DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and HELLS

DIOPT Version :10

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_001275996.1 Gene:HELLS / 3070 HGNCID:4861 Length:884 Species:Homo sapiens


Alignment Length:909 Identity:275/909 - (30%)
Similarity:407/909 - (44%) Gaps:208/909 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   539 VPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVG-----MKANDDAEV 598
            :....|:....|.....:|:..|.|..:.....:..:.||:|:|...:|..     :....:.:.
Human    26 ITPAMLEEEEQLEAAGLERERKMLEKARMSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQ 90

  Fly   599 LEERFYKNGV--KPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDY 661
            |||:..|..:  |.|.|.|::..|...|                     .||...::..|...|.
Human    91 LEEQKKKEKLERKKESLKVKKGKNSIDA---------------------SEEKPVMRKKRGREDE 134

  Fly   662 YQDLRAVCTSETTQSRSKKSKK------GRKSKLKVED-----DEDRPVKHYTPPPEKPTT---- 711
            ..::..|.:.|...|.:||:||      ...:.|.|||     |.:..:|.......:..|    
Human   135 SYNISEVMSKEEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFF 199

  Fly   712 DLKKKYEDQPAFLEG----TGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYS 772
            |..:|...||...:.    ||..:..||:||:.|||..|..||:.|||||||||||:|.:..:..
Human   200 DPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIAL 264

  Fly   773 LYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSK 837
            :.:.| ..|||||..|||||.||..||:.:.||...:.|.|.::.|..:..|             
Human   265 MIQRG-VPGPFLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRN------------- 315

  Fly   838 VSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLL 902
            :.:.:.|.....|::||:|:...|...|....|..|:|||.||:|:.:.:..|.|..:....|||
Human   316 IYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLL 380

  Fly   903 LTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQ--------GEFAD--VSKEEQVKRLH------- 950
            ||||||||||.||:.|||||..|.|:||::|:        .|.|:  ::||.:...||       
Human   381 LTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQERI 445

  Fly   951 ------------------------------------------EMLGPHMLRRLKTDVLKNMPSKS 973
                                                      |:|.|.:|||||:||...:|.|.
Human   446 PRMYVSEFTDEGFFEGKLPSRKDLYDIRPYENTYLLKLHTNFEILTPFLLRRLKSDVALEVPPKR 510

  Fly   974 EFIVRVELSAMQKKFYKFILTK------------------------------NY----------E 998
            |.:|...||..|:.||..|:.:                              ||          |
Human   511 EVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELE 575

  Fly   999 ALNSK------------------SGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEI 1045
            .|.|:                  ....:..|.||||.|:||||||||.....:..|..    ::|
Human   576 KLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQE----FKI 636

  Fly  1046 N-SLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQ 1109
            : .|...:||.::|.:||.:||.:.|:||:|||||.|||||.|:.....:.:.|:||.::.:.|:
Human   637 DEELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSERE 701

  Fly  1110 EAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMI 1174
            :.:..||. ..:.|:||:|||||||||||..|||||||||||||.:|:||..|.|||||...|::
Human   702 KNMHSFNT-DPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVV 765

  Fly  1175 YRFVTRNSVEERVTQVAKRKMMLTHLVVRPG--MGGK-GANFTKQELD--DILRFGTEDLFKEDD 1234
            ||.||.|::::::.:.|..|..|..|::...  .||: |.|.:|..||  :::     :|.|..|
Human   766 YRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLNLSKNFLDPKELM-----ELLKSRD 825

  Fly  1235 KEEAIH------YDDKAVAELLDRTNRGIEEKESWA--NEYLSSFKVASYATKEEEEEEETEII 1290
            .|..|.      ..||.:..||||::. |::..:..  .|.:..||:.     |..|:...|.:
Human   826 YEREIKGSREKVISDKDLELLLDRSDL-IDQMNASGPIKEKMGIFKIL-----ENSEDSSPECL 883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357
TNG2 <282..422 CDD:227367
PHD1_CHD_II 380..422 CDD:277006
PHD2_CHD_II 440..482 CDD:277007
CD1_tandem_CHD3-4_like 487..557 CDD:349314 2/17 (12%)
CD2_tandem_CHD3-4_like 610..664 CDD:349309 9/53 (17%)
PLN03142 720..>1234 CDD:215601 219/640 (34%)
DUF1087 <1292..1334 CDD:461922
CHDII_SANT-like 1380..1517 CDD:461920
CHDCT2 1757..1902 CDD:462358
HELLSNP_001275996.1 DEXHc_HELLS_SMARCA6 220..499 CDD:350767 98/292 (34%)
PLN03142 221..>869 CDD:215601 226/672 (34%)
Blue background indicates that the domain is not in the aligned region.

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