DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and Hells

DIOPT Version :10

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_032260.2 Gene:Hells / 15201 MGIID:106209 Length:821 Species:Mus musculus


Alignment Length:848 Identity:261/848 - (30%)
Similarity:400/848 - (47%) Gaps:167/848 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   551 MIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIV 615
            |:...|:.:|.|          ..:.||:|:|...:|..:.:......:|::..:...|.|.|..
Mouse    32 MLEEAQKSWDRE----------STEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEK 86

  Fly   616 QRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDD--IQGLRQAIDYYQDLRAVCTSETTQSRS 678
            ::                :..:|...||..:..|:.  ::..|...|...::..|.:.|...|.:
Mouse    87 KK----------------RSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVA 135

  Fly   679 KKSK-----KGRKSKLKVED-----DEDRPVKHYTPPPEKPTT----DLKKKYEDQPAFLEG--- 726
            ||.|     ....:.|.|||     |.:..:|.......:..:    |..:|...||...:.   
Mouse   136 KKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKH 200

  Fly   727 -TGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLS 790
             ||..:..||:||:.|||..|..||:.|||||||||||:|.:..:..:.:.| ..|||||..|||
Mouse   201 FTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRG-VPGPFLVCGPLS 264

  Fly   791 TLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSY 855
            ||.||..||:.:.|:...:.|.|.::.|..:.:|             :.:.:.|.....|::||:
Mouse   265 TLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKN-------------IHKRQGTLQIHPVVVTSF 316

  Fly   856 ELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLN 920
            |:...|...|....|..|:|||.||:|:.:.:..|.|..:....|||||||||||||.||:.|||
Mouse   317 EIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLN 381

  Fly   921 FLSRDKFNDLQAFQ--------GEFAD--VSKEEQ---VKRLHEMLGPHMLRRLKTDVLKNMPSK 972
            ||..|.|:||::|:        .|.|:  ::||.:   :..||::|.|.:|||||:||...:|.|
Mouse   382 FLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPK 446

  Fly   973 SEFIVRVELSAMQKKFYKFILTK------------------------------NYEALNSKSG-- 1005
            .|.:|...|...|:.||..|:.:                              ||..|:....  
Mouse   447 REVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSEL 511

  Fly  1006 -------------------GG-------SCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYE 1044
                               |.       :..|.||||.|:|||||||:.....:..|..    ::
Mouse   512 EKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQE----FK 572

  Fly  1045 IN-SLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLR 1108
            |: .|...:||.::|.:||.:||.:.|:||:|||||.|||||.|:.....:.:.|:||.::.:.|
Mouse   573 IDEELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSER 637

  Fly  1109 QEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVM 1173
            ::.|..||. ....|:||:|||||||||||..|||||||||||||.:|:||..|.|||||...|:
Mouse   638 EKNIYSFNT-DPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVV 701

  Fly  1174 IYRFVTRNSVEERVTQVAKRKMMLTHLVV-----RPGMGG--KGANF-TKQELDDILRFGTEDLF 1230
            :||.||.|::::::.:.|..|..|..|::     :.|..|  :..|| ..:||.::|:....:..
Mouse   702 VYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYERE 766

  Fly  1231 KEDDKEEAIHYDDKAVAELLDRT--------NRGIEEKESWANEYLSSFKVASYATKEEEEEEET 1287
            .:..:|:.|  .|:.:..||||:        :|.|:.|       ...||:.     |..|:...
Mouse   767 VKGSREKVI--SDEDLELLLDRSDLIDQMKASRPIKGK-------TGIFKIL-----ENSEDSSA 817

  Fly  1288 EII 1290
            |.:
Mouse   818 ECL 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..191 CDD:462357
TNG2 <282..422 CDD:227367
PHD1_CHD_II 380..422 CDD:277006
PHD2_CHD_II 440..482 CDD:277007
CD1_tandem_CHD3-4_like 487..557 CDD:349314 1/5 (20%)
CD2_tandem_CHD3-4_like 610..664 CDD:349309 8/55 (15%)
PLN03142 720..>1234 CDD:215601 213/597 (36%)
DUF1087 <1292..1334 CDD:461922
CHDII_SANT-like 1380..1517 CDD:461920
CHDCT2 1757..1902 CDD:462358
HellsNP_032260.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..120 9/57 (16%)
DEXHc_HELLS_SMARCA6 203..436 CDD:350767 96/246 (39%)
PLN03142 204..>781 CDD:215601 212/597 (36%)
helicase domain I 226..238 9/11 (82%)
helicase domain Ia 258..266 5/7 (71%)
helicase domain II 334..341 4/6 (67%)
helicase domain III 363..370 6/6 (100%)
helicase domain IV 429..439 6/9 (67%)
helicase domain IVa 547..559 9/11 (82%)
'helicase domain IVb 602..609 5/6 (83%)
helicase domain V 655..668 11/12 (92%)
helicase domain VI 686..693 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

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