Protein Alignment Mi-2 and Zranb3

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_006249763.1
• Gene: Zranb3 / 304761
• RGDID: 1564952
• Length: 1083
• Species: Rattus norvegicus
• Alignment Length: 1010
• Identity: 235/1010 - (23%)
• Similarity: 362/1010 - (35%)
• Gaps: 296/1010 - (29%)

  Fly   700 KHYTPPPEKPTTDLKKKYEDQPAFL-EGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKT 763
            |...|.|.  |:.|..:...|..|| :....:|.|:|.:||   .::..:|...::|||||||||
  Rat    34 KRKAPTPW--TSYLTNEASAQLDFLPDKLRAKLLPFQKDGI---VFALRRGGRCMVADEMGLGKT 93

  Fly   764 IQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSF 828
            ||.:...| .|||   ..|.|:.||.|....|..|.|.|.|                    ||..
  Rat    94 IQAIAISY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIP--------------------ELEP 134

  Fly   829 EEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDA-ACLGSID---WAVLVVDEAHRLKSNQSKFF 889
            ||..:..:|....|....:..||  .|.|::.|| ..|.::|   :.|::|||:|.:||..:...
  Rat   135 EEINVITNKTDTGRIATSRVTVL--GYGLLTTDAETLLEALDRQNFRVVIVDESHYMKSRTAARS 197

  Fly   890 RILNSYTIAYK----LLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADV-----SKEEQ 945
            :||  ..:..|    :||||||.....||||..:..|...:|.....:...:.:.     .|..|
  Rat   198 KIL--LPMVQKAQRAILLTGTPALGRPEELFMQIEALFPQRFGTWVEYAKRYCNAHIRYFGKRRQ 260

  Fly   946 --------VKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVR------------VELSAMQKKFYK 990
                    :..||::|...|:||||::||..:|.|    ||            .||:|..:::.|
  Rat   261 WDCRGASNLSELHQLLNDIMIRRLKSEVLSQLPPK----VRQRIPFDLAPATVKELNASFEEWQK 321

  Fly   991 FILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKL 1055
            .:...:..|:.:..|     ||..|.               .:.|...||.:       |...|:
  Rat   322 LMRAPDAGAMETVMG-----LITRMF---------------KQTAIAKAGAV-------KDYIKM 359

  Fly  1056 VLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNA-PG 1119
            :|.:..||        .|:|:....||....:.:...:.:|.||||.:..:.|...:::|.. |.
  Rat   360 LLQNDSLK--------FLVFAHHLSMLQACTEAVIESKARYIRIDGSVPSSERIHLVNQFQKDPD 416

  Fly  1120 AQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVE 1184
            .:  |.:||.:|.|.|:....|..|:..:..|:|.:..||..|||||||.:.|.|:..:...:::
  Rat   417 TR--VAILSIQAAGQGLTFTAASHVVFAELFWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLD 479

  Fly  1185 ERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQEL----DDILRFG---------TEDLFKEDDKE 1236
            ..:..:..||..:|         |...|..|::|    ||..::|         ..|.|:|....
  Rat   480 SLMWAMLNRKAQVT---------GSTLNGRKEKLQATEDDKEKWGFLQFAEAWTPSDSFEELKDP 535

  Fly  1237 EAIHYDD---------------KAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKE------ 1280
            ...|::.               |...|........::||.:.|::      ..:.||||
  Rat   536 VFTHFEKEKQHDIRSFFLPKPRKRPLETSGDAAEAVKEKTTVASD------PRNMATKEGTTDKN 594

  Fly  1281 --EEEE---------------EETEIIKQDAENSDPAYWVK-------------------LLRH- 1308
              |.|.               ||...::..|.:.|..:.||                   .|..
  Rat   595 GVEPETKRLKSLSTRDHCSALEEKPSLQAKATSIDGVHEVKSPLASPALSEKRWQCGFCTFLNDP 659

  Fly  1309 ---HYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGG 1370
               :.|..:...||:.|...|                        |||..|...|    |.:...
  Rat   660 GLPYCEMCESPQGRAAGLNHR------------------------QDNNKEEKEE----SQKSTS 696

  Fly  1371 DDD---------FDDQNGAERKAKRR----LERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLN 1422
            .:|         ..:|...||.|:.:    .|:..:...||:       .|...|.|.:....::
  Rat   697 KNDQARLHCVKPCSEQPEVERLARNKEETSKEQLSNSDTPPV-------CETFMFCASKNTDRIH 754

  Fly  1423 AIMRYGMP------PQDAFNSQWLVRDLRG----KSERNFKAYVSLFMRHLCEPGADNAETFADG 1477
            ...:.|.|      |.|.....|  .||..    |..|      ||.:|.:.|
  Rat   755 LYTKDGKPMNCNFIPLDIKLDLW--EDLPAIFQLKQNR------SLILRFVRE------------ 799

  Fly  1478 VPREGLS--RQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAAL---E 1537
              ..||:  :|.|:.:.|  .|.|..|...|.|....:      |.....|...|:|||..   :
  Rat   800 --WSGLTAMKQRVIRKSG--QLFRSPVLALEEITKQQA------KESSTRRYITKEDVATASMNK 854

  Fly  1538 APPTGGN---VDKSATTSNSVT--PATSAAPSPAP 1567
            ....||:   :.|.:.|.|..|  |..:..|||.|
  Rat   855 VKNEGGHIRLITKGSLTQNPSTKKPDRARVPSPNP 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309
		PLN03142	720..>1234	CDD:215601	149/561 (27%)
		DUF1087	<1292..1334	CDD:461922	10/64 (16%)
		CHDII_SANT-like	1380..1517	CDD:461920	32/152 (21%)
		CHDCT2	1757..1902	CDD:462358
Zranb3	XP_006249763.1	HepA	<18..491	CDD:440319	143/530 (27%)
		DEXHc_HARP_SMARCAL1	64..283	CDD:350768	73/249 (29%)
		ZnF_RBZ	648..670	CDD:197784	2/21 (10%)
		RanBP2-type Zn finger	648..667	CDD:275376	2/18 (11%)
		HNHc	<1014..1053	CDD:238038