Protein Alignment Mi-2 and kis

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Alignment Length: 2310
• Identity: 572/2310 - (24%)
• Similarity: 886/2310 - (38%)
• Gaps: 688/2310 - (29%)

  Fly    15 EEAQEDNAPAAELSNDSDAPLKPNQ-NDEDDDYDPED--------SRRKKK---GKKRKTRKGEE 67
            |....|:.|.:::...|:...|..: .||..|..|:.        |||.:|   .:.|:....||
  Fly  1401 ESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEE 1465

  Fly    68 KGRKKK----------KRKKN------ESEEDSDFVQHDEEVEYPSTSKR-GRKRKEEKQAAKEK 115
            .|..:|          |:::|      ||:.:.|.:........|..|:. ..||:..:...::|
  Fly  1466 GGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKK 1530

  Fly   116 ESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVA 180
                    .::||.         :.:|::|...|.        ..|:.:.:.|...|..     :
  Fly  1531 --------YIDDVM---------LRFSDDENSLLV--------ASPVKKDKKPSANASN-----S 1565

  Fly   181 AKWREFCESNPHIQQEGGAAGSGG-----------SAGQARSVTGDEPEEPR-----SSRSSRNE 229
            ....:..::.|....||.||...|           |..:|.|.|....|:.|     ::.::.:.
  Fly  1566 NAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSS 1630

  Fly   230 KPDDIY----------------------EEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPT 272
            ||:.:|                      |..:::.:|:..|.|:...|.........:|.|..
  Fly  1631 KPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDE-- 1693

  Fly   273 LKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDG 337
             |.|..|:.|:|.:|.|               |..|:.|....|.||   .|:.|:|..:.:|:
  Fly  1694 -KFKTEGESKKDLTDSE---------------ETKLESSAMEVDSKE---ESEPDDSKKSDEDN- 1738

  Fly   338 SGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQG-GEIILCDTCPRAYH 401
                  :.|.|.::.::..|.:|..|    ||.:....:.::..:..::. ...:|.....:...
  Fly  1739 ------KDKDKMEVDDEVGKSDKESK----PEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPE 1793

  Fly   402 LVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLN 466
            .|..:.|:||......|.. .:|: |:.|:..||.:.|.....|:...|
  Fly  1794 TVLEKMEVDEKANDDQSAV-SKAE-GSDEKSTDDSNPEEATTEKNKESL---------------- 1840

  Fly   467 PPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWA-QRSNDDGPSTSKGSKNSNS----RVREYFI 526
                               .:.|:.|::.....: ::.||:  .|....:|...    .|.|||:
  Fly  1841 -------------------EIEGEKERVKEGEESVKKENDE--KTEADMENKPEPVFIDVEEYFV 1884

  Fly   527 KWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRY-KRIQRHKDKVGM 590
            |:.|.||.||||                           :.||.|.:.|.|. .:|:|.:.|...
  Fly  1885 KYRNFSYLHCEW---------------------------RTEEELLKGDRRVAAKIRRFQQKQSQ 1922

  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWE-EEGDDIQG 654
            :.|....:.:|.|.::..:.:.::...|....|:.:.:..|||||:.|||:..||| ||..|...
  Fly  1923 QLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDK 1987

  Fly   655 LRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYED 719
            :.|.:.:         ::..|....||||                        :|..:|.||.|.
  Fly  1988 IEQYLRF---------NKIPQRSEWKSKK------------------------RPHPELWKKLEK 2019

  Fly   720 QPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFL 784
            .|.:..|.  .|.|||:||:|||::||....:.|||||||||||||::||::|:|:.| .|||||
  Fly  2020 TPVYKGGN--SLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFL 2081

  Fly   785 VAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSF--EEGAIRGSKVSRLRTTQYK 847
            |..||||:.||:||||.|. |...:.|.|...|:.:|::.|..:  |.|.:....:        |
  Fly  2082 VIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPI--------K 2137

  Fly   848 FNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNL 912
            ||||:|::|:|..|...|.:.:|.:.|:|||||||:...|....|....:.:::||:|||||||:
  Fly  2138 FNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNI 2202

  Fly   913 EELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIV 977
            .|||.|||||...:|:..:.|..||..:..||:|.:|..:|.|.||||||.||.|::..|.|.|:
  Fly  2203 SELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETII 2267

  Fly   978 RVELSAMQKKFYKFILTKNYEALNSKSGGGSC---SLINIMMDLKKCCNHPYLFPSAAEEATTAA 1039
            .|||:.:|||:|:.||.:|:..|  |.|..|.   :|:|.||:|:|||.||||...|.|:..
  Fly  2268 EVELTNIQKKYYRGILEQNFSFL--KKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQ--- 2327

  Fly  1040 GGLYEINS------------LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGE 1092
               |:..|            |..:|||:||:.|:|.:|||..|||||||||.:.||||||:|...
  Fly  2328 ---YDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYR 2389

  Fly  1093 QYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI 1157
            :|.:|||||.|.|.||||||||::.||:.:|||||.|:||||||||..|||||||||||||.||:
  Fly  2390 KYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDL 2454

  Fly  1158 QAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRP--GMGGKGAN---FTKQE 1217
            ||.:|.|||||...|.|||.:.||:.|..:...|..|:.|...|::.  ..|.|..|   .:|:|
  Fly  2455 QAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKE 2519

  Fly  1218 LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEE 1282
            ::|:|:.|......:||     :..||...|.:|...:...:..:..:|..|:|..||:|....
  Fly  2520 IEDLLKKGAYGAVMDDD-----NAGDKFCEEDIDSILKRRTQVITMESEKGSTFSKASFAASGN- 2578

  Fly  1283 EEEETEIIKQDAENSDPAYWVKLLRH-------HYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVA 1340
                    :.|....||.:|.|..:.       ......||:..|..:.:...|:..:.|
  Fly  2579 --------RSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYGHED----- 2630

  Fly  1341 ADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRD--------DRPLP 1397
                         ..|.|||.|:       :::.|::.|...:::||.|:||        |..:|
  Fly  2631 -------------VMELNSEESS-------NENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIP 2675

  Fly  1398 ---PLLARVG------GN--------IE--VLGFNARQRKSFL------------------NAIM 1425
               ..||.:|      ||        :|  :|.|...:....|                  ..|:
  Fly  2676 RERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIIL 2740

  Fly  1426 RYGM------------------PPQDAFNSQWLVRDLR------------GKSER---------- 1450
            .|.:                  |.:|. ..|.:.||..            |||.:
  Fly  2741 LYCLQVYKGDEKIKTFIWDLITPTEDG-EVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAP 2804

  Fly  1451 ------------------------------NFKAYVSLFM-----RHLCEPGADNAETFADGVPR 1480
                                          |..|..:...     .|..:....:|:.:.:|..:
  Fly  2805 GSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYK 2869

  Fly  1481 EGLSR--QHVLTRIGVMSLIRKKV-QEF-EHINGYYSMPELILKP-------------------- 1521
            :.|.|  ..||.|:.::..|:.:| .:| :.|.....:.||.::|
  Fly  2870 KHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKS 2934

  Fly  1522 ---------CEPVR----------------SALKQDVAALEAP----------PTGGNVDKSATT 1551
                     ||..|                .|...|:|....|          ..|..||...||
  Fly  2935 LLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTT 2999

  Fly  1552 SNSVTPAT------------------SAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQE 1598
            :...:.:|                  |:..|.:..:..|.||   :|.|.|.|:..:|..|.|
  Fly  3000 TTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDK---TESENDATTVSESSYKSE-- 3059

  Fly  1599 AEEDKKPGDVKQENPVEEAAGDTKPSDAEVKT----------EVAKT-EPKEETKDPEVKEEPKT 1652
                ..||               |.||.:|..          |:|.| :||....|.:|......
  Fly  3060 ----VLPG---------------KGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSC 3105

  Fly  1653 EEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGA 1717
            :..:....:.......|.|...|..::.|..|..:.||.:..|..|..||.|...:|..|..:|
  Fly  3106 DPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEG- 3169

  Fly  1718 EDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQD 1782
             |..|........||:    |...|..:.......
  Fly  3170 -DKTESCTNNATTNIS----TTTTTTTITNTTTTT------------------------------ 3199

  Fly  1783 IQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAM 1847
                      |.|..                                  :||..|...|  |
  Fly  3200 ----------NNPSS----------------------------------KAANSNNTTD--H--- 3215

  Fly  1848 SLNARFAEVECLAESHQHL---SKESLAGNKP------------------ANAVLHKVLN----- 1886
                        |.|:.||   .:||:||:.|                  .|..|.:|:.
  Fly  3216 ------------ANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRN 3268

  Fly  1887 -QLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQG 1950
             :.|||....|   ::|.|.::..||::.....:.:|:..:|.:.:|:..:.....||..|  .|
  Fly  3269 YKKEELKLQQK---AKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDA--SG 3328

  Fly  1951 TTLPAF--TSGPAGNFANFRPQFSVPGQLSNNSGV 1983
            .:|.|.  :.|.:.:.|......|..|..|.:..|
  Fly  3329 RSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQV 3363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	6/52 (12%)
		TNG2	<282..422	CDD:227367	27/140 (19%)
		PHD1_CHD_II	380..422	CDD:277006	6/42 (14%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	18/74 (24%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	17/54 (31%)
		PLN03142	720..>1234	CDD:215601	247/535 (46%)
		DUF1087	<1292..1334	CDD:461922	9/48 (19%)
		CHDII_SANT-like	1380..1517	CDD:461920	40/260 (15%)
		CHDCT2	1757..1902	CDD:462358	23/171 (13%)
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	22/98 (22%)
		PTZ00121	<1419..1923	CDD:173412	118/631 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	23/95 (24%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	17/66 (26%)
		PLN03142	2029..>2606	CDD:215601	262/608 (43%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196