Protein Alignment Mi-2 and kis

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_061512916.1
• Gene: kis / 1277495
• VectorBaseID: AGAMI1_002666
• Length: 6890
• Species: Anopheles gambiae
• Alignment Length: 2566
• Identity: 609/2566 - (23%)
• Similarity: 954/2566 - (37%)
• Gaps: 895/2566 - (34%)

  Fly     2 ASEEENDDNFQEEEEAQEDNAPAAELSNDSDA--------PLKPNQNDEDDDYDPEDSRRKKKGK 58
            ||.::.:|:...|.:..:|.:.||.::..|:|        |:     :|..|:|  |....|..|
Mosquito  1871 ASVKDGEDHEGGEVDGGDDQSKAAAITTTSEATEGSGSGVPM-----EEVTDFD--DIPVSKISK 1928

  Fly    59 KRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGM- 122
            ...|::.:|        ||..:||.:   ..:.|.|.|:.||..:..|:.|:...|..|:||..
Mosquito  1929 TEPTKEEDE--------KKEAAEEGA---TAEPEPETPTKSKSKKSSKKSKEPGSEGGSSSSSRN 1982

  Fly   123 -------------------------------------------------------PSVE-DVCSA 131
                                                                   |.:| |....
Mosquito  1983 RSRPSGGGSSSSRRSGGSKSSGGGSKSRSRRSRMIVTESDGEGDDLLSTPPPSPPPDMEADSSKR 2047

  Fly   132 FSVCNVE-IEYSEEELQSLTTYKAFMHHVRPILQKENPKI---------AAPKLVMLVAAKWREF 186
            .|..|.: .:|.::.:...:..::.|....|...:::.:.         .||..|.|...
Mosquito  2048 RSARNTQRKKYVDDVMLRFSDDESGMMSPAPSGSRKDRRSDGGSDRKEGLAPTEVALAGG----- 2107

  Fly   187 CESNPHIQQEGGAAGSGGS----AGQARSVTG--------------------------------- 214
                     |.||..:.||    ||:|.||.|
Mosquito  2108 ---------EAGAVAADGSVAGVAGEASSVVGTGSEQAGDENKVSTSEGAKAAPEAVELGPDGKP 2163

  Fly   215 -DEPEEPRSS--------------------RSSRNE-KPD---------------DIYEEAVEEE 242
             |:..:|.::                    |..|.| |||               ...||||:.|
Mosquito  2164 IDDSSKPNANYVYVNTSEEDSMVVQYVLAVRKGRRELKPDPPPPPPKEKTPEPAEGSAEEAVKSE 2228

  Fly   243 EEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSD---------EEQDASG-ASE 297
            .:|.||      |.:..| .|...:....|:|.:  ||..::.|:         |:.|||| .::
Mosquito  2229 PKEGEE------KAAAVG-DGSETTAAEATVKEE--GKELKEVSEDGEDKKKEAEDVDASGEVAD 2284

  Fly   298 RD-------SDLEFERMLQKSDDSADEKEAPVSSKADNSA-----PAAQDDGSGAPVVRKKAKTK 350
            ::       :|:..|  ..:...|.:||.:|.|..|:..|     |:|:|        ..||:.|
Mosquito  2285 KEAAPTTTATDVPME--TSEETKSTEEKISPESDTANTGAEPEQKPSAED--------ASKAEEK 2339

  Fly   351 IGNKFKKKNKLKKTKNFP-EGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPE 414
            :....::...:...|:.| |.::||.:.:...:|.||..:..:.|.   |.....:|.:.:|||
Mosquito  2340 METDEQESVGVAAEKDTPAEEKEGEEKKEASADVDQQQVKEPVADA---ATAKESMETDAEEPP- 2400

  Fly   415 GKWSCPHCEADGGAAEEED-------------DDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLN 466
             |....:..|:...||:.:             |....|......||.|.:..:.         .:
Mosquito  2401 -KTESVNTAAEDKTAEQPNGEPAVEEKPARVADKPEAEATEATADGVEKMEVEG---------ES 2455

  Fly   467 PPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSR----------- 520
            ...:..|:||            ..|..::    .:.|.:.|.||.:.|..:..:
Mosquito  2456 EGTEKKPEGD------------DAAADVV----KKESAEGGESTDEKSSEAVKKEEGESASTETD 2504

  Fly   521 ----------VREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEAD 575
                      |.|||:|:.|.||.||||                           :.|:.|.:.|
Mosquito  2505 EKKPEPVYIDVEEYFVKYRNFSYLHCEW---------------------------RTEDELLKGD 2542

  Fly   576 TRY-KRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRV--INHRTARDGSTM--YLVKW 635
            .|. .:|:|...|...:.|....:.||.|     .|:::.|.||  ::.....:|.|:  |||||
Mosquito  2543 KRVGNKIKRFLMKQQQQLNIFESLDEEPF-----NPDFVEVDRVLDVSELVDDEGKTVKHYLVKW 2602

  Fly   636 RELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVK 700
            :.|||:.||||.| ||:..|:  |:.|.               |.:|...||:.|.:
Mosquito  2603 KSLPYEDSTWELE-DDVDQLK--IEQYY---------------KFNKIPPKSEWKTK-------- 2641

  Fly   701 HYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQ 765
                  ::|..|..|...:.|.|..|.  :|.|||:||:|||||||.:|.:.|||||||||||||
Mosquito  2642 ------KRPHPDQWKALPESPTFKGGN--KLRPYQLEGLNWLRYSWYKGNNCILADEMGLGKTIQ 2698

  Fly   766 TVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEE 830
            ::||:.|:|:.| .||||||..||||:.||:||||.|. :...|.|.|...||.:|::.|:.:.
Mosquito  2699 SLTFVNSVYEYG-IRGPFLVIAPLSTIPNWQREFEGWT-EMNVIVYHGSATSRQMIQDYEVHYR- 2760

  Fly   831 GAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSY 895
                 ::..:|.....|||||:|::|:|..|...|.:..|...|:|||||||:...|....|...
Mosquito  2761 -----TETGKLIRDITKFNVLITTFEMIVTDYQDLKNFTWRACVIDEAHRLKNRNCKLLEGLRQL 2820

  Fly   896 TIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRR 960
            .:.:::||:|||||||:.|||.|||||...:|...:.|..||..:..|.:|.:|..:|.|.||||
Mosquito  2821 NLEHRVLLSGTPLQNNVNELFSLLNFLEPSQFACSEEFLREFGSLKTESEVLKLQALLKPMMLRR 2885

  Fly   961 LKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEAL-NSKSGGGSCSLINIMMDLKKCCNH 1024
            ||.||.|::..|.|.||.|||:.:|||:|:.||.:|:..| ...:.....:|:|.||:|:|||.|
Mosquito  2886 LKDDVEKSLAPKEETIVEVELTNIQKKYYRGILEQNFSFLMKGTTSANIPNLMNTMMELRKCCIH 2950

  Fly  1025 PYLFPSAAEEAT--------TAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKM 1081
            |||...|.::..        ..|...|:  :|..::||:||:.|:|.:|:|..|||||||||.:.
Mosquito  2951 PYLLNGAEDQIQYDYRQQHGEDAESYYK--NLIVSSGKMVLIDKLLPKLRANGHRVLIFSQMVRC 3013

  Fly  1082 LDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVII 1146
            ||||||:|..::|.:|||||.|.|.|||.||||::.|.:.:|||||.|:||||||||..||||||
Mosquito  3014 LDILEDYLMYKKYPFERIDGRIRGNLRQAAIDRYSKPDSDRFVFLLCTKAGGLGINLTAADTVII 3078

  Fly  1147 YDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGA 1211
            |||||||.||:||.:|.|||||...|.|||.:.||:.|..:...|..|:.|...|::....|:..
Mosquito  3079 YDSDWNPQNDLQAQARCHRIGQQKMVKIYRLLCRNTYEREMFDKASLKLGLDKAVLQSMNTGQNK 3143

  Fly  1212 NFT-----KQELDDILRFG---------TEDLFKEDD---------------KEEAIHYDDKAVA 1247
            :.|     |:|::|:|:.|         ..|.|.|:|               .|:...:...:.|
Mosquito  3144 DGTQRQLSKKEIEDLLKKGAYGAVMDDDAGDKFCEEDIDSILLRRTQVITMESEKGSTFSKASFA 3208

  Fly  1248 ELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEE--------------------------- 1285
            ...:|::..|::.:.| |::....::...|.:::|.|:
Mosquito  3209 ASANRSDINIDDPDFW-NKWAKKAEIDPTACEKDETEDLVIAEPRRRTQIKRYGHDDGVMDISDE 3272

  Fly  1286 ---------------------------ETEIIKQDAENSD--P---------------------- 1299
                                       |.:.::|..::.|  |
Mosquito  3273 SSGEQGSDGEEGGIGLKTRSKRTRGAKERKKLQQQMQHDDYVPRDRETLAVLGADEVSYGNWARS 3337

  Fly  1300 --------------AYWVKLL------RHHYEQHQEDVGRSL----------------------- 1321
                          |.|.::|      |...||..||..|.:
Mosquito  3338 ECFKVEKGLLSHGWARWTEILEQGQFKRGWREQDVEDCARVILLYCLERYQGDEKIKNFIWDLIT 3402

  Fly  1322 -----------------------GKGKRVRKQVNY---------------TDGG-----VVA--- 1340
                                   |:..:.||..:.               ::||     |:|
Mosquito  3403 PNEGGEQREIARNHSGLHNLVPRGRNAKGRKSTSTCTTPKRDSSNSAATGSNGGGGGSPVIAQPA 3467

  Fly  1341 ------------ADTTRDDSNWQDNGSEYNSEYSAGSDEDGG--------------DDDFDDQNG 1379
                        ||...|.|:   |.|...:|.||.|..|.|              |:.:|.:..
Mosquito  3468 GSTTPAPQCSGTADANEDASS---NSSGTKAEKSAKSGSDTGGTTTPVSDPHHWSKDEKYDTETL 3529

  Fly  1380 AERKAKRRLERRDDRPLPPLLARVGGNI--EVLGFNARQRKSFLNAIMRYGMPP--QDAFNSQW- 1439
            .:...|:.|.|..::.|  |..|:...|  ||||....|.....||......||  .|.....|
Mosquito  3530 LDINYKKHLTRHANKVL--LRVRMLYYIKHEVLGDLVNQINEGANASDLPIRPPPTPDQLPCSWW 3592

  Fly  1440 ---------LVRDLRGKSE--RNFKAYVSLFMRHLCEPG---------------------ADNAE 1472
                     ||...:...|  |..:|...|..:..|.||                     .||.|
Mosquito  3593 NPNCCDRSLLVGTYKHGCENYRGMRADPMLCFQSHCGPGDGTVEETTIVKETDDDANSKLGDNEE 3657

  Fly  1473 TFADGVPREGLSRQHVLTR---IGVMSLIRKKVQEFEHINGYYSM----------PELILKPCEP 1524
            ...||||.|       .||   :|:.|    |..:.|...|..|.          |||.....:.
Mosquito  3658 DPEDGVPSE-------TTRSASVGIES----KDDDEESTVGTASAAPTPAPSDMNPELAWPTMQD 3711

  Fly  1525 VRSALKQDVAALE-------------------APPTGGNVDKSATTSNSVTPATSAAP---SPAP 1567
            :.:.|::.:.:.:                   .||.|.......|:|:..||:|:..|   :| |
Mosquito  3712 LNTRLRRVITSYQRNYKKEELKQQQKAKLQTIVPPAGTPTLTGQTSSSPSTPSTTPGPMIVTP-P 3775

  Fly  1568 ASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKP--------------------------- 1605
            ..::|:             .|:.|.::|:|:.::.::|
Mosquito  3776 LQQQGQ-------------PAQLSALQQQQQQQQQQQPQVPGGPSMGVGLNHPSATGPLGAAVGG 3827

  Fly  1606 -------------------GDVKQENPVEEAAGDT----------------------------KP 1623
                               ..|:|:..:...:|::                            .|
Mosquito  3828 AAVSGAVGIGLGTAGSPQGKGVQQQQSLPSTSGNSGTGGLQAPTAGMPTAADFSLMLSLGLGLNP 3892

  Fly  1624 SD----AEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKE 1684
            :|    |.:..:......|.|.::   |.|....|:|:.:::.   ||......::::.:.::..
Mosquito  3893 ADPNQLANIDLQKLAMYLKMERRE---KNELVMRERERIRLEQ---IPKRWTRREENEFIRVLTG 3951

  Fly  1685 DGELEKPSASSP-----------------------------------------KDQKAVAAATSA 1708
            .|...:|:|:.|                                         .|:|.:......
Mosquito  3952 YGIDLQPNATVPTPDWSRFKVFAKLDKKTDENLSDFYKVFIAMCKRQAGVKLSDDEKGLEGLVDD 4016

  Fly  1709 ATGATGKGAEDSLEVLKR--------KFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHD 1765
            .|....|...|.||:|.:        |...||      .|....|:.....:||        |||
Mosquito  4017 VTEDHAKLILDRLELLSKARQIVKHPKLDENI------RLCENNLDTPDWWIPG--------RHD 4067

  Fly  1766 YWLLAGIVTHGYGRWQDIQNDIRFAIINEP-FKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQ 1829
            ..||..::.:|..|.:.:       |:.:| |.       |.|...|:|        |.|.::.|
Mosquito  4068 RELLRAVLKYGIYRSEQL-------ILADPDFP-------FYESAKKYL--------QQLEMQIQ 4110

  Fly  1830 LRRAAYLNLAQDPSHPAMSLNARFAEVECL--AESHQHLSKESLAGNKPA--------------- 1877
            |:....|.:..|.:..|.:..|..|....:  |.|.:.::..::.|:.|.
Mosquito  4111 LQNQQLLKMQADAAAKADAAAAAAANATTVKPAASPEKMAAAAVGGDLPVKQEKDAVAPVVASME 4175

  Fly  1878 ----NAVLHKVLNQLEEL--LSDMKSDVSRL 1902
                .||...||.::|.:  ||.:|.:|..:
Mosquito  4176 VDGEKAVTEVVLPKVEPVAPLSPVKKEVEEV 4206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	7/62 (11%)
		TNG2	<282..422	CDD:227367	36/162 (22%)
		PHD1_CHD_II	380..422	CDD:277006	10/41 (24%)
		PHD2_CHD_II	440..482	CDD:277007	6/41 (15%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	18/90 (20%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	24/57 (42%)
		PLN03142	720..>1234	CDD:215601	245/536 (46%)
		DUF1087	<1292..1334	CDD:461922	15/146 (10%)
		CHDII_SANT-like	1380..1517	CDD:461920	44/186 (24%)
		CHDCT2	1757..1902	CDD:462358	36/168 (21%)
kis	XP_061512916.1	None