Protein Alignment Mi-2 and chd-7

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_491426.2
• Gene: chd-7 / 172079
• WormBaseID: WBGene00007053
• Length: 2967
• Species: Caenorhabditis elegans
• Alignment Length: 2296
• Identity: 548/2296 - (23%)
• Similarity: 866/2296 - (37%)
• Gaps: 699/2296 - (30%)

  Fly     3 SEEENDDNFQEEEEAQ-----EDNAPAA-ELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRK 61
            |:.:...|.|:::...     ...|||: |.|...|....|:|........|..|
 Worm   559 SQHQTQPNQQQQQHPSGYGIGVSTAPASMEPSQSVDQSAPPSQAQIPATSTPSTS---------- 613

  Fly    62 TRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVE 126
                        .:::|...|..||         ||:|     ..:|...|.|    :...|||.
 Worm   614 ------------SQQQNAYPEFPDF---------PSSS-----GYQEPTVAPE----AIPSPSVS 648

  Fly   127 DVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHV---RPILQKENPKI-----AAPKLVMLVAAKW 183
            |.....|..|      ::|||:::..:..:..|   .||::::.||.     ..|...:....::
 Worm   649 DPIMPQSSQN------DQELQAISDQQEILEDVPKEEPIIEEDEPKYEYSQETIPVEELKDEVEF 707

  Fly   184 REFCESNPHI------------QQEGGAAG-SGGS------AGQARSVTGDEPE---EPRSSRSS 226
            :|..:|..::            .:||..|| |.|:      .....::..:||:   :|......
 Worm   708 KEDQQSTSNLLEDDTGIDNFVKNEEGAEAGYSNGTPLDQVEQNDYENIEKEEPQVSVDPEPVEVE 772

  Fly   227 RNEKPDD----------IYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKI------ 275
            ..::|.|          ..||..||..||..||.:|....|        |..:...:|.
 Worm   773 AQQEPADTEEYPIPSVGTIEEPAEEPAEEPVEEPEPMDDSS--------PVDQSTPVKADDIENF 829

  Fly   276 ----KLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDD 336
                :..|:.:....:::.:||.|.....|::.|    :.||::      ..:|..:.||:..:|
 Worm   830 AGVEETFGEEEEVQDEDDDEASSAKSSKDDIKEE----EDDDTS------TITKDMSEAPSETND 884

  Fly   337 GSGAPVVRKKAKTKIGNKFKKKN----------KLKKTKNFPEGEDGEHEHQDYCEVCQQGGEII 391
            |...|  ...|...:|....||.          |.:|.|:..:.:|.:...|......:.||
 Worm   885 GFTEP--STPATPLMGATSSKKKSYRRPAVVVAKSRKKKSVDDSDDDDFYPQRGRGKKKGGG--- 944

  Fly   392 LCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADG--GAAEEEDDDEHQEFCRVCKDGGELLCCD 454
                                   ||......:..|  ||..:::|||
 Worm   945 -----------------------GKKKADPTDEAGVEGAKSDDEDDE------------------ 968

  Fly   455 SCPSAYHTFCLNPPLDT-IPDGDWRCPRCSCPPLTGKAEKIITWRW------------AQRSNDD 506
                    |.:.  :|| .||           |.....|||:..|.            |:.|.::
 Worm   969 --------FLMK--IDTPAPD-----------PNAMVVEKILNMRMGKVEKKVPETEVAEGSEEN 1012

  Fly   507 G--------------------------PSTSKGSKNSN----SRVREYFIKWHNMSYWHCEWVPE 541
            |                          .|.||....:|    ..|.::.|||...||.||||
 Worm  1013 GEEKSEEKVKKEPKENGENGESVGNGESSKSKTESETNEIEEEEVEQFLIKWKGRSYVHCEW--- 1074

  Fly   542 VQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYK-RIQRHK-DKVGMKANDDAEVLEERFY 604
                                    |....|.|.|.|.: :|:|.| .|:.....||.:
 Worm  1075 ------------------------KTAAELLEIDKRVEAKIKRFKVKKMSSYIEDDED------- 1108

  Fly   605 KNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEE----EGDDIQ--GLRQAIDYYQ 663
               ...:::||.||::..|..||....|:||:.|.|::.|||.    ..|.::  ..||.||
 Worm  1109 ---FNSDFVIVDRVVDLITEDDGQEFVLIKWKSLGYEEVTWEPIEMIPADKVELWRERQVID--- 1167

  Fly   664 DLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTG 728
                                  .:|::   ::.||     .|.|.......|.:::        |
 Worm  1168 ----------------------PAKIR---EKQRP-----EPEEWKKMSTSKVWKN--------G 1194

  Fly   729 MQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLV 793
            ..|..||.||::||.|.:....:.|||||||||||:||:|||..:|..| ..|||||.|||||:.
 Worm  1195 NSLREYQFEGVDWLLYCYYNAQNCILADEMGLGKTVQTITFLSRIYDYG-IHGPFLVVVPLSTIQ 1258

  Fly   794 NWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELI 858
            ||.||||.|. |...|.|.|...:|.|:::.|:.:::   |.......:....|.:.|:|::|.:
 Worm  1259 NWVREFETWT-DMNAIVYHGSAYAREVLQQYEVFYDK---RHCGAKNWKKNFVKIDALITTFETV 1319

  Fly   859 SMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILN---SYTIAYKLLLTGTPLQNNLEELFHLLN 920
            ..|...|..|.|.|.|:|||||||:...|.  ::|   ::.:.:::||||||||||::|||.|||
 Worm  1320 VSDVEFLKKIPWRVCVIDEAHRLKNRNCKL--LVNGLLAFRMEHRVLLTGTPLQNNIDELFSLLN 1382

  Fly   921 FLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQ 985
            ||...:|::...|..:|.....::||::|.|:|.|.||||||.||.|::..|.|.|:.|:||.||
 Worm  1383 FLHPQQFDNSATFLEQFGSCQTDDQVQKLQEILKPMMLRRLKEDVEKSLGPKEETIIEVQLSDMQ 1447

  Fly   986 KKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAE--------------EAT 1036
            ||||:.||.:|:..|  ..|..:.||:|:||:|:||||||:|...|.|              |.|
 Worm  1448 KKFYRAILERNFSHL--CKGTSAPSLMNVMMELRKCCNHPFLINGAEEAIMNDFRLAHPDWDEET 1510

  Fly  1037 TAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDG 1101
            .|.      .:|.:|:||:||:.|:|.:|:...|:|||||||.|:||:||:||....|.:|||||
 Worm  1511 LAH------KALIQASGKVVLIEKLLPKLRKDGHKVLIFSQMVKVLDLLEEFLISMSYPFERIDG 1569

  Fly  1102 GITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRI 1166
            .:.|.|||.|||||:...:.:|||||.||||||||||..||||||:||||||.||:||.:|.|||
 Worm  1570 NVRGDLRQAAIDRFSKENSDRFVFLLCTRAGGLGINLTAADTVIIFDSDWNPQNDLQAQARCHRI 1634

  Fly  1167 GQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVR--PGMGGKGANFTKQELDDILRFGTEDL 1229
            ||...|.:||.:|.|:.|..:...|..|:.|...|::  ..:..:|...:|::::::|:.|....
 Worm  1635 GQKKLVKVYRLITSNTYEREMFDKASLKLGLDKAVLQSTTALKAEGTALSKKDVEELLKKGAYGS 1699

  Fly  1230 FKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDA 1294
            .. |::.|:..::::.:..:|.|..:.|..:   |.:..|.|..|::.:...:.:        |.
 Worm  1700 IM-DEENESSKFNEEDIETILQRRTQTITLE---AGQKGSLFAKATFNSSHNKGD--------DI 1752

  Fly  1295 ENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDG-GVVAADTTRDDSNWQDNGSEYN 1358
            :..||.:|.|..    |:.|.|          |.|.....|| .::..:..:....:::|..|
 Worm  1753 DIDDPEFWTKWA----EKAQVD----------VEKATATPDGRELIIEEPRKRTKRFEENKDE-- 1801

  Fly  1359 SEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDD-------RP------------LPPLLARVG 1404
                  .|.||.::..:.:.||..|.|||....:|       ||            :..:||:.|
 Worm  1802 ------GDSDGSEESGNRKRGAAEKRKRRRGNDEDGDYSGSYRPDELATSKAEYFKVEKVLAQYG 1860

  Fly  1405 ----------GNIEV-------------------LGFNARQRKSFLNAIMRYGMPPQ------DA 1434
                      |.:|:                   ...:.|.|:...|.|...|:...      ..
 Worm  1861 WGRWAEIKKYGELEISEQDIEHMSRTLLLHCIREFRGDDRIRQFVFNLIRPQGIQENQKLGAGSM 1925

  Fly  1435 FNSQWLVRDLRGKSERNFKAYV--SLFMRHLCEP-------------------GADNA------- 1471
            :|..|     .|..|.|..::.  |.|.||:...                   |.:.|
 Worm  1926 YNQGW-----AGLPEFNPPSFALDSAFQRHVHRHANKLMVKIDMLKHLEIHLIGDERALVEDFNV 1985

  Fly  1472 --------------ETFADGVP------------REGLSR------------------------- 1485
                          |||.:|..            |.||..
 Worm  1986 KWTDIKLPEMPTISETFIEGWDSDCDKCFLIGCWRHGLDNFDAIRVDENLCFAEKNLAVWPGQTD 2050

  Fly  1486 -----QHVLTR---------IGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRS-ALKQDVAA 1535
                 :.:||.         ...::..:::.|||..:                ||| .:|.::.
 Worm  2051 FWLRFRRLLTSSQKSVHDPVYNKLNWTKREEQEFIRV----------------VRSYGVKTNIG- 2098

  Fly  1536 LEAPPTGGNVD------------------------------KSATTSNSVTP-----ATSAAPSP 1565
                 .|||.|                              :.|..||.:.|     |.|..|.|
 Worm  2099 -----EGGNEDWTIFKTLSPILEKKTDEDCHEQLMCVLAMCQRAQGSNDLKPIDLKRAMSIDPMP 2158

  Fly  1566 APASEKGEDKDKDSEK---------EKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGD- 1620
            ...:.|..::.....|         |.:....|.:.:......:.||:..::..:..:::.|.:
 Worm  2159 TRKAIKMMNRISLMRKVHTMVQTLSELNLELCETTGMPSGWCMQHDKELMEICDQCGLDQLAANV 2223

  Fly  1621 -TKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEK-------EKVDDKKPIPPTTVIDDDDD 1677
             .||:..::      ..|.|.|....:.|...|.|..|       |.|:|.         |.:|.
 Worm  2224 LNKPAFTKI------VRPSETTLLRRLLEIVATIESGKWCGVADVETVNDS---------DSEDK 2273

  Fly  1678 DVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHT 1742
            ..|......:.:.......:.|:..|||.:|::.|:.|.:        ||...|..|.....:..
 Worm  2274 KDMAAVAAAQAQFLRLQQQQQQQQQAAAVAASSSASRKAS--------RKRPNNDNDAKMRAMQQ 2330

  Fly  1743 LWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKG-NFL 1806
            :.:.:..:.  ..||            |.::                |::..|..|....| |..
 Worm  2331 MLMGQGGSG--AAEY------------ASMI----------------ALMLMPQMMAASGGQNMT 2365

  Fly  1807 EIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESL 1871
            ..:.:.|.:...:|....|.::|..:.:....|......|.:..|..|:...:|.:....:..:.
 Worm  2366 AAQQQALNQMLTMLIAGAVQQQQQAQPSTSKGASSSQSSAQANQAAQAQAAAVALAQVAAAASAS 2430

  Fly  1872 AGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARI--------------PPVAQRLQMSERS 1922
            ..:..|.||..: ...||.||:     :|..||.||.:              |..::.....|.:
 Worm  2431 TSSADAQAVAQQ-QQVLEALLA-----MSMNPAALAALTGTSSSTGTSTPSAPKKSKPAPQKEST 2489

  Fly  1923 ILSRLAATAGNASNAAQLMAQ 1943
            ..:..||.|.:|..||...||
 Worm  2490 SSATAAAAAASAQAAALAAAQ 2510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	11/60 (18%)
		TNG2	<282..422	CDD:227367	26/149 (17%)
		PHD1_CHD_II	380..422	CDD:277006	4/41 (10%)
		PHD2_CHD_II	440..482	CDD:277007	5/42 (12%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	21/111 (19%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	20/59 (34%)
		PLN03142	720..>1234	CDD:215601	232/532 (44%)
		DUF1087	<1292..1334	CDD:461922	10/41 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	41/283 (14%)
		CHDCT2	1757..1902	CDD:462358	24/145 (17%)
chd-7	NP_491426.2	Atrophin-1	<387..>666	CDD:460830	32/152 (21%)
		PRK12323	<582..732	CDD:481241	37/195 (19%)
		CD1_tandem_CHD5-9_like	979..1095	CDD:349315	30/153 (20%)
		CD2_tandem	1112..1162	CDD:349306	16/49 (33%)
		PLN03142	1197..>1803	CDD:215601	254/654 (39%)
		SANT	2073..2133	CDD:197842	11/81 (14%)
		BRK	2672..2716	CDD:197800