKPTT 711
            :..:..||.|::|.::.||...:                |:.:.|||:...|  ....||||.|.
  Fly   246 IALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTC 310

  Fly   712 DLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMG--LGKTIQTVTFLYSLY 774
            .:|.|..:|...|:.....                 .|...::.||..  |.||.:...|.....
  Fly   311 HVKTKKINQFRILDDDDND-----------------AGDKAVVEDEQKDLLAKTPEPEVFSSDEE 358

  Fly   775 KEGHCRGPF-----LVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIR--------ENEL 826
            :|....|.:     ||..|:|.:..|..|             :..|.::..||        .:|:
  Fly   359 EEHLSNGRYPSANTLVVCPMSVMCQWAHE-------------VASKVAQNAIRVLTFHGPNRHEI 410

  Fly   827 SFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLG------SIDWAVLVVDEAHRLKSNQ 885
            ..|  |.|            .:::::|||.|:..:....|      ::.|..:::||||.:::::
  Fly   411 GIE--AFR------------SYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSK 461

  Fly   886 SKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQV--KR 948
            :.....:..........|||||:||...::|.||.|::...|.|||.::...    .|..:  :|
  Fly   462 TNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL----NESMLGHRR 522

  Fly   949 LHEMLGPHMLRR----------------LKTDVLKNMPSKSEFIVRVELSAMQKK-FYKFILTK- 995
            |:.::.|.||||                ||.:::....||:|..|...|||:.|| |.:|:|.:
  Fly   523 LNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQRE 587

  Fly   996 ------NYEALNS----------------------KSGG--------GSCSLINIMMDLKKCCNH 1024
                  ||.:|..                      ||.|        |...|: :::.|::.|.|
  Fly   588 KGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPGEKILGIYILV-LLLRLRQFCCH 651

  Fly  1025 PYL-------------------------------------------------------------- 1027
            |.|
  Fly   652 PGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFK 716

  Fly  1028 --------------------FPSAA--EEATTAAGGLYEIN------SLTKAAGKL-VLLSKMLK 1063
                                .|:|:  |:...:|..|..:|      ...:.:.|| :::.|:.:
  Fly   717 LEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQNPIFQFIRPSAKLKMVIDKLEE 781

  Fly  1064 QLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLS 1128
            .|...|.::::.||....|.|:...|:...::....:|.:|...|:..:..|||...:: |.|||
  Fly   782 LLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFNANNEKR-VLLLS 845

  Fly  1129 TRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKR 1193
            ..|||:|:||..|:.::|.|..|||..:.||..|.:|.||.....|||::.:::||:|:..:...
  Fly   846 LTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDC 910

  Fly  1194 KMMLTHLVVRPGMGGK 1209
            |:.:.. ||.|..||:
  Fly   911 KLEIAK-VVLPEEGGE 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CHROMO	490..558	CDD:237991	10/66 (15%)
		CHROMO	615..667	CDD:214605	9/52 (17%)
		SNF2_N	734..1028	CDD:278600	82/452 (18%)
		DEXDc	751..907	CDD:238005	34/176 (19%)
		Helicase_C	1053..1167	CDD:278689	36/114 (32%)
		DUF1087	<1292..1337	CDD:283996
		DUF1086	1380..1517	CDD:283992
		CHDCT2	1756..1927	CDD:285336
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	188/914 (21%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	81/383 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467131
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930