Protein Alignment Mi-2 and isw-1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001379931.1
• Gene: isw-1 / 175944
• WormBaseID: WBGene00002169
• Length: 1009
• Species: Caenorhabditis elegans
• Alignment Length: 1076
• Identity: 312/1076 - (28%)
• Similarity: 477/1076 - (44%)
• Gaps: 242/1076 - (22%)

  Fly   674 TQSRSKKSKK----GRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKK-----YEDQPAFLEGTGM 729
            |:.|.:.|||    |.....|.|.:||          |:...|..|.     ::..|.::|..
 Worm    78 TKKRGRPSKKNGIDGDHRHRKTEQEED----------EEMVADAIKSDDLVIFDKSPFYIENG-- 130

  Fly   730 QLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVN 794
            ::..||:.|:|||.......|:.|||||||||||:||::.:..:....:...|.||.||.|||.|
 Worm   131 EMRDYQVRGLNWLASLQHNKINGILADEMGLGKTLQTISMIGYMKHYKNKASPHLVIVPKSTLQN 195

  Fly   795 WEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELIS 859
            |..||:.|.|....:..|||:.:|                 ::|.|......||:|..|:||::.
 Worm   196 WANEFKKWCPSINAVVLIGDEAAR-----------------NQVLRDVILPQKFDVCCTTYEMML 243

  Fly   860 MDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSR 924
            .....|..::|..:::|||||:|:.:||....:.......:||:|||||||||.||:.|||||..
 Worm   244 KVKTQLKKLNWRYIIIDEAHRIKNEKSKLSETVRELNSENRLLITGTPLQNNLHELWALLNFLLP 308

  Fly   925 DKFNDLQAFQGEFAD---VSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQK 986
            |.|.....|...|::   ....:.|:|||::|.|.:|||:|:||.|::..|.|..|.|.||.||:
 Worm   309 DIFTSSDDFDSWFSNDAMSGNTDLVQRLHKVLQPFLLRRIKSDVEKSLLPKKEVKVYVGLSKMQR 373

  Fly   987 KFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSA--AEEATTAAGGLYEINSLT 1049
            ::|..:|.|:.:.:|.........|:||:|.|:||.||||||..|  ....||.       ..|.
 Worm   374 EWYTKVLMKDIDIINGAGKVEKARLMNILMHLRKCVNHPYLFDGAEPGPPFTTD-------QHLV 431

  Fly  1050 KAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDR 1114
            ..:||:|:|.|:|.:.|.|..|||||||.::|||:||||.....|:|.|:||......|..||:.
 Worm   432 DNSGKMVVLDKLLMKFKEQGSRVLIFSQFSRMLDLLEDFCWWRHYEYCRLDGSTPHEDRSNAIEA 496

  Fly  1115 FNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVT 1179
            :|||.:::|:|:|:||||||||||||||.||||||||||.:|:||..|||||||..:|.::|.:|
 Worm   497 YNAPDSKKFIFMLTTRAGGLGINLATADVVIIYDSDWNPQSDLQAMDRAHRIGQKKQVRVFRLIT 561

  Fly  1180 RNSVEERVTQVAKRKMMLTHLVVRPG-MGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDD 1243
            .|:|:||:.:.|:.|:.|.::|::.| |........|.::..::|.|.|.:|..  |:..|..||
 Worm   562 ENTVDERIIEKAEAKLRLDNIVIQQGRMSEAQKTLGKGDMISMIRHGAEQVFAA--KDSTISDDD 624

  Fly  1244 KAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRH 1308
              :..:|::.    |.|.:..||.:......:......|:..:..:.:.:.||
 Worm   625 --IDTILEKA----EVKTAELNEKMGKIDENNLRNMTFEDNAKFTVYQFEGEN------------ 671

  Fly  1309 HYEQHQEDVGRSLGKG-------KRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSD 1366
             |:..|.|     |.|       ||.||                  :|:|.: ..|.....||
 Worm   672 -YKAKQAD-----GMGHFWIEPPKRERK------------------ANYQVD-LYYKEAMRAG-- 709

  Fly  1367 EDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFL---NAIMRY- 1427
                       |..|:::|.      .||..|         :|..|....|:.|.   ..|..|
 Worm   710 -----------NPTEKQSKA------PRPKLP---------QVFDFQFYPRRLFELLDKEIYHYR 748

  Fly  1428 -----------GMPPQDA----FNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADG 1477
                       .:||::|    ...|.|:.:.|..:::..:....|..:.:.:......:.|..|
 Worm   749 KTIGYVAERPKDVPPKEAEKRQAEEQKLINNARPLTDKEQEEKAELLTQSVTDWTKREFQQFVRG 813

  Fly  1478 VPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSM----------PELILKPCE--------- 1523
            ..:.|        |..:.|:.::..:..|.|..|..:          .|.:|...|
 Worm   814 NEKYG--------REDLESIAKEMERPLEEIQSYAKVFWERIEELQDSEKVLSQIEKGEARIQRK 870

  Fly  1524 -PVRSALKQDVAALEAP------PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEK 1581
             .|:.||...:|..:||      ..|.|..|:.|                      |::|:....
 Worm   871 YAVKKALDAKIAKYKAPFQQLRISYGTNKGKTYT----------------------EEEDRFLVC 913

  Fly  1582 EKDKTSAEKSEVKQE-------------------QEAEE------------DKKPGDVKQENPVE 1615
            |..:...:|..|.:|                   :.|.|            :::.|:|.:..||.
 Worm   914 ETHRLGHDKENVFEELRQSVRMAPQFRFDWFLKSRTAMELQRRCNTLITLIEREMGEVVESKPVI 978

  Fly  1616 EAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPK 1651
            ..|.|.|.|   |..:::|:......|  :||..||
 Worm   979 VTAADKKKS---VAKDLSKSSGTPTAK--KVKATPK 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309
		PLN03142	720..>1234	CDD:215601	210/519 (40%)
		DUF1087	<1292..1334	CDD:461922	11/48 (23%)
		CHDII_SANT-like	1380..1517	CDD:461920	26/165 (16%)
		CHDCT2	1757..1902	CDD:462358
isw-1	NP_001379931.1	PLN03142	48..1008	CDD:215601	310/1073 (29%)