DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and CHD4

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_001264.2	Gene:	CHD4 / 1108	HGNCID:	1919	Length:	1912	Species:	Homo sapiens

Alignment Length:	2029	Identity:	1108/2029 - (54%)
Similarity:	1372/2029 - (67%)	Gaps:	243/2029 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEE 67
            ||||:.|                .|.|:|..|..| :|:||.:.|..::...|..||:|.:|..:
Human    15 SEEEDMD----------------ALLNNSLPPPHP-ENEEDPEEDLSETETPKLKKKKKPKKPRD 62

  Fly    68 KGRKKKKRKKNE-----------SEEDSDFVQHDEEVEYPSTSK-----RGRKRKEEKQAAKEKE 116
            ....|.||:|.|           |.|..:||:.:|||...|.|:     .|:|:|::....|||:
Human    63 PKIPKSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKK 127

  Fly   117 SASSGMPSVED---------------VCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKE 166
            |.|......|:               :...:.:.:::..:|||:.::||.||||...|||::..:
Human   128 SKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAK 192

  Fly   167 NPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQA---RSVTGDEPEEPRSSRSSRN 228
            |||||..|::|::.||||||..:||.....|.:..:..:|..|   ..||..|...|
Human   193 NPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPP-------- 249

  Fly   229 EKPDDIYEEAVEEEEEEEEEEKKPRRKRSG--RGKKGRRPS-GKVPTLKIKLLG---KRKRDSSD 287
              |..: |..:.:.:.:|.:....|||..|  |....::|. .||..|||||.|   ||||.||:
Human   250 --PPPV-EVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSE 311

  Fly   288 EEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIG 352
                       |.||:.|         :|..:|.::|.:.:....::...|     |||.:|
Human   312 -----------DDDLDVE---------SDFDDASINSYSVSDGSTSRSSRS-----RKKLRT--- 348

  Fly   353 NKFKKKNKLKKTKNFPEGEDG-EHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGK 416
            .|.|||.:.:.|     ..|| |.:|||||||||||||||||||||||||:|||:|::::.||||
Human   349 TKKKKKGEEEVT-----AVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGK 408

  Fly   417 WSCPHCEADG-------------------GAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHT 462
            |||||||.:|                   |...||:||.|.||||||||||||||||:|||:||.
Human   409 WSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHI 473

  Fly   463 FCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQ--------RSNDDGPSTSKGSKNSNS 519
            .||||||..||:|:|.||||:||.|.||.:||:.|:|.|        |..|..|:|.........
Human   474 HCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGR 538

  Fly   520 RVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRH 584
            ..|::|:||..||||||.||.|:||::|..:|.|::|||.||:|||..:...||..:|.::
Human   539 PERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRK---- 599

  Fly   585 KDKVGMKANDDAEV--LEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEE 647
                    |.|.:.  :|||||:.|:||||:::.|::||...:.|...||:|||:||||:::||.
Human   600 --------NKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWES 656

  Fly   648 EGDDIQGLRQAIDY------YQDLRAVCTSETTQSRSKKSKKGRKSKL-KVEDDEDRPVKHYTPP 705
            |..:||      ||      |.:.|.:...|    ..:..||.:|.|| |:|           .|
Human   657 EDVEIQ------DYDLFKQSYWNHRELMRGE----EGRPGKKLKKVKLRKLE-----------RP 700

  Fly   706 PEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFL 770
            ||.||.|...|||.||.:|:.||..|||||:||:||||:||.||.|||||||||||||:||..||
Human   701 PETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFL 765

  Fly   771 YSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR- 834
            ||||||||.:|||||:.||||::|||||||:||||.|.:||:|||||||:|||||.|||:.|||
Human   766 YSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRG 830

  Fly   835 GSKVSRL-RTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA 898
            |.|.||: :....||:|||||||||::|.|.|||||||.|:||||||||:|||||||:||.|::.
Human   831 GKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQ 895

  Fly   899 YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKT 963
            :|||||||||||||||||||||||:.::|::|:.|..||||::||:|:|:||:|||||||||||.
Human   896 HKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKA 960

  Fly   964 DVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLF 1028
            ||.||||||:|.|||||||.||||:||:|||:|:||||::.||...||:|::|||||||||||||
Human   961 DVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLF 1025

  Fly  1029 PSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQ 1093
            |.||.||.....|:|:.::|.:|:|||:||.||||.||...||||||||||||||:||||||.|.
Human  1026 PVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEG 1090

  Fly  1094 YKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQ 1158
            ||||||||||||.:||||||||||||||||.||||||||||||||||||||||||||||||||||
Human  1091 YKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQ 1155

  Fly  1159 AFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILR 1223
            ||||||||||..||||||||||.|||||:|||||:||||||||||||:|.|..:.:||||||||:
Human  1156 AFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILK 1220

  Fly  1224 FGTEDLFKE-------DDKE----EAIHYDDKAVAELLDRTNRGIEEKE-SWANEYLSSFKVASY 1276
            ||||:|||:       |:||    ..|||||||:..||||.....|:.| ...||||||||||.|
Human  1221 FGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQY 1285

  Fly  1277 ATKE----EEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGG 1337
            ..:|    ||||.|.|||||: |:.||.||.|||||||||.|||:.|:||||||:||||||.||
Human  1286 VVREEEMGEEEEVEREIIKQE-ESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDG- 1348

  Fly  1338 VVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRD-DRPLPPLLA 1401
                  :::|.:|||:.|:..|:||..|:|  ||:|||:::.|.|:..|:..|.| |:|||||||
Human  1349 ------SQEDRDWQDDQSDNQSDYSVASEE--GDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLA 1405

  Fly  1402 RVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEP 1466
            |||||||||||||||||:||||||||||||||||.:||||||||||||:.|||||||||||||||
Human  1406 RVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEP 1470

  Fly  1467 GADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQ 1531
            |||.|||||||||||||||||||||||||||||||||||||:||.:|||||     ..|....|.
Human  1471 GADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPEL-----AEVEENKKM 1530

  Fly  1532 DVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQ- 1595
            ......:|.|     .:.:|.....|.|   |:|.|.:|.|...:::|.||::....|| |||.
Human  1531 SQPGSPSPKT-----PTPSTPGDTQPNT---PAPVPPAEDGIKIEENSLKEEESIEGEK-EVKST 1586

  Fly  1596 --EQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKE 1658
              |...|..:.|....::..|.     .:|.:.|.|.|  |.|.||.|::| ::.||| ...:.|
Human  1587 APETAIECTQAPAPASEDEKVV-----VEPPEGEEKVE--KAEVKERTEEP-METEPK-GAADVE 1642

  Fly  1659 KVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEV 1723
            ||::|..|..|.::.:|.::....:|..|:...:..:|||                ...|...:.
Human  1643 KVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKD----------------LNDEKQKKN 1691

  Fly  1724 LKRKFMFNIADGGFTELHTLWLNEEKAA-VPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDI 1787
            :|::||||||||||||||:||.|||:|| |..:.||||||||||||||||:.|||.||||||||.
Human  1692 IKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDP 1756

  Fly  1788 RFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNAR 1852
            |:||:|||||.::.:|||||||||||||||||||||||||||||||||||:::|||||:|:||.|
Human  1757 RYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTR 1821

  Fly  1853 FAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQ 1917
            ||||||||||||||||||:||||||||||||||.||||||||||:||:|||||:|||||||.|||
Human  1822 FAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQ 1886

  Fly  1918 MSERSILSRLAATA 1931
            ||||:||||||..|
Human  1887 MSERNILSRLANRA 1900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	25/51 (49%)
		PHD1_CHD_II	380..422	CDD:277006	34/41 (83%)
		PHD2_CHD_II	440..482	CDD:277007	32/41 (78%)
		CHROMO	490..558	CDD:237991	29/75 (39%)
		CHROMO	615..667	CDD:214605	21/57 (37%)
		SNF2_N	734..1028	CDD:278600	214/295 (73%)
		DEXDc	751..907	CDD:238005	115/157 (73%)
		Helicase_C	1053..1167	CDD:278689	101/113 (89%)
		DUF1087	<1292..1337	CDD:283996	32/44 (73%)
		DUF1086	1380..1517	CDD:283992	118/137 (86%)
		CHDCT2	1756..1927	CDD:285336	145/170 (85%)
CHD4	NP_001264.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157		42/158 (27%)
		CHDNT	164..216	CDD:285335	25/51 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..360		41/155 (26%)
		PHD1_CHD_II	372..414	CDD:277006	34/41 (83%)
		PHD2_CHD_II	451..493	CDD:277007	32/41 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..538		6/27 (22%)
		CHROMO	<540..577	CDD:237991	19/36 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..603		9/36 (25%)
		CHROMO	622..676	CDD:214605	21/59 (36%)
		SNF2_N	729..1025	CDD:278600	214/295 (73%)
		DEXDc	746..904	CDD:238005	115/157 (73%)
		DEAH box	873..876		2/2 (100%)
		Helicase_C	1068..1164	CDD:278689	89/95 (94%)
		DUF1087	1302..1352	CDD:283996	36/57 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1344..1401		26/65 (40%)
		DUF1086	1385..1521	CDD:283992	117/135 (87%)
		Neuromodulin	<1517..1649	CDD:284117	46/154 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1525..1562		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1589		8/19 (42%)
		Required for interaction with PCNT. /evidence=ECO:0000269\|PubMed:17626165	1577..1912		207/350 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1594..1644		16/58 (28%)
		CHDCT2	1726..1896	CDD:285336	145/169 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I541
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2018	1.000	Inparanoid score	I54
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm40687
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4509
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910