Protein Alignment Mi-2 and fft2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_587731.1
• Gene: fft2 / 2539045
• PomBaseID: SPCC1235.05C
• Length: 1284
• Species: Schizosaccharomyces pombe
• Alignment Length: 1132
• Identity: 293/1132 - (25%)
• Similarity: 464/1132 - (40%)
• Gaps: 293/1132 - (25%)

  Fly   465 LNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWH 529
            |.||          .|....||:|                         :.:.|:.:|..
pombe   240 LTPP----------APPVELPPVT-------------------------TTSPNAIIRSV----- 264

  Fly   530 NMSYWHCEWVPEVQLDVHHPLMIRSFQRKYD--------------------MEEPPKFEES---- 570
               .|...:||:..:   |.::....|.|:|                    ::|..:|::|
pombe   265 ---QWIRSFVPQAPI---HQVINTLAQTKWDETAALSILSQKYLSCDLGIPIQEHKRFKQSPVAS 323

  Fly   571 -LDEADTRYKRIQRHK----DKVGMKANDDAEVL-------------------EERFYKNGVKPE 611
             :....:..:.:|..|    ||.....||..:..                   |:.||.:..:||
pombe   324 NMPTYGSSNRTVQSQKRSIRDKYIQMPNDSTQASLMPSYTRKTSNASKKLTTEEDEFYDSEEEPE 388

  Fly   612 WLI----------VQRVINHRTARDGS---------TMYLVKWRELPYD---KSTWEEEGDDI-- 652
            .::          |...||..||::.|         :..|::.|  |:.   ::...:..||:
pombe   389 AIVHRDTSALERTVLNFINSSTAKELSDTASCPLSHSKLLLEHR--PFQTLAEACIIKHPDDVPS 451

  Fly   653 ----QGLRQAID----------------YYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDR 697
                :|.|:..:                ||.....:...|...:|..|.......||::.:.|..
pombe   452 KPGRRGRRREKNPMGQKIVNACMETMEGYYAIDNLIAKCEFLGNRISKGMASWGIKLEMSNGELN 516

  Fly   698 PVKHYTPPPE-KPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLG 761
            .|...:.|.| ...:|..|...:||..| .:.:||..||:.|:|||...:.|.:..|||||||||
pombe   517 IVDMESVPTEAADNSDFPKFVTEQPKTL-ASDVQLKSYQLVGVNWLHLLYQQKLSGILADEMGLG 580

  Fly   762 KTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENEL 826
            ||.|.|.|...|.::|| .||.||.||.|||.||.||...:.|......|.|.:..||.|||
pombe   581 KTCQVVAFFALLLEQGH-HGPHLVVVPSSTLENWLRELARFCPSLRVEPYYGSQQERANIRE--- 641

  Fly   827 SFEEGAIRGSKVSRLRTTQYKFNVLLTSYELIS---MDAACLGSIDWAVLVVDEAHRLKSNQSKF 888
            :.||..|             |:::|:|:|:|.:   .|.:.|...::.|.|.||.|.||:..|:.
pombe   642 AIEENEI-------------KYDILVTTYQLATNNKEDRSFLKHQNFDVCVYDEGHYLKNRMSER 693

  Fly   889 FRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKF-NDLQAFQGEF-------ADVSK--- 942
            ::.|.:....::||||||||||||:||..||.|:..:.| :|:......|       ||:.:
pombe   694 YKHLMNLNANFRLLLTGTPLQNNLKELVSLLAFILPNMFDSDMDDLDVIFKAKPTADADIEQALL 758

  Fly   943 -EEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYK--FILTKNYEAL---- 1000
             ::::.|...|:.|.:|||.|..||.::|.|::.|...:||..|.:.|.  ..|.||.:..
pombe   759 SKQRISRAKTMMTPFVLRRRKNQVLNDLPKKTQIIEHCKLSENQLEIYNRYAALQKNQQLRRDDK 823

  Fly  1001 -------NSKSGGGSCSLINIMMDLKKCCNHPYLFPS--------------AAEEATTAAGGLY- 1043
                   :.:|.|.|.|..:::|.|:|..||..||..              ..||....|...|
pombe   824 RNKRSKNDEESDGKSLSAGHVLMQLRKAANHALLFRKFYDDEKLKQMAKDIMQEEQYKNANEQYI 888

  Fly  1044 ----------EINSLTKA----------------AGKLVLLSKMLKQLKAQNHRVLIFSQMTKML 1082
                      |::.|.::                :||:.:|.::|.::|.:..|:|:|||.|:||
pombe   889 YEDMEVMSDFELHRLCRSFPTLQSYTLKDDPWMDSGKIRVLKELLPKMKEEGSRILLFSQFTQML 953

  Fly  1083 DILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIY 1147
            ||||..|:..:..|.|:||.....:||:.||:|:.. ....||||||:|||.|||||.|:.||:|
pombe   954 DILEQVLDTLKISYVRLDGSTQVEVRQDIIDQFHKE-EDVTVFLLSTKAGGFGINLACANVVILY 1017

  Fly  1148 DSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGAN 1212
            |..:||.:|:||..||||:||..:|.:.|.:|.|::||.:.::|..|:.|
pombe  1018 DCSYNPFDDLQAEDRAHRVGQVREVTVIRLITDNTIEEYIQKLANTKLAL--------------- 1067

  Fly  1213 FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEK-ESWANEYLSSFKVASY 1276
                           |:....|.::.....::.|.::||..|.|...| |...||....|||:|.
pombe  1068 ---------------DMSLSSDGKDREEIGERLVQDMLDEENNGNNTKPEITGNESDGEFKVSSS 1117

  Fly  1277 ATKEEEEEEET------------EIIKQDAENSDPAYWVKLLRHHYEQHQEDVG------RSLGK 1323
            ...::.:.|||            .:.|.|..:.|....:|.     |...|.|.      |...|
pombe  1118 NNSKQTDAEETNTGVPLEGSQPNSVEKTDLADGDEKANIKT-----EMKSETVEGDNKELRETMK 1177

  Fly  1324 GKRVRKQVNYTDGGVVAADTTRDDSNWQ------DNGSEYNSEYSAGSDEDGGDDDF-DDQNGAE 1381
            |:.|:...|   ..|.::.::.::.|..      |..:|.:...|.......||... ::|..|.
pombe  1178 GENVQTDSN---AAVPSSKSSTEEPNESVLSGHLDLDTEASPVVSTIEKTTKGDVSVTEEQQSAN 1239

  Fly  1382 RKAKRRLERRDDRPLPPLLARVGGNIE 1408
            ...:......::...|.:|.:|..:||
pombe  1240 IDGQLEKPEIEESKKPDVLNQVSLSIE 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007	4/16 (25%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	7/69 (10%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	17/97 (18%)
		PLN03142	720..>1234	CDD:215601	194/582 (33%)
		DUF1087	<1292..1334	CDD:461922	11/47 (23%)
		CHDII_SANT-like	1380..1517	CDD:461920	6/29 (21%)
		CHDCT2	1757..1902	CDD:462358
fft2	NP_587731.1	HepA	<539..1067	CDD:440319	192/546 (35%)
		PHA03151	1091..>1234	CDD:177546	33/150 (22%)