Protein Alignment Mi-2 and Smarcad1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_031984.1
• Gene: Smarcad1 / 13990
• MGIID: 95453
• Length: 1021
• Species: Mus musculus
• Alignment Length: 1289
• Identity: 306/1289 - (23%)
• Similarity: 494/1289 - (38%)
• Gaps: 399/1289 - (30%)

  Fly     7 NDDNFQEEEEAQEDNAPAAELSNDSDAPLKP-NQNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGR 70
            |.|.|:.|:.::.:.||.|........|..| :.:.|:::.:.|.||
Mouse     5 NLDRFRFEKRSKIEEAPEAAPQPSQARPSSPISLSAEEENAEGEGSR------------------ 51

  Fly    71 KKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRK----EEKQAAKEKESASSGMPSVEDVCSA 131
                    .:..|||..:..|:...|......||..    :.::|.:|....||....|...||:
Mouse    52 --------ANTPDSDVTEKTEDSSVPEPPDNERKASLSCFQNQRAIQEYIDLSSDTEDVSPNCSS 108

  Fly   132 ------FSVCNVEI--EYSEEELQSLTTYKAFMHHVRPILQKENPKIA---APKLVMLVAAKWRE 185
                  ||...|.|  |.||:|          ..|..|.:.:.|....   ..:|..|..||.:.
Mouse   109 TVQEKKFSKDTVIIVSEPSEDE----------ESHDLPSVTRRNDSSELEDLSELEDLKDAKLQT 163

  Fly   186 FCESNPH------IQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEE 244
            ..|..|.      ::.....:...|:...|..:.||....||..:.|.:.:.||:         .
Mouse   164 LKELFPQRSDSDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEEDDV---------N 219

  Fly   245 EEEEEKKPRRKRSGRGKKGRRPSG---KVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFER 306
            :::..|:||..|.....:....|.   |..::.:||   :|...:.::|:.     |:...|.|.
Mouse   220 DDQSVKQPRGDRGEESNESAEASSNWEKQESIVLKL---QKEFPNFDKQEL-----REVLKEHEW 276

  Fly   307 MLQKSDDS----ADEKEAPVSSKAD--NSAPAAQDDGSGAPVVRKKAKTKIG-------NKFKKK 358
            |..::.:|    |::::...:|:::  |....|::........:.|.|.||.       ||.:||
Mouse   277 MYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNATKIKMKQKISVKPQNGFNKKRKK 341

  Fly   359 NKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCE 423
            |.....|..   ||.|::                                             ..
Mouse   342 NVFNPKKAV---EDSEYD---------------------------------------------SG 358

  Fly   424 ADGGAAEEEDDDEHQEFCRVCKDG--GELLCCDSCPSAYHTFCLNPPLD-TIPDGDWRCPRCSCP 485
            :|.|::.:||....:|   |.:||  |::|         |...::...: |:      .|:||
Mouse   359 SDAGSSLDEDYSSCEE---VMEDGYKGKIL---------HFLQVSSIAELTL------IPKCS-- 403

  Fly   486 PLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPL 550
              ..||:||...|  ..:|.:...|.....|..|   |..|       |:|:.|
Mouse   404 --QKKAQKITELR--PFNNWEALFTKMSKINGLS---EDLI-------WNCKTV----------- 443

  Fly   551 MIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIV 615
                                :.|.|...:.:.:.:| :..|......:|
Mouse   444 --------------------IQERDVVIRLMNKCED-ISNKLTKQVTML---------------- 471

  Fly   616 QRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKK 680
                   |...|.                |..|
Mouse   472 -------TGNGGG----------------WNRE-------------------------------- 481

  Fly   681 SKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYS 745
                                                   ||:.| ...:.|.|||..|:|||...
Mouse   482 ---------------------------------------QPSLL-NQSLSLKPYQKVGLNWLALV 506

  Fly   746 WGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCIT 810
            ...|::.|||||||||||||.:.||..|::||: :||.|:.||.||:.||.||..||.|....:.
Mouse   507 HKHGLNGILADEMGLGKTIQAIAFLAYLFQEGN-KGPHLIVVPASTIDNWLREVNLWCPSLNVLC 570

  Fly   811 YIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELI---SMDAACLGSIDWAV 872
            |.|.::.|..||.|                :......:||::|:|...   |.|.:....:....
Mouse   571 YYGSQEERKQIRFN----------------IHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNY 619

  Fly   873 LVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFL-------SRDKFNDL 930
            .:.||.|.||:..|..::.|.:.....:|||||||:||||.||..||||:       |..:...:
Mouse   620 AIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRM 684

  Fly   931 QAFQGEFAD---VSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAM---QKKFY 989
            .:.:.:.||   :.::|::....:::.|.:|||:|.:|||.:|.|.:   |:||.||   |::.|
Mouse   685 FSSKTKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKD---RIELCAMSEKQEQLY 746

  Fly   990 KFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHP-----YLFPSAAEEAT----------TAA 1039
            ..:..:..:::|:..  .:..:.|:||.|:|..|||     |..|...:|.:          .|.
Mouse   747 SGLFNRLKKSINNLE--KNTEMCNVMMQLRKMANHPLLHRQYYTPEKLKEMSQLMLKEPTHCEAN 809

  Fly  1040 GGL----------YEINSLTKA----------------AGKLVLLSKMLKQLKAQNHRVLIFSQM 1078
            ..|          :|::.|.|.                :||...|..:|.:||.:..||::|||.
Mouse   810 PDLIFEDMEVMTDFELHVLCKQYQHINSYQLDMDLILDSGKFRALGCILSELKQKGDRVVLFSQF 874

  Fly  1079 TKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADT 1143
            |.||||||..|:..|::|.|:||....:.|...||.||. ....|||||||:||||||||.:|:.
Mouse   875 TMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNT-DMDIFVFLLSTKAGGLGINLTSANV 938

  Fly  1144 VIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMML 1197
            ||::|.|.||:||.||..|.||:||..:|::.:.:::.::||.:.::.::|:.|
Mouse   939 VILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKL 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	13/57 (23%)
		TNG2	<282..422	CDD:227367	24/152 (16%)
		PHD1_CHD_II	380..422	CDD:277006	0/41 (0%)
		PHD2_CHD_II	440..482	CDD:277007	8/44 (18%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	14/69 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	4/53 (8%)
		PLN03142	720..>1234	CDD:215601	183/535 (34%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
Smarcad1	NP_031984.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		20/102 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..151		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..246		10/53 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..366		11/84 (13%)
		HepA	<480..992	CDD:440319	183/606 (30%)
		DEGH box	623..626		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	716..733		8/19 (42%)
		DEAD box	1000..1003