DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mi-2 and ERCC6L2

DIOPT Version :10

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_064592.3 Gene:ERCC6L2 / 375748 HGNCID:26922 Length:1550 Species:Homo sapiens


Alignment Length:1486 Identity:303/1486 - (20%)
Similarity:523/1486 - (35%) Gaps:525/1486 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   693 DDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGT-GMQLHPYQIEGINWLRYSWGQGIDTILAD 756
            ||||.. |.|.|..:.|::.:..|..|....:..| ...|..||.||..:|...:..|...||.|
Human    85 DDEDLE-KPYFPNRKFPSSSVAFKLSDNGDSIPYTINRYLRDYQREGTRFLYGHYIHGGGCILGD 148

  Fly   757 EMGLGKTIQTVTFLYS-LYKEG------------------------HCRGPFLVAVPLSTLVNWE 796
            :||||||:|.::||.: |:|:|                        ..:..||:..|||.|.||:
Human   149 DMGLGKTVQVISFLAAVLHKKGTREDIENNMPEFLLRSMKKEPLSSTAKKMFLIVAPLSVLYNWK 213

  Fly   797 REFELWAPDFYCITYI-GDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISM 860
            .|.:.|.  ::.:|.: |::      ::|||              :|..|.|..:.||:||.:.:
Human   214 DELDTWG--YFRVTVLHGNR------KDNEL--------------IRVKQRKCEIALTTYETLRL 256

  Fly   861 DAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRD 925
            ....|.|::|:.::||||||:|:.:::...::.:.....::.||||.||||::||:.::::....
Human   257 CLDELNSLEWSAVIVDEAHRIKNPKARVTEVMKALKCNVRIGLTGTILQNNMKELWCVMDWAVPG 321

  Fly   926 KFNDLQAFQGEFAD---------VSKEE------QVKRLHEMLGPHMLRRLKTDVLKNMPSKSEF 975
            .......|:.:|:|         .:|.|      .::||.:.:....|||.||.:...:|.|.:.
Human   322 LLGSGTYFKKQFSDPVEHGQRHTATKRELATGRKAMQRLAKKMSGWFLRRTKTLIKDQLPKKEDR 386

  Fly   976 IVRVELSAMQKKFYKFIL-TKNYEALNSKSGGGSCS----------------------LINIMMD 1017
            :|...|:..||..|:.:| |::...:...|...:|.                      .::.:..
Human   387 MVYCSLTDFQKAVYQTVLETEDVTLILQSSEPCTCRSGQKRRNCCYKTNSHGETVKTLYLSYLTV 451

  Fly  1018 LKKCCNHPYL------------------------FPSAAEEATTAAGGLYEINSLTKAAGKLVLL 1058
            |:|..||..|                        ||...:::..||   :|..|..|.:||:.:|
Human   452 LQKVANHVALLQAASTSKQQETLIKRICDQVFSRFPDFVQKSKDAA---FETLSDPKYSGKMKVL 513

  Fly  1059 SKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQF 1123
            .::|...:....:||:||..||:||:|:.:.......|.|:||......|.:.:..||:  .|..
Human   514 QQLLNHCRKNRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNS--TQDV 576

  Fly  1124 -VFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEE-- 1185
             :.|:||.|||||:|...|:.|:::|..|||.||:||..||:||||...|.:.|.::..:|||  
Human   577 NICLVSTMAGGLGLNFVGANVVVLFDPTWNPANDLQAIDRAYRIGQCRDVKVLRLISLGTVEEIM 641

  Fly  1186 RVTQVAKRKMMLTHLVVRPGMGGKGA-------NFTKQELDDILRFGTEDLFKEDDKEEAIHYDD 1243
            .:.|:.|:::   |.||   :|.:.|       ..:|:...::  ||..:|||...:...:   .
Human   642 YLRQIYKQQL---HCVV---VGSENAKRYFEAVQGSKEHQGEL--FGIHNLFKFRSQGSCL---T 695

  Fly  1244 KAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEE----EEETEIIKQDA-----ENSDP 1299
            |.:.|...:...||....:|..|...:.|:......:.:|    |:..|.:.::|     :.|| 
Human   696 KDILEREGQVEAGIMTATTWLKEGPPAHKLEMPRQPDCQECRGTEQAAEPLAKEACDLCSDFSD- 759

  Fly  1300 AYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDN----------- 1353
                          :|.||.:                |:..|.....||:...:           
Human   760 --------------EEPVGAT----------------GIKTAKNKAPDSSKASSSPGQLTLLQCG 794

  Fly  1354 -GSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQR 1417
             .....::..|..|.||.... ||::..|:......|.:|        |....|.:.||.:..|:
Human   795 FSKLLETKCKAVEDSDGNTAS-DDESSDEQPTCLSTEAKD--------AGCEKNQDSLGTSKHQK 850

  Fly  1418 KSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREG 1482
               |:.|:.                                                    |:| 
Human   851 ---LDNILN----------------------------------------------------PKE- 859

  Fly  1483 LSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDK 1547
                                   :||  :|...::           |:|::              
Human   860 -----------------------KHI--FYKSEKI-----------LEQNI-------------- 874

  Fly  1548 SATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKE---KDKTSAEKSEVKQEQEAEEDKKPGDVK 1609
                                :|:..|.|.|:::|.   ::.|.:|.|:|....:...::.|    
Human   875 --------------------SSKSDEKKIKNTDKHCILQNVTESEDSDVICPTQYTTERFP---- 915

  Fly  1610 QENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEK-VDDK------KPIP 1667
             :|.:.     .||             |.|.::|.|.:...||...:..: .|||      |.:.
Human   916 -DNSIR-----FKP-------------PLEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLS 961

  Fly  1668 P-------------TTVIDDDDDDVMI--------------VKEDGELEKPSASSPKDQKAVAAA 1705
            |             |:.|.|:.||:.|              .|...|.:|...:|||........
Human   962 PENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELHNSPKTMNKTNQV 1026

  Fly  1706 TSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLA 1770
            .:|......:..:|          ::.:|...:..|               :....:.|      
Human  1027 YAANEDHNSQFIDD----------YSSSDESLSVSH---------------FSFSKQSH------ 1060

  Fly  1771 GIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNK----FLARR-FKLLEQALVIEEQL 1830
                    |.:.|::...|:             :.|...||    |:.|: .|...:.:|.:|| 
Human  1061 --------RPRTIRDRTSFS-------------SKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQ- 1103

  Fly  1831 RRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDM 1895
                        |:.:|.......:......|:|::...|.|.|..:....|.|. :|::.    
Human  1104 ------------SYESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVF-ELKQF---- 1151

  Fly  1896 KSDVSRLPATLA--------------RIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPA 1946
                |:|||.:|              .:|...:..|.||.||                       
Human  1152 ----SQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSI----------------------- 1189

  Fly  1947 GFQGTTLPAFTSGPAG---------NFANF----------RPQFSVPGQLSNNSGV 1983
                 :||.:.|.|..         |...|          |.||.......|:|.|
Human  1190 -----SLPLYISNPVNQKKKKVYHTNQTTFIIGETPKGIRRKQFEEMASYFNSSSV 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357
TNG2 <282..422 CDD:227367
PHD1_CHD_II 380..422 CDD:277006
PHD2_CHD_II 440..482 CDD:277007
CD1_tandem_CHD3-4_like 487..557 CDD:349314
CD2_tandem_CHD3-4_like 610..664 CDD:349309
PLN03142 720..>1234 CDD:215601 164/612 (27%)
DUF1087 <1292..1334 CDD:461922 6/46 (13%)
CHDII_SANT-like 1380..1517 CDD:461920 15/136 (11%)
CHDCT2 1757..1902 CDD:462358 24/149 (16%)
ERCC6L2NP_064592.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Tudor_ERCC6L2 18..73 CDD:410471
HepA <107..651 CDD:440319 155/570 (27%)
DEXHc_ERCC6L2 123..371 CDD:350763 72/269 (27%)
DEAH box 272..275 2/2 (100%)
Atypical PIP-box. /evidence=ECO:0000269|PubMed:37014751 785..796 0/10 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 808..848 12/48 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 914..1002 21/110 (19%)
VIGSSK <1118..1142 CDD:464308 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1354..1410
Blue background indicates that the domain is not in the aligned region.

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