DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and chd-3

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_510140.1	Gene:	chd-3 / 181421	WormBaseID:	WBGene00000482	Length:	1787	Species:	Caenorhabditis elegans

Alignment Length:	2039	Identity:	918/2039 - (45%)
Similarity:	1191/2039 - (58%)	Gaps:	390/2039 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NDDNFQ--EEEEAQEDNAPAAELSNDSDAPLKPNQND---EDDDYDPEDSRRKKKGKKRKTRKGE 66
            :||..:  :.:|..|:::..||...|.:..:..::.:   |:....|..|.:||...|:|
Worm     2 SDDQHESIDGDETMEEDSMLAEGHEDGEEDVGEDEEEVETEESQGVPTTSEKKKPPPKKK----- 61

  Fly    67 EKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSA 131
             ||.||..:|||             ..:||...|                |.|:      ::.:|
Worm    62 -KGGKKSSKKKN-------------NCDYPDPYK----------------STSA------EISAA 90

  Fly   132 FSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQE 196
            ..:.:|:::|.:||.||:|..|.|...|:|.:.|.||.....|:..|...|::||   ..|:...
Worm    91 IGLTDVDVDYEQEEFQSITNLKNFSSLVKPYILKVNPGTNVTKMYPLFQVKYKEF---QDHMTAH 152

  Fly   197 GGAAGSGGSAGQARS--------VTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPR 253
            |.:...     |.|:        ||..|...|:.:|||                         .|
Worm   153 GKSIQK-----QQRAKFVPVPVPVTPQEKIIPQKTRSS-------------------------AR 187

  Fly   254 RKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEK 318
            |||                          ||.||.|     ....|||.|||.::::.:...||
Worm   188 RKR--------------------------RDGSDGE-----GGGHDSDQEFEALIKQHEKQQDE- 220

  Fly   319 EAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDG--EHEHQDYC 381
                   |:.....|:.:.:.|.|.::||..:.....|:..|          |.|  |..||:.|
Worm   221 -------AEKGKEEARINRAAAKVDKRKAALESARASKRARK----------EQGVVEENHQENC 268

  Fly   382 EVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGG---AAEEEDDDEHQEFCRV 443
            |||.|.||::|||||.||||:.|::..:::||||.|||||||..|.   ..|||....:.::||:
Worm   269 EVCNQDGELMLCDTCTRAYHVACIDENMEQPPEGDWSCPHCEEHGPDVLIVEEEPAKANMDYCRI 333

  Fly   444 CKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGP 508
            ||:...:|.||:|||:||.:|::|||..||:|:|.||||..|....:.|||::|||.:.|..:..
Worm   334 CKETSNILLCDTCPSSYHAYCIDPPLTEIPEGEWSCPRCIIPEPAQRIEKILSWRWKEISYPEPL 398

  Fly   509 STSKGSKNSNS-------------RVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYD 560
            ...:|.:.|..             |.||:|:||..::||.|||:.|..:||:...::|.:.||.|
Worm   399 ECKEGEEASKDDVFLKPPRKMEPRREREFFVKWKYLAYWQCEWLSETLMDVYFTALVRMYWRKVD 463

  Fly   561 MEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTAR 625
            .|.||.||||         .:.||      .::.|...|.||||:.||||||:.:.|:|||.:..
Worm   464 SENPPIFEES---------TLSRH------HSDHDPYKLRERFYQYGVKPEWMQIHRIINHLSYA 513

  Fly   626 DGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQA-IDYYQDLRAVCTSETTQSRSKKSKKGRKSK- 688
            .....|||||:||.|:.:|||.:..||.....| |.|:.....:...|..::..|...|.|::|
Worm   514 KSQQDYLVKWKELSYEHATWERDDTDIANYEDAIIKYWHHRERMLNDEVPRNVQKMIAKQREAKG 578

  Fly   689 LKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTI 753
            |..::||   |.......||  .|:.||||.||.|:..||..|||||:|||||||:.|..|.|.|
Worm   579 LGPKEDE---VTSRRKKREK--IDILKKYEVQPDFISETGGNLHPYQLEGINWLRHCWSNGTDAI 638

  Fly   754 LADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSR 818
            ||||||||||:|::||||:|.||||.:||||:|.||||::|||||.|||.||||.:||:||::||
Worm   639 LADEMGLGKTVQSLTFLYTLMKEGHTKGPFLIAAPLSTIINWEREAELWCPDFYVVTYVGDRESR 703

  Fly   819 AVIRENELSFEEGAIRGS-KVSRLRTTQ-YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRL 881
            .||||:|.||.:||:||. |||:::|.: .||:|||||||.|:||.|.|.|||||.|||||||||
Worm   704 MVIREHEFSFVDGAVRGGPKVSKIKTLENLKFHVLLTSYECINMDKAILSSIDWAALVVDEAHRL 768

  Fly   882 KSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQV 946
            |:|||.||:.|..|.|.|::|||||||||||||||||||||:.|:||.|::|..||:::|||:|:
Worm   769 KNNQSTFFKNLREYNIQYRVLLTGTPLQNNLEELFHLLNFLAPDRFNQLESFTAEFSEISKEDQI 833

  Fly   947 KRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSL 1011
            ::||.:||||||||||.|||..||||.|.||||||||||||:||.|||:|::|||.|:||...||
Worm   834 EKLHNLLGPHMLRRLKADVLTGMPSKQELIVRVELSAMQKKYYKNILTRNFDALNVKNGGTQMSL 898

  Fly  1012 INIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFS 1076
            |||:|:|||||||||||..|..||.....|:||.::|.|.|||.|||.|||::||...|||||||
Worm   899 INIIMELKKCCNHPYLFMKACLEAPKLKNGMYEGSALIKNAGKFVLLQKMLRKLKDGGHRVLIFS 963

  Fly  1077 QMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATA 1141
            |||.||||||||.:.|.||||||||.|||..||:||||:|||||:||||||||||||||||||||
Worm   964 QMTMMLDILEDFCDVEGYKYERIDGSITGQQRQDAIDRYNAPGAKQFVFLLSTRAGGLGINLATA 1028

  Fly  1142 DTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGM 1206
            ||||||||||||||||||||||||:||.:|||||||||:.|||||:|.|||:||:|||||||.|:
Worm  1029 DTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKGSVEERITSVAKKKMLLTHLVVRAGL 1093

  Fly  1207 GGK-GANFTKQELDDILRFGTEDLFKEDD----------------KEEAIHYDDKAVAELLDRT- 1253
            |.| |.:.:|.||||:||:|||:||||::                .|:.|.:||.||..||||.
Worm  1094 GAKDGKSMSKTELDDVLRWGTEELFKEEEAPVEGADGEGTSSKKPNEQEIVWDDAAVDFLLDRNK 1158

  Fly  1254 ---NRGIEEKESWANEYLSSFKVASYATKE----EEEEEETEIIKQDAENSDPAYWVKLLRHHYE 1311
               .:..|:||.|.||||||||||:|.|||    :::|:|||:||:..|..||.||.|||:||||
Worm  1159 EEEGQDGEKKEHWTNEYLSSFKVATYNTKEADDADDDEDETEVIKEGTEEQDPNYWEKLLKHHYE 1223

  Fly  1312 QHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQ--DNGSEYNSEYSAGSDEDGG---- 1370
            |.||...:.||||||||:||||.... :..|.:..::..|  |:||||.|        |.|
Worm  1224 QDQETELQKLGKGKRVRRQVNYASEN-MGQDWSAQNNQQQEEDDGSEYGS--------DNGELLQ 1279

  Fly  1371 -DDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDA 1434
             |:|::::       :||.|.|.:: ||||||:|.|.|||||||.||||:|.||:||:||||||.
Worm  1280 TDEDYEER-------RRRREERSEK-LPPLLAKVNGQIEVLGFNPRQRKAFYNAVMRWGMPPQDL 1336

  Fly  1435 FNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIR 1499
            ..|.|.|||||.|||:.||||.||||||||||..||:::|.||||||||:||.||:|||:||::|
Worm  1337 TQSSWQVRDLRNKSEKVFKAYSSLFMRHLCEPVVDNSDSFMDGVPREGLNRQAVLSRIGLMSILR 1401

  Fly  1500 KKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPS 1564
            |||||||..||.:||||                                 |....:..|..|:.|
Worm  1402 KKVQEFEKFNGEWSMPE---------------------------------TREKMLATAAQASVS 1433

  Fly  1565 PAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVK 1629
            ..|...|                     :| |:..:.|:.|.||.|.|
Worm  1434 NLPGMIK---------------------IK-EEPIDIDETPMDVDQSN----------------- 1459

  Fly  1630 TEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSAS 1694
              :.|||  |...:.:|:||||.            |..|
Worm  1460 --ITKTE--ELASEVKVEEEPKA------------PRLP-------------------------- 1482

  Fly  1695 SPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEI 1759
                                             :.|||.|||:||||:||:||||.|..|:||||
Worm  1483 ---------------------------------YKFNICDGGYTELHSLWINEEKVARNGKEYEI 1514

  Fly  1760 WHRRHDYWLLAGIVTHGYGRW----QDIQNDIRFAIINEPFKMDVGKG---NFLEIKNKFLARRF 1817
            ||||||:||||.:..:||||:    |||.||.:|:|:||||| ..|..   ||.::|||||||||
Worm  1515 WHRRHDFWLLAAVAVYGYGRYQINFQDIMNDPKFSIVNEPFK-QTGADPATNFADVKNKFLARRF 1578

  Fly  1818 KLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLH 1882
            |||||:|||||||||||::|..|.|.... .|...|:|:|..|::|.::::||..||:.|||:||
Worm  1579 KLLEQSLVIEEQLRRAAHINKQQSPDQVG-QLAQHFSELEHTADAHVNIARESNNGNRNANAILH 1642

  Fly  1883 KVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAG 1947
            |.|.||::||||:|:||:|||||::::.||.:|||||||.||||| ..|.:...|....|..|:|
Worm  1643 KCLAQLDDLLSDLKTDVARLPATISQVRPVTERLQMSERQILSRL-VVAKDPDAAPSKPALPPSG 1706

  Fly  1948 FQGTTLPAFTSGPAGNFANFRPQF 1971
                  |..|.....||...:|:|
Worm  1707 ------PFITPLFNQNFTTIQPKF 1724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	18/51 (35%)
		PHD1_CHD_II	380..422	CDD:277006	25/41 (61%)
		PHD2_CHD_II	440..482	CDD:277007	22/41 (54%)
		CHROMO	490..558	CDD:237991	24/80 (30%)
		CHROMO	615..667	CDD:214605	20/52 (38%)
		SNF2_N	734..1028	CDD:278600	204/295 (69%)
		DEXDc	751..907	CDD:238005	106/157 (68%)
		Helicase_C	1053..1167	CDD:278689	95/113 (84%)
		DUF1087	<1292..1337	CDD:283996	27/44 (61%)
		DUF1086	1380..1517	CDD:283992	91/136 (67%)
		CHDCT2	1756..1927	CDD:285336	104/177 (59%)
chd-3	NP_510140.1	CHDNT	97..149	CDD:285335	18/54 (33%)
		TNG2	<180..311	CDD:227367	60/204 (29%)
		PHD1_CHD_II	268..309	CDD:277006	25/40 (63%)
		PHD2_CHD_II	330..372	CDD:277007	22/41 (54%)
		CHROMO	381..461	CDD:237991	24/79 (30%)
		CHROMO	501..555	CDD:214605	20/53 (38%)
		SNF2_N	619..915	CDD:278600	204/295 (69%)
		DEXDc	636..794	CDD:238005	106/157 (68%)
		Helicase_C	940..1054	CDD:278689	95/113 (84%)
		DUF1087	1199..1252	CDD:283996	31/53 (58%)
		DUF1086	1299..1418	CDD:283992	85/118 (72%)
		CHDCT2	1511..1687	CDD:285336	104/177 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167451
Domainoid	1	1.000	408	1.000	Domainoid score	I354
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1605	1.000	Inparanoid score	I36
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm14435
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4509
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800