Protein Alignment Mi-2 and Smarca2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001004446.2
• Gene: Smarca2 / 361745
• RGDID: 1302988
• Length: 1597
• Species: Rattus norvegicus
• Alignment Length: 1720
• Identity: 435/1720 - (25%)
• Similarity: 719/1720 - (41%)
• Gaps: 433/1720 - (25%)

  Fly    48 PEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAA 112
            ||..:...:||  :|..|.::.::::::::.:.::     |..::.:.|....:.:.:::::|..
  Rat   199 PETLQLAVQGK--RTLPGMQQQQQQQQQQQQQQQQ-----QQPQQPQQPQQQTQAQPQQQQQQQQ 256

  Fly   113 KEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVM 177
            :.....|...||..               .:|.|.:              .|....|::||
  Rat   257 QPPALVSYNRPSGP---------------GQELLMT--------------AQNTQQKLSAP---- 288

  Fly   178 LVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEP--------RSSRSSRNEKPDDI 234
              |...|. ..:.|...|....|..|.|..|      ..|.:|        :.||.|..:||..:
  Rat   289 --APSGRP-SPAPPAATQPTATAVPGPSVQQ------PAPGQPSPVLQLQQKQSRISPIQKPQGL 344

  Fly   235 YEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLK---------IKLLGKRKRDSSDEEQ 290
            ....:.:|.|...:.:...|.:......|..|    |.|:         ::||..:::    ..|
  Rat   345 DPVEILQEREYRLQARIAHRIQELESLPGSLP----PDLRTKATVELKALRLLNFQRQ----LRQ 401

  Fly   291 DASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKF 355
            :......||:.|                |..::|||                 .|::|.:...:.
  Rat   402 EVVACMRRDTTL----------------ETALNSKA-----------------YKRSKRQTLREA 433

  Fly   356 KKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCP 420
            :...||:|.:...:......:||:|.....|
  Rat   434 RMTEKLEKQQKIEQERKRRQKHQEYLNSILQ---------------------------------- 464

  Fly   421 HCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCP 485
                            |      .||..|          ||.
  Rat   465 ----------------H------AKDFKE----------YHR----------------------- 474

  Fly   486 PLTGKAEK----IITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDV 546
            .:.||.:|    :.||.         .:|.:..|....|:.:     ..|.....|     ..:.
  Rat   475 SVAGKIQKLSKAVATWH---------ANTEREQKKETERIEK-----ERMRRLMAE-----DEEG 520

  Fly   547 HHPLMIRSFQRK--YDMEEPPKFEESLDEADTRYKRIQRHKDKV-----GMKANDDAEVLEERFY 604
            :..|:.:...|:  |.:::..::..:|......:|:.|..|:|.     ..||.::||..|....
  Rat   521 YRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRRKKAEENAEGGEPALG 585

  Fly   605 KNG-------------VKPEWLIVQRVINHRTARDGSTMYLVKWREL--PYD----------KST 644
            .:|             ||.......:|:....|...|  .|..|.|:  .|:          :|.
  Rat   586 PDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKAS--QLDAWLEMNPGYEVAPRSDSEESESD 648

  Fly   645 WEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKP 709
            :|||.::.:..||..:     ..:.....::..|:|..|......|.:.|::..:::.....:..
  Rat   649 YEEEDEEEESSRQETE-----EKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSY 708

  Fly   710 TT---DLKKKYEDQPAFL-EGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFL 770
            .|   .:.::.|.|.|.| .||   |..||::|:.|:...:...::.||||||||||||||:..:
  Rat   709 YTVAHAISERVEKQSALLINGT---LKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALI 770

  Fly   771 YSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRG 835
            ..|.:.....||:|:.||||||.||..||:.|||....|:|.|..                |:|.
  Rat   771 TYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTP----------------AMRR 819

  Fly   836 SKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA-Y 899
            |.|.:||:.  |||||||:||.|..|...|..|.|..::|||.||:|::..|..::||::.:| .
  Rat   820 SLVPQLRSG--KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPR 882

  Fly   900 KLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ----------GEFADVSKEEQ---VKRLHE 951
            ::|||||||||.|.||:.|||||....|.....|:          ||..|:::||.   ::|||:
  Rat   883 RILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHK 947

  Fly   952 MLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK------FILTKNYEALNSKSGGGSCS 1010
            :|.|.:|||||.:|...:|.|.|::::.::||:||..|:      .:||...|. :.|..||:.:
  Rat   948 VLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEK-DKKGKGGAKT 1011

  Fly  1011 LINIMMDLKKCCNHPYLFPSAAEEATTAAG---GLYEINSLTKAAGKLVLLSKMLKQLKAQNHRV 1072
            |:|.:|.|:|.|||||:|....|......|   |:.....|.:|:||..||.::|.:|:|.||||
  Rat  1012 LMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRV 1076

  Fly  1073 LIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGIN 1137
            |:|.|||.::.|:||:.....:.|.|:||......|...:.:||.||:|.|:|||||||||||:|
  Rat  1077 LLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLN 1141

  Fly  1138 LATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV 1202
            |..||||:|:|||||||.|:||..|||||||.|:|.:.|..|.|||||::...||.|:.:...|:
  Rat  1142 LQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVI 1206

  Fly  1203 RPGMGGKGANFTKQE--LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWAN 1265
            :.||..:.::..::.  |..||.      .:|:::||....||:.:.:::.|..   ||.:.:..
  Rat  1207 QAGMFDQKSSSHERRAFLQAILE------HEEENEEEDEVPDDETLNQMIARRE---EEFDLFMR 1262

  Fly  1266 EYLSSFKVASYATKE-----EEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGK 1325
            ..:...:..:...|.     ||:|..:.|||.|||         :.|...|:.:|.:   .|:|.
  Rat  1263 MDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAE---------VERLTCEEEEEKI---FGRGS 1315

  Fly  1326 RVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLER 1390
            |.|:.|:|:|        ...:..|            ..:.|||..::.::    |.:.|:|..|
  Rat  1316 RQRRDVDYSD--------ALTEKQW------------LRAIEDGNLEEMEE----EVRLKKRKRR 1356

  Fly  1391 R--DDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAF--NSQWLVRDLRGKSER- 1450
            |  |..|       |..::|    .|::|:         |.||.:..  |...|.:.:....:.
  Rat  1357 RNVDKDP-------VKEDVE----KAKKRR---------GRPPAEKLSPNPPKLTKQMNAIIDTV 1401

  Fly  1451 -NFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSM 1514
             |:|...::      |....|::     :..||.|....|:.:.:....||::.|      ||
  Rat  1402 INYKDRCNV------EKVPCNSQ-----LEIEGNSSGRQLSEVFIQLPSRKELPE------YY-- 1447

  Fly  1515 PELILKPC------EPVRS-------ALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPA 1566
             |||.||.      |.:|:       .|::||..|.......|::.|....:|:     ...|..
  Rat  1448 -ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSI-----VLQSVF 1506

  Fly  1567 PASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVK-QENPVEEAAGDT-----KPSD 1625
            .::.:...|:::||:|    |.|:.|.:.|:|:|.:.|...|| :.|..||...||     :|:.
  Rat  1507 KSARQKIAKEEESEEE----SNEEEEEEDEEESEAEAKSVKVKIKLNKKEEKGRDTGKGKKRPNR 1567

  Fly  1626 AEVKTEVAKTEPKEETKDPEVKEEPKTEEK 1655
            .:.|..|:..:..||..:.|..|...|:::
  Rat  1568 GKAKPVVSDFDSDEEQDENEQSEASGTDDE 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	8/52 (15%)
		TNG2	<282..422	CDD:227367	17/139 (12%)
		PHD1_CHD_II	380..422	CDD:277006	2/41 (5%)
		PHD2_CHD_II	440..482	CDD:277007	5/41 (12%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	11/73 (15%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	13/65 (20%)
		PLN03142	720..>1234	CDD:215601	223/539 (41%)
		DUF1087	<1292..1334	CDD:461922	11/41 (27%)
		CHDII_SANT-like	1380..1517	CDD:461920	29/142 (20%)
		CHDCT2	1757..1902	CDD:462358
Smarca2	NP_001004446.2	PHA03378	<74..389	CDD:223065	40/242 (17%)
		QLQ	173..207	CDD:462622	2/7 (29%)
		HSA	443..515	CDD:214727	19/174 (11%)
		BRK	596..639	CDD:462196	9/44 (20%)
		DEXHc_SMARCA2	708..958	CDD:350821	108/270 (40%)
		PLN03142	727..>1209	CDD:215601	214/503 (43%)
		SnAC	1266..1333	CDD:464219	21/98 (21%)
		Bromodomain	1340..>1426	CDD:445827	22/120 (18%)
		Bromo_SNF2L2	1389..1513	CDD:99947	29/148 (20%)