Protein Alignment Mi-2 and CG7376

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_648034.1
• Gene: CG7376 / 38715
• FlyBaseID: FBgn0035689
• Length: 1270
• Species: Drosophila melanogaster
• Alignment Length: 1489
• Identity: 259/1489 - (17%)
• Similarity: 453/1489 - (30%)
• Gaps: 579/1489 - (38%)

  Fly    41 DEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEY-PSTSKRGRK 104
            ||.....|||....:.||||...|                   .:.|:|.||:.. ....:..|.
  Fly    11 DEVPPESPEDPTEFRYGKKRWVFK-------------------DNLVEHKEEILICIEKCQNART 56

  Fly   105 RKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAF------------MH 157
            ||.:.::.:::..:...:.|.|.  :......:|:|..|:.|...  :|.|            ..
  Fly    57 RKLKFRSIRQESGSCILVLSHEQ--THVRAREIEMEVGEQVLPLF--FKDFRGSLEFEVAQQEKE 117

  Fly   158 HVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRS 222
            |.||:     ......||...:..|.|:    ..|::||             ||:     :.|:.
  Fly   118 HKRPL-----KTYVTTKLYDALYEKHRQ----TVHVEQE-------------RSL-----DLPKR 155

  Fly   223 SRSSRNEKPDDIYEEAVEEEEEEEE-----------------------------EEKKPR----- 253
            .:|...:.........:..|::..:                             ||:.|:
  Fly   156 FQSQLRKYQQRTVSWMLGREQQITQVPANFIVLHAIDGITRVFKHKYCLQFYPFEEEIPKISLPP 220

  Fly   254 ----RKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDS 314
                ....|.||       .|..|.:.|:..|.:||            ..:|...:|:.:.||
  Fly   221 GGILADEMGLGK-------TVEFLAMLLMNPRPQDS------------YRNDYWHQRLEEFSD-- 264

  Fly   315 ADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQD 379
                |.|:                                  |::::.|            :.:.
  Fly   265 ----EVPL----------------------------------KRSRISK------------KDEV 279

  Fly   380 YCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEA----------DGGAA----- 429
            :|...::.|:.:.|..|.|..|.:|:  .:.|..:....||.|.:          :.||.
  Fly   280 FCICTKKHGKRVQCTKCRRWQHEMCM--TISEKSDLPHLCPSCWSELVKSGERLVESGATIIVSP 342

  Fly   430 -------------------------------------------------------------EEED 433
                                                                         :.:.
  Fly   343 NAIKMQWFEEIHKHISPSLKVLLYFGLHSTFWVSPFDLAQYDVVLTDYTILRNEIYHTTDFKSDR 407

  Fly   434 DDEHQE-------------FCRVCKDGGELLCCDSCPS----------AYHTFCLNPPLDTIPD- 474
            ...||:             :.|||.|..:::  :|..|          |.:.:.:...:|.:|.
  Fly   408 QMRHQQRYMRPNSPLLMVNWWRVCLDEAQMV--ESSTSAAAEMVRMLPAINRWAVTGTIDELPPL 470

  Fly   475 ----GDWRCPRCSCPP-----------LTGKAEKII------TWRWAQRSNDDGPSTSKGSKNSN 518
                |.   |....||           |..|.|.::      .||           |.|
  Fly   471 LEFVGR---PEVCRPPDAWQTVDKAFQLNYKCEPLLELLEHSLWR-----------TCK------ 515

  Fly   519 SRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQR 583
            |:|.      |.:.      :|. |.:|.|.|.:.:.:..|..||..|..|....|..::.|  .
  Fly   516 SKVE------HELG------IPP-QTEVVHRLELSNVESLYYREEHLKCHEQFLAAVAKHTR--H 565

  Fly   584 HKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQR-----VINHRTARDGSTMYLVKWRELPYDKS 643
            :.|.....|:...::|     :..:||...|.|.     |.|...:   ||.||.....|...||
  Fly   566 NADNSSCLASISPQLL-----RIILKPFLRIRQTCSVPVVFNSNVS---STDYLHPQDLLARLKS 622

  Fly   644 TWEEE--------GDDIQGLR----------QAIDYYQDLRAVCTSETTQSRS------------ 678
            ..|.|        .....||.          |||.||..|..:......|:.|
  Fly   623 NNENECKTELRTWASSYNGLAAIYFIKNDFPQAIKYYNLLLKLANEYNEQNISVDSVLQIHAIYN 687

  Fly   679 ------------------KKSKKGRKSKLK---VEDDE---DRPVKHYTPPPEKPTTDLKKKYE- 718
                              .|..:.:.|:|:   :||:.   :..:..|....|| .::|:|::|
  Fly   688 LLQASSLAPAEHKLTELEHKKYQAQMSRLEWKYLEDNTRVLESALSSYNENLEK-VSELEKRFEG 751

  Fly   719 ---DQPAFLEGTGMQLHP-----------------YQIEGIN------WLRYSWGQGI----DTI 753
               |..|.:......||.                 .::|.:|      :....|...:    .|:
  Fly   752 STLDLLATMVNHKTSLHDAIWNKVRDDFFRQNISVERLENVNSMAGMLYFMDIWHNKLQNLKSTL 816

  Fly   754 LAD---------------EMGLGKTIQTVTFLYSL-------------------YKEGHCRGPFL 784
            :|:               :.|:..:::.:.|:.::                   .|..:||
  Fly   817 IAEFEFLKGVMQQACEAIKTGVLLSMEIINFIENVTVCHLTDILDANKDKPVKPKKHRYCR---- 877

  Fly   785 VAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIREN------ELSFEEGAIRGSKVSRLRT 843
                |..:.:...:||       |:.:....|.:|.:.|.      |:||.:     |..:.||:
  Fly   878 ----LCLIRDSLNQFE-------CLLFAKKLDEKATVTEGLENPSMEISFIK-----SIFAFLRS 926

  Fly   844 ----------TQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA 898
                      .|.|..:|....:|:.........:::.|...||....|
  Fly   927 KQDFSEWKEECQSKLELLSCLQDLVKFQIKYWIEVEYMVKAFDELEMCK---------------- 975

  Fly   899 YKLLLTGTP-LQNNLE----ELFHLLNFLSRDKFNDLQAFQGEFADV-SKEEQVKRLHEMLG--P 955
            .::|||..| .|:|..    :|...|.|   :::| ||..|..|..: .:.:.:|.|.|...  |
  Fly   976 MRILLTDDPEEQSNYRILACQLDEQLQF---NQYN-LQTSQLNFTRLCGRLKYLKHLKEDSADKP 1036

  Fly   956 HMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKK 1020
            ..:.:.:.||...|.....|:.:..|.:|::|             |.::|...|.|
  Fly  1037 CPICQTQDDVRYVMMVCGHFVCQHCLDSMRRK-------------NGRAGVTKCPL--------- 1079

  Fly  1021 CC--NHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQN--HRVLIFSQMTKM 1081
             |  :.|.|:.|....|..:..|.:.    ||.:..:.|:.|    :|.:|  .::::|||...:
  Fly  1080 -CRQDSPQLYYSVRPGAHKSIIGDFS----TKISSVVELVLK----IKGENEQEKIIVFSQWQAI 1135

  Fly  1082 L-DILEDF-LEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTV 1144
            | :|.... |.|.|::         .....:..|.|..|.:.....|:....|..|:||..|..|
  Fly  1136 LIEIARALSLNGIQFR---------NKCTNKDFDDFKNPLSNVTCLLMPLSKGSKGLNLIEATHV 1191

  Fly  1145 IIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEER----VTQVAKRKMMLTH 1199
            .:.:...||.::.||..|.||.||.....::||:...::||.    :|.......:.||
  Fly  1192 FLVEPILNPGDERQAIGRIHRFGQKRPTKVHRFIVNETIEENILSLITSADDTTTLSTH 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	13/64 (20%)
		TNG2	<282..422	CDD:227367	20/139 (14%)
		PHD1_CHD_II	380..422	CDD:277006	10/41 (24%)
		PHD2_CHD_II	440..482	CDD:277007	11/56 (20%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	15/75 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	21/76 (28%)
		PLN03142	720..>1234	CDD:215601	109/575 (19%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
CG7376	NP_648034.1	DEXQc_SHPRH	160..513	CDD:350828	54/441 (12%)
		PHD_SF	281..320	CDD:473978	10/40 (25%)
		TPR	636..669	CDD:197478	8/32 (25%)
		RING_Ubox	1036..1082	CDD:473075	13/68 (19%)
		SF2_C_SNF	1104..1225	CDD:350180	34/137 (25%)