Protein Alignment Mi-2 and Chd9

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_038953982.1
• Gene: Chd9 / 307726
• RGDID: 1306795
• Length: 2883
• Species: Rattus norvegicus
• Alignment Length: 2058
• Identity: 539/2058 - (26%)
• Similarity: 811/2058 - (39%)
• Gaps: 596/2058 - (28%)

  Fly     7 NDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGRK 71
            |.:|||    ....:.|....||...:|:      ..|..||.||             |...|.
  Rat   331 NSNNFQ----ILHSSHPQGNYSNSKLSPM------HMDFPDPADS-------------GPPMGH- 371

  Fly    72 KKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSG-MPSVEDVCSAFSVC 135
                 .|:..|.:.|...||.:.:...|     ..|.......::....| :|..::  |.|...
  Rat   372 -----FNDHVETNGFSSLDENLLHQVES-----HAEPFAGLDPEDLLQEGLLPQFDE--SPFGQD 424

  Fly   136 NVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKW-------REFCESNPHI 193
            |.. ...:.:|.     :.|..|:     ...|...|...:...|..|       .:...|..|:
  Rat   425 NSN-HVLDHDLD-----RQFTSHL-----MARPSDMAQTQLQYQARGWPSPLPNSHQHVPSRSHL 478

  Fly   194 ---QQEGGAAGSGGSAGQAR------SVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEE-- 247
               :|...:..|.||...:|      .|..::....::...|:.||.:.|..||:...:|..|
  Rat   479 CLQRQPPSSKKSDGSGTYSRLQNTQVRVMSEKKPRKKAESESKQEKANRIISEAIARAKERGERN 543

  Fly   248 ------------------EEKKPRR-KRSGRGKKGRRPSG--------KVPTLKIKLLG---KRK 282
                              |||:.:| |...:.:..|:|..        |:..| |..||   ||:
  Rat   544 IPRVMSPENFPSSSVDGKEEKRAQRVKSKPKDRDNRKPKACSKLKEKTKIGKL-IITLGKNHKRR 607

  Fly   283 RDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKA 347
            .:||||..||            |:|.|
  Rat   608 SESSDELSDA------------EQMPQ-------------------------------------- 622

  Fly   348 KTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEP 412
                 :.||:::..|:..|      .:.:.:.|.|
  Rat   623 -----HTFKEQHSQKRRSN------RQVKRKKYAE------------------------------ 646

  Fly   413 PEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDW 477
                      :|:|...|||                                        ..|..
  Rat   647 ----------DAEGRQCEEE----------------------------------------VRGSL 661

  Fly   478 RCPRCSCPPLTGK-----------------AEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYF 525
            :..|.|.|| .|:                 .:||:..|..::....|....         :.|:|
  Rat   662 KVKRTSAPP-PGEQPLQLFVENPSEEDAAIVDKILACRTVKKEVSPGVMLD---------IEEFF 716

  Fly   526 IKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGM 590
            :|:.|.||.||||..|.||     |..:..|:|                      |:|.|.:...
  Rat   717 VKYKNYSYLHCEWATEQQL-----LKDKRIQQK----------------------IKRFKLRQAQ 754

  Fly   591 KANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGST-----MYLVKWRELPYDKSTWEEEGD 650
            :|:..|::.||.|     .|:::.|.|::......|..|     .|||||..|||:.||||
  Rat   755 RAHFLADMEEEPF-----NPDYVEVDRILEVSFCEDKDTGESVVYYLVKWCSLPYEDSTWE---- 810

  Fly   651 DIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDE----DRPVKHYTPPPEKPTT 711
                |::.:|.                           .|:|:.|    .||   .|...::|.:
  Rat   811 ----LKEDVDL---------------------------AKIEEFEQLQASRP---DTRQLDRPPS 841

  Fly   712 DLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKE 776
            ::.||.:....:..|.  ||..||:||:|||.::|....:.|||||||||||||::||||.:...
  Rat   842 NIWKKIDQSREYKNGN--QLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEVLLT 904

  Fly   777 GHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEG---AIRGSKV 838
            | .|||||:..||||:.||||||..|. |...:.|.|...||.:|::.|:.|.:.   .|||:
  Rat   905 G-IRGPFLIIAPLSTIANWEREFRTWT-DINVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGA-- 965

  Fly   839 SRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLL 903
                   |:|..::|::|:|......|.:|:|..:::|||||||:...|....|....:.:|:||
  Rat   966 -------YRFQAIITTFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLL 1023

  Fly   904 TGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKN 968
            |||||||.:||||.||:||...:|.....|..||.|:..||||::|..:|.|.||||||.||.|.
  Rat  1024 TGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKR 1088

  Fly   969 MPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSC-SLINIMMDLKKCCNHPYLFPSAA 1032
            :..|.|.|:.|||:.:|||:|:.||.||:..|:..:|..:. :|:|.||:|:||||||||...|.
  Rat  1089 LAPKEETIIEVELTNIQKKYYRAILEKNFSFLSKGAGQTNVPNLVNTMMELRKCCNHPYLIKGAE 1153

  Fly  1033 E-------EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLE 1090
            |       :....:...:.:.::.::||||||:.|:|.::||..|:|||||||.:.||||||:|.
  Rat  1154 EKIIGEFRDTYNPSASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLI 1218

  Fly  1091 GEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHN 1155
            .::|.||||||.:.|.|||.|||||:.|.:.:|||||.||||||||||..|||.||:||||||.|
  Rat  1219 HKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQN 1283

  Fly  1156 DIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGAN------FT 1214
            |:||.:|.|||||...|.:||.|||||.|..:...|..|:.|...|:: .|.|:.:|      .:
  Rat  1284 DLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLDKAVLQ-SMSGRDSNVSGIQQLS 1347

  Fly  1215 KQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATK 1279
            |:|::|:||.|......|::.|.:...::.....||.||.....|.|...    |:|..||:...
  Rat  1348 KKEIEDLLRRGAYGAIMEEEDEGSKFCEEDIDQILLRRTKTITIESEGCG----STFAKASFVAS 1408

  Fly  1280 EEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGK------RVRKQVNYTDGGV 1338
            ..         :.|....||.:|.|..:    :.:.|:....|:..      |:|||
  Rat  1409 GN---------RTDISLDDPNFWQKWAK----KAELDLDAISGRNSLVIDTPRIRKQ-------- 1452

  Fly  1339 VAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARV 1403
                 ||..|..:|..:|.:...|.|.::.......|...|..|....|:|:
  Rat  1453 -----TRPFSATKDELAELSEAESEGEEKPKLRRPCDRSGGYGRTECFRVEK------------- 1499

  Fly  1404 GGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGA 1468
              |:.|.|: .|.|:     |:.:|     .|..|....|:.... |...||..:..|     |.
  Rat  1500 --NLLVYGW-GRWRE-----ILSHG-----RFKRQLNEHDVEVIC-RALLAYCLVHYR-----GD 1545

  Fly  1469 DNAETF--------ADGVPRE-----GLSRQHVLTRIGVMSLIRKKV---------QEFEHINGY 1511
            :..:.|        .||..||     |||......|.|      |||         |:.|.:..|
  Rat  1546 EKIKGFIWDLITPTEDGQTRELQNHLGLSAPVPRGRKG------KKVKTQTSSFDIQKAEWLRKY 1604

  Fly  1512 YSMPELILKP----------CEPVRSA------LKQDVAALEAPPTGGNVDKSATTSNSVTPATS 1560
              .||.:|:.          |..|...      |||:|...|:......||  |:..:...|...
  Rat  1605 --NPEQLLQDEGYKKHVKHHCNKVLLRVRMLYYLKQEVIGNESQKVFDGVD--ASDIDVWVPEPD 1665

  Fly  1561 AAPSPAPASEKGEDKD------KDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAG 1619
            .:..||...:...||.      |...::.:...|:.:....|:..:.|:|      ....|:.|.
  Rat  1666 HSEVPAAWWDFDADKSLLIGVFKHGYEKYNTIRADPALCFLERVGKPDEK------AVAAEQRAN 1724

  Fly  1620 DTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKE 1684
            |....|.|               |||.|..|..   .|:.::|....|...||.|.:..:|
  Rat  1725 DYMDGDVE---------------DPEYKPAPAI---FKDDIEDDVSSPGDLVIADGEGQLM---- 1767

  Fly  1685 DGE---LEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELH-TLWL 1745
            :|:   ...|||.:.:.::.:.|..     .|.|    :..:.:.:..|::.......|: ...|
  Rat  1768 EGDKVYWPTPSALTTRLRRLITAYQ-----RTNK----NRHIQQAQPTFSVPASVMQPLYEEAAL 1823

  Fly  1746 NEEKAAVPGREYEIWHRRH--DYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEI 1808
            |.:.||...|: :.|.||.  |::.:..                .|.::.:|     .:|.|...
  Rat  1824 NPKMAAKIERQ-QRWTRREEADFYRVVS----------------TFGVVFDP-----DRGQFDWT 1866

  Fly  1809 KNKFLARRFKLLEQALVIEEQL-------RRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHL 1866
            |.:.|||..|..:.:|  |:.|       ||...|...::...|.:.:              |.:
  Rat  1867 KFRALARLHKKTDNSL--EKYLCAFMAMCRRVCRLPSKEELVDPNIFI--------------QPI 1915

  Fly  1867 SKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARI 1909
            ::|.      |:..|:::     |||..::....|.|....|:
  Rat  1916 TEER------ASRTLYRI-----ELLRKVREQALRHPQLFERL 1947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	8/59 (14%)
		TNG2	<282..422	CDD:227367	15/139 (11%)
		PHD1_CHD_II	380..422	CDD:277006	2/41 (5%)
		PHD2_CHD_II	440..482	CDD:277007	1/41 (2%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	19/86 (22%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	19/58 (33%)
		PLN03142	720..>1234	CDD:215601	244/530 (46%)
		DUF1087	<1292..1334	CDD:461922	11/47 (23%)
		CHDII_SANT-like	1380..1517	CDD:461920	35/158 (22%)
		CHDCT2	1757..1902	CDD:462358	27/153 (18%)
Chd9	XP_038953982.1	KLF3_N	217..375	CDD:410554	16/72 (22%)
		PTZ00121	<510..>765	CDD:173412	73/433 (17%)
		CD1_tandem_CHD5-9_like	685..749	CDD:349315	22/99 (22%)
		CD2_tandem_CHD5-9_like	769..827	CDD:349310	22/92 (24%)
		PLN03142	858..>1479	CDD:215601	272/662 (41%)
		BRK	2475..2515	CDD:462196
		BRK	2549..2593	CDD:197800