Protein Alignment Mi-2 and LOC1271255

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: XP_061510596.1
• Gene: LOC1271255 / 1271255
• VectorBaseID: AGAMI1_006303
• Length: 3078
• Species: Anopheles gambiae
• Alignment Length: 2355
• Identity: 464/2355 - (19%)
• Similarity: 757/2355 - (32%)
• Gaps: 764/2355 - (32%)

  Fly     5 EENDDNFQEEE----------EAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDP--EDSRRKKKG 57
            |.:.|..:.|:          ::...::.::..|::|.:.|..:.|........  ..:||.:|.
Mosquito   470 ERSKDQHRNEQCKKRLLDSSSDSSSSSSSSSSSSSNSTSQLSGSGNSSSKKAKEALRHNRRLRKS 534

  Fly    58 --KKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASS 120
              :|||....:|:|..||:|::..|:..||      |.|         ||.|:...|...|:...
Mosquito   535 AKEKRKPSSADERGAGKKRREQIYSDSSSD------EAE---------KRSEDGGRADGDENLLD 584

  Fly   121 GMPS-VEDVCS--------AFSV----CNVEIEYSEEELQSLTTYK-----AFMHHVRPILQKEN 167
            |:.| |:|:.|        |..|    .:.|.:..|.|.:|..|.|     |.....||.|.|..
Mosquito   585 GVLSGVDDIMSDVHDIIPDAVGVVQDFLDGEQQRQEREERSEETRKRSGAGAGKEPTRPALSKSV 649

  Fly   168 PKIAAPKLVMLVAAKWREFCESNPHI---QQEGGAAGSGG-----------SAGQARSVTGDE-- 216
            ..:...:.......:....|..:..|   ...||||||||           |:..|.....||
Mosquito   650 KDMTEAEREEYEDMQIERLCNISTLIGCRNAAGGAAGSGGPTSAASKSKESSSSAAAKKKKDENN 714

  Fly   217 -----------------PEEPRSSRSSRNEKPDDIYE----------EAVEEE--------EEEE 246
                             |.||:|..||.:||  |:.|          |.::::        ||..
Mosquito   715 MEHFLNHENGSDDTATAPLEPQSDESSESEK--DVVETEEQFLQKCNETMKQQLLNQLSSSEETS 777

  Fly   247 EEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDA---SGASERDSDLEFERML 308
            |||.......||..:......|: |.      |..|.||.|....:   |.....||.|...:..
Mosquito   778 EEEDNLDGLLSGEEEDDNSADGR-PN------GTGKEDSDDSSAGSLVESFLKRHDSKLAERKER 835

  Fly   309 QKSDDSADEKEAPVSSKADNSA----------PAAQDDGSGAPVVRKKAKTKIGNKFKKK----- 358
            :|..:..:......:.:||:|.          ..|..|...|...:|:.:|::.|...|:
Mosquito   836 KKQLNERENGNLLTNGQADDSGDNIGGESSAEQQATKDSERAETPKKQTRTELANPKDKELFSND 900

  Fly   359 ----NKLKKTKNFP------------EGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEP 407
                .|..|::..|            .|.:.|.|..      ....::.:.|..|:
Mosquito   901 LFDGEKSDKSEKTPRKRRKRINARKARGSESERESS------SADSDLEMLDGTPK--------- 950

  Fly   408 ELDEPPEGKWSCP--------HCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFC 464
                ..:.|.:.|        ....:..||..:........|    :|..:
Mosquito   951 ----KRQRKRAAPVSLETFDFSASLNASAAPRKSKTPASTAC----EGSTI-------------- 993

  Fly   465 LNPPLDTIPDGD--------WRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTS---KGSKNSN 518
            ..|...|.|.||        ...|..|.|..|      .|...|..:...|.||:   ||||:..
Mosquito   994 AKPSPSTTPSGDGIKGKQAKTSSPAPSDPDAT------TTGSGAAATAASGSSTAGKQKGSKDGQ 1052

  Fly   519 SRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQR 583
            ..:
Mosquito  1053 DCI-------------------------------------------------------------- 1055

  Fly   584 HKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEE 648
               .:...::||||::.....:|...|:....:|:
Mosquito  1056 ---SLSSDSSDDAELITGDLEENKTVPDKEPKRRI------------------------------ 1087

  Fly   649 GDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKK---GRKSKLKVEDDE-DRPVKHYTPPPEKP 709
                             ||:.|::.....:||::|   ||.::||.:.:: .:.:..|.|.|.:
Mosquito  1088 -----------------RAMLTNDELAEETKKAQKEEEGRTARLKKKHEQLKKFLASYLPGPGE- 1134

  Fly   710 TTDLKKKYED--------QPAFLEGTGMQLHPYQIEGINWLRY--SWG--------QGIDTILAD 756
             ::|...|:.        .|..::    .|.|:|||||.:: |  ::|        .|...|||.
Mosquito  1135 -SELVLDYDSVRKQAICVHPEIVK----LLKPHQIEGIKFM-YDNTYGSVDALPKHSGSGCILAH 1193

  Fly   757 EMGLGKTIQTVTFLYSLYKEGHCRGP------FLVAVPLSTLVNWEREFELWAPDF--------Y 807
            .||||||:|.::.|:::     .|.|      .||..|.||::||:.|...|....        |
Mosquito  1194 CMGLGKTLQMISLLHTV-----MRYPQLMTNRVLVICPKSTVMNWKEEIARWQGTIRTGYQMKVY 1253

  Fly   808 CITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQY----KFNVLLTSYEL----------- 857
            |                   |.:...:..|::.|:...|    ...|:|..||.
Mosquito  1254 C-------------------FPDVCTQNDKIAVLKRWYYCKSPNCGVMLIGYEAFRALINYERRK 1299

  Fly   858 --ISMDAACLGSIDWAVL-------VVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLE 913
              :.:.:|.||.|...:|       :.||.|::|:.:|.....::......:::|||||:||||:
Mosquito  1300 GSVGLRSAKLGLIKEYLLNPGADLVICDEGHQIKNKRSAISEAVSKIKTRRRIMLTGTPIQNNLK 1364

  Fly   914 ELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKR---------------LHEMLGPHMLRRLKT 963
            |.:.::||:........:.|...:|:..|..|.|.               ||..|. ..::|.:.
Mosquito  1365 EYYCMVNFIKPSFLGSDKEFSNLYANPIKNGQCKDSDHQSIKIMKQRSYVLHNKLS-KFVQRKEA 1428

  Fly   964 DVLKN-MPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSG-GGSCSLINIMMD---LKKCCN 1023
            .|||. :|.|.|:::.|.|:.:|:|.|:..|..|....|..:| .|......::.|   |:|...
Mosquito  1429 AVLKEFLPEKFEYVLFVPLTPVQEKMYEVFLQMNDYTNNDVTGEPGRTKKFKLIADYTSLRKIWT 1493

  Fly  1024 HPYLFPSAAEEAT-----------TA----------------AGGLYEINSLTK----------- 1050
            ||.:...|.|.|.           ||                :|.|...|...:
Mosquito  1494 HPKVLEKAWESANLEKNRRDAARKTATPDSDDESPDDHNDIKSGQLSVTNDWWRQYLQIADLESL 1558

  Fly  1051 -AAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFL-------EGEQYK------------ 1095
             .:.||.:|.::||....:..:||||:....:|:::|.|:       |..|..
Mosquito  1559 FPSNKLWILFEILKHCNERGEKVLIFTAFVSVLNMVEHFMAKIHHQEENPQLSDAYAYSAFKGPW 1623

  Fly  1096 -----YERIDGGITGTLRQEAIDRFNAP-GAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPH 1154
                 |.|:||....::|.:.|..||.| ..:...||:|.:|||.||||..|:.|||.|:.|||.
Mosquito  1624 EPGKDYYRLDGKTQKSIRHQMITSFNDPQNKRTKCFLISAKAGGQGINLTGANRVIILDTSWNPS 1688

  Fly  1155 NDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELD 1219
            ||.|...|..|:||..|..:||.:...::||:|...:..|..|:..||           .:|::|
Mosquito  1689 NDQQNIFRIFRLGQKRKCYVYRLIAAGTMEEKVYSRSVTKQALSFRVV-----------DEQQID 1742

  Fly  1220 DILRFG------TEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYA- 1277
            ....:|      |.....|..:|..|...|..:|.||          .::.|:.|...:..|..
Mosquito  1743 RHYSYGELAELYTLTKVSEMTRETPILPADDILASLL----------RTYPNKILKYHEHDSLLE 1797

  Fly  1278 ------TKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNY--- 1333
                  ..|||::|.....:::.:|::...::..|..........:|..||..........|
Mosquito  1798 NKPEQDLSEEEKKEAWAAYEREIQNNENRSYLSQLNSMGAAAAAQLGGLLGSSAYGSPMAPYYAS 1862

  Fly  1334 ----------TDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRL 1388
                      ..||.               |..|.|:|:|......|......|....::....:
Mosquito  1863 AMGYPGAMGLPMGGA---------------GDMYRSDYAASYGSSMGRPPLYMQYAGSQQYSTLM 1912

  Fly  1389 ERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFK 1453
               :|.......|::..:..:.|..|          |.|||||            |.|.|.....
Mosquito  1913 ---NDPAFATAFAKMYSSFPLSGAGA----------MDYGMPP------------LGGHSSPMAN 1952

  Fly  1454 AYVSLF--MRHLCEPGADNAET-----------------------FADGVPREGLSRQHVLTRIG 1493
            ...|:.  :.....||...|.|                       ...|....||| ...||.:.
Mosquito  1953 GAQSMLPPIGPASSPGGGGASTGKGGGGGGYGTTASLASMLSLLSGKSGAGASGLS-PSALTSLS 2016

  Fly  1494 VMSLIRKKVQEFEHINGYY-------SMPELILKPCEPVRSALKQDVAALEAP-------PTGGN 1544
            ...|..........:..::       :.|.....|.:.:....:...::|.:|       |:|
Mosquito  2017 QSLLGGSSSSSLAELAAHHTALSSSGASPSAHYSPLKQMSDYAQSGASSLLSPNALQASAPSG-- 2079

  Fly  1545 VDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVK 1609
              .|.:...|:..|....|.||..|..|.....||     .|.|..:.:.::..|.
Mosquito  2080 --LSISNITSLQKANPPQPPPASKSSSGSSSSYDS-----VTKALFNRLTEQMSAS--------- 2128

  Fly  1610 QENPVEEAAGDTKPSDAEVKTEVAKTEPKE-ETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVID 1673
                ....||.:.|           ..|:. ....|.:..:|::      ......|:..::.:.
Mosquito  2129 ----ALATAGVSSP-----------FSPRNVPLLSPTLDNQPRS------SAGGAFPLTASSPMT 2172

  Fly  1674 DDDDDVMIVK-EDGELEKPSASSPKDQKAVAAATSAATG-----ATGKGAEDSLEVLKRKFMFNI 1732
            .:....:.|. ........|.|:|....:.|.|.|.:.|     :|..|.:.|..|...:    .
Mosquito  2173 SNSGSALTVPISSSNSSNSSISTPSLLSSTAMALSLSIGQGPPKSTTAGEQPSSLVANNR----S 2233

  Fly  1733 ADGGFTE--------LHTLWLNEEKAAVPGR---------EYEIWHRRHDYWLLAGIVTHGYGRW 1780
            |...|.|        ..:|......:|||.|         |.|...||         .:....:.
Mosquito  2234 AGDSFAENRLPVTPPAPSLRSGPVSSAVPARTPTAAANPSEEEDKSRR---------TSTVPAKA 2289

  Fly  1781 QDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHP 1845
            ||:.|             ..|.||           .|.....:..:..        :...:|||.
Mosquito  2290 QDVSN-------------KSGTGN-----------NFNSTPYSTTVTP--------SSVMEPSHT 2322

  Fly  1846 AMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIP 1910
            ...........:.|:...|.|.       ||:.|.:....|.|:          :.:||.:...|
Mosquito  2323 NSGGKDTAKSTKTLSNMVQQLP-------KPSTAKVSAKQNSLQ----------TAVPAAVPPAP 2370

  Fly  1911 PV-----AQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQGTTLPAFTSGPAGNF----AN 1966
            |:     ..|||::..:|.:.:::.   :|.|.|.:|:     .|...|..   |:..|    ||
Mosquito  2371 PIISNPMPSRLQLARANIANSVSSA---SSPAQQALAK-----SGALKPRV---PSPTFKMTAAN 2424

  Fly  1967 FRP-QFSVPGQLSNN 1980
            .:| ..|.|..||.:
Mosquito  2425 KQPTAASKPSPLSRS 2439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	12/57 (21%)
		TNG2	<282..422	CDD:227367	29/181 (16%)
		PHD1_CHD_II	380..422	CDD:277006	4/49 (8%)
		PHD2_CHD_II	440..482	CDD:277007	8/49 (16%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	10/72 (14%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	2/53 (4%)
		PLN03142	720..>1234	CDD:215601	166/651 (25%)
		DUF1087	<1292..1334	CDD:461922	6/54 (11%)
		CHDII_SANT-like	1380..1517	CDD:461920	26/168 (15%)
		CHDCT2	1757..1902	CDD:462358	21/144 (15%)
LOC1271255	XP_061510596.1	None