Protein Alignment Mi-2 and let-418

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_504523.1
• Gene: let-418 / 178970
• WormBaseID: WBGene00002637
• Length: 1829
• Species: Caenorhabditis elegans
• Alignment Length: 1993
• Identity: 919/1993 - (46%)
• Similarity: 1192/1993 - (59%)
• Gaps: 361/1993 - (18%)

  Fly     1 MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKG 65
            |::||  |.:..:.||:.|:.:...:.:.:::...:..|.||....:.:.|.|||.|      ||
 Worm     1 MSTEE--DPSLVDAEESMEEGSVTQDATEETEEEEEQEQGDEAGPSERKRSSRKKGG------KG 57

  Fly    66 EEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCS 130
            .:||.||.....::.|...         .|.|||                          |:||:
 Worm    58 GKKGSKKSAAAASKVEIPD---------PYNSTS--------------------------EEVCA 87

  Fly   131 AFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQ 195
            |..:.:||.:|.|||.|.::..|.|...::|.:.:.||.....|:..:...|::|:   ..|:..
 Worm    88 AIGLTDVEFDYDEEEFQGISNLKTFSSIIKPQILEANPGTNVSKMYPMFQVKYKEY---QDHMAA 149

  Fly   196 EGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRG 260
            :|                                                     ||.:|:: ||
 Worm   150 QG-----------------------------------------------------KPVQKQA-RG 160

  Fly   261 KKGRRPSGKVPTL-------KIKLLGKRKRDSSDEEQDASGASERDSDLEFERML----QKSDDS 314
            .|  .|:...|.:       |.:...:::|||     ||.     |||.|||..:    |..||.
 Worm   161 SK--TPAVSTPVIPPRSAPTKTRSARRKRRDS-----DAP-----DSDQEFEAFIKQQEQLEDDL 213

  Fly   315 ADEKE-APVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQ 378
            ..:|| |.:...|:.     ::...||....:.|         ||.||:|      ||  |.|:.
 Worm   214 VKDKEDARIKRAAER-----EEKKKGALEAARAA---------KKAKLEK------GE--EAENN 256

  Fly   379 DYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADG-GAAEEEDDDEHQEFCR 442
            ||||.|:|.||::||||||||||.||::..::|||||.|||.||...| ...:||...::.|||:
 Worm   257 DYCEECKQDGELLLCDTCPRAYHTVCIDENMEEPPEGDWSCAHCIEHGPEVVKEEPAKQNDEFCK 321

  Fly   443 VCKDGGELLCCDSCPSAYHTFCLNPPLDTIP-DGDWRCPRCSCPPLTGKAEKIITWRW------- 499
            :||:...||.||||..::|.:|::|||..:| :..|.||||.......|.|||:.|||
 Worm   322 ICKETENLLLCDSCVCSFHAYCIDPPLTEVPKEETWSCPRCETVKPEHKIEKILCWRWKEIPYPE 386

  Fly   500 ----AQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYD 560
                .:.::.|........|....|.||:|:||..:|||.|.||.|:.|:||..::|..:.||.|
 Worm   387 PLEAGKEASSDDAMLKPPRKMEPRREREFFVKWKYLSYWQCSWVSEMLLEVHFRMLILLYWRKND 451

  Fly   561 MEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTAR 625
            .:.||:||||:..        :.|.|       :|...|.||||:.|:||||:.:.|:|||::..
 Worm   452 SDAPPEFEESVTS--------RHHSD-------NDPYKLRERFYQYGIKPEWMQIHRIINHQSYA 501

  Fly   626 DGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQA-IDYYQDLRAVCTSETTQSRSKKSKKGRKSK- 688
            .....|||||:||.||::|||.:..:|....:| |.|:|...:....:..::..|...|.|::|
 Worm   502 KSQQDYLVKWKELSYDQATWERDDSNIANYEEAIIKYWQHRESKLNEDIPKNVQKMIAKHREAKG 566

  Fly   689 LKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTI 753
            |..::||.:..|.     ||  .|::||||.||.::..||.:|||||:||:||||:.|..|.|.|
 Worm   567 LPPKEDEKKKKKR-----EK--IDIRKKYEVQPDYVTETGGKLHPYQLEGLNWLRHCWSNGTDAI 624

  Fly   754 LADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSR 818
            ||||||||||:|::||||||.|||||:||||:|.||||::|||||.|.|.||||.:||:|.:|:|
 Worm   625 LADEMGLGKTVQSLTFLYSLMKEGHCKGPFLIAAPLSTIINWEREAEQWCPDFYVVTYVGLRDAR 689

  Fly   819 AVIRENELSFEEGAIR-GSKVSRLRTTQ-YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRL 881
            .|:||:|.||.|||:| |.|.|:::||: .||:|||||||.|:||...|.||:|..|||||||||
 Worm   690 VVLREHEFSFVEGAVRSGPKASKMKTTENMKFHVLLTSYETINMDKTILSSIEWGALVVDEAHRL 754

  Fly   882 KSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQV 946
            |:|||.||:.||.|||.|::||||||||||||||||||||||:::||.|:||..||.::|||:|:
 Worm   755 KNNQSLFFKNLNEYTIHYRVLLTGTPLQNNLEELFHLLNFLSKERFNQLEAFTAEFNEISKEDQI 819

  Fly   947 KRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSL 1011
            ::||.:||||||||||.|||..||||||.||||||||||||:||.|||:|::|||.|:||...||
 Worm   820 EKLHNLLGPHMLRRLKADVLTGMPSKSELIVRVELSAMQKKWYKNILTRNFDALNVKNGGTQMSL 884

  Fly  1012 INIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFS 1076
            :|::|:|||||||||||..|..||.....|:||..:|.|.:||.|||.|||::||...|||||||
 Worm   885 MNVLMELKKCCNHPYLFVKAELEAPKEKNGMYEGTALIKNSGKFVLLQKMLRKLKDGGHRVLIFS 949

  Fly  1077 QMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATA 1141
            |||:||||:||..|.|.|:||||||.|.|.:||:||||:||||||||:|||||||||||||||||
 Worm   950 QMTRMLDIMEDLCEYEGYRYERIDGSIMGQMRQDAIDRYNAPGAQQFIFLLSTRAGGLGINLATA 1014

  Fly  1142 DTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGM 1206
            ||||||||||||||||||||||||:||.:|||||||||:.||||::|.|||:||:|.|||||.|:
 Worm  1015 DTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKKSVEEKITSVAKKKMLLNHLVVRAGL 1079

  Fly  1207 GGK-GANFTKQELDDILRFGTEDLFKED---------DKEEA----IHYDDKAVAELLDRTNR-- 1255
            ||| |...:|.||||:||:|||:||.||         :|:.|    |.:||.||..||||:|:
 Worm  1080 GGKEGKTMSKTELDDVLRWGTEELFSEDLDAAEGEGSEKKGAAAQEIVWDDAAVDALLDRSNKEE 1144

  Fly  1256 ------GIEEKESWANEYLSSFKVASYATK-----EEEEEEETEIIKQDAENSDPAYWVKLLRHH 1309
                  | |||..|.||||||||||||.||     |||||||||:||:|.:..||.||.|||:||
 Worm  1145 TPAGEDG-EEKAEWQNEYLSSFKVASYQTKETEGQEEEEEEETEVIKEDEKEPDPDYWEKLLKHH 1208

  Fly  1310 YEQHQEDVGRSLGKGKRVRKQVNY------TDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDED 1368
            |||.:|...:.||||||||||:||      ||..  ..:.|:||.:  ||.|...|:...|.:.|
 Worm  1209 YEQDREIELQKLGKGKRVRKQINYASENMGTDWS--KQNQTQDDDD--DNESYRGSDNGDGLNSD 1269

  Fly  1369 GGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQD 1433
              :||:|:      |.||   |||:..:|||:|:|.|.:|:||||.||||:|..|:||:||||||
 Worm  1270 --EDDYDE------KKKR---RRDEEKMPPLMAKVNGQVEILGFNPRQRKAFYGAVMRWGMPPQD 1323

  Fly  1434 AFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLI 1498
            :..|||||||||.|||:.|:||.|||||||||||||..:||.||||||||:|||||.|||::||:
 Worm  1324 SHQSQWLVRDLRNKSEKVFRAYASLFMRHLCEPGADGHDTFNDGVPREGLNRQHVLGRIGLLSLV 1388

  Fly  1499 RKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAP 1563
            |:||||||..||.:||||:             ||....:|      .:.||..|:..||.....|
 Worm  1389 RRKVQEFEQYNGQWSMPEI-------------QDEVLAKA------ANGSAQGSSRSTPKPKEEP 1434

  Fly  1564 SPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEV 1628
            ...|.     :|:..:|.....||...::.:.||.|             ||:|      |.|
 Worm  1435 KEEPM-----EKEDATETVNGATSEPATDAESEQNA-------------PVDE------PMD--- 1472

  Fly  1629 KTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSA 1693
             |:.|| |||||                        ||                    |.|||.|
 Worm  1473 -TDEAK-EPKEE------------------------PI--------------------ETEKPRA 1491

  Fly  1694 SSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYE 1758
            :.|                              .|.|||.||||||||:||.||||.|..|:|||
 Worm  1492 ARP------------------------------SFKFNICDGGFTELHSLWANEEKVARNGKEYE 1526

  Fly  1759 IWHRRHDYWLLAGIVTHGYGRWQ----DIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKL 1819
            ||:||||||||||:|.|||||:|    ||.||.||:::|||||....:....:||.||:.|||||
 Worm  1527 IWYRRHDYWLLAGVVVHGYGRFQANFNDIINDPRFSVLNEPFKEVGAEATGSDIKAKFMQRRFKL 1591

  Fly  1820 LEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKV 1884
            :||:|||||||||||:.|....|.:.. .|..|||::|.:|||..:::|||.|||:.|||||||.
 Worm  1592 IEQSLVIEEQLRRAAHANRHLQPDNVG-PLAQRFADLENIAESQANIAKESSAGNRNANAVLHKT 1655

  Fly  1885 LNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRL 1927
            |.||:|:|||||:||||||:|..::..|.:||.|:||.|||||
 Worm  1656 LVQLDEILSDMKADVSRLPSTFTQLATVTERLNMTERQILSRL 1698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	14/52 (27%)
		TNG2	<282..422	CDD:227367	58/144 (40%)
		PHD1_CHD_II	380..422	CDD:277006	27/41 (66%)
		PHD2_CHD_II	440..482	CDD:277007	19/42 (45%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	26/80 (33%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	23/54 (43%)
		PLN03142	720..>1234	CDD:215601	357/525 (68%)
		DUF1087	<1292..1334	CDD:461922	26/47 (55%)
		CHDII_SANT-like	1380..1517	CDD:461920	91/136 (67%)
		CHDCT2	1757..1902	CDD:462358	89/148 (60%)
let-418	NP_504523.1	CHDNT	95..147	CDD:462357	14/54 (26%)
		PHD1_CHD_II	258..300	CDD:277006	27/41 (66%)
		RanBP2-type Zn finger	295..323	CDD:275375	11/27 (41%)
		PHD_SF	320..362	CDD:473978	18/41 (44%)
		CD1_tandem_CHD3-4_like	370..448	CDD:349314	26/77 (34%)
		CD2_tandem_CHD3-4_like	486..539	CDD:349309	22/52 (42%)
		PLN03142	590..>1114	CDD:215601	357/523 (68%)
		DUF1087	1188..1235	CDD:461922	28/46 (61%)
		CHDII_SANT-like	1276..1406	CDD:461920	90/132 (68%)
		CHDCT2	1525..1673	CDD:462358	89/148 (60%)