DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and AIRE

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_000374.1	Gene:	AIRE / 326	HGNCID:	360	Length:	545	Species:	Homo sapiens

Alignment Length:	398	Identity:	80/398 - (20%)
Similarity:	132/398 - (33%)	Gaps:	133/398 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 GQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVP 271
            |:.:.:....|::...|:..:..||..:.:..|       ...:.|.::::....:...|:...|
Human    91 GRLQPILDSFPKDVDLSQPRKGRKPPAVPKALV-------PPPRLPTKRKASEEARAAAPAALTP 148

  Fly   272 T------LKIKLLGKRKRDSSDEE---------QDASGASER-----DSDLEFER------MLQK 310
            .      .::|....:|.:||.|:         |..|.:.:|     ..|:...|      ::|:
Human   149 RGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQ 213

  Fly   311 SDDSADEKEAPVSSKADNSAPAA-QDDGSG----------APVVRKK---------AKTKIGNKF 355
            ..:|...|:. :....:...|:. :|.|||          .|:||.|         .:.::|
Human   214 VFESGGSKKC-IQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLG--- 274

  Fly   356 KKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCP 420
             ::..:......|.......:::|.|.||:.|||:|.||.||||:||.||.|.|.|.|.|.|.|.
Human   275 -QQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCS 338

  Fly   421 HC------EADGGAAEEEDDDEHQEF--------------------------------------- 440
            .|      |....|.|....:...|.
Human   339 SCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSA 403

  Fly   441 ------------------------------CRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDG 475
                                          |.||.||.::|.|..|.:|:|..|..|...:.|..
Human   404 APLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGT 468

  Fly   476 DWRCPRCS 483
            ..||..||
Human   469 GLRCRSCS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335
		PHD1_CHD_II	380..422	CDD:277006	24/41 (59%)
		PHD2_CHD_II	440..482	CDD:277007	15/110 (14%)
		CHROMO	490..558	CDD:237991
		CHROMO	615..667	CDD:214605
		SNF2_N	734..1028	CDD:278600
		DEXDc	751..907	CDD:238005
		Helicase_C	1053..1167	CDD:278689
		DUF1087	<1292..1337	CDD:283996
		DUF1086	1380..1517	CDD:283992
		CHDCT2	1756..1927	CDD:285336
AIRE	NP_000374.1	LXXLL motif 1	7..11
		Sp100	16..102	CDD:281203	1/10 (10%)
		LXXLL motif 2	63..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..178		13/83 (16%)
		SAND	197..>250	CDD:295351	10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..290		10/59 (17%)
		Interaction with histone H3 not methylated at 'Lys-4'	295..298		0/2 (0%)
		PHD1_AIRE	298..340	CDD:277014	24/41 (59%)
		Interaction with histone H3 not methylated at 'Lys-4'	304..312		4/7 (57%)
		Interaction with histone H3 not methylated at 'Lys-4'	331..335		2/3 (67%)
		Herpes_IE68	<332..375	CDD:280616	8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..382		3/33 (9%)
		LXXLL motif 3	414..418		0/3 (0%)
		PHD2_AIRE	433..475	CDD:277015	15/41 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..508
		LXXLL motif 4	516..520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900