DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and Chd3

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_017169944.1	Gene:	Chd3 / 216848	MGIID:	1344395	Length:	2111	Species:	Mus musculus

Alignment Length:	2142	Identity:	1090/2142 - (50%)
Similarity:	1339/2142 - (62%)	Gaps:	328/2142 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEENDDNFQEEEEAQEDN-----------APAAELSNDSDA------------PLKPNQNDEDDD 45
            |||.|:..:|.|.|.||:           .|..:.|.|..:            ||.|....:.||
Mouse    25 EEEGDEEEEEVEAADEDDEEEDEEGVLGRGPGHDRSRDRHSPPSCHLFPPPPPPLPPPPPPDKDD 89

  Fly    46 YDPEDS----RRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRG---- 102
            .....|    :::|:|.|::.   |.|..|.:||||.:|||:..    .|..||...|:.|
Mouse    90 IRLLPSALGVKKRKRGPKKQK---ENKPGKPRKRKKLDSEEEFG----SERDEYREKSESGGSEY 147

  Fly   103 ------------RKRKEEKQAAKEKESASSGMPSVEDVCSA-----FSVCNVEIEYSEEELQSLT 150
                        |::||:|...:::.....|...||...||     :.:.:||..:|||:..:||
Mouse   148 GTGPGRKRRRKHREKKEKKTKRRKRGEGDGGHKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLT 212

  Fly   151 TYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGD 215
            .||||...:||::.|:||||...|::.::.||||||..:||.   :|.||....:|..|.:...:
Mouse   213 NYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPF---KGSAAAVAAAAAAAAAAVAE 274

  Fly   216 EPEEPRSSRS--SRNEKPDDIYEEAVEE------EEEEEEEEKKPRRKRSGRGKKGRRPSG---- 268
            :.....||.:  :.:..|..:......|      ...:.:|.|.|..||  |.|..|.|.|
Mouse   275 QVSAAVSSATPIAPSGPPPALPPPPAPEIQPPPIRRAKTKEGKGPGHKR--RNKSPRVPDGRKKL 337

  Fly   269 ---KVPTLKIK---LLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKAD 327
               |:..||||   |.||||:..|...|...|                  ...:.:|:.:.|.:.
Mouse   338 RGKKMAPLKIKLGLLGGKRKKAGSCAFQSEEG------------------HEPEAEESDLDSGSV 384

  Fly   328 NSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFP-----EGEDG-EHEHQDYCEVCQQ 386
            :||....|    .||..||.|.  |...:||   ||....|     |..|| |.:||||||||||
Mouse   385 HSASGWPD----GPVRAKKLKR--GRPGRKK---KKVLGCPAVTGEEEVDGYETDHQDYCEVCQQ 440

  Fly   387 GGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHC----------------EADGGAAEEEDDD 435
            |||||||||||||||||||:||||..||||||||||                |.:|...|:|::|
Mouse   441 GGEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEEYEEEGEEGEKEEED 505

  Fly   436 EHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRW- 499
            :|.|:||||||||||||||:|.|:||..||||||..||:|:|.||||:||.|.|:.:||:.|||
Mouse   506 DHMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWG 570

  Fly   500 -------AQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQR 557
                   |.:..|..|.............||:|:||..:|||||.|..|:||::.|.:|.|::||
Mouse   571 EPPVAVPAPQQADGNPDVPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQR 635

  Fly   558 KYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHR 622
            |.||:|||..:....|.|.:       .||..:|....|| :||::|:.|:||||:.|.|:|||.
Mouse   636 KNDMDEPPPLDYGSGEDDGK-------SDKRKVKDPHYAE-MEEKYYRFGIKPEWMTVHRIINHS 692

  Fly   623 TARDGSTMYLVKWRELPYDKSTWEE------EGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKS 681
            ..:.|:..|||||::||||:|||||      |.||     ....|::....:...:..|.|
Mouse   693 MDKKGNYHYLVKWKDLPYDQSTWEEDEMNIPEYDD-----HKQSYWRHRELIMGEDPAQPR---- 748

  Fly   682 KKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSW 746
             |.:|.|.:::.|         .||..||.|...|||.||.|:..||..||.||:||:||||:||
Mouse   749 -KYKKKKKELQGD---------GPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSW 803

  Fly   747 GQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITY 811
            .||.||||||||||||||||:.||||||||||.:|||||:.||||::||||||::|||.||.:||
Mouse   804 AQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTY 868

  Fly   812 IGDKDSRAVIRENELSFEEGAIRGSK--VSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLV 874
            .|||||||:|||||.|||:.||:|.|  ....|..|.||:|||||||||::|.|.||||.||.||
Mouse   869 TGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLV 933

  Fly   875 VDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD 939
            ||||||||:|||||||:||.|.|.:|||||||||||||||||||||||:.::||:|:.|..||||
Mouse   934 VDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD 998

  Fly   940 VSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKS 1004
            :|||:|:|:||::||||||||||.||.||||:|:|.|||||||.||||:||:|||:|:|||||:.
Mouse   999 ISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRG 1063

  Fly  1005 GGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQN 1069
            ||...||:|||||||||||||||||.||.|:.....|.||..:|.|::|||:||.|||::||.|.
Mouse  1064 GGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKSSGKLLLLQKMLRKLKEQG 1128

  Fly  1070 HRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGL 1134
            ||||||||||||||:|||||:.|.||||||||||||.|||||||||||||||||.||||||||||
Mouse  1129 HRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGL 1193

  Fly  1135 GINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTH 1199
            ||||||||||||:|||||||||||||||||||||||||||||||||.|||||:||||||||||||
Mouse  1194 GINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTH 1258

  Fly  1200 LVVRPGMGGKGANFTKQELDDILRFGTEDLFKE----DDKEE---AIHYDDKAVAELLDRTNRGI 1257
            ||||||:|.|..:.:||||||||:||||:|||:    ::|||   .||||::|:|.||||.....
Mouse  1259 LVVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDAT 1323

  Fly  1258 EEKE-SWANEYLSSFKVASYATKEEE--EEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGR 1319
            |:.: ...||||||||||.|..:||:  ||.|.|||||: ||.||.||.|||||||||.|||:.|
Mouse  1324 EDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQE-ENVDPDYWEKLLRHHYEQQQEDLAR 1387

  Fly  1320 SLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKA 1384
            :|||||||||||||.       |..::|   |||    .||||.||:|:  |:|||::....|::
Mouse  1388 NLGKGKRVRKQVNYN-------DAAQED---QDN----QSEYSVGSEEE--DEDFDERPEGRRQS 1436

  Fly  1385 KRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSE 1449
            ||:|....|:|||||||||||||||||||.||||:||||:||:||||||||.:||||||||||:|
Mouse  1437 KRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLVRDLRGKTE 1501

  Fly  1450 RNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSM 1514
            :.||||||||||||||||||.:|||||||||||||||.||||||||||::|||||||||||.:||
Mouse  1502 KEFKAYVSLFMRHLCEPGADGSETFADGVPREGLSRQQVLTRIGVMSLVKKKVQEFEHINGRWSM 1566

  Fly  1515 PELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGE------ 1573
            |||:..|     ||..:..:...:|.........|:|:||  |.||...:||| ||||:
Mouse  1567 PELMPDP-----SAESKRSSRASSPTKTSPTTPEASTTNS--PCTSKPATPAP-SEKGDGVRTPL 1623

  Fly  1574 DKDKDSEKEKDKTSAEKSEVKQEQEAE---------------------EDKKPGDVKQENPVEEA 1617
            ||| |:|.:::|.. :.|:|.::.|||                     ||:.||...:..|....
Mouse  1624 DKD-DTENQEEKPE-KNSKVGEKMEAEVDSPSPAPSLGERLEHRKILLEDEAPGVPGETEPEPGY 1686

  Fly  1618 AGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIV 1682
            .||.:.|            ..|.|.....:|:|...::.:|:.:.:     |..:....:|   |
Mouse  1687 RGDREKS------------ASEPTPGERGEEKPLDVQEHRERTEGE-----TGDLGKRAED---V 1731

  Fly  1683 KEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNE 1747
            |.|.||.   ...|:|:..          ..|:..|   :|.|.:|||||||||||||||||.||
Mouse  1732 KADRELR---LGPPRDEPR----------PNGRREE---KVEKPRFMFNIADGGFTELHTLWQNE 1780

  Fly  1748 EKAAV-PGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNK 1811
            |:||: .|:..||||||||||||||||.|||.||||||||.:|||||||||.:..||||||:|||
Mouse  1781 ERAAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQNDAQFAIINEPFKTEANKGNFLEMKNK 1845

  Fly  1812 FLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKP 1876
            |||||||||||||||||||||||||||:|:|:||||:|:|||||.||||||||||||||||||||
Mouse  1846 FLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESHQHLSKESLAGNKP 1910

  Fly  1877 ANAVLHK-------VLNQLEELLSDMKSDVSR-------------LPATLARIPPVAQRLQMSER 1921
            |||||||       ...:.....|:....::.             :|.|..|.||...|.|..:
Mouse  1911 ANAVLHKGKGRGGPARGRAHNAASEPAGGIAERHEGRCDPPASHAVPNTPHRSPPSDVRAQHPQ- 1974

  Fly  1922 SILSRLAATAGNASNAAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFSVPGQLSNNSGV 1983
                                   |||.||......|.             ..||.|.:.|||
Mouse  1975 -----------------------PAGQQGHGASPHTG-------------LSPGSLRHTSGV 2000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	24/51 (47%)
		PHD1_CHD_II	380..422	CDD:277006	38/41 (93%)
		PHD2_CHD_II	440..482	CDD:277007	30/41 (73%)
		CHROMO	490..558	CDD:237991	26/75 (35%)
		CHROMO	615..667	CDD:214605	24/57 (42%)
		SNF2_N	734..1028	CDD:278600	217/295 (74%)
		DEXDc	751..907	CDD:238005	115/157 (73%)
		Helicase_C	1053..1167	CDD:278689	100/113 (88%)
		DUF1087	<1292..1337	CDD:283996	33/44 (75%)
		DUF1086	1380..1517	CDD:283992	110/136 (81%)
		CHDCT2	1756..1927	CDD:285336	119/190 (63%)
Chd3	XP_017169944.1	CHDNT	200..253	CDD:369683	24/52 (46%)
		PHD1_CHD_II	434..476	CDD:277006	38/41 (93%)
		PHD2_CHD_II	510..552	CDD:277007	30/41 (73%)
		CD1_tandem_CHD3-4_like	557..635	CDD:349314	27/77 (35%)
		CD2_tandem_CHD3-4_like	680..734	CDD:349309	27/58 (47%)
		PLN03142	771..>1325	CDD:215601	406/553 (73%)
		DEXHc_CHD3	788..1019	CDD:350813	167/230 (73%)
		DUF1087	<1364..1407	CDD:368924	32/49 (65%)
		DUF1086	1430..1569	CDD:368921	110/138 (80%)
		PHA03169	1589..>1759	CDD:223003	50/210 (24%)
		CHDCT2	1790..>1917	CDD:369684	109/126 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I537
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2023	1.000	Inparanoid score	I51
Isobase	1	0.950	-	0	Normalized mean entropy	S1566
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm42760
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.830