Protein Alignment Mi-2 and Iswi

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Alignment Length: 1077
• Identity: 310/1077 - (28%)
• Similarity: 477/1077 - (44%)
• Gaps: 212/1077 - (19%)

  Fly   673 TTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTD--------LKK--KYEDQPAFLEGT 727
            |..::|....|||..|:|.:|.|.....|.....|:...:        .|:  :::..||:::..
  Fly    62 TNSAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKSG 126

  Fly   728 GMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTL 792
              ::..|||.|:||:...:..||:.|||||||||||:||::.|..|....:..||.:|.||.|||
  Fly   127 --EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTL 189

  Fly   793 VNWEREFELWAPDFYCITYIGDKDSR-AVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYE 856
            .||..||:.|.|....:..|||:|:| ..||:..:..|                  ::|.:||||
  Fly   190 QNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGE------------------WDVCVTSYE 236

  Fly   857 LISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNF 921
            :...:.:.....:|..||:|||||:|:.:||...||..:..|.:||:|||||||||.||:.||||
  Fly   237 MCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNF 301

  Fly   922 LSRDKFNDLQAFQGEF---ADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSA 983
            |..|.||..:.|...|   ..:..:..:.|||.:|.|.:|||||.:|.|.:..|.|..:.|.||.
  Fly   302 LLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSK 366

  Fly   984 MQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS- 1047
            ||:.:|..:|.|:.:.:|.........|.||:|.|:||.||||||..|      ..|..|..::
  Fly   367 MQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGA------EPGPPYTTDTH 425

  Fly  1048 LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAI 1112
            |...:||:.:|.|:|.:|:.|..|||||||||:|||||||:.....|.|.|:||......|...|
  Fly   426 LVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQI 490

  Fly  1113 DRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRF 1177
            ..||...:.:|:|:||||||||||||||||.||||||||||..|:||..|||||||..:|.::|.
  Fly   491 QEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRL 555

  Fly  1178 VTRNSVEERVTQVAKRKMMLTHLVVRPG--MGGKGANFTKQELDDILRFGTEDLF--KEDDKEEA 1238
            :|.::|||::.:.|:.|:.|..:|::.|  :..:.....|.|:.:|:|||...:|  ||.|
  Fly   556 ITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETD---- 616

  Fly  1239 IHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWV 1303
              ..|:.:..:|:|......|::: |.:.|....:.::......|...:.:.:.:.|:     |
  Fly   617 --ITDEDIDVILERGEAKTAEQKA-ALDSLGESSLRTFTMDTNGEAGTSSVYQFEGED-----W- 672

  Fly  1304 KLLRHHYEQHQEDVGRSLGKGKRVRKQVNY------------TDGGVVAADTTRDDSNWQD---- 1352
                 ..:|....:|..:...||.|| .||            ::.....|.........||
  Fly   673 -----REKQKLNALGNWIEPPKRERK-ANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFF 731

  Fly  1353 --------NGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEV 1409
                    :...|....:.|.......:...|....:|:.:|:::..:  ||.....:...|:..
  Fly   732 PPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAE--PLTEEEIQEKENLLS 794

  Fly  1410 LGFNA---RQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNA 1471
            .||.|   |....|:.|..:||....|.     :.:|:.||:......|.::|.....|
  Fly   795 QGFTAWTKRDFNQFIKANEKYGRDDIDN-----IAKDVEGKTPEEVIEYNAVFWERCTE------ 848

  Fly  1472 ETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAAL 1536
                                          :|:.|.|.|.....|..::....::.||.|.::..
  Fly   849 ------------------------------LQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRY 883

  Fly  1537 EAP------PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDK-----------DKDSEKE-- 1582
            .||      ..|.|..|:.|                    :.||:           ||::..|
  Fly   884 RAPFHQLRLQYGNNKGKNYT--------------------EIEDRFLVCMLHKLGFDKENVYEEL 928

  Fly  1583 ----------------KDKTSAEKSE--------VKQEQEAEEDKKPGDVKQENPVEEAAGDTKP 1623
                            |.:|:.|...        :::|....|:|:..:.|::.|
  Fly   929 RAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKAP---------- 983

  Fly  1624 SDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKV 1660
                 |..|:.......:..|....:||..:|.|.:|
  Fly   984 -----KGSVSAGSGSASSNTPAPAPQPKASQKRKSEV 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309
		PLN03142	720..>1234	CDD:215601	219/522 (42%)
		DUF1087	<1292..1334	CDD:461922	10/53 (19%)
		CHDII_SANT-like	1380..1517	CDD:461920	24/139 (17%)
		CHDCT2	1757..1902	CDD:462358
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	297/1012 (29%)