Protein Alignment Mi-2 and xnp-1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001020958.1
• Gene: xnp-1 / 172077
• WormBaseID: WBGene00006961
• Length: 1359
• Species: Caenorhabditis elegans
• Alignment Length: 1537
• Identity: 332/1537 - (21%)
• Similarity: 532/1537 - (34%)
• Gaps: 561/1537 - (36%)

  Fly    28 SNDSDAPLKPNQNDEDDDYDP----EDSRRKKKGKKRKTRKGEE-----KGRKKKKRKKNESEED 83
            |.|||..:     .||:|.:.    |:.|::|:.:|.|.::..|     |.|..||||.:.||||
 Worm     8 SEDSDGHV-----IEDEDLEMARQIENERKEKRAQKLKEKREREGKPPPKKRPAKKRKASSSEED 67

  Fly    84 SDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQS 148
            .|    |||.....:||:.|||     |..|.||..|  ...||...:.|...|:.:..|:..:.
 Worm    68 DD----DEEESPRKSSKKSRKR-----AKSESESDES--DEEEDRKKSKSKKKVDQKKKEKSKKK 121

  Fly   149 LTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVT 213
            .||..:           |:                    |.:...:::.....|..:..|..|.:
 Worm   122 RTTSSS-----------ED--------------------EDSDEEREQKSKKKSKKTKKQTSSES 155

  Fly   214 GDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLL 278
            .:|.||.|..:.|:..|...:.:.|  |..||.:|::||.:|    .|||         ||.|..
 Worm   156 SEESEEERKVKKSKKNKEKSVKKRA--ETSEESDEDEKPSKK----SKKG---------LKKKAK 205

  Fly   279 GKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKAD-------NSAPAAQDD 336
            .:.:.:|.||::      .:.|..:.:::::|..:|.|  |||...|.:       :|..:::.:
 Worm   206 SESESESEDEKE------VKKSKKKSKKVVKKESESED--EAPEKKKTEKRKRSKTSSEESSESE 262

  Fly   337 GSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQ----GGEIILCDTCP 397
            .|......|::..|  .|.||...:||..:..|.|:.:      .||..|    |...::.|:
 Worm   263 KSDEEEEEKESSPK--PKKKKPLAVKKLSSDEESEESD------VEVLPQKKKRGAVTLISDS-- 317

  Fly   398 RAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHT 462
                    |.|.|:..|              :|..|.:|     :|.|.
 Worm   318 --------EDEKDQKSE--------------SEASDVEE-----KVSKK---------------- 339

  Fly   463 FCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIK 527
                                       ||:|       |.|::.|..:|:||...|
 Worm   340 ---------------------------KAKK-------QESSESGSDSSEGSITVN--------- 361

  Fly   528 WHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKA 592
                                         ||...:|.|         :.:.|.|.....|: .|.
 Worm   362 -----------------------------RKSKKKEKP---------EKKKKGIIMDSSKL-QKE 387

  Fly   593 NDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQ 657
            ..|||..|:...|...|.     |:..|      |..:                |||
 Worm   388 TIDAERAEKERRKRLEKK-----QKEFN------GIVL----------------EEG-------- 417

  Fly   658 AIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPA 722
                 :||..:.|..::|         ||.|..|.|            |:..|.|.:.|   :|.
 Worm   418 -----EDLTEMLTGTSSQ---------RKLKSVVLD------------PDSSTVDEESK---KPV 453

  Fly   723 FLEGTGMQ-LHPYQIEGINWLRYSWG---------QGIDTILADEMGLGKTIQTVTFLYSLY--- 774
            .:..:.:: |.|:|..||.:: |...         :|...|||..||||||:|.:|||:::.
 Worm   454 EVHNSLVRILKPHQAHGIQFM-YDCAFESLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHE 517

  Fly   775 KEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENEL-SFE--EGAIRGS 836
            |.|......||.||.:.::||.:||:.|..|        :.:....|..||| |::  |...|..
 Worm   518 KIGEKCKRVLVVVPKNVIINWFKEFQKWLVD--------NDEELDTIDVNELDSYKTIEDRRRAL 574

  Fly   837 KVSRLRTTQYKFNVLLTSYELI-------------------SMDAA------CLGSIDWAVLVVD 876
            |......|.   :|::..|:|.                   .::.|      .|.:....::|.|
 Worm   575 KAWHSSKTP---SVMIIGYDLFRILTVEDDPKKKKPKNRNRRLEKAKEDFRKYLQNPGPDMVVCD 636

  Fly   877 EAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVS 941
            |||:||::.|...:.:.......::.||||||||||.|...::||:..........|...|.::.
 Worm   637 EAHKLKNDDSALSKCMVKILTKRRICLTGTPLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNII 701

  Fly   942 KEEQVKRLHEMLGPHMLRRLKT--DVLKN-------------MPSKSEFIVRVELSAMQKKFYKF 991
            ...:.|....:....|.||...  |.||.             :|.|.|:::.|..:..|...|..
 Worm   702 NRGRTKDASPLEVSFMKRRCHVLYDHLKKCVDRKDYRVLTEAIPPKQEYVINVRQTERQCALYNA 766

  Fly   992 IL------------------------TKNYEAL-------------------------------- 1000
            .|                        |..|:.:
 Worm   767 FLNDIVGDSGLSKRLLPDYHMFSRIWTHPYQLVLHEQRMERERVMREDAEEEADFIDDGDGSESE 831

  Fly  1001 ---NSKSGGGSCSLINIMMD--------LKKCCNHPYLFPSAAEE---------------ATTAA 1039
               :.|||..|.|..::::.        .||..|.|.:..:|.::               ..||.
 Worm   832 SEGSFKSGSESDSGKSVVLSSDDEGSSKKKKNGNKPEIKKTAPQKKRKFLNSDDEDEEDGEDTAM 896

  Fly  1040 GGLYE-INSLTKAAG------------------------------------KLVLLSKMLKQLKA 1067
            ..|.: |....:.||                                    ||:||.:::|:.:.
 Worm   897 AILQDGIRQSKRLAGEEADLRDTDTPPEYTGWFARLGLVKEEDRDDFALSNKLILLVEIIKKCEE 961

  Fly  1068 QNHRVLIFSQMTKMLDILE----------------------------DFLEGEQYKYERIDGGIT 1104
            ...::|:|||..:.|.:::                            .:||||.|.  .|||.:.
 Worm   962 IGDKLLVFSQSLESLTLIKRMLEYMAGTGQWFADGHEALNAEGEETWSWLEGEDYM--TIDGSVQ 1024

  Fly  1105 GTLRQEAIDRFNAP-GAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQ 1168
            ...|......||.| ..:..:.|:|||||.||.|:..|:.|||:|:.|||.:|.|:..|.:|.||
 Worm  1025 SGKRDAVQTSFNDPLNLRARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQ 1089

  Fly  1169 ANKVMIYRFVTRNSVEERV--TQVAKRKMMLTHL----VVRPGMGGKGANFTKQELDDILRFGTE 1227
            ...|.||||:.:.::|||:  .||.|....:..:    :.|..:|        .:|.::.:| |.
 Worm  1090 TKPVYIYRFIAQGTMEERIYKRQVTKESTSMRVVDEAQIQRHYLG--------NDLTELYQF-TP 1145

  Fly  1228 DLFKEDDKEEAIHYDDKAVAELLDRTNRG----IEEKESWANEYLSSFKVASYATKEEEEEEETE 1288
            ..|..|.:.......|:.:|:::.:....    ||....:||               .|:|:.||
 Worm  1146 STFDPDVEISCAPPKDRLLADVIHKNQHAVVDYIEHDTLFAN---------------VEDEKLTE 1195

  Fly  1289 IIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQ 1330
            ...:||       |.     .||:.:        .|..||.|
 Worm  1196 QEMKDA-------WT-----DYEKDK--------SGMPVRAQ 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	5/52 (10%)
		TNG2	<282..422	CDD:227367	31/150 (21%)
		PHD1_CHD_II	380..422	CDD:277006	9/45 (20%)
		PHD2_CHD_II	440..482	CDD:277007	2/41 (5%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	10/69 (14%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	6/53 (11%)
		PLN03142	720..>1234	CDD:215601	164/723 (23%)
		DUF1087	<1292..1334	CDD:461922	9/39 (23%)
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
xnp-1	NP_001020958.1	HepA	<390..1124	CDD:440319	183/811 (23%)
		DEAD-like_helicase_N	463..720	CDD:475120	71/268 (26%)