DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and Chd1

DIOPT Version :9

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:NP_031716.2 Gene:Chd1 / 12648 MGIID:88393 Length:1711 Species:Mus musculus


Alignment Length:1985 Identity:539/1985 - (27%)
Similarity:855/1985 - (43%) Gaps:545/1985 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 DSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKE 114
            |....:.|....::.|::.|........:.|...||          .|:|:.|         :.:
Mouse     6 DEESVRNGSGESSQSGDDCGSASGSGSGSSSGSSSD----------GSSSQSG---------SSD 51

  Fly   115 KESAS-SGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVML 178
            .:|.| ||                    |:.|.:|.|:             :||...|.|..|  
Mouse    52 SDSGSDSG--------------------SQSESESDTS-------------RENKVQAKPPKV-- 81

  Fly   179 VAAKWREFCESNPHI----------------QQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSR 227
               ...||.:|:|.|                ||:..|:.:.||...:.|   .|..:..||.:.|
Mouse    82 ---DGAEFWKSSPSILAVQRSAMLRKQPQQAQQQRPASSNSGSEEDSSS---SEDSDDSSSGAKR 140

  Fly   228 NEKPDDIYE--------EAVEEEEEEEEEEK----------KPRRKRSGRGKKGRRPS--GKVPT 272
            .:..|:.::        ::..:.|.|||.:|          :|:.|...|..:.|..|  ||   
Mouse   141 KKHNDEDWQMSGSGSPSQSGSDSESEEERDKSSCDGTESDYEPKNKVRSRKPQNRSKSKNGK--- 202

  Fly   273 LKIKLLGKRKR--DSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQD 335
               |:||::||  |||::|.|    .:.|:|                                  
Mouse   203 ---KILGQKKRQIDSSEDEDD----EDYDND---------------------------------- 226

  Fly   336 DGSGAPVVRKKAKTKIGNKFKKKNKLKKTKN--FPEGEDGEHEHQDYCEVCQQGGEIILCDTCPR 398
                                |:.::.:.|.|  :.|.|:.:.:..|..|||   ||         
Mouse   227 --------------------KRSSRRQATVNVSYKEDEEMKTDSDDLLEVC---GE--------- 259

  Fly   399 AYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTF 463
                     ::.:|.:               ||.:..|....|||.:.|.               
Mouse   260 ---------DVPQPED---------------EEFETIERVMDCRVGRKGA--------------- 285

  Fly   464 CLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKW 528
                                    ||....|    :|..:  ||...:...:|......:|.|||
Mouse   286 ------------------------TGATTTI----YAVEA--DGDPNAGFERNKEPGDIQYLIKW 320

  Fly   529 HNMSYWHCEWVPEVQLDVHHPLMIRSFQR----KYDMEEPPKFEESLDEADTRYKRIQRHKDKVG 589
            ...|:.|..|..|..|...:   :|..::    |...:|..::.::....|..|...|:      
Mouse   321 KGWSHIHNTWETEETLKQQN---VRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQ------ 376

  Fly   590 MKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTM--YLVKWRELPYDKSTWEEEGDDI 652
             :..||            :..::.||:|:|.|...:..:.:  |..||:.|||.:.:||:.....
Mouse   377 -ELTDD------------LHKQYQIVERIIAHSNQKSAAGLPDYYCKWQGLPYSECSWEDGALIS 428

  Fly   653 QGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKY 717
            :..:..||.|          .::::||.:                |.|......::|.....|| 
Mouse   429 KKFQTCIDEY----------FSRNQSKTT----------------PFKDCKVLKQRPRFVALKK- 466

  Fly   718 EDQPAFLEG-TGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRG 781
              ||:::.| .|::|..||:.|:|||.:||.:|...||||||||||||||::||..|:.|....|
Mouse   467 --QPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYG 529

  Fly   782 PFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQY 846
            |||:.||||||.:|:||.:.||.....:.|:||.:||.:||.:|....:            |.:.
Mouse   530 PFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWMHPQ------------TKRL 582

  Fly   847 KFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNN 911
            |||:|||:||::..|.|.||.::||.:.||||||||::.|..::.|..:...::||:|||||||:
Mouse   583 KFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNS 647

  Fly   912 LEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFI 976
            |:||:.||:|:..:||:..:.|:.|... .:|.....||:.|.|.:|||:|.||.|::|:|.|.|
Mouse   648 LKELWSLLHFIMPEKFSSWEDFEEEHGK-GREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQI 711

  Fly   977 VRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLF--PSAAE-----E 1034
            :|:|:||:||::||:|||:||:||:..|.|.:...:||||:|||||||.||.  |...|     |
Mouse   712 LRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQE 776

  Fly  1035 ATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERI 1099
            |         :..|.:::|||:||.|:|.:|:.:.:||||||||.:|||||.::|:..|:.::|:
Mouse   777 A---------LQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRL 832

  Fly  1100 DGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAH 1164
            ||.|.|.||::|:|.|||.|::.|.|||||||||||||||:||||:|:||||||.||:||.:|||
Mouse   833 DGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAH 897

  Fly  1165 RIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV-RPGMGGK-----------GANFTKQE 1217
            ||||..:|.|||.||:.||||.:.:.||:||:|.|||: |....||           ...|.|:|
Mouse   898 RIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEE 962

  Fly  1218 LDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKE----SWANEYLSSFKVASYAT 1278
            |..||:||.|:||||.:.||. ...:..:.|:|.|..  ..|.|    |..:|.||.||||:::.
Mouse   963 LSAILKFGAEELFKEPEGEEQ-EPQEMDIDEILKRAE--THENEPGPLSVGDELLSQFKVANFSN 1024

  Fly  1279 KEEEE-EEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRS--------LGKGKRVRKQVNYT 1334
            .:|:: |.|.|   ::::|     |.:::.....:..|:..|.        |.:.:...||::: 
Mouse  1025 MDEDDIELEPE---RNSKN-----WEEIIPEEQRRRLEEEERQKELEEIYMLPRMRNCAKQISF- 1080

  Fly  1335 DGGVVAADTTRDDSNWQDNGSE---YNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPL 1396
                              ||||   ..|...:|||.|         :.:||  ||..:|...|.:
Mouse  1081 ------------------NGSEGRRSRSRRYSGSDSD---------SISER--KRPKKRGRPRTI 1116

  Fly  1397 PPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQ--DAFNSQWLVRD--LRGKSERNFKAYVS 1457
            |        ...:.||:..:.:.|:.:..::|.|.:  ||     :.||  |..|||.:.:.   
Mouse  1117 P--------RENIKGFSDAEIRRFIKSYKKFGGPLERLDA-----IARDAELVDKSETDLRR--- 1165

  Fly  1458 LFMRHLCEPGADNA-ETFADGVPREG--LSRQHVLT-RIGVMSLIRKKV--QEFEHINGYYSMPE 1516
              :..|...|...| :..:.|..|.|  |.:....| ||..:.:..|.|  .|.|.|..:.|:|.
Mouse  1166 --LGELVHNGCVKALKDSSSGTERAGGRLGKVKGPTFRISGVQVNAKLVIAHEDELIPLHKSIPS 1228

  Fly  1517 LILKPCEPVRSALKQDVAALEAPPTGGNVDKS------------ATTSNSVTPATSAAPSPAPAS 1569
               .|.|..:..:.....|.......|..|.|            :.....:.|..|......|  
Mouse  1229 ---DPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLSLTHKILP-- 1288

  Fly  1570 EKGEDKDKDSEKEKDKTSAE-----------KSEVKQ-------EQEAEEDKKPGDVKQENPVEE 1616
               :|.||..:.::.:|.|:           |.|.::       ::.....||...:|.....||
Mouse  1289 ---DDPDKKPQAKQLQTRADYLIKLLSRDLAKREAQRLCGAGGSKRRKTRAKKSKAMKSIKVKEE 1350

  Fly  1617 AAGDTKPSDAEVKTEVAKTEPKEETKDPEVKE-EPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVM 1680
            ...|:.|..:|          |.:..|.::.: :|:::::.|:.|....|:..|.    ..:.|.
Mouse  1351 IKSDSSPLPSE----------KSDEDDDKLNDSKPESKDRSKKSVVSDAPVHITA----SGEPVP 1401

  Fly  1681 IVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLK--RKFMFNIADGGFTELHTL 1743
            |.:|..||::.:.|..|::.....|.........||..:. |.|:  |:.:..|.| ..||....
Mouse  1402 IAEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSER-EQLEHTRQCLIKIGD-HITECLKE 1464

  Fly  1744 WLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEI 1808
            :.|.|       :.:.|  |.:.|:                                    |:..
Mouse  1465 YSNPE-------QIKQW--RKNLWI------------------------------------FVSK 1484

  Fly  1809 KNKFLARRF-KLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAE--SHQHLSKES 1870
            ..:|.||:. ||.:.|:    :.|:.:..|..|: |:.|.:...|..::|.|.|  :|...|::|
Mouse  1485 FTEFDARKLHKLYKHAI----KKRQESQQNSDQN-SNVATTHVIRNPDMERLKENTNHDDSSRDS 1544

  Fly  1871 LAGNKPANAV--LHKVLNQLEELLSDMKSDVSRLP 1903
            .:.::..:..  .||..:|.:   |..|||..:.|
Mouse  1545 YSSDRHLSQYHDHHKDRHQGD---SYKKSDSRKRP 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 11/51 (22%)
PHD1_CHD_II 380..422 CDD:277006 6/41 (15%)
PHD2_CHD_II 440..482 CDD:277007 4/41 (10%)
CHROMO 490..558 CDD:237991 15/71 (21%)
CHROMO 615..667 CDD:214605 15/53 (28%)
SNF2_N 734..1028 CDD:278600 139/293 (47%)
DEXDc 751..907 CDD:238005 70/155 (45%)
Helicase_C 1053..1167 CDD:278689 71/113 (63%)
DUF1087 <1292..1337 CDD:283996 7/52 (13%)
DUF1086 1380..1517 CDD:283992 37/146 (25%)
CHDCT2 1756..1927 CDD:285336 30/153 (20%)
Chd1NP_031716.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..250 68/367 (19%)
CHROMO 304..353 CDD:237991 12/51 (24%)
Chromo 388..441 CDD:278797 16/62 (26%)
SNF2_N 482..763 CDD:278600 139/293 (47%)
DEXDc 498..643 CDD:238005 70/156 (45%)
DEAH box 612..615 2/2 (100%)
HDA2-3 716..969 CDD:288366 134/261 (51%)
Helicase_C 801..900 CDD:278689 63/98 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1119 16/78 (21%)
PRK12279 <1276..1466 CDD:138835 42/210 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1322..1407 18/98 (18%)
DUF4208 1407..1498 CDD:290618 25/137 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1503..1588 20/78 (26%)
DUF1777 1581..>1697 CDD:285811
PHA03420 1591..>1691 CDD:177648
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1657
3 X 5 AA repeats of H-S-D-H-R 1629..1645
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1670..1711
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.870

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