Protein Alignment Mi-2 and hrp3

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001342861.1
• Gene: hrp3 / 2543064
• PomBaseID: SPAC3G6.01
• Length: 1388
• Species: Schizosaccharomyces pombe
• Alignment Length: 1638
• Identity: 460/1638 - (28%)
• Similarity: 686/1638 - (41%)
• Gaps: 473/1638 - (28%)

  Fly   223 SRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRD--- 284
            |.|...|:.|.:..|....::|..|..       |..|...:|.......|..:|.|.|:..
pombe    11 SSSKAIEQLDHVQTETPNLKQEMSESP-------SNSGVASKRKLQSTEWLDPELYGLRRSGRTR 68

  Fly   285 -------SSDEEQDASGASER-----DSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDG 337
                   .:|:::|...:..|     .|.....|.::..||.|:.    |:|:...|     ||.
pombe    69 SNPGRYVDTDDQEDVFPSKHRKGTRNGSSFSRHRTIRDLDDEAES----VTSEESES-----DDS 124

  Fly   338 S--GAPVVR---KKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCP 397
            |  |.|..|   ||:.|.:.::.:..::..|..|:  .||...|
pombe   125 SYGGTPKKRSRQKKSNTYVQDEIRFSSRNSKGVNY--NEDAYFE--------------------- 166

  Fly   398 RAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHT 462
                                          :.|||:::|..|                    |.|
pombe   167 ------------------------------SFEEEEEEEMYE--------------------YAT 181

  Fly   463 FCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIK 527
            .....|.|                 |...:.::..|..:..:...||..          .|:.||
pombe   182 EVSEEPED-----------------TRAIDVVLDHRLIEGHDGSTPSED----------YEFLIK 219

  Fly   528 WHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYD-------------MEEPPKFEESLDEADTRYK 579
            |.|.|:.||.|.|...:.     |||. .:|.|             .|:|....|.::..|
pombe   220 WVNFSHLHCTWEPYNNIS-----MIRG-SKKVDNHIKQVILLDREIREDPTTTREDIEAMD---- 274

  Fly   580 RIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKST 644
             |::.:.:         |..||  ||.        |.|::......|||..|||||::|.||..|
pombe   275 -IEKERKR---------ENYEE--YKQ--------VDRIVAKHLNSDGSVEYLVKWKQLLYDFCT 319

  Fly   645 WEEE-------GDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHY 702
            ||..       ..:||..::            ..|:..|.|:.:..|          ..|| |:
pombe   320 WEASSIIEPIAATEIQAFQE------------REESALSPSRGTNYG----------NSRP-KY- 360

  Fly   703 TPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTV 767
                        :|.|.||:::  ||.:|..:|:.|:||:.|.|.:..:.|||||||||||:|||
pombe   361 ------------RKLEQQPSYI--TGGELRDFQLTGVNWMAYLWHKNENGILADEMGLGKTVQTV 411

  Fly   768 TFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGA 832
            .||..|.......|||||.|||||:..|:....|||.|..||:|:|:..||.|||:.|. :.:|
pombe   412 AFLSYLAHSLRQHGPFLVVVPLSTVPAWQETLALWASDMNCISYLGNTTSRQVIRDYEF-YVDG- 474

  Fly   833 IRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTI 897
                      |.:.|||:|||:||.:..|.:.|.:|.|..:.:|||||||:::|..:..|:.:..
pombe   475 ----------TQKIKFNLLLTTYEYVLKDRSVLSNIKWQYMAIDEAHRLKNSESSLYEALSQFKN 529

  Fly   898 AYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLK 962
            :.:||:||||||||:.||..|::||...||...:....|..|..:|..::.|.|.|.|::|||||
pombe   530 SNRLLITGTPLQNNIRELAALVDFLMPGKFEIREEINLEAPDEEQEAYIRSLQEHLQPYILRRLK 594

  Fly   963 TDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEAL-NSKSGGGSCSLINIMMDLKKCCNHPY 1026
            .||.|::|||||.|:|||||.:|..:||.|||:||..| .|.|.|...||:||:::|||..||||
pombe   595 KDVEKSLPSKSERILRVELSDLQMYWYKNILTRNYRVLTQSISSGSQISLLNIVVELKKASNHPY 659

  Fly  1027 LFPSAAEEATTAAGGLYEINS----------LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKM 1081
            ||....|      ..:.:|||          |...:||:|||.|:|.:|:...|||||||||.:|
pombe   660 LFDGVEE------SWMQKINSQGRRDEVLKGLIMNSGKMVLLDKLLSRLRRDGHRVLIFSQMVRM 718

  Fly  1082 LDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVII 1146
            ||||.|:|....|.::|:||.:...:|:.:||.||||.:..||||||||||||||||.|||||||
pombe   719 LDILGDYLSLRGYPHQRLDGTVPAAVRRTSIDHFNAPNSPDFVFLLSTRAGGLGINLMTADTVII 783

  Fly  1147 YDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGA 1211
            :||||||..|:||.:|||||||.|.||:||.::::::||.|.:.|:|||:|.:.::..|:..|..
pombe   784 FDSDWNPQADLQAMARAHRIGQKNHVMVYRLLSKDTIEEDVLERARRKMILEYAIISLGVTDKQK 848

  Fly  1212 N-----FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDR-----TNRGIEEKESWANE 1266
            |     |:.:||..||:||..::||.::.::.:  :|..:.|:|:.     |:..:........|
pombe   849 NSKNDKFSAEELSAILKFGASNMFKAENNQKKL--EDMNLDEILEHAEDHDTSNDVGGASMGGEE 911

  Fly  1267 YLSSFKVASYAT--------------KEEEEE---EETEIIKQDAENS--------------DPA 1300
            :|..|:|..|..              |.|||:   ||.|.:||:.|.|              .|:
pombe   912 FLKQFEVTDYKADVSWDDIIPLTEREKFEEEDRLREEEEALKQEIELSSRRGNRPYPSSAVESPS 976

  Fly  1301 YWVKLLRHHYEQHQEDVGRSLGKGKR--------VRKQV---------------NYTDGGVVAAD 1342
            |               .|.|..|.|:        :.|::               .|.| .|..||
pombe   977 Y---------------SGTSERKSKKQMLKDEVLLEKEIRLLYRAMIRYGSLEHRYND-IVKYAD 1025

  Fly  1343 TTRDDSN-----WQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLAR 1402
            .|..|::     ..|..:......|| :::|..:|  ...|.:.|||              ||..
pombe  1026 LTTQDAHVIKKIAADLVTASRKAVSA-AEKDLSND--QSNNKSSRKA--------------LLIT 1073

  Fly  1403 VGGNIEVLGFNARQRKSFLNAI-MRYGMPPQDAFNS---------------QWLVRD----LRGK 1447
            ..|   |...||......||.: :.|...|...:::               ||..|:    |.|.
pombe  1074 FKG---VKNINAETLVQRLNDLDILYDAMPTSGYSNFQIPMHVRSVHGWSCQWGPREDSMLLSGI 1135

  Fly  1448 SERNFKAYV------------SLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRK 1500
            .:..|.|::            .:|:.       |..:| .:.||::..:::             |
pombe  1136 CKHGFGAWLEIRDDPELKMKDKIFLE-------DTKQT-DNSVPKDKENKE-------------K 1179

  Fly  1501 KVQEFEHI--NGYYSMPELILKPCEPVRSALKQ-----DVAALEAPPTGGNVDKSATTSN----- 1553
            ||....|:  .|.|.:            |||::     .:.:..|..|.|.......|:|
pombe  1180 KVPSAVHLVRRGEYLL------------SALREHHQNFGIKSSPAISTNGKTQPKKQTANRRQSG 1232

  Fly  1554 -----SVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQE-- 1611
                 |.....||..:|:||..:...|....:.:.:..|.|:|..:.....:.:|..|:|...
pombe  1233 KPNVKSAQKIESATRTPSPAISESRKKPSSKDTKIETPSREQSRSQTASPVKSEKDDGNVSLNAE 1297

  Fly  1612 ---------NPV--------EEAAGDTKPSDAEVKTEVAKTEPK--EETKDPEVKEEPKTEEKE- 1656
                     .||        ::::|..:....::.||...|..|  |:|.:....||..|..|.
pombe  1298 QKARCKELMYPVRKHMKRLRKDSSGLGRAELVKLLTECLTTIGKHIEKTVNDTPSEEKATVRKNL 1362

  Fly  1657 ---------KEKV 1660
                     ||:|
pombe  1363 WMFACYFWPKEEV 1375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367	25/159 (16%)
		PHD1_CHD_II	380..422	CDD:277006	0/41 (0%)
		PHD2_CHD_II	440..482	CDD:277007	4/41 (10%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	17/69 (25%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	18/60 (30%)
		PLN03142	720..>1234	CDD:215601	248/529 (47%)
		DUF1087	<1292..1334	CDD:461922	10/78 (13%)
		CHDII_SANT-like	1380..1517	CDD:461920	31/170 (18%)
		CHDCT2	1757..1902	CDD:462358
hrp3	NP_001342861.1	CD1_tandem_CHD1_yeast_like	189..250	CDD:349312	20/93 (22%)
		CD2_tandem	286..339	CDD:349306	21/62 (34%)
		PLN03142	339..>895	CDD:215601	260/613 (42%)
		Cdh1_DBD_1	997..1081	CDD:408024	21/104 (20%)
		DUF4208	1300..1384	CDD:464035	16/76 (21%)