DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and Chd4

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_006505344.1	Gene:	Chd4 / 107932	MGIID:	1344380	Length:	1950	Species:	Mus musculus

Alignment Length:	2058	Identity:	1114/2058 - (54%)
Similarity:	1375/2058 - (66%)	Gaps:	263/2058 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNQNDEDDDYDPEDSRRKKKGKKRKTRKGEE 67
            ||||:.|                .|.|:|..|..| :|:||.|.|..::...|..||:|.:|..:
Mouse    15 SEEEDMD----------------ALLNNSLPPPHP-ENEEDPDEDLSEAETPKLKKKKKPKKPRD 62

  Fly    68 KGRKKKKRKKNE-----------SEEDSDFVQHDEEVEYPSTSK-----RGRKRKEEKQAAKEKE 116
            ....|.||:|.|           |.|..:||:.:|||...|.|:     .|:|:|::....|||:
Mouse    63 PKIPKSKRQKKERLLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKK 127

  Fly   117 SASSGMPSVED---------------VCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKE 166
            |.|......|:               :...:.:.:::..:|||:.::||.||||...|||::..:
Mouse   128 SKSKRKEEEEEEDEDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAK 192

  Fly   167 NPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQA---RSVTGDEPEEPRSSRSSRN 228
            |||||..|::|::.||||||..:||.....|.:..:..:|..|   ..||..|...|
Mouse   193 NPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPP-------- 249

  Fly   229 EKPDDIYEEAVEEEEEEEEEEKKPRRKRSG--RGKKGRRPS-GKVPTLKIKLLG---KRKRDSSD 287
              |..: |..:.:.:.:|.:....|||..|  |....::|. .||..|||||.|   ||||.||:
Mouse   250 --PPPV-EVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSE 311

  Fly   288 EEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIG 352
                       |.||:.|         :|..:|.::|.:.:....::...|     |||.:|.
Mouse   312 -----------DDDLDVE---------SDFDDASINSYSVSDGSTSRSSRS-----RKKLRTA-- 349

  Fly   353 NKFKKKNKLKKTKNFPEGEDG-EHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGK 416
             |.|||.:.:.|     ..|| |.:|||||||||||||||||||||||||:|||:|::::.||||
Mouse   350 -KKKKKGEEEVT-----AVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGK 408

  Fly   417 WSCPHCEADG-------------------GAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHT 462
            |||||||.:|                   |...||:||.|.||||||||||||||||:|||:||.
Mouse   409 WSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDPEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHI 473

  Fly   463 FCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQ--------RSNDDGPSTSKGSKNSNS 519
            .||||||..||:|:|.||||:||.|.||.:||:.|:|.|        |..|..|:|.........
Mouse   474 HCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGR 538

  Fly   520 RVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRH 584
            ..|::|:||..||||||.||.|:||::|..:|.|::|||.||:|||..:...||..:|.::
Mouse   539 PERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRK---- 599

  Fly   585 KDKVGMKANDDAEV--LEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEE 647
                    |.|.:.  :|||||:.|:||||:::.|::||...:.|...||:|||:||||:::||.
Mouse   600 --------NKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWES 656

  Fly   648 EGDDIQGLRQAIDY------YQDLRAVCTSETTQSRSKKSKKGRKSKL-KVEDDEDRPVKHYTPP 705
            |..:||      ||      |.:.|.:...|    ..:..||.:|.|| |:|           .|
Mouse   657 EDVEIQ------DYDLFKQSYWNHRELMRGE----EGRPGKKLKKVKLRKLE-----------RP 700

  Fly   706 PEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFL 770
            ||.||.|...|||.||.:|:.||..|||||:||:||||:||.||.|||||||||||||:||..||
Mouse   701 PETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFL 765

  Fly   771 YSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR- 834
            ||||||||.:|||||:.||||::|||||||:||||.|.:||:|||||||:|||||.|||:.|||
Mouse   766 YSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRG 830

  Fly   835 GSKVSRL-RTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIA 898
            |.|.||: :....||:|||||||||::|.|.|||||||.|:||||||||:|||||||:||.|::.
Mouse   831 GKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQ 895

  Fly   899 YKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKT 963
            :|||||||||||||||||||||||:.::|::|:.|..||||::||:|:|:||:|||||||||||.
Mouse   896 HKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKA 960

  Fly   964 DVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLF 1028
            ||.||||||:|.|||||||.||||:||:|||:|:||||::.||...||:|::|||||||||||||
Mouse   961 DVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLF 1025

  Fly  1029 PSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQ 1093
            |.||.||.....|:|:.::|.:|:|||:||.||||.||...||||||||||||||:||||||.|.
Mouse  1026 PVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEG 1090

  Fly  1094 YKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQ 1158
            ||||||||||||.:||||||||||||||||.||||||||||||||||||||||||||||||||||
Mouse  1091 YKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQ 1155

  Fly  1159 AFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILR 1223
            ||||||||||..||||||||||.|||||:|||||:||||||||||||:|.|..:.:||||||||:
Mouse  1156 AFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILK 1220

  Fly  1224 FGTEDLFKE-------DDKE----EAIHYDDKAVAELLDRTNRGIEEKE-SWANEYLSSFKVASY 1276
            ||||:|||:       |:||    ..|||||||:..||||.....|:.| ...||||||||||.|
Mouse  1221 FGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQY 1285

  Fly  1277 ATKE----EEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDG- 1336
            ..:|    ||||.|.|||||: |:.||.||.|||||||||.|||:.|:||||||:||||||.||
Mouse  1286 VVREEEMGEEEEVEREIIKQE-ESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGS 1349

  Fly  1337 ----GVV-------AADTTRD---------DSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAE 1381
                ||.       ...:||.         ..:|||:.|:..|:||..|:|  ||:|||:::.|.
Mouse  1350 QEDRGVCGRPRPPPTGRSTRAVGPAHLPSLPPDWQDDQSDNQSDYSVASEE--GDEDFDERSEAP 1412

  Fly  1382 RKAKRRLERRD-DRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLR 1445
            |:..|:..|.| |:||||||||||||||||||||||||:||||||||||||||||.:||||||||
Mouse  1413 RRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLR 1477

  Fly  1446 GKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHING 1510
            ||||:.||||||||||||||||||.|||||||||||||||||||||||||||||||||||||:||
Mouse  1478 GKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNG 1542

  Fly  1511 YYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDK 1575
            .:|||||     ..|....|.......:|.|     .:.:|.....|.|   |:|.|.:|.|...
Mouse  1543 RWSMPEL-----AEVEENKKMSQPGSPSPKT-----PTPSTPGDTQPNT---PAPVPPAEDGIKI 1594

  Fly  1576 DKDSEKEKDKTSAEKSEVKQ---EQEAEEDKKPGDVKQENPV-----EEAAGDTKPSDAEVKTEV 1632
            :::|.||::.|..|| |||.   |...|..:.|.......|.     |:.....:|.:.|.|.|
Mouse  1595 EENSLKEEESTEGEK-EVKSTAPEATVECAQPPAPAPATAPATATAPEDDKAPAEPPEGEEKVE- 1657

  Fly  1633 AKTEPKEETKDPEVKEEPKTEEK---EKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSAS 1694
             |.|.||.|::|     .:||.|   |.|||::|..:..|.::.:|.::....:|..::...:..
Mouse  1658 -KAEVKERTEEP-----METEAKGTTEVEKVEEKSAVDLTPIVVEDKEEKKEEEEKKDVMLQNGE 1716

  Fly  1695 SPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAA-VPGREYE 1758
            :|||.            :..|..::|    |::||||||||||||||:||.|||:|| |..:.||
Mouse  1717 TPKDL------------SDEKQKKNS----KQRFMFNIADGGFTELHSLWQNEERAATVTKKTYE 1765

  Fly  1759 IWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQA 1823
            ||||||||||||||:.|||.||||||||.|:||:|||||.::.:|||||||||||||||||||||
Mouse  1766 IWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQA 1830

  Fly  1824 LVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQL 1888
            ||||||||||||||:::|||||:|:||.|||||||||||||||||||:||||||||||||||.||
Mouse  1831 LVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQL 1895

  Fly  1889 EELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATA 1931
            ||||||||:||:|||||:|||||||.|||||||:||||||..|
Mouse  1896 EELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRA 1938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335	25/51 (49%)
		PHD1_CHD_II	380..422	CDD:277006	34/41 (83%)
		PHD2_CHD_II	440..482	CDD:277007	32/41 (78%)
		CHROMO	490..558	CDD:237991	29/75 (39%)
		CHROMO	615..667	CDD:214605	21/57 (37%)
		SNF2_N	734..1028	CDD:278600	214/295 (73%)
		DEXDc	751..907	CDD:238005	115/157 (73%)
		Helicase_C	1053..1167	CDD:278689	101/113 (89%)
		DUF1087	<1292..1337	CDD:283996	33/49 (67%)
		DUF1086	1380..1517	CDD:283992	118/137 (86%)
		CHDCT2	1756..1927	CDD:285336	145/170 (85%)
Chd4	XP_006505344.1	CHDNT	164..217	CDD:369683	25/52 (48%)
		PHD1_CHD_II	372..414	CDD:277006	34/41 (83%)
		PHD2_CHD_II	451..493	CDD:277007	32/41 (78%)
		CD1_tandem_CHD3-4_like	498..576	CDD:349314	30/77 (39%)
		CD2_tandem_CHD3-4_like	619..673	CDD:349309	24/59 (41%)
		PLN03142	724..>1281	CDD:215601	403/556 (72%)
		DEXHc_CHD4	726..957	CDD:350814	167/230 (73%)
		DUF1087	1302..1351	CDD:368924	36/49 (73%)
		DUF1086	1413..1549	CDD:368921	117/135 (87%)
		DUF4775	<1564..>1682	CDD:374284	39/133 (29%)
		CHDCT2	1764..1934	CDD:369684	145/169 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I537
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2023	1.000	Inparanoid score	I51
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46056
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm42760
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	LDO	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4509
SonicParanoid	1	1.000	-	-		X547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910