Protein Alignment Mi-2 and fft1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_593325.1
• Gene: fft1 / 2541983
• PomBaseID: SPAC20G8.08C
• Length: 944
• Species: Schizosaccharomyces pombe
• Alignment Length: 770
• Identity: 215/770 - (27%)
• Similarity: 336/770 - (43%)
• Gaps: 155/770 - (20%)

  Fly   501 QRSNDD-----GPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYD 560
            :.:|:|     .|:......|.::.:.|           :.:.:.||.::...|..:.....:||
pombe   220 EETNEDDLLGQSPTACTTDANIDNSIPE-----------NSDKIEEVSIESSGPSEVEDEMSEYD 273

  Fly   561 ME-----EPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVIN 620
            :.     .....:|.::.:....|.::....|....:.:.||.|.:|           .......
pombe   274 VRVLNFLNESTLQEIVEVSGCESKVVEYFISKRPFPSLEKAEALCQR-----------NAHAATG 327

  Fly   621 HRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVC------TSETTQSRSK 679
            .|...||..:    .|:|.  .||:|        :.|..|....|.|.|      .|.|.:|...
pombe   328 KRKKSDGRNV----GRKLV--NSTYE--------VLQGFDAVDSLIAKCERYGAMISNTMRSWHN 378

  Fly   680 KSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRY 744
            ..             :|:.::.:.   ...|..:..:|..|......:|:.|..|||.|:|||..
pombe   379 LF-------------DDKKMEQFL---NTSTGSISYEYNSQQPSSIASGITLKSYQIVGLNWLCL 427

  Fly   745 SWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCI 809
            .:...:..|||||||||||.|.::||.|| ||...:...||.||.|||.||.||||.:.|.....
pombe   428 MYKAKLSGILADEMGLGKTCQVISFLASL-KEKGIQNRHLVVVPSSTLGNWLREFEKFCPSLRVE 491

  Fly   810 TYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELIS---MDAACLGSIDWA 871
            :|.|.:..|.                :|...|..|.  |:||:|:|:|.|   .|.:.|....:.
pombe   492 SYSGTQSERI----------------NKRYYLMDTD--FDVLVTTYQLASGSRDDRSFLRKQRFD 538

  Fly   872 VLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKF-NDLQAFQG 935
            :.:.||.|.||:..|:.::.|.:....::||:|||||||||:||..||.|:....| |::|....
pombe   539 ISIFDEGHYLKNRMSERYKHLMNIPANFRLLITGTPLQNNLKELISLLAFMLPKVFDNNMQGLDI 603

  Fly   936 EF-------ADVSK----EEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFY 989
            .:       .|:.:    :|::.|...::.|.:|||.|.:||.::|.|.:.:....:...|...|
pombe   604 IYKIKTTSDGDIERAYLSQERISRAKTIMNPFILRRRKENVLSDLPPKIQHVEYCHMEETQLSLY 668

  Fly   990 KFIL-TKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPS--------------AAEEATTAA 1039
            ..:| .||....|.:         ||:|.|:|...|..||.|              ..|:|...|
pombe   669 LSVLELKNLVNANRE---------NILMQLRKAALHQLLFRSQYNLETLSLMSKRILREDAYLDA 724

  Fly  1040 GGLY-----------EINSLTKA----------------AGKLVLLSKMLKQLKAQNHRVLIFSQ 1077
            ...|           |::.|...                :.|:..|..:||:.: .|.|:|||||
pombe   725 NPQYIFEDMEVMSDFELHKLADQYRHLHPFALKGKPWMDSAKVKKLCSLLKKSR-PNERILIFSQ 788

  Fly  1078 MTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATAD 1142
            .|::|||||..|.....::.|:||......||:.||.|:. .....||||||::||.||||..|:
pombe   789 FTQVLDILEYVLNTLDLEFLRLDGSTPVETRQQLIDDFHT-NENYKVFLLSTKSGGFGINLTCAN 852

  Fly  1143 TVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMML 1197
            .||::|..:||.:|:||..||||:||...|.:||.:|:|::||.:.::|..|:.|
pombe   853 IVILFDCSFNPFDDMQAEDRAHRVGQTRPVHVYRLITKNTIEENIRRLANTKLTL 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	8/60 (13%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	10/53 (19%)
		PLN03142	720..>1234	CDD:215601	179/535 (33%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
fft1	NP_593325.1	HepA	<411..907	CDD:440319	177/525 (34%)