Protein Alignment Mi-2 and ercc6l2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001362231.1
• Gene: ercc6l2 / 100127871
• XenbaseID: XB-GENE-952480
• Length: 1397
• Species: Xenopus tropicalis
• Alignment Length: 1193
• Identity: 285/1193 - (23%)
• Similarity: 470/1193 - (39%)
• Gaps: 309/1193 - (25%)

  Fly   693 DDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQ--------LHPYQIEGINWLRYSWGQG 749
            ||||.....:  |..:|...|    |:.|  |..|.:.        |..||.:||.:|...:.:.
 Frog    78 DDEDLEKPFF--PDRRPHGPL----ENFP--LSNTAVSVPYTINRYLRDYQRDGITFLYKHFSRS 134

  Fly   750 IDTILADEMGLGKTIQTVTFLYS-LYKEGH-------------------C-----RGPFLVAVPL 789
            :..||.|:||||||||.:.||.: |.|:|.                   |     :..||:..||
 Frog   135 VGCILGDDMGLGKTIQVIAFLAAILGKKGTREDIENNMPEFLLRTVKKVCSSSSPKKVFLIVSPL 199

  Fly   790 STLVNWEREFELWAPDFYCITYI-GDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLT 853
            |.|.||:.|.|.|.  ::.:|.| |:|                  :.|::|||:  |.||.:.||
 Frog   200 SVLYNWKDELETWG--YFRLTLIHGNK------------------KDSEISRLK--QGKFEIALT 242

  Fly   854 SYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHL 918
            :||.:.:....:.||||:.:||||.||:|:.:::..:::.......::.||||.||||:|||:.:
 Frog   243 TYETLRLCLDEINSIDWSAVVVDEVHRIKNPKARVTQVMKEIRCKVRIGLTGTILQNNMEELWCV 307

  Fly   919 LNFL----------SRDKFNDLQAFQGEFADVSKEE------QVKRLHEMLGPHMLRRLKTDVLK 967
            :::.          .::||::...: |:..:.:|.|      .::.|...|.|..|||.|..:.:
 Frog   308 MDWAVPGYLGSSSQFKEKFSNPVEY-GQRHNATKRELATGRKAIQTLANKLSPFFLRRTKALISQ 371

  Fly   968 NMPSKSEFIVRVELSAMQKKFYKFIL-TKNYEALNSKSGGGSCS--------------------- 1010
            .:|.|.:.|:...||..||..|:.:| |::...:  ..||..||
 Frog   372 QLPKKEDRIIFCSLSEFQKAVYQTVLETQDVNLV--LQGGEPCSCKSGRKRRKCCYKENMFGESV 434

  Fly  1011 ---LINIMMDLKKCCNHPYL-------------------------FPSAAEEATTAAGGLYEINS 1047
               ..:.:..|:|..||..|                         ||....::..||   :|..|
 Frog   435 RTLYFSYLAILRKVANHAALLQTDTSTSKKQEAHIKRVCNEVFSKFPEFVRQSKDAA---FETLS 496

  Fly  1048 LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAI 1112
            ..:.:||:.:|.::|...:....:||:||..||:||:||.:.......|.|:||......|.:.:
 Frog   497 NPRYSGKMKVLQQLLNHCRKNKDKVLLFSFSTKLLDVLERYSMASGLDYRRLDGNTKAEERMKIV 561

  Fly  1113 DRFNAPGAQQF-VFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYR 1176
            ..||.  .|.. :.|:||.|||||:|...|:.|:::|..|||.||:||..||:||||...|.::|
 Frog   562 KEFNT--MQDVNICLVSTMAGGLGLNFIGANVVVVFDPTWNPANDLQAIDRAYRIGQCRDVKVFR 624

  Fly  1177 FVTRNSVEERV--TQVAKRKMMLTHLVV------RPGMGGKGANFTKQELDDILRFGTEDLFKED 1233
            ||:..:|||.:  .||.|:::...  ||      |.....:|:...|.||     ||..:|||..
 Frog   625 FVSLGTVEEMIYLRQVYKQQLQCA--VVGSENAKRYFEAVQGSKEHKGEL-----FGVNNLFKLR 682

  Fly  1234 DKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSS---------------------------- 1270
            .:...:..|      :|:| .:.:|:..:.|:.|:|.
 Frog   683 PQGSCLTRD------ILER-EKQVEDGVTSASMYVSQTPVTVDTEMGADIDSDDPKVGAKHCQRF 740

  Fly  1271 FKVAS--YATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHY---------------------EQ 1312
            ||.::  :::..:||...|.::|.....|:.....:|..|.|                     |.
 Frog   741 FKESTFDFSSDSDEETNGTSVMKPSKMPSNSDNRRQLTLHQYGFSKMLEREITTDNKKTSLPGES 805

  Fly  1313 HQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSN----------WQDNGSEYNSEYSAGSDE 1367
            :...:..::..||:..:.|...:..|...:.:.|:|.          .||.|.:. |.....::.
 Frog   806 NTSILNVNMSSGKKSSRTVLENENVVSETEYSSDESGEDIVLSTQVCKQDKGKKI-SIIKCIAES 869

  Fly  1368 DGGDDDFDDQNGAERKAKRR-----LERRDDRPLPPL------------------LARVGGNIEV 1409
            |..|.|.|..:...|:....     .:..||..:|..                  .|:....|||
 Frog   870 DSSDIDLDTSDNTNRQPVNSSCDDISDESDDIEIPNKYRSGNTGKLKDSFNNKYDAAKDSQTIEV 934

  Fly  1410 LGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETF 1474
            ...:.........:...|...||.:.|.:..:...:.|::..|:              ...|.|.
 Frog   935 FTSSDDDNLQIKKSSPSYEDTPQKSSNLRMHMESRKRKNKSVFQ--------------IKKAITH 985

  Fly  1475 ADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSA--LKQDVAALE 1537
            .:||...|.|...||..:..::.|...    :|:.|.......:.:  ..||..  ||| .:.|.
 Frog   986 QEGVKYNGSSLDKVLDGVEGVAYIHSN----QHVVGSSKAENQLSR--WAVRDVFELKQ-FSQLP 1043

  Fly  1538 APPTGGNVDKSATTSNSVTP--------ATSAAPS---PAPASEK------------GEDKDKDS 1579
            |..|...:.||...|:.:||        .|.:.|.   |....:|            ||......
 Frog  1044 ANITPLKITKSEYVSDKMTPLRKTEKDLETKSYPMLQYPVTHQQKKVHRVGKTTFLVGETPKALQ 1108

  Fly  1580 EKEKDKTSAEKSEVKQEQEAEE-DKKPGDVKQENPVEE-------AAGDTKPSDAEVKTEVAKTE 1636
            .|:..:.:|..:....||.|.. .....||:| |.:.|       .||:..|..|:::.
 Frog  1109 RKQFQEMAAHFNMASAEQFAHHISSVKSDVRQ-NMLREYYISKYSEAGELYPVQAQLEL------ 1166

  Fly  1637 PKEETKDPEVKEEPKTEEKEKEK 1659
              :|.|:.:.||:.|...|.::|
 Frog  1167 --QEDKEHKTKEQGKLATKRRQK 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309
		PLN03142	720..>1234	CDD:215601	180/622 (29%)
		DUF1087	<1292..1334	CDD:461922	8/62 (13%)
		CHDII_SANT-like	1380..1517	CDD:461920	25/159 (16%)
		CHDCT2	1757..1902	CDD:462358
ercc6l2	NP_001362231.1	Tudor_ERCC6L2	11..66	CDD:410471
		HepA	<78..651	CDD:440319	177/612 (29%)
		DEXHc_ERCC6L2	116..364	CDD:350763	80/270 (30%)
		VIGSSK	<1005..1030	CDD:464308	3/30 (10%)