DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp32 and USP3

DIOPT Version :9

Sequence 1:	NP_001262074.2	Gene:	Usp32 / 40169	FlyBaseID:	FBgn0036913	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_006528.2	Gene:	USP3 / 9960	HGNCID:	12626	Length:	520	Species:	Homo sapiens

Alignment Length:	420	Identity:	101/420 - (24%)
Similarity:	159/420 - (37%)	Gaps:	143/420 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   635 SRLATVRQVGEFLCEQLRLKSEDIRLWHVPQLDNGAILLEEDAMCLKELLIRDNDQL---LLEIR 696
            ::|..|::|.|                |:..|:|.|...:..    |:..:.:|..|   ||::.
Human   106 TKLGLVQKVRE----------------HLQNLENSAFTADRH----KKRKLLENSTLNSKLLKVN 150

  Fly   697 NKDLTWPEELGSLATAQCGQGAGTPGDRRRLTRSSIMSVHAPGATGLHNLGNTCFMNAALQVLFN 761
                      || .||.|                         ||||.||||||||||.||.|.|
Human   151 ----------GS-TTAIC-------------------------ATGLRNLGNTCFMNAILQSLSN 179

  Fly   762 TQPLAQYFQREMHRFEVNAANKLG-----TKGQ------LAMRYAELLKEVWTATTRSVAPLKLR 815
            .:....|| :|:...|:......|     |:.|      |...:.:.|..:|..:..:.:|..|.
Human   180 IEQFCCYF-KELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLF 243

  Fly   816 FCVNKYAPQFAGGGQHDSQELLEWLLDALHEDL----NRVMEKPYSELKDSNGRPDKIVAAEAWS 876
            :.|.|..|.|.|..|.|:.|.:.:|||.||.:|    |.|......:...:....:|.....|
Human   244 YVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGA-- 306

  Fly   877 QHHARNQSIIIDLFYGQLKSKVSCLGCGHESVRFDPFSLLSLPLPVENYIYFEVLVILLDGSVPI 941
                  .:::..:|.|.|:::|:||.||.||.:||||..|||.:|
Human   307 ------STVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIP-------------------- 345

  Fly   942 KYGFRLNSDCKYSHLKHKLS------TMCSLPPNLMLVCELWNSQIRQVLNDDE-------KLRT 993
                        |..:.|.|      .:|||...|....:|      :.|::.|       |.:.
Human   346 ------------SQFRSKRSKNQENGPVCSLRDCLRSFTDL------EELDETELYMCHKCKKKQ 392

  Fly   994 QSAKELYVYQLPEQSMRTRSNSGLSMHIEQ 1023
            :|.|:.::.:||:.         |.:|:::
Human   393 KSTKKFWIQKLPKV---------LCLHLKR 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp32	NP_001262074.2	FRQ1	186..317	CDD:227455
		UBP12	486..>1002	CDD:227847	97/397 (24%)
		Peptidase_C19	<1480..1737	CDD:351799
USP3	NP_006528.2	zf-UBP	29..105	CDD:307999
USP3	NP_006528.2	UCH	159..508	CDD:306860	82/311 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910