Protein Alignment Mi-2 and Etl1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 899
• Identity: 250/899 - (27%)
• Similarity: 388/899 - (43%)
• Gaps: 246/899 - (27%)

  Fly   509 STSKGSKNSNSRVREYFIKWHNMSY----WHCEWVP---EVQLDVHHPLMIRSFQRKYDMEEP-- 564
            |.|..:|:|.|.:|::.|..:..|.    ...|.||   .:|      :|..|.....|.:.|
  Fly    13 SASSSAKSSLSDLRQFRINKNASSVVASPSRTERVPGKKRIQ------VMADSDSDGNDSQTPKK 71

  Fly   565 PKFEESLDEADTRY---KRIQRHKDKVGM-----KANDDAEVLEERFYKNGVKPEWLIVQRVINH 621
            .|.|.::.|.:.||   .:|..|.|.:.:     :.|.|. ....|:.:...||
  Fly    72 TKLELTVKEKEERYMAAAKISPHFDTMAIQESLSRTNWDV-AASVRYLRENCKP----------- 124

  Fly   622 RTARDGSTMYLVKWRELPYDKSTWEEEGDDIQG-------------LRQAIDYYQDLRAVCTSET 673
                        |....|..||..:...:.|.|             ::|:.|...|      |:.
  Fly   125 ------------KGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYD------SDD 171

  Fly   674 TQSRSKKSKKGRKSK----------LKVED----DEDRPVKHYTPPPEKPTTDLKKKYE------ 718
            :.|.......|::.|          ::::.    .|.:.:......|....:||::|.|
  Fly   172 SDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDLRQKLESIRMSG 236

  Fly   719 -----------------------------------------DQPAFLEGTGMQLHPYQIEGINWL 742
                                                     :||..| .:|:||..|||.|:|||
  Fly   237 DLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLL-SSGLQLADYQIIGLNWL 300

  Fly   743 RYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFY 807
            .....|.::.|||||||||||||.:.||..|.:.|..:...|:.||.|||.|||.|...|.|:..
  Fly   301 TVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELV 365

  Fly   808 CITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELI-------SMDAACL 865
            ...|.|.:|.|..:|..   |.:....|            |:||||:|.::       .|...|
  Fly   366 VEKYHGSQDERRRMRGR---FAKDGFTG------------FDVLLTTYHIVGSTPEERKMFRVC- 414

  Fly   866 GSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKF--- 927
             .:|:  ::.||||.||:..::.:..|.:.....::|||||||||||.||..||.|:....|
  Fly   415 -KLDY--VIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKS 476

  Fly   928 -NDLQAF-------QGEFADVS--KEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELS 982
             .|:::.       .|:..:||  :|.|::|...::.|.:|||||.|||||:|.|...:.:|.:|
  Fly   477 IEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMS 541

  Fly   983 AMQKKFYKFILTKNYEALN--SKSGGGSCSL-----INIMMDLKKCCNHP--------------- 1025
            :.||.:|       :|.::  |.:.|..||.     |.|||::::..|||
  Fly   542 SQQKIYY-------HELVDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGF 599

  Fly  1026 ----------------YLFPSAAEEATTAAGGLYEI------------NSLTKAAGKLVLLSKML 1062
                            |:|   .|.|..:...:|::            ::|...:||.:.|..:|
  Fly   600 SKRLANASSFKKTNEQYIF---EELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLL 661

  Fly  1063 KQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLL 1127
            .:|||:.||||:|||.|.||||:|::|...::.:.|:||.....:||:.|..||...: .|||||
  Fly   662 PKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLL 725

  Fly  1128 STRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAK 1192
            ||:|||:||||..|||.:|:|.|:||:||.||..|.||:||...|.|||.::.:::||.:...|:
  Fly   726 STKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAE 790

  Fly  1193 RKMMLTHLVVRPGMGGKGANFTKQELDD------ILRFGTEDLFKEDDKEEAIH 1240
            .|:.|.            .:.|..|..:      :::..|..|..:.|:||.::
  Fly   791 EKLKLE------------KDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLN 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	14/54 (26%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	9/66 (14%)
		PLN03142	720..>1234	CDD:215601	199/589 (34%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	6/40 (15%)
		HepA	<276..795	CDD:440319	194/549 (35%)