DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and mit1

DIOPT Version :9

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_595385.1 Gene:mit1 / 2541336 PomBaseID:SPBP35G2.10 Length:1418 Species:Schizosaccharomyces pombe


Alignment Length:1485 Identity:405/1485 - (27%)
Similarity:626/1485 - (42%) Gaps:373/1485 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 MPSVEDVCSAFSVCNVEIEYSEEELQSLTT-YKAFMHHVRPILQKENPKIAAPKLVMLVAAKWRE 185
            ||..:|     |:|.:.:.  .|.|..|.. |.|....|:.||. ||....:.|.:         
pombe     1 MPKEDD-----SLCKIVVR--REPLDVLLPYYDASETTVQKILH-ENDSTLSVKFL--------- 48

  Fly   186 FCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRS-------SRNEKPDDIYEEAVEEEE 243
                                ||....:..||.::.::.::       .::.|....|..:.:::|
pombe    49 --------------------AGVEALIKKDELDKYKNGKACLRVWLKHKSRKRYHGYMTSTDKDE 93

  Fly   244 EEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDS------SDE-EQDASGASERDSD 301
            ||:.:     ......|.|..|.|.:  |.|.| .||....:      ||| ..|::.:|..|::
pombe    94 EEKND-----YLLKSNGSKVLRDSTR--TKKFK-FGKEFHCALNPSFVSDETASDSATSSSSDTN 150

  Fly   302 LEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKN 366
            .:..|        .:..|..:|..:.|..                  :..|:.....::::.|:|
pombe   151 KKVNR--------KEHNELSLSHLSFNDT------------------SDFGSSDLSSSEIESTEN 189

  Fly   367 ----------FPEGEDG-EHEHQDYCEVC------QQGGEIILCDTCPRAYHLVCLE-PELDE-- 411
                      :.:|.|. :..|...|..|      ..|...:.||.|...||..|.. |.|::  
pombe   190 DNKAPYFSLLYSDGFDFIKFLHVCVCVKCHGREHRSSGKNFVYCDHCSNVYHYDCSPLPSLNKET 254

  Fly   412 ---PPEGKWSCPHCEAD-----------GGAAEEED--------DDEH----QEFCRVCKDGGEL 450
               ..:..:.||.|..:           .|.:..:|        |.|.    ..:|:..:     
pombe   255 RNYSQQNGFICPLCSKNSKDVLCNTGFVSGVSSGQDLVIPPSLADRESLSILVNYCKSIR----- 314

  Fly   451 LCCDSCPSAYHTFCLNPPLDTIPDGDWR----------CPRCSCPPLTGKAEKIITWRWAQRSND 505
            ..|..|....:.|.    ||:.|....|          |..||..|.  ..|:||.||   ..|.
pombe   315 FRCFRCRRVEYFFY----LDSNPLSIQRTITHFIKKLVCNECSMHPC--DIEEIIAWR---TLNS 370

  Fly   506 DGPSTSKGSKN--SNSRV----REYFIKWHNMSYWHC-----EWVPEVQLDVHHPLMIRSFQRKY 559
            ..||.:..|.|  |.|.:    ||||::....||.||     .|:..:.|         :.::.:
pombe   371 LYPSKATLSNNFVSTSDLSFWSREYFVRSKGKSYLHCFWCSASWLAGISL---------AKKKNF 426

  Fly   560 DMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTA 624
            |..|...::.:.......|..|.:..| |..::..:|...:.:..|:.:|              |
pombe   427 DGLENASYDATKPIIPVSYTIIDKVWD-VQYRSGKNARTAKYKTKKHQLK--------------A 476

  Fly   625 RDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKL 689
            ....|...|.||.|.|..|.||..                     ..||.::|.|...||....|
pombe   477 ISEVTFAFVSWRGLTYYMSNWEPP---------------------PKETDRNRWKAWLKGYSDLL 520

  Fly   690 KVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTIL 754
            :....|..|.....  .:.|.|:|  ::..||:|::|.  .|.|||::|:|||...|......||
pombe   521 ECLWIEKAPTASIN--IDLPFTNL--EWHSQPSFIKGG--TLMPYQLKGLNWLYLRWYTHHPCIL 579

  Fly   755 ADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRA 819
            |||||||||:|.::|:..|:....| .|.||.||.:|:.|||||.:.|||.......:|.:.:|:
pombe   580 ADEMGLGKTVQVISFISVLFYRHKC-FPVLVIVPHATVANWERELKKWAPFLQINVLVGSEKNRS 643

  Fly   820 VIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSN 884
            ::|:..|           :::........:||:.|...:..:.:.|....|.||:|||..|||::
pombe   644 LVRDYRL-----------INQKDPKHVSTHVLVISASNVEREISLLRKFQWKVLIVDEGQRLKND 697

  Fly   885 QSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKE------ 943
            ||..|..|:|....:||||||||||||:.|||:||.||:..|.|        .|::.|.      
pombe   698 QSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFNLLQFLNPMKIN--------AAELEKRYSIIDT 754

  Fly   944 EQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEAL-------N 1001
            |:|..||::|.|..|||:|::||.|.|:|.|.|:.:.::.:||..||.||:||...|       |
pombe   755 EKVTELHQILKPFFLRRVKSEVLDNFPTKVEVIIPLSMTPVQKGLYKSILSKNLSLLRNITGYAN 819

  Fly  1002 SKSGGG--SCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEI--NSLTKAAGKLVLLSKML 1062
            :.|.||  :.||.||:|.|:|...|||::....|:....    ||:  .||.:|:.|.::|..::
pombe   820 TSSSGGQRTTSLNNILMQLRKTLAHPYIYSPDIEDRNLP----YELAMRSLEEASCKFLILRLLV 880

  Fly  1063 KQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLL 1127
            .:|..:.||:|:|||..:.||||||:.|.:...|.|.||..:...||.|||.||||.::...|||
pombe   881 PKLITRGHRILLFSQFIQQLDILEDWFEYKNIAYARFDGASSEMERQSAIDSFNAPNSELSCFLL 945

  Fly  1128 STRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAK 1192
            ||||||:|||||:||||||.|.|:|||.|:||.:||||.||..||:::...||:||||::.|.|:
pombe   946 STRAGGVGINLASADTVIILDPDFNPHQDMQAIARAHRYGQKKKVLVFVLTTRDSVEEKIIQNAQ 1010

  Fly  1193 RKMMLTHLVVRPGMGGKGANF-TKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRG 1256
            :|::|.||:|.    ....|. ::::|:.|||.|...||:|...|.:|.|::.:|..|:....: 
pombe  1011 KKLVLDHLIVE----SLDQNHNSEKDLESILRHGARALFEEAGDEPSIKYNEYSVELLISEAEK- 1070

  Fly  1257 IEEKES----------------WANEYLSSFKVASYATKE----EEEEEETEIIKQ---DA--EN 1296
             :|..|                |.|:::||   ..|..||    :||:..:.|:||   ||  |.
pombe  1071 -QEDTSTDESDIKSNKFGFFRVWDNKHISS---NHYEVKENVLVDEEDVWSVILKQREKDAMLEK 1131

  Fly  1297 SDPAYWVKLLRHHYEQHQ-EDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDN-----GS 1355
            :|.....:.||.|::.|. ||              :|..|..        ||:::..|     ||
pombe  1132 TDETTSNRRLRAHHKIHYGED--------------LNIYDNS--------DDTDYTVNDRSSPGS 1174

  Fly  1356 EYNSE------------------YSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLAR 1402
            .:..|                  |.:..:.:..:|:.|.|..|:                     
pombe  1175 PFPIETETISSITDTLSDKQKLKYDSSVNIENLNDESDSQKSAD--------------------- 1218

  Fly  1403 VGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVS 1457
                   :.|::...||.|..     .|.:|.||......:|...::.....|::
pombe  1219 -------VHFDSILAKSLLAT-----TPKEDEFNKTLSTINLEVANKLTSSEYIN 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 11/52 (21%)
PHD1_CHD_II 380..422 CDD:277006 13/53 (25%)
PHD2_CHD_II 440..482 CDD:277007 9/51 (18%)
CHROMO 490..558 CDD:237991 22/78 (28%)
CHROMO 615..667 CDD:214605 10/51 (20%)
SNF2_N 734..1028 CDD:278600 121/308 (39%)
DEXDc 751..907 CDD:238005 57/155 (37%)
Helicase_C 1053..1167 CDD:278689 61/113 (54%)
DUF1087 <1292..1337 CDD:283996 13/50 (26%)
DUF1086 1380..1517 CDD:283992 11/78 (14%)
CHDCT2 1756..1927 CDD:285336
mit1NP_595385.1 PHD 214..268 CDD:214584 13/53 (25%)
SNF2_N 559..847 CDD:278600 120/307 (39%)
DEXDc 577..720 CDD:238005 57/154 (37%)
Helicase_C 870..985 CDD:278689 61/114 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0383
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000546
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45623
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.870

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